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Prediction of chemical short-range order in high-/medium-entropy alloys

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Journal of Materials Science & Technology 2024年第2期169卷 115-123页

作者： Pei-Yu Cao Jing Wang Ping Jiang yun-Jiang Wang Fu-Ping Yuan Xiao-Lei wu State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of ScienceBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Chemical short-range orders(CSROs),as the built-in sub-nanoscale entities in a high-/medium-entropy alloy(H/MEA),have aroused an ever-increasing *** multi-principal elements in an H/MEA to form a complex concentrated solution,a variety of sub-systems of species exist to induce the metastable ordered compounds as candidates for ultimate *** issues remain pending on the origin of CSROs as to how to judge if CSRO will form in an H/MEA and particularly,what kind of CSROs would be stably produced if there were multiple ***,the first-principles method,along with the proposed local formation energy calculation in allusion to the atomic-scale chemical heterogeneities,is used to predict the CSRO formation based on the mechanical stability,thermodynamic formation energy,and electronic *** simulations are detailed in an equiatomic ternary VCoNi MEA with three kinds of potential compounds,i.e.,L1_(1),L1_(2),and B2,in the face-centered cubic *** turns out that L1_(1)is stable but hard to grow up so as to become the final CSRO.L1_(1)is further predicted as CSROs in CrCoNi,but unable to form in FeCoNi and CrMnFeCoNi *** predictions are consistent with the experimental *** findings shed light on understanding the formation of *** method is applicable to other H/MEAs to design and tailor CSROs by tuning chemical species/contents and thermal processing for high performance.

关键词： Short-range order High-entropy alloy Microstructure First-principles calculation Gibbs free energy Local electronic density of states

Understanding the Thermal Impedance of Silicone Rubber/Hexagonal Boron Nitride Composites as Thermal Interface Materials

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Chinese Journal of Polymer Science 2024年第3期42卷 352-363,I0008页

作者： Yuan Ji Shi-Da Han Hong wu Shao-yun Guo Feng-Shun Zhang Jian-Hui Qiu The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyPolymer Research InstituteSichuan UniversityChengdu 610065China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Department of Mechanical Engineering Faculty of Systems Science and TechnologyAkita Prefectural UniversityAkita 015-0055Japan

Silicone rubber(SR) composites are most widely used as thermal interface materials(TIMs) for electronics heat dissipation. Thermal impedance as the main bottleneck limiting the performance of TIMs is usually neglected. Herein, the thermal impedance of SR composites loaded with different levels of hexagonal boron nitride(h-BN) as TIMs was elaborated for the first time by the ASTM D 5470 standard test and finite element analysis. It was found that elastic modulus and surface roughness of SR composites increased with the increase of h-BN content, indicating that the conformity was reduced. When the assembly pressure was 0.69 MPa, there existed an optimal h-BN content at which the contact resistance was minimum(0.39 K·cm^(2)·W^(-1)). Although the decreased bond line thickness(BLT) by increasing the assembly pressure was beneficial to reduce the thermal impedance, the proper assembly pressure should be selected to prevent the warpage of the contact surfaces and the increase in contact resistance, according to the compression properties of the SR composites. This study provides valuable insights into fabrication of high-performance TIMs for modern electronic device applications.

关键词： Thermal interface materials Hexagonal boron nitride Thermal impedance Surfaces

Development of antibody-drug conjugates in cancer:Overview and prospects

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Cancer Communications 2024年第1期44卷 3-22页

作者： Dan-yun Ruan Hao-Xiang wu Qi Meng Rui-Hua Xu Department of Clinical Research Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhouGuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China

In recent years,remarkable breakthroughs have been reported on antibody-drug conjugates(ADCs),with 15 ADCs successfully entering the market over the past *** substantial development has positioned ADCs as one of the fastest-growing domains in the realm of anticancer drugs,demonstrating their efficacy in treating awide array of ***,there is still an unmet clin-ical need forwider application,better efficacy,and fewer side effects of *** ADC generally comprises an antibody,a linker and a payload,and the combina-tion has profound effects on drug structure,pharmacokinetic profile and ***,optimization of the key components provides an opportunity to develop ADCs with higher potency and fewer side *** this review,we comprehen-sively reviewed the current development and the prospects of ADC,provided an analysis of marketed ADCs and the ongoing pipelines globally as well as in China,highlighted several ADC platforms and technologies specific to different pharmaceutical enterprises and biotech companies,and also discussed the new related technologies,possibility of next-generation ADCs and the directions of clinical research.

