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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin hou huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Type Synthesis and Characteristic Analysis of a Family of 2-DOF Rotational Decoupled Parallel Mechanisms

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Chinese Journal of Mechanical Engineering 2009年第6期22卷 833-840页

作者： ZENG Daxing hou Yulei huang Zhen LU Wenjuan College of Mechanical Engineering Yanshan University Qinhuangdao 066004 China

It is widely used for the rotational parallel mechanism in the field of spatial orientation. While owing to the existence of coupling, the forward kinematic solution and the control of the general rotational parallel mechanism are especially difficult. If decoupling can be realized, the kinematic analysis of the mechanism will be very simple. Presently, the research of the parallel mechanism is focused on the inverse solution and structure optimization, and there is a lack of rotation decoupled parallel mechanisms （DPMs）. So this paper proposes a family of 2 degree of freedom （DOF） rotational DPMs based on the four-bar linkage mechanism, and performs a characteristic analysis. This family of DPMs is composed of a moving platform, a fixed base and three limbs. Taking U_RRU SPU DPM as an example, the motion feature of this DPM is analyzed with the constraint screw method, and its mobility is calculated by using the Modified Kutzbach-Grtibler criterion. The inverse and forward displacement problems of the proposed parallel mechanism are solved. The decoupled feature of the proposed parallel mechanism is validated by the deduction of the expression of the Jaeobian matrix. Three kinds of singularity conditions of this DPM are discussed, and the atlases of the output parameter concerning different geometric parameters are plotted with the theory of the physical model of the solution space. The proposition and characteristic analysis of the novel rotational DPMs in this paper should be useful for further research and application of the parallel mechanisms.

关键词： parallel mechanism rotational decoupled constraint screw method atlases

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Microglia regulation of synaptic plasticity and learning and memory

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Neural Regeneration Research 2022年第4期17卷 705-716页

作者： Jessica Cornell Shelbi Salinas hou-Yuan huang Miou Zhou Graduate College of Biomedical Sciences Western University of Health SciencesPomonaCAUSA

Microglia are the resident macrophages of the central nervous *** possess varied morphologies and *** normal physiological conditions,microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic *** the C1 q,C3 and CR3"Eat Me"and CD47 and SIRPα"Don't Eat Me"complement pathways,as well as other pathways such as CX3 CR1 signaling,resting microglia regulate synaptic pruning,a process crucial for the promotion of synapse formation and the regulation of neuronal activity and synaptic *** mediating synaptic pruning,resting microglia play an important role in the regulation of experience-dependent plasticity in the barrel cortex and visual cortex after whisker removal or monocular deprivation,and also in the regulation of learning and memory,including the modulation of memory strength,forgetfulness,and memory *** a response to brain injury,infection or neuroinflammation,microglia become activated and increase in *** microglia change to an amoeboid shape,migrate to sites of inflammation and secrete proteins such as cytokines,chemokines and reactive oxygen *** molecules released by microglia can lead to synaptic plasticity and learning and memory deficits associated with aging,Alzheimer's disease,traumatic brain injury,HIV-associated neurocognitive disorder,and other neurological or mental disorders such as autism,depression and post-traumatic stress *** a focus mainly on recently published literature,here we reviewed the studies investigating the role of resting microglia in synaptic plasticity and learning and memory,as well as how activated microglia modulate disease-related plasticity and learning and memory *** summarizing the function of microglia in these processes,we aim to provide an overview of microglia regulation of synaptic plasticity and learning and memory,and to discuss the possibility of microglia manipul

关键词： aging Alzheimer's disease cognitive deficits experience-dependent plasticity learning and memory mental disorders microglia synaptic plasticity synaptic pruning

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Effects of Y_2O_3 on the microstructure and wear resistance of cobalt-based alloy coatings deposited by plasma transferred arc process

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Rare Metals 2007年第2期26卷 103-109页

作者： hou Qingyu huang Zhenyi GAO Jiasheng Anhui Key Laboratory of Metal Materials and Processing School of Materials Science and Engineering Anhui University of Technology Ma＇anshan 243002 China

Cobalt-based alloys with different Y2O3 contents were deposited on Q235A-carbon steel using plasma transferred arc （PTA） welding machine. The effect of Y2O3 on the microstructure and wear resistance properties of the cobait-based alloys were investigated using an optical microscope, a scanning electron microscope （SEM）, X-ray diffraction （XRD）, and transmission electron microscopy （TEM）. It was found that a cobalt-based solid solution with a face-centered cubic crystal structure was presented accompanied by the secondary phase M7C3 with a hexagonal crystal structure in the Y2O3-free cobalt-based alloy coating. Several stacking faults exist in the cobalt-based solid solution. The addition of Y2O3 leads to the existence of the Y2O3 phase in the Y2O3-modified coatings. Though stacking fault exists in the Y2O3-modified coatings, its density increases. The addition of Y2O3 can refine the microstructure and can increase the wear resistance properties when its contents are less than or equal to 0.8 wt.%. However, further increase of its contents will lead to the agglomeration of undissolved Y2O3 particles at the γ-Co grain boundary, and will lead to a coarse microstructure and lower wear resistance properties.

