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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu xia Wenting Ye Yan Sun Jing Cai Fubing yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Prospects on mangrove knowledge services in the smart era: From plant atlas to knowledge graphs

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Science China Earth Sciences 2025年第1期 111-127页

作者： Zhi-Wei hou Wenlong JING Cheng-Zhi QIN Ji YANG Qing xia xiaoling YIN Key Laboratory of Guangdong for Utilization of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and Application Guangzhou Institute of Geography Guangdong Academy of Sciences Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences School of Traffic & Transportation Engineering Changsha University of Science and Technology

Mangroves are crucial to the ecological security of the Earth and human well-being. Their management, conservation, and restoration are of great importance and necessitate the support of spatio-temporal information and multidisciplinary knowledge such as biology and ecology. Traditional knowledge services such as plant atlas provide illustrated textual knowledge of mangroves. However, this kind of service is oriented to information retrieval and is incapable of effectively mining and utilizing fragmented knowledge from multi-source heterogeneous data, facing the problem of “massive data, rare knowledge”. Knowledge graphs are capable of extracting, organizing, and fusing the knowledge contained in massive data into semantic networks that can be understood and computed by computers. They provide a solution for the realization of intelligent knowledge services. Focusing on the urgent need for mangrove knowledge acquisition, formal representation, and intelligent services, this paper proposes a research prospect on mangrove knowledge graphs and knowledge services. We first analyze the similarities and differences between various domain-specific concepts of Tupu. On this basis, we define the mangrove knowledge graph as a large-scale knowledge base that integrates multi-disciplinary knowledge and spatio-temporal information with mangrove ecosystems as the core. Then, we propose a research framework for mangrove knowledge services that can realize the transformation from multi-modal data to intelligent knowledge services, including multiple research levels such as ubiquitous data sensing and aggregation, knowledge organization and graph construction, and intelligent mangrove knowledge services. Subsequently, the methods and workflow for constructing mangrove knowledge graphs are introduced. Finally, we discuss the challenges and possible future directions of mangrove knowledge services in the smart era, including the construction of a mangrove knowledge system that integra

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数字化头影测量在正畸实践教学中的应用

医学教育研究与实践 2019年第5期27卷 863-866页

作者：侯玉霞付丹蓉李海振王菲管丽敏苏晓霞西安交通大学口腔医院正畸科

目的在正畸头影测量的实践教学中应用数字化软件作为教学方法,探索数字化头影测量技术在实践教学中应用的可行性和教学效果。方法在西安交通大学口腔医院120名本科生及参加口腔正畸临床培训的学生中,利用Dolphin数字化头影测量软件进行S... 详细信息

目的在正畸头影测量的实践教学中应用数字化软件作为教学方法,探索数字化头影测量技术在实践教学中应用的可行性和教学效果。方法在西安交通大学口腔医院120名本科生及参加口腔正畸临床培训的学生中,利用Dolphin数字化头影测量软件进行Steiner、Tweed、Wits等分析法的实践教学,每位学生同时进行传统和数字化头影描绘和测量,回收实验报告及调查问卷,评估数字化头影测量在实践教学中的教学质量及满意度。结果每位同学都能完成实践课程要求内容,实验报告合格率为100%。从完成质量来看,头影描图质量评分没有差异(P>0.05)。常用的头影测量Steiner、Tweed、Wits分析法的测量准确度评分两者也没有差异(P>0.05)。头影测量完成时间两者具有统计学差异(P<0.001),数字化头影测量速度更快。调查问卷发出120份,回收120份,回收率为100%。学生对于教学效果,学习收获和满意度方面评价均高于91%。96.6%的学生认为数字化教学相较于传统的临床教学更适合于头影测量内容的学习;96.6%的学生对Dolphin软件中头影测量相关功能非常感兴趣;100%的学生认为数字化技术可以大大简化繁重的临床工作,并表示将在以后的头影测量描记过程中尽可能使用数字化技术。结论 Dolphin软件在数字化头影测量教学中取得了很好的教学效果和学生满意度,为口腔正畸学数字化教学提供了宝贵经验,值得进一步完善及推广。

关键词：口腔正畸学数字化头影测量实践教学

Multi-temporal remote sensing of land cover change and urban sprawl in the coastal city of Yantai, China

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International Journal of Digital Earth 2013年第S02期6卷 137-154页

作者： Xinyang yu Anding Zhang Xiyong hou Mingjie Li Yingxiao xia Department of Geography and Planning Ludong UniversityYantaiP.R.China Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantaiP.R.China Optical Remote Sensing Department Institute for Coastal Research of Helmholtz-Zentrum GeesthachtCenter for Materials and Coastal ResearchGeesthachtGermany Branch of Yantai Land and Resource Bureau MupingP.R.China

