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2018-2022年某三甲医院耐碳青霉烯类铜绿假单胞菌临床分离株分布及耐药性

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中华医院感染学杂志 2024年第5期34卷 658-662页

作者：张绮萍陆锦琪金建文王霄腾侯国新嘉兴市第一医院感控与公共卫生部浙江嘉兴314000 嘉兴市第一医院消化内科浙江嘉兴314000 嘉兴市第一医院肿瘤内科浙江嘉兴314000

目的了解2018-2022年某三甲医院耐碳青霉烯类铜绿假单胞菌(CRPA)临床分离株的分布特征及耐药情况。方法收集2018年1月1日-2022年12月31日嘉兴市第一医院各临床科室送检标本培养出的铜绿假单胞菌(PA)2358株,进行菌株培养、鉴定及药敏试... 详细信息

目的了解2018-2022年某三甲医院耐碳青霉烯类铜绿假单胞菌(CRPA)临床分离株的分布特征及耐药情况。方法收集2018年1月1日-2022年12月31日嘉兴市第一医院各临床科室送检标本培养出的铜绿假单胞菌(PA)2358株,进行菌株培养、鉴定及药敏试验,统计并分析CRPA的分布及耐药性。结果 2018-2022年共检出PA2358株,其中CRPA407株,CRPA总检出率为17.26%,5年间CRPA检出率整体呈下降趋势(P<0.05)。CRPA感染主要为60岁以上的老年男性患者、夏季检出率较高。标本来源以痰液为主(75.92%),其次是尿液(5.65%)。科室来源主要是重症医学科(24.32%)、重症康复科(15.48%)和呼吸内科(15.23%)。CRPA对亚胺培南和美罗培南总耐药率高达96.32%和79.04%,对多数头孢菌素类、β-内酰胺类和喹诺酮类耐药率高于45%,对阿米卡星、庆大霉素较为敏感,耐药率在12%以下;对哌拉西林/他唑巴坦耐药率呈上升趋势(P<0.05),对阿米卡星、庆大霉素、环丙沙星耐药率呈下降趋势(P<0.05)。结论医院应加强对易感人群、重点科室CRPA的耐药性监测,加强病原学标本送检和抗菌药物临床应用管理,采取有效的防控措施,防止CRPA的医院流行和播散。

关键词：碳青霉烯类铜绿假单胞菌临床分布抗菌药物耐药性多重耐药

Deep learning for joint channel estimation and feedback in massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 83-93页

作者： Jiajia guo Tong Chen Shi Jin Geoffrey Ye Li xin Wang Xiaolin hou National Mobile Communications Research Laboratory Southeast UniversityNanjing210096China Department of Electrical and Electronic Engineering Imperial College LondonLondonSW72AZUK DOCOMO Beijing Communications Laboratories Co. LtdBeijingChina

The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base ***,the accurate CsI is difficult to obtain due to the large amount of feedback overhead caused by massive *** this paper,we propose a deep learning based joint channel estimation and feedback framework,which comprehensively realizes the estimation,compression,and reconstruction of downlink channels in FDD massive MIMO *** networks are constructed to perform estimation and feedback explicitly and *** explicit network adopts a multi-Signal-to-Noise-Ratios(SNRs)technique to obtain a single trained channel estimation subnet that works well with different SNRs and employs a deep residual network to reconstruct the channels,while the implicit network directly compresses pilots and sends them back to reduce network *** module is also designed to generate data-bearing *** results show that the two proposed networks exhibit excellent performance of reconstruction and are robust to different environments and quantization errors.

关键词： Channel estimation CSI feedback Deep learning Massive MIMO FDD

Analysis of Cardiovascular Risk Factors in Newly Defined Stage 1 Hypertension among Chinese on the Basis of the 2017 ACC/AHA Hypertension Guidelines

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Biomedical and Environmental Sciences 2020年第1期33卷 48-52页

作者： LIANG Kai WANG Chuan YAN Fei YANG Jun Peng TIAN Meng WANG Ling Shu hou xin guo CHEN Li Department of Endocrinology Qilu Hospital of Shandong UniversityInstitute of Endocrinology and Metabolism DiseaseShandong UniversityKey Laboratory of Endocrinology and Metabolism DiseaseShandong Province Medicine&HealthJinan 250012ShandongChina

In 2017,American College of Cardiology(ACC)/American Heart Association(AHA)et *** released the latest guidelines for adult hypertension,exactly including prevention,diagnosis,assess and treatment,in which blood pressure levels greater than 130/80 mm Hg were defined as hypertension[1].Based on these modified guidelines,the morbidity of hypertension in US increased from 32%to 46%.