关键词： cobalt-based alloy plasma transferred arc (PTA) Y2O3 microstructure wear resistance

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Fuel design real-time to control HCCI combustion

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Chinese Science Bulletin 2006年第21期51卷 2673-2680页

作者： hou Yuchun huang Zhen LU Xingcai FANG Junhuan ZU Linlin Institute of Internal Combustion Engine Shanghai Jiao Tong UniversityShanghai 200030 China

In order to achieve lower emissions and extensive load in the homogeneous charge com- pression ignition (HCCI) engine system, a novel fuel design concept that high-octane number fuel and high-cetane number fuel are mixed real-time to con- trol HCCI combustion is proposed in this study. HCCI combustion fueled with iso-octane/n-heptane mix- tures controlled real-time on a single-cylinder HCCI combustion engine is studied. The test results show that the equivalence ratio of n-heptane in mixtures decides ignition and controls the combustion phase of HCCI combustion. The addition of iso-octane ex- tends knocking limit in equivalence ratio somewhat, but knocking occurrence mainly depends on the total concentration of mixture. Although operating range in equivalence ratio becomes narrow with the increas- ing proportion of iso-octane, the maximum load of HCCI combustion fueled with iso-octane/n-heptane mixtures controlled real-time is increased about 80% more than that of pure n-heptane. When iso-octane/ n-heptane mixtures are controlled in optimized method, it is proved that the load of HCCI combustion can be fully extended and emissions can be de- creased remarkably, while at the same time the higher indicated thermal efficiencies are obtained over the extensive operation range.

关键词： HCCI 燃料设计实时控制正庚烷异辛烷

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Various phenotypes of autosomal dominant cone-rod dystrophy with cone-rod homeobox mutation in two Chinese families

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1915-1923页

作者： Hui Cui Xin Jin Qing-Hua Yang Ling-Hui Qu Bao-Ke hou Zhao-Hui Li hou-Bin huang Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China Department of Ophthalmology the 74th Army Group HospitalGuangzhou 510318Guangdong ProvinceChina Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya 572000Hainan ProvinceChina

AIM:To present the clinical manifestations of 5 autosomal dominant cone-rod dystrophy(ad CORD)patients from two Chinese families with cone-rod homeobox(CRX)mutation(p.R41W),and to explore the clinical heterogeneity of ad CORD with CRX mutation(p.R41W).METHODS:Interrogation and ophthalmological examinations were undertaken in all patients and unaffected *** of clinical features was performed by visual acuity,slit lamp examination,visual field examination,fundoscopy,autofluorescence and spectral domain optical coherence *** next-generation sequencing was applied as a useful tool to identify the causative mutation of CORD ***:A CRX missense mutation c.121C>T was identified in all patients,resulting in an amino acid change from arginine acid to tryptophan(p.R41W).The patients presented with early onset,progressive and different severities with ***:This is the first report of the clinical phenotype of CRX mutation(p.R41W)in Chinese families,and the mutation can lead to a wide range of various retinal phenotypes.

关键词： cone-rod homeobox cone-rod dystrophy mutation

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Designing current–strain-assisted superconductor–ferromagnet multi-bit memories

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Chinese Physics B 2022年第11期31卷 619-625页

作者： Hasnain Mehdi Jafri Jing Wang Xiao-Ming Shi De-Shan Liang hou-Bing huang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

Current superconducting memory devices lack the basic quality of high memory density for practical memories,mainly due to the size limitations of superconducting quantum interference ***,we propose a superconductor–ferromagnet bilayer device with strain-pulse-assisted multi-bit ladder-type memory,by using strain-engineered ferromagnet domain structure to control carrier concentration in the superconductor,which is simulated by coupled Landau–Lifshitz–Gilbert and Ginzburg–Landau ***-and strain-pulses are observed to deterministically control the resistivity of superconductor for one and two-bit device *** average carrier concentration of superconductor is observed to have multiple metastable states that can be controllably switched using current-pulse and strain-pulse to determine multiple resistivity *** findings confirm the eligibility of superconductor–ferromagnet bilayers to be used as ladder-type multibit memories and open a new way for further theoretical and experimental investigations of the cryogenic memories.

