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Design and preparation of a new multi-targeted drug delivery system using multifunctional nanoparticles for co-delivery of siRNA and paclitaxel

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Journal of Pharmaceutical Analysis 2021年第2期11卷 163-173页

作者： Sara Hosayni Nasab Amin Amani hossein Ali ebrahimi Ali Asghar Hamidi Department of Agronomy and Plant Breeding Faculty of Agriculture and Natural ResourcesUniversity of Mohaghegh ArdabiliArdabilIran Biotechnology Research Center Tabriz University of Medical SciencesTabrizIran Department of Pharmaceutics School of PharmacyArdabil University of Medical SciencesArdabilIran Department of Medicinal Chemistry Faculty of PharmacyTabriz University of Medical SciencesTabrizIran

Drug resistance is a great challenge in cancer therapy using chemotherapeutic agents. Administration of these drugs with siRNA is an efficacious strategy in this battle. Here, the present study tried to incorporate siRNA and paclitaxel(PTX) simultaneously into a novel nanocarrier. The selectivity of carrier to target cancer tissues was optimized through conjugation of folic acid(FA) and glucose(Glu) onto its surface. The structure of nanocarrier was formed from ternary magnetic copolymers based on FeCopolyethyleneimine(FeCo-PEI) nanoparticles and polylactic acid-polyethylene glycol(PLA-PEG) gene delivery system. Biocompatibility of FeCo-PEI-PLA-PEG-FA(NPsA), FeCo-PEI-PLA-PEG-Glu(NPsB) and FeCo-PEI-PLA-PEG-FA/Glu(NPsAB) nanoparticles and also influence of PTX-loaded nanoparticles on in vitro cytotoxicity were examined using MTT assay. Besides, siRNA-FAM internalization was investigated by fluorescence microscopy. The results showed the blank nanoparticles were significantly less cytotoxic at various concentrations. Meanwhile, siRNA-FAM/PTX encapsulated nanoparticles exhibited significant anticancer activity against MCF-7 and BT-474 cell lines. NPsAB/siRNA/PTX nanoparticles showed greater effects on MCF-7 and BT-474 cells viability than NPsA/siRNA/PTX and NPsB/siRNA/***, they induced significantly higher anticancer effects on cancer cells compared with NPsA/siRNA/PTX and NPsB/siRNA/PTX due to their multi-targeted properties using FA and Glu. We concluded that NPsAB nanoparticles have a great potential for co-delivery of both drugs and genes for use in gene therapy and chemotherapy.

关键词： Paclitaxel siRNA Targeted drug delivery Magnetic nanoparticles Polymeric drug delivery

Effect of Various Field Shapers on Magnetic Pressure in Electromagnetic Inward Tube Forming

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Journal of Iron and Steel Research International 2012年第S1期19卷 86-89页

作者： Ehsan Garzan hossein ebrahimi Ali Reza Fallahi Arezoodar Department of Mechanical Eng. AMIRKABIR University of TechnologyTehranIran

In this paper,the influence of various field shapers and their shapes on the distribution of the magnetic flux densities and applied forces on the work-piece in the electromagnetic inward tube forming are studied numerically using the FEA software *** the model was verified with experimental results and thereafter four kinds of field shapers(conical,cylindrical,concave and convex)were *** of their geometries,such as air gap between field shaper and tube work-piece,height of the step in single and multiple stepped field shaper on magnetic flux densities and magnetic pressures were *** results of this research can be applied to design field shaper,tube compression technology,and improve the efficiency of the *** is seen that magnetic force decreases if height of step in convex field shaper increases but effective forming region *** air gap has also a positive influence on magnetic field *** the object of this research is limited to field shaper for inward tube forming,the results can also be applied to the field shaper for tube bulging.

关键词： Inward tube forming Electromagnetic forming Field shaper Magnetic pressure Geometric parameters

Analytical study of care quality and moral distress in clinical situations and patient care

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Frontiers of Nursing 2019年第4期6卷 327-334页

作者： Masoumeh Hasanlo Arezo Azarm Parvaneh Asadi Kourosh Amini hossein ebrahimi Mohammad Asghari Jafarabadi Department of Surgical Technology Zanjan University of Medical SciencesZanjanIran Education and Treatment Center of Beheshti Zanjan University of Medical SciencesZanjanIran Kermanshah University of Medical Sciences KermanshahIran Zanjan Social Determinations of Health Research Center Zanjan University of Medical SciencesZanjanIran Department of Psychiatric Nursing Faculty of Nursing and MidwiferyTabriz University of Medical SciencesTabrizIran Health Services Management Research Center Faculty of Public HealthTabriz University of Medical SciencesTabrizIran

Objective: Nursing profession conventionally meets a high standard of ethical behavior and action. One of the ethical challenges in nursing profession is moral distress. Nurses frequently expose to this phenomenon which leads to different consequences such as being bored by delivering patient care that decline care quality and make it challenging to achieve health purposes. This study was conducted to investigate the association between the aspects of moral distress and care ***: In this descriptive–analytical study, 545 nurses of intensive and cardiac care units and dialysis and psychiatric wards were recruited by census sampling. Three questionnaires, Sociodemographics, Moral Distress Scale, and Quality Patient Care Scale, were distributed among the participants and collected within 9 months. Data analysis was conducted by descriptive statistics, analysis of variance, and the least significant difference in SPSS ***: Investigating moral distress domains(ignoring patient, decision-making power, and professional competence) and care quality domains(psychosocial, physical, and communicational) demonstrated that in being exposed to moral distress, ignoring patient had no effect on psychosocial domain(P=0.056), but decision-making and professional competence of moral distress had positive effect on psychosocial, physical(bodily), and communication domains of care ***: Because moral distress domains are effective on patient care quality, it is recommended to enhance the knowledge of nurses, especially beginners, about moral distress, increase their strength alongside standardizing nursing services in decisionmaking domains, improve the professional competence, and pay attention to patients.

关键词： quality of healthcare moral distress clinical situations nurse patients

Space-Time-Frequency Coded for Multiband-OFDM Based on IEEE 802.15.3a WPAN

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International Journal of Communications, Network and System Sciences 2009年第7期2卷 664-668页

作者： Kamal MOHAMED-POUR hossein ebrahimi 不详

In this paper, Multiband-OFDM UWB system based on IEEE 802.15.3a standard is studied and simulated with spatial, time and frequency (STF)coding scheme. The using of STF coding method can guarantee both full symbol rate and full diversity advantages. The simulation results show that the STF code uses multi- path-rich and random-clustering characteristics of UWB channel environment on the performance of MB- OFDM system.

关键词： IEEE 802.15.3a UWB MB-OFDM MIMO Space-Time-Frequency Coding

CSRWA:Covert and Severe Attacks Resistant Watermarking Algorithm

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Computers, Materials & Continua 2025年第1期82卷 1027-1047页

作者： Balsam Dhyia Majeed Amir hossein Taherinia Hadi Sadoghi Yazdi Ahad Harati Faculty of Engineering Ferdowsi University of MashhadMashhad***Iran Department of Computer Techniques Engineering Imam Al-Kadhum CollegeBaghdad10087Iraq

Watermarking is embedding visible or invisible data within media to verify its authenticity or protect *** watermark is embedded in significant spatial or frequency features of the media to make it more resistant to intentional or unintentional *** of these features are important perceptual features according to the human visual system(HVS),which means that the embedded watermark should be imperceptible in these ***,both the designers of watermarking algorithms and potential attackers must consider these perceptual features when carrying out their *** two roles will be considered in this paper when designing