关键词： CKD Analysis Cardiovascular Risk Factors Newly Defined Stage 1 Hypertension Chinese the Basis the 2017 ACC/AHA Hypertension Guidelines AHA ACC

Fractures interaction and propagation mechanism of multi-cluster fracturing on laminated shale oil reservoir

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Petroleum Science 2024年第4期21卷 2600-2613页

作者： Jia-xin Lv Bing hou Key Laboratory of Petroleum Engineering Ministry of Education China University of Petroleum (Beijing) State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) Department of Petroleum Engineering China University of Petroleum (Beijing) at Karamay

The continental shale reservoirs of Jurassic Lianggaoshan Formation in Sichuan Basin contain thin lamina, which is characterized by strong plasticity and developed longitudinal shell limestone *** improve the production efficiency of reservoirs by multi-cluster fracturing, it is necessary to consider the unbalanced propagation of hydraulic fractures and the penetration effect of fractures. This paper constructed a numerical model of multi-fracture propagation and penetration based on the finite element coupling cohesive zone method; considering the construction cluster spacing, pump rate,lamina strength and other parameters studied the influencing factors of multi-cluster fracture interaction propagation; combined with AE energy data and fracture mode reconstruction method, quantitatively characterized the comprehensive impact of the strength of thin interlayer rock interfaces on the initiation and propagation of fractures that penetrate layers, and accurately predicted the propagation pattern of hydraulic fractures through laminated shale oil reservoirs. Simulation results revealed that in the process of multi-cluster fracturing, the proportion of shear damage is low, and mainly occurs in bedding fractures activated by outer fractures. Reducing the cluster spacing enhances the fracture system's penetration ability, though it lowers the activation efficiency of lamina. The high plasticity of the limestone interlayer may impact the vertical propagation distance of the main fracture. Improving the interface strength is beneficial to the reconstruction of the fracture height, but the interface communication effect is limited. Reasonable selection of layers with moderate lamina strength for fracturing stimulation, increasing the pump rate during fracturing and setting the cluster spacing reasonably are beneficial to improve the effect of reservoir stimulation.

关键词： Laminated shale Multi-cluster fracturing Cross-layer Cohesive zone model Acoustic emission technique

Metal-organic-framework-derived copper-based catalyst for multicomponent C-S coupling reaction

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Chinese Journal of Chemical Engineering 2024年第6期70卷 1-8页

作者： Lixin Chen Hui Zhang Linxi hou xin Ge Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Department of Materials-Oriented Chemical Engineering School of Chemical EngineeringFuzhou UniversityFuzhou 350116China Qingyuan Innovation Laboratory Quanzhou 362801China

Copper-based metal-organic frameworks(Cu-MOFs)are a promising multiphase catalyst for catalyzing C-S coupling reactions by virtue of their diverse structures and ***,the unpleasant odor and instability of the organosulfur,as well as the mass-transfer resistance that exists in multiphase catalysis,have often limited the catalytic application of Cu-MOFs in C-S coupling *** this paper,a Cu-MOFs catalyst modified by cetyltrimethylammonium bromide(CTAB)was designed to enhance mass transfer by increasing the adsorption of organic substrates using the long alkanes of ***,elemental sulfur was used to replace organosulfur to achieve a highly efficient and atom-economical multicomponent C-S coupling reaction.

关键词： Design Copper-based metal-organic frameworks (Cu-MOFs) Adsorption C-S coupling reaction Multiphase reaction

Presentation of the Berry-Tabor conjecture in Levy plates

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Chinese Physics B 2024年第10期33卷 240-247页

作者： Chao Li guo-Lin hou School of Mathematical Sciences Inner Mongolia UniversityHohhot 010021China

The Berry-Tabor(BT)conjecture is a famous statistical inference in quantum chaos,which not only establishes the spectral fluctuations of quantum systems whose classical counterparts are integrable but can also be used to describe other wave *** this paper,the BT conjecture has been extended to Lévy *** predicted by the BT conjecture,level clustering is present in the spectra of Lévy *** consequence of level clustering is studied by introducing the distribution of nearest neighbor frequency level spacing ratios P(r),which is calculated through the analytical solution obtained by the Hamiltonian *** work investigates the impact of varying foundation parameters,rotary inertia,and boundary conditions on the frequency spectra,and we find that P(r)conforms to a Poisson distribution in all *** reason for the occurrence of the Poisson distribution in the Lévy plates is the independence between modal frequencies,which can be understood through mode functions.