关键词： superconductor-ferromagnet bilayer cryogenic memories superconducting memories vortex memories

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Phase-field simulation of superconductor vortex clustering in the vicinity of ferromagnetic domain bifurcations

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Chinese Physics B 2020年第12期29卷 99-102页

作者： Hasnain Mehdi Jafri Jing Wang Chao Yang Jun-Sheng Wang hou-Bing huang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

Superconductors and ferromagnets are highly non-compatible materials due to the natures of their respective electronic *** when artificially brought together,they develop interesting characteristics,one of which,vortex clustering,is discussed here in this ***-field and micromagnetic simulations are performed to investigate the superconductor and ferromagnet bilayer,*** ferromagnet with uniaxial anisotropy is observed to develop the maze domain,whereas the superconductor subjected to the influence of the ferromagnetic stray field displays a vortex *** vortices in superconductors at certain locations are observed to be precisely located over magnetic domain *** enhanced out-of-plane stray field at bifurcations around the curved domain walls and the convergent Lorentz force due to screening currents in superconductor are attributed to the formation of clusters at bifurcation *** of the inter-vortex spacing between straight and bifurcated domain is clearly *** importantly,inter-vortex spacing is predicted to serve as a precise tool to map local ferromagnet domain shapes.

关键词： superconductor–ferromagnet bilayer vortex pinning vortex clustering bifurcated domains

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Molecular Cloning of Myostatin Partial cDNA of Beijing Duck and Its Expression in Breast Muscle

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Agricultural Sciences in China 2006年第6期5卷 468-472页

作者： WANG Yong-sheng hou Shui-sheng huang Wei KANG Jun-mei State Key Laboratory of Animal Nutrition Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100094 P.RChina

In this experiment, 500 bp cDNA of myostatin gene was cloned from a Beijing duck＇s breast, The duck myostatin gene was found to have 98, 96, 95, 88, and 87% sequence similarity at the cDNA level with domestic goose, chicken, domestic pigeon, human, and pig, respectively. The predicted amino acid sequence has an overall similarity with a comparable region of turkey 99%, domestic goose 98%, and chicken 99%. Conserved domains of deduced amino acids showed that it belonged to the TGF-beta family. Myostatin expression in breast muscle was higher at 28, 35, and 42 days than at 7, 14, and 21 days. The pattern of myostatin expression was closely parallel to the trend of breast muscle growth, suggesting that myostatin might play an important role in breast muscle development. It was possible to postulate that myostatin may be a major determinant of muscle mass in breast muscle, as shown in other species.

关键词： Beijing duck myostatin cloning and sequence analysis expression

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Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families

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Current Medical Science 2024年第4期44卷 820-826页

作者： Xiao-lu HAO Ran CHEN Wei LIU Bao-ke hou Ling-hui QU Zhao-hui LI Da-jiang WANG Xin JIN hou-bin huang Senior Department of Opthalmology the Third Medical Center of Chinese PLA General HospitalBeijing100039China Bolin Eye Care Group Beijing100098China Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya572000China Department of Ophthalmology the 74th Army Group HospitalGuangzhou510318China

Objective To examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype *** A comprehensive questionnaire and ophthalmological assessments were administered to both affected patients and unaffected *** clinical feature analysis included the evaluation of visual acuity,intraocular pressure,slit-lamp anterior segment examination,fundus photography,and spectral domain optical coherence *** identify the mutation responsible for aniridia,targeted next-generation sequencing was used as a beneficial *** A total of 4 mutations were identified,consisting of two novel frameshift mutations(c.314delA,p.K105Sfs*33 and c.838_845dup AACACACC,p.S283Tfs*85),along with two recurring nonsense mutations(c.307C>T,p.R103X and c.619A>T,p.K207*).Complete iris absence,macular foveal hypoplasia,and nystagmus were consistent in these PAX6 haplotype-deficient Chinese aniridia families,while corneal lesions,cataracts,and glaucoma exhibited heterogeneity both among the families and within the same *** In our study,two novel PAX6 mutations associated with aniridia were identified in Chinese families,which expanded the phenotypic and genotypic spectrum of PAX6 *** also analyzed the clinical characteristics of PAX6 haplotype deficiency in Chinese aniridia families.

关键词： aniridia PAX6 mutation haplotype deficiency phenotype genotype

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