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Prototype of the readout electronics for the RICH PID detector in the STCF

Nuclear Science and Techniques 2022年第6期33卷 148-160页

作者： Bao-lin hou Lei Zhao Jia-Jun Qin Ye-Qun Qi Jia-Ming Li Zi-Yu Yang Shu-Bin Liu Qi An State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China

The ring imaging Cherenkov(RICH) detector for particle identification(PID) is being evaluated for the future super tau-charm facility(STCF) complex. In this work, the prototype readout electronics for the RICH PID detector is designed. The prototype RICH PID detector is based on a thick gas electron multiplier combined with a micromegas detector for Cherenkov light detection. Considering that there will be a large number(~ 690,000) of detector channels in future RICH detector, the readout electronics faces many challenges to precisely measuring time and charge information, such as reducing the noise,increasing density, and improving precision. The requirements of the readout electronics are explored, the downselection of the ASICs is made and thus a prototype readout electronics is designed and implemented. Tests are also conducted to evaluate the performance of the prototype readout electronics, and the results indicate that the time resolution is better than ~ 1 ns(RMS) when the input charge is greater than ~ 12 fC based on the APV25chip, while the time resolution is better than ~ 1 ns(RMS) at an input charge of over ~ 48 fC based on the AGET and STCF ASIC chips, and the equivalent noise charge is better than ~ 0.5 fC(RMS) @ 20 pF based on the three ASICs. The test results indicate that the prototype readout electronics design meets the requirement of the future RICH PID detector and thus provides a reference for future engineering.

关键词： Readout electronics Time measurement Charge measurement RICH PID detector STCF

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Special issue on genome wide association study

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Quantitative Biology 2021年第2期9卷 105-106页

作者： lin hou Qiongshi Lu Can Yang Hongyu Zhao Center for Statistical Science Department of Industrial EngineeringMOE Key Laboratory of BioinformaticsSchool of Life SciencesTsinghua UniversityBeijing 100084China Department of Biostatistics and Medical Informatics Department of StatisticsCenter for Demography of Health and AgingUniversity of Wisconsin-MadisonWl 53726USA Department of Mathematics the Hong Kong University of Science and TechnologyHong KongChina Department of Biostatistics Yale School of Public HealthNew HavenCT 06510USA Department of Genetics Yale UniversityNew HavenCT 06510USA Program of Computational Biology and Bioinformatics Yale UniversityNew HavenCT 06510USA

Since the first success of genome wide association study(GWAS)was reported in 2005 by Hoh and colleagues on the identification of a major gene for age related macular degeneration,many thousands of published studies have reported reproducible association signals between hundreds of thousands of genetic variants and thousands of traits and diseases in the past 16 *** is a growing number of biobanks with up to one million participants developed across the world to facilitate genetic studies of complex traits through ***,many consortium projects have been initiated to collect diverse types of data that have proved very valuable for integrated analysis of GWAS *** rich data present both great opportunities and challenges to scientists on data management,computation,analysis,integration,and *** special issue of Quantitative Biology collects nine papers that cover major progresses,challenges,and future directions for GWAS analysis.

关键词： hundreds GWAS initiated

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Investigation of carbonyl amidation and O-methylation during biosynthesis of the pharmacophore pyridyl of antitumor piericidins

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Synthetic and Systems Biotechnology 2022年第3期7卷 880-886页

作者： Wanlu Li Wenyu Zhang Yijia Cheng Yaoyao Shen Jianzhao Qi hou-Wen lin Yongjun Zhou Research Center for Marine Drugs State Key Laboratory of Oncogenes and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling712100ShaanxiChina

Piericidins are a large family of bacterialα-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude *** backbones of piericidins are derived fromβ,δ-diketo carboxylic acids,which are offloaded from a modular polyketide synthase(PKS)and putatively undergo a carbonyl amidation beforeα-pyridone ring *** tailoring modifications to theα-pyridone structure mainly include the verified hydroxylation and O-methylation of the C-4′position and an unidentified C-5′***,we describe a piericidin producer,terrestrial Streptomyces conglobatus,which contains a piericidin biosynthetic gene cluster in two different *** of the amidotransferase gene pieD resulted in the accumulation of two fatty acids that should be degraded from the nascent carboxylic acid released by the PKS,supporting the carbonyl amidation function of PieD duringα-pyridone ring *** of the O-methyltransferase gene pieB1 led to the production of three piericidin analogues lacking C-5′O-methylation,therefore confirming that PieB1 specifically catalyses the tailoring ***,bioactivity analysis of the mutant-derived products provided clues regarding the structure-function relationship for antitumor *** work addresses two previously unidentified steps involved in pyridyl pharmacophore formation during piericidin biosynthesis,facilitating the rational bioengineering of the biosynthetic pathway towards valuable antitumor agents.