关键词： Berry-Tabor conjecture frequency spectra Hamiltonian approach Lévy plates

Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment

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World Journal of Diabetes 2024年第4期15卷 735-757页

作者： Jing Gao Ying Zou Xiao-Yu Lv Li Chen xin-guo hou Department of Endocrinology Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Institute of Endocrine and Metabolic Diseases Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Endocrine and Metabolic Diseases Shandong Province Medicine&HealthJinan 250012Shandong ProvinceChina Department of Endocrinology Jinan Clinical Research Center for Endocrine and Metabolic DiseaseJinan 250012Shandong ProvinceChina

BACKGROUND The cognitive impairment in type 2 diabetes mellitus(T2DM)is a multifaceted and advancing state that requires further exploration to fully ***-roinflammation is considered to be one of the main mechanisms and the immune system has played a vital role in the progression of the *** To identify and validate the immune-related genes in the hippocampus associated with T2DM-related cognitive *** To identify differentially expressed genes(DEGs)between T2DM and controls,we used data from the Gene Expression Omnibus database *** identify T2DM module genes,we used Weighted Gene Co-Expression Network *** the genes were subject to Gene Set Enrichment ***-protein interaction network construction and machine learning were utilized to identify three hub *** cell infiltration analysis was *** three hub genes were validated in GSE152539 via receiver operating characteristic curve *** experiments including reverse transcription quantitative real-time PCR,Western blotting and immunohistochemistry were conducted both in vivo and in *** identify potential drugs associated with hub genes,we used the Comparative Toxicogenomics Database(CTD).RESULTS A total of 576 DEGs were identified using *** taking the intersection of DEGs,T2DM module genes,and immune-related genes,a total of 59 genes associated with the immune system were ***,machine learning was utilized to identify three hub genes(H2-T24,Rac3,and Tfrc).The hub genes were associated with a variety of immune *** three hub genes were validated in *** experiments were conducted at the mRNA and protein levels both in vivo and in vitro,consistent with the bioinformatics ***,11 potential drugs associated with RAC3 and TFRC were identified based on the *** Immune-related genes that differ in expression in the hippocampus are closely linked to microgli

关键词： Bioinformatics analysis Type 2 diabetes mellitus Cognitive impairment Hippocampus Immune Microglia

Configuration Synthesis and Grasping Performance Analysis of Multi-Loop Coupling Capture Mechanism for Launch and Recovery of Torpedo-Shaped Autonomous Underwater Vehicle

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China Ocean Engineering 2024年第3期38卷 453-466页

作者： ZHANG guo-xing XIA xin-lu guo Jin-wei School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis

Composition operators on weighted Bergman spaces induced by doubling weights

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Science China Mathematics 2024年第7期67卷 1571-1598页

作者： xin guo Maofa Wang School of Mathematics and Statistics Wuhan UniversityWuhan430072China

Given a doubling weightωon the unit disk D,let A_(ω)^(p) be the space of all the holomorphic functions f,where∥f∥A_(ω)^(p):=(∫_(D)|f(z)|_(p)ω(z)dA(z))^(1/p)<∞.We completely characterize the topological connectedness of the set of composition operators on A_(ω)^(p).As an application,we construct an interesting example which reveals that two composition operators on A_(α)^(p) in the same path component may fail to have a compact difference and give a negative answer to the Shapiro-Sundberg question in the(standard)weighted Bergman *** addition,we completely describe the central compactness of any finite linear combinations of composition operators on A_(ω)^(p) in three terms:a Julia-Carathéodory-type function-theoretic characterization,a power-type characterization,and a Carleson-type measure-theoretic characterization.

关键词： composition operator linear combination linearly connected weighted Bergman space doubling weight