The importance of accurately mapping and monitoring land cover changes over time is increasing,especially in rapidly growing coastal *** this study,three pairs of Landsat images of Yantai,a representative coastal city in China,from 1989,1999,and 2009 were selected to monitor land cover changes and urban sprawl *** improve the classification accuracy,three classification methods together with the minimum noise fraction(MNF)and pixel purity index(PPI)calculations were performed on the *** classification results showed that the overall five-class classification accuracies averaged 91.38%for the 20-year period,which produced an accuracy of 83.78%for change *** analysis of change maps indicated that from 1989 to 2009,the percentage of urban area increased from 31.41%to 50.28%of the total area,and the newly urbanized area was mainly located in residential areas and the reclaimed harbor *** of the relationships between urban area and its driving forces obtained from statistical data found that the urban sprawl of Yantai before 2000 was relatively extensive,which is consistent with the conclusion drawn by using remote sensing *** research results could be used as inputs for sustainable urban management and establishing Digital Earth database.

关键词： land cover change urban sprawl multi-temporal remote sensing coastal city

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研究生助教参与正畸学实验教学模式探讨

中国美容医学 2020年第2期29卷 131-134页

作者：王芮韩丽仙储光吉玲玲侯玉霞郭昱成陕西省牙颌疾病临床研究中心陕西西安710004 西安交通大学口腔医院正畸科陕西西安710004 宁夏盐池县人民医院口腔科宁夏盐池751500

目的:通过探讨西安交通大学口腔正畸学实验课研究生助教模式,对今后正畸学实验教学管理及研究生助教的施行提出一些建议,充分发挥研究生助教模式在正畸学实验教学中的作用。方法:对西安交通大学口腔医学专业完成正畸课程的在读本科四年... 详细信息

目的:通过探讨西安交通大学口腔正畸学实验课研究生助教模式,对今后正畸学实验教学管理及研究生助教的施行提出一些建议,充分发挥研究生助教模式在正畸学实验教学中的作用。方法:对西安交通大学口腔医学专业完成正畸课程的在读本科四年级学生(n=44)和正畸学专业二、三年级的研究生助教(n=18)分别就该模式授课好评度、最喜欢的课程内容和总体评价等内容进行问卷调查。结果:本科生对以研究生助教为主的教学模式和以教师为主的教学模式总体好评率分别为85.45%和86.82%,差异不具有统计学意义(P>0.05)。研究生助教为主的教学模式不足之处主要在于研究生的答疑水平和激发学习积极性的能力与教师水平之间存在差异。结论:研究生助教不仅补充了紧缺的教师资源,并且也很大程度地提升了研究生科研和逻辑思维能力。弥补了本科生实验课师生资源的不平衡问题,优化本科生教学质量,同时提高在读研究生综合素质,需要完善对研究生助教的指导、管理和考核,进一步提升正畸学实验课教学质量。

关键词：口腔正畸学研究生助教模式实验教学教学模式

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数字化正畸平台在正畸学临床教学中的应用

中国美容医学 2019年第8期28卷 147-150页

作者：王菲黄倩倩李海振郭昱成王爽侯玉霞西安交通大学口腔医院正畸科陕西省颅颌面精准医学研究重点实验室

目的:探讨Ortholink优领数字化正畸平台对正畸学临床教学效果的影响,为提高正畸学临床教学质量提供依据和建议。方法:采用随机分组设计的教学实验,将口腔正畸科2017及2018届研究生共30名,分为对照组15名和实验组15名。对照组实施传统的... 详细信息

目的:探讨Ortholink优领数字化正畸平台对正畸学临床教学效果的影响,为提高正畸学临床教学质量提供依据和建议。方法:采用随机分组设计的教学实验,将口腔正畸科2017及2018届研究生共30名,分为对照组15名和实验组15名。对照组实施传统的临床病例教学模式,实验组将Ortholink优领数字化正畸平台融入临床病例教学。教学效果评估采用理论知识考核及临床实践能力考核、问卷调查(满意度)方式进行。结果:实验组实践技能考核成绩中病例分析得分高于对照组,差异有统计学意义(P0.05)。实验组理论知识掌握方面满意度与对照组比较,差异无统计学意义(P>0.05);但临床思维培养、新进展了解掌握满意度高于对照组(P<0.05);激发学习兴趣满意度显著高于对照组(P<0.01);临床技能掌握满意度低于对照组(P<0.05)。结论:Ortholink优领数字化正畸平台融入传统正畸临床教学能够促进正畸研究生临床教学,但其在临床检查及临床技能掌握方面还存在一些问题,需要进一步改善。

关键词：数字化正畸 Ortholink优领数字化正畸平台临床教学问卷调查临床思维实践技能

Intrinsic conductive cellulose nanofiber induce room-temperature reversible and robust polyvinyl alcohol hydrogel for multifunctional self-healable biosensors