关键词： companies breakthrough payload

Improving flight performance of UAVs by ice shape modulation

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Chinese Journal of Aeronautics 2024年第8期37卷 49-62页

作者： Jiajun ZHANG Xuecheng LIU Hua LIANG Like XIE Biao WEI Haohua ZONG yun wu Yinghong Li National Key Lab of Aerospace Power System and Plasma Technology Air Force Engineering UniversityXi’an 710038China Institute of Aero-Engine School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

Aircraft icing poses a great threat to flight *** response to the characteristics of high-power consumption,large volume,and heavy weight of traditional anti-/de-icing technologies,the concept of ice shape modulation is proposed,which is called ice tolerant ***,the flight performance of Unmanned Aerial Vehicle(UAV)was compared in three states:no ice,full ice,and modulated ice through flight *** was found that ice shape modulation has a significant improvement effect on the aerodynamic performance of aircraft under icing *** the three modulated ice shape conditions in this experiment,the lift coefficient of the UAV under different ice shape modulation conditions increased by 18%–33%,and the stalling angle was delayed by 3°-5°.Subsequently,the pressure distribution,streamlines in the flow field,and detached vortex distribution of the UAV model in these three states were obtained through numerical simulation,to study the mechanism of ice shape modulation on the aerodynamic performance of *** simulation found that the reason for the improvement of the wings effect after ice shape modulation is that the modulated area forms a leading-edge protrusion structure similar to a vortex *** structure prolongs the mixed flow region on the wings surface and reduces the trend of flow separation,which plays a role in increasing lift and reducing drag for UAVs under icing ***,a reverse reachable set that can be used for unexpected state recovery is used as the definition of flight safety boundaries,and an aircraft dynamics model is established to obtain flight safety boundaries for different *** has found that the flight safety boundary of the UAV in a no ice state is greater than that in a modulated ice state,and the safety boundary in a modulated ice state is greater than that in a full ice *** with the full ice state,the flight safety boundary after modulation has expanded by 27.0%.The sch

关键词： Ice shape modulation Aerodynamic performance Reachable set Flight safety UAV

Molecular cloning,characterization and promoter analysis of LbgCWIN1 and its expression profiles in response to exogenous sucrose during in vitro bulblet initiation in lily

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Horticultural Plant Journal 2024年第2期10卷 545-555页

作者： Cong Gao Shiqi Li yunchen Xu Yue Liu Yiping Xia Ziming Ren yun wu Genomics and Genetic Engineering Laboratory of Ornamental Plants Institute of Landscape ArchitectureCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhouZhejiang 310058China Laboratory of Flower Bulbs Department of Landscape ArchitectureSchool of Civil Engineering and ArchitectureZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China

Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellular space, are key enzymes participating in sucrose allocation in higher plants. Previous studies have shown that CWINs play an essential role in bulblet initiation process in bulbous crops, but the underlying molecular mechanism remains unclear. Here, a CWIN gene of Lilium brownii var. giganteum(Lbg) was identified and amplified from genomic DNA. Quantitative RT-PCR assays revealed that the expression level of LbgCWIN1 was highly upregulated exactly when the endogenous starch degraded in non-sucrose medium during in vitro bulblet initiation in Lbg. Phylogenetic relationship, motif, and domain analysis of LbgCWIN1 protein and CWINs in other plant species showed that all sequences of these CWIN proteins were highly conserved. The promoter sequence of LbgCWIN1 possessed a number of alpha-amylase-, phytohormone-, light-and stress-responsive cis-elements. Meanwhile, β-glucuronidase(GUS) assay showed that the 459 bp upstream fragment from the translational start site displayed maximal promoter activity. These results revealed that LbgCWIN1 might function in the process of in vitro bulblet initiation and be in the response to degradation of endogenous starch.

关键词： Lilium brownii var.giganteum LbgCWIN1 Phylogenetic analysis Promoter analysis Bulblet initiation

Vision Transformers with Hierarchical Attention

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Machine Intelligence Research 2024年第4期21卷 670-683页

作者： yun Liu Yu-Huan wu Guolei Sun Le Zhang Ajad Chhatkuli Luc Van Gool Institute for Infocomm Research(I2R) A*STARSingapore 138632Singapore Institute of High Performance Computing(IHPC) A*STARSingapore 138632Singapore Computer Vision Lab ETH ZürichZürich 8092Switzerland School of Information and Communication Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 611731China

This paper tackles the high computational/space complexity associated with multi-head self-attention(MHSA)in vanilla vision *** this end,we propose hierarchical MHSA(H-MHSA),a novel approach that computes self-attention in a hierarchical ***,we first divide the input image into patches as commonly done,and each patch is viewed as a ***,the proposed H-MHSA learns token relationships within local patches,serving as local relationship ***,the small patches are merged into larger ones,and H-MHSA models the global dependencies for the small number of the merged *** last,the local and global attentive features are aggregated to obtain features with powerful representation *** we only calculate attention for a limited number of tokens at each step,the computational load is reduced ***,H-MHSA can efficiently model global relationships among tokens without sacrificing fine-grained *** the H-MHSA module incorporated,we build a family of hierarchical-attention-based transformer networks,namely *** demonstrate the superiority of HAT-Net in scene understanding,we conduct extensive experiments on fundamental vision tasks,including image classification,semantic segmentation,object detection and instance ***,HAT-Net provides a new perspective for vision *** and pretrained models are available at https://***/yun-liu/HAT-Net.