关键词： Polyketide Pyridine Polyketide synthase(PKS) Natural product biosynthesis

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A self-guidance biological hybrid drug delivery system driven by anaerobes to inhibit the proliferation and metastasis of colon cancer

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Asian Journal of Pharmaceutical Sciences 2022年第6期17卷 892-907页

作者： Huijuan Zhang Yaping Wang Mengting Li Kexuan Cao Zijun Qi ling Zhu Zhenzhong Zhang lin hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450000China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450000China

Colorectal cancer is often accompanied by multiple organ *** Bifidobacterium Infantis(BI)bacterial can selectively grow in hypoxic colorectal tumor microenvironment(TME),to own the natural advantage of preferentially colorectal tumor ***,a self-guidance biological hybrid drug delivery system(BI-ES-Fe Alg/DOX)based on BI was constructed to inhibit the proliferation and metastasis of colon *** demonstrated that BI-ES-Fe Alg/DOX could overcome physical barriers to target and accumulate in colon tumor *** DOX was released to kill tumor cells along with the phase transition(solid to liquid)of Fe Alg hydrogel,due to Fe3+was reduced to Fe^(2+)by intracellular ***,BI-ES selectively colonized into tumors and expressed endostatin(ES)protein to down-regulate VEGF and b FGF expression,exerting anti-angiogenic ***,Fe Alg catalyzed H_(2)O_(2)in the local tumor to generate cytotoxic·OH,further enhancing the antitumor *** pharmacodynamic result in AOM/DSS model proved that BI-ES-Fe Alg/DOX had the best therapeutic effect,with the final V/V0of 2.19±0.57,which was significantly lower than the other ***,on CT-26tumor-bearing model,it also showed an outstanding anti-tumor effect with inhibition rate of 82.12%±3.08%.In addition,lung metastases decreased significantly in tumor metastasis model after BI-ES-Fe Alg/DOX treatment.

关键词： Bifidobacterium Infantis Hypoxia targeting TME-responsive drug release Comprehensive treatment Colon tumor

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Spatiotemporal transformable nano-assembly for on-demand drug delivery to enhance anti-tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 103-118页

作者： Chenglin Liang Ge Zhang linlin Guo Xinyi Ding Heng Yang Hongling Zhang Zhenzhong Zhang lin hou School of Pharmaceutical Sciences Key Laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou UniversityZhengzhou 450001China

Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells ***,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific *** detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive *** arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide *** can degrade the extracellularmatrix,leading to the enhanced penetration of *** targets tumor cells,releases DOX to induce senescence,and recruits effector immune ***,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor *** vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice *** work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.

关键词： Cells senescence Tumor stroma Structure transformable Programmed delivery Anti-tumor immunotherapy

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Molecular Cloning,Expression Analysis and Localization of Exo70A1 Related to Self Incompatibility in Non-Heading Chinese Cabbage(Brassica campestris ***)

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Journal of Integrative Agriculture 2013年第12期12卷 2149-2156页

作者： WANG Li GE Ting-ting PENG Hai-tao WANG Cheng LIU Tong-kun hou Xi-lin LI Ying Horticultural Department Nanjing Agricultural University State Key Laboratory of Crop Genetics and Germplasm Enhancement Key Laboratory of Southern Vegetable Crop Genetic Improvement Ministry of Agriculture