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Nano Research 2023年第2期16卷 3156-3167页

作者： Zhouyu Miao Yi Song Yanjuan Dong Dan Ge JiaXin Shui xia He hou-Yong yu The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education Zhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Sci-Tech University Huzhou Research Institute Co. LTDHuzhou 313000China

Polyvinyl alcohol(PVA)hydrogels are widely used for flexible sensors by adding various conductive substances due to their excellent mechanical properties and self-healing ***,most of the conductive substances added to PVA hydrogel sensors are currently complicated to prepare,costly,and environmentally ***,to overcome this challenge,we successfully prepared intrinsic conductive cellulose nanofiber(G-CNF)by simply applying sulfuric acid and a low-energy water bath with heat treatment,and obtained a powerful multifunctional self-healing PGC hydrogel biosensor using dynamic chemical cross-linking of PVA and borax with glycerol and *** obtained PGC hydrogels have excellent mechanical properties(strain:950%),good adhesion ability,robust self-healing properties,and room-temperature reversibility,due to the presence of conductive networks and hydrogen bonds within PGC ***,PGC hydrogels with the graphene structured G-CNF have a fast response to various signals and good stability with gauge factor(GF)values up to 1.83,as well as a sensitive response to temperature(temperature coefficient of resistance(TCR)up to 1.9),which can be designed as a variety of biosensors,such as human motion monitoring,information encryption/transmission,and real-time temperature monitoring ***,PGC hydrogels as multifunctional self-healing hydrogel biosensors pave the way for the development of flexible biosensors in wearable devices,human–computer interaction,and artificial-related applications.

关键词： polyvinyl alcohol(PVA)hydrogels conductive cellulose nanofiber conductive network multifunctional biosensor

Optimization of group control strategy and analysis of energy saving in refrigeration plant

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Energy and Built Environment 2022年第4期3卷 525-535页

作者： Tu Daixin xia Hongwei Yin Huijuan yu Hao hou Wen Tianjin University Research Institute of Architechtural Design&Urban Planning Tianjin 300073PR China Beijing Johnson Control Co. LtdBeijing 100000PR China

This study proposes a group control system optimization strategy coupled with a refrigeration plant model for a primary pump variable flow system,in order to improve the automation level of the refrigeration plant and maximize the energy saving ***,the control variables,optimization objectives,and operational con-straints of the entire system were ***,by collecting the operational data for each component and combining these data with theoretical analysis,the sub models were designed and the input parameters,output parameters,and optimization variables of each sub-model were ***,the sub-models were coupled and the control variables of the operational combination,leading to the lowest overall system energy consumption,were obtained using a particle swarm optimization ***,considering a medical building in North China as an example,the application effectiveness of the optimal control strategy of the refrigeration plant was *** results showed that the energy-savings of the group control system after the optimization of the re-frigerator,chilled water pump,cooling water pump,and cooling tower could reach 9.42,8.04,5.67,and 14.64%,*** is a remarkable energy-savings *** research described in this study also provides some reference for the design of group control systems in refrigeration plants.

关键词： Group control system Control strategy optimization Particle swarm optimization

Spatial analysis of land use change effect on soil organic carbon stocks in the eastern regions of China between 1980 and 2000

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Geoscience Frontiers 2017年第3期8卷 597-604页

作者： Xueqi xia Zhongfang Yang yuan Xue Xin Shao Tao yu Qingye hou School of Earth Sciences and Resources China University of Geosciences Beijing 100083 China Chongqing Institute of Land Surveying and Planning Chongqing 404000 China

Spatial distributions of 0-20 cm soil carbon sources/sinks caused by land use changes from the year 1980 to 2000 in an area of 2.97 ~ 106 km2 in eastern China were investigated using a land use dataset from a recent soil geochemical survey. A map of soil carbon sourcesJsinks has been prepared based on a spatial analysis scheme with GIg. Spatial statistics showed that land use changes had caused 30.7 ＋ 13.64 Tg of surface soil organic carbon loss, which accounts for 0.33% of the total carbon storage of 9.22 Pg. The net effect of the carbon source was estimated to be ~ 71.49 Tg soil carbon decrease and ~ 40.80 Tg increase. Land use changes in Northeast China （NE） have the largest impact on soil organic carbon storage compared with other regions. Paddy fields, which were mainly transformed into dry farmland in NE, and constructed land in other regions, were the largest carbon sources among the land use types. Swamp land in NE was also another large soil carbon source when it was transformed into dry farmland or paddy fields. Dry farmland in the NE region formed the largest soil organic carbon sink, as some were trans- formed into paddy fields, forested land, and other land use types with high SOCD.

关键词： Land use change Soil organic carbon GIS Eastern China