关键词： Vision transformer hierarchical attention global attention local attention scene understanding.

Neuroimmune interactions and their roles in neurodegenerative diseases

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Fundamental Research 2024年第2期4卷 251-261页

作者： Bai-Rong Chen Ting wu Ting-Hui Chen yun Wang Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesKey Laboratory for NeuroscienceMinistry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

The nervous system possesses bidirectional,sophisticated and delicate communications with the immune *** neuroimmune interactions play a vitally important role in the initiation and development of many disorders,especially neurodegenerative *** scientific advancements have made tremendous progress in this field during the last few years,neuroimmune communications are still far from being *** organizing recent research,in this review,we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral *** these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains *** will also facilitate a view of the diseases from a holistic,pluralistic and interconnected perspective,thus providing a basis of developing novel and effective methods to diagnose,intervene and treat diseases.

关键词： Nervous system Immune system Neuroimmune interactions Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis

Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase

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Science China Chemistry 2024年第7期67卷 2382-2391页

作者： Ke-Wei Chen Jia-Nan Chen Jun Zhang Chao Wang Tian-Yu Sun yun-Dong wu Key Laboratory of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicSchool of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Changping Laboratory Beijing 102200China

Fluoroacetate dehalogenases(FAcD),a homodimeric enzyme,catalyzes the conversion of fluoroacetic acid to glycolic acid(GoA).It has been proved that the enzyme has a half-of-the-site ***,its catalytic(C)subunit converts the first substrate to a covalent intermediate;then,the non-catalytic(NC)subunit binds a second substrate and promotes the conversion of the intermediate in the C subunit into the final *** the release of the product,the C subunit becomes the NC subunit,and the previous NC subunit becomes the C *** elucidate the detailed mechanism behind this cooperative catalysis,we have conducted microsecond-scale MD simulations along the reaction *** simulations indicate that the substrate in the NC subunit induces W185 and Y141 adopting an open conformation in the C *** opening of W185(C)facilitates the entry of catalytic water,enhancing the catalytic activity for product formation,while the opening of Y141(C)creates an unfavorable environment for product binding,promoting its *** interaction network analysis reveals that the substrate in the NC subunit can induce conformational changes through a conserved water chain at the interface.

关键词： enzyme catalysis molecular dynamics cooperative effect pre-reaction state

Stackelberg Game-Based Optimal Dispatch for PEDF Park and Power Grid Interaction under Multiple Incentive Mechanisms

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Energy Engineering 2024年第10期121卷 3075-3093页

作者： Weidong Chen yun Zhao Xiaorui wu Ziwen Cai Min Guo Yuxin Lu Integrated Energy Research Institute Electric Power Research Institute of Guangxi Power Grid Co.Ltd.Nanning530023China Guangxi Key Laboratory of Intelligent Control and Maintenance of Power Equipment Nanning530023China Institute of Electricity Consumption and Measurement Technology CSG Electric Power Research InstituteGuangzhou510663China

The integration of photovoltaic,energy storage,direct current,and flexible load(PEDF)technologies in building power systems is an importantmeans to address the energy crisis and promote the development of green *** friendly interaction between the PEDF systems and the power grid can promote the utilization of renewable energy and enhance the stability of the power *** this purpose,this work introduces a framework of multiple incentive mechanisms for a PEDF park,a building energy system that implements PEDF *** incentive mechanisms proposed in this paper include both economic and noneconomic aspects,which is the most significant innovation of this *** modeling the relationship between a PEDF park and the power grid into a Stackelberg game,we demonstrate the effectiveness of these incentive measures in promoting the friendly interaction between the two *** this game model,the power grid determines on the prices of electricity trading and incentive subsidy,aiming to maximize its revenue while reducing the peak load of the PEDF *** the other hand,the PEDF park make its dispatch plan according to the prices established by the grid,in order to reduce electricity consumption expense,improve electricity utility,and enhance the penetration rate of renewable *** results show that the proposed incentive mechanisms for the PEDF park can help to optimize energy consumption and promote sustainable energy practices.

关键词： Demand response(DR) incentives photovoltaic energy storage direct current and flexible load(PEDF) reputation Stackelberg game