The exocyst is a conserved protein complex,and required for vesicles tethering,fusion and polarized ***70A1,the exocyst subunit,is essential for assembly of the exocyst *** better understand potential roles of Exo70A1 in non-heading Chinese cabbage（Brassica campestris ***）,we obtained the full-length cDNA of Exo70A1 gene,which consisted of 1 917 bp and encoded a protein of 638 amino *** showed BcExo70A1 shared 94.9% identity with Brassica oleracea ***（AEI26267.1）,and clustered into a same group with other homologues in *** *** and Brassica *** localization analysis showed BcExo70A1 was localized to punctate structures in cytosol of onion epithelial *** showed that BcExo70A1 was widely presented in stamens,young stems,petals,unpollinated pistils,roots and leaves of self compatible and incompatible *** transcripts of BcExo70A1 in non- heading Chinese cabbage declined during initial 1.5 h after incompatible pollination,while an opposite trend was presented after compatible *** study reveals that BcExo70A1 could play essential roles in plant growth and development,and is related to the rejection of self pollen in non-heading Chinese cabbage.

关键词： Exo70A1 gene expression subcellular localization self-incompatibility non-heading Chinese cabbage

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Fluid Inclusion and H-O Isotope Geochemistry of the Phapon Gold Deposit, NW Laos: Implications for Fluid Source and Ore Genesis

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Journal of Earth Science 2019年第1期30卷 80-94页

作者： linnan Guo Shusheng Liu lin hou Jieting Wang Meifeng Shi Qiming Zhang Fei Nie Yongfei Yang Zhimin Peng Chengdu Center China Geological Survey Tianjin North China Geological Exploration Bureau

The Phapon gold deposit, located in northern Laos, is a unique large-scale gold deposit in Luang Prabang-Loei metallogenic belt. It is hosted in the Lower Permian limestone and controlled by a NE-trending ductile-brittle fault system. There are three types of primary ore including auriferous calcite vein type, disseminated type, and breccia type, and the first two are important in the Phapon gold deposit. Based on fluid inclusion petrography and microthermometry, three types of primary fluid inclusions including type 1 liquid-rich aqueous, type 2 vapor-rich aqueous and type 3 daughter mineralbearing aqueous were identified in hydrothermal calcite grains. The ore-forming fluids are normally homogeneous, as indicated by the widespread type 1 inclusions with identical composition. The coexistence of type 1 and type 2 inclusions, showing similar final homogenization temperature but different compositions, indicate that fluid immiscibility did locally take place in both two types of ores. The results of microthermometry and H-O isotopes geochemistry indicate that there are little differences on ore-fluid geochemistry between the auriferous calcite vein-type and disseminated type ores. The oreforming fluids are characterized by medium-low temperatures(157–268 oC) and low salinity(1.6 wt.%–9.9 wt.% NaCl eq.). It is likely to have a metamorphic-dominant mixed source, which could be associated with dehydration and decarbonisation of Lower Permian limestone and Middle–Upper Triassic sandstones during the dynamic metamorphism. The fluid-wallrock interaction played a major role, and the locally occurred fluid-immiscible processes played a subordinate role in gold precipitation. Combined with the regional and ore deposit geology, and ore-fluid geochemistry, we suggest that the Phapon gold deposit is best considered to be a member of the epizonal orogenic deposit class.

关键词： fluid inclusion H-O isotopes fluid source ore genesis Phapon gold deposit northern Laos

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Enhanced uplink non-orthogonal multiple access for 5G and beyond systems

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Frontiers of Information Technology & Electronic Engineering 2018年第3期19卷 340-356页

作者： Wen-jia LIU Xiao-lin hou Lan CHEN DOCOMO Beijing Communications Laboratories Co. Ltd.

Uplink non-orthogonM multiple access （NOMA） is a promising technique to meet the requirements of the fifth generation （5G） and beyond systems. Various NOMA schemes have been proposed in both academia and industry. However, most existing schemes assume equal average received power, which limits the performance. We propose three enhancements of uplink NOMA to achieve the requirements of massive connectivity and high reliability in 5G, where unequal average received power is exploited as part of the multiple access signature. First, the optimal sequences targeting to generalized Welch-bound equality （GWBE） are obtained for unequal average received power. Then user grouping with multi-level received powers is proposed for better successive interference cancellation （SIC） at the receiver. Finally, sequence grouping based on the cross-correlation properties of sequences is proposed to reduce inter-and intra-group interference. Simulation results show that by incorporating multi-level received powers and sequence grouping into existing NOMA schemes, for an NOMA system with 400% overloading and fixed signature allocation, 3 dB and 10 dB signal-to-noise ratio （SNR） gains at 0.1 block error rate （BLER） target can be achieved compared with existing NOMA schemes and orthogonal multiple access （OMA）, respectively. Besides, 0.01 BLER target can be achieved while an error floor exists in existing NOMA schemes. Under random sequence selection, collision probability is reduced by multi-level powers. In addition, GWBE sequences achieve lower BLER than existing sequences and the gain is large especially for low BLER requirements. This shows that the proposed scheme can support larger connectivity and higher reliability.

关键词： Uplink non-orthogonal multiple access Generalized Welch-bound equality Multi-level received powers Sequence grouping

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Geology, Geochronology, and Hf Isotopic Composition of the Pha Lek Fe Deposit, Northern Laos: Implications for Early Permian Subduction-Related Skarn Fe Mineralization in the Truong Son Belt

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Journal of Earth Science 2019年第1期30卷 109-120页

作者： lin hou Shusheng Liu linnan Guo Fuhao Xiong Chao Li Meifeng Shi Qiming Zhang Siwei Xu Songyang Wu Chengdu Center China Geological Survey Key Laboratory of Tectonic Controls on Mineralization and Hydrocarbon Accumulation of Ministry of Land and Resources Chengdu University of Technology National Research Center of Geoanalysis Chinese Academy of Geological Science China University of Geosciences

The Truong Son metallogenic belt in central Laos and Vietnam is an important Fe-Cu-Sn-Au polymetallic ore district. The Pha Lek Fe deposit is closely related to Late Carboniferous– Early Permian I-type granitic magmatism, and contains >50 Mt @ 45% to 50% of Fe ore. Ore minerals occur mainly as magnetite and hematite in the skarn alteration zone between a granitic pluton and metamorphosed Middle–Upper Devonian carbonates. The granitic pluton comprises granodiorite and granite, with zircon U-Pb dating indicating synchronous emplacement at 288.2±1.3 and 284.9±1.2 Ma, respectively. Zircons from these granitoids have ε_(Hf)(t) values of 2.9–11.2 and relatively young TDM2 ages(<1.0 Ga), indicating an origin by partial melting of depleted mafic crust or magma mixing. Previous studies have shown that these granitoids have high Y, Yb, and K_2O contents, and low Sr and Na_2O contents, which are interpreted as the melting of mafic continental crust. Pyrite of the main mineralization stage yields an ^(187)Re/^(188)Os-^(187)Os/^(188)Os isochron age of 287±17 Ma, indicating that mineralization is associated with Pha Lek granitic magmatism. A Late Carboniferous–Early Permian subduction-related skarn-type Fe mineralization model is proposed for the Pha Lek deposit. More evidence is needed to verify a hypothesis of volcanic overprinting during Late Triassic post-collisional extension.

关键词： Truong Son belt Pha Lek Fe deposit granitic intrusions geochronology Hf isotopic composition.

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磁流体特性对磁流变火炮后坐阻尼器性能的影响

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爆炸与冲击 2006年第3期26卷 245-249页

作者：侯保林南京理工大学机械工程学院江苏南京210094

针对火炮后坐磁流变阻尼器的特点,以某单管25 mm火炮实验用磁流变阻尼器为研究对象,基于Herschel-Bulkley本构模型,建立了该炮磁流变后坐阻尼器的轴对称一维层流模型,获得了不同磁场作用下阻尼力随活塞速度的变化规律。运用火炮的后坐... 详细信息

针对火炮后坐磁流变阻尼器的特点,以某单管25 mm火炮实验用磁流变阻尼器为研究对象,基于Herschel-Bulkley本构模型,建立了该炮磁流变后坐阻尼器的轴对称一维层流模型,获得了不同磁场作用下阻尼力随活塞速度的变化规律。运用火炮的后坐运动方程,计算了不同磁流体特性指数下,火炮的后坐位移和后坐速度。计算结果表明,磁流体特性指数的变化对磁流变后坐阻尼器的性能影响显著。

关键词：流体力学磁流变阻尼器 Herschel-Bulkley模型火炮后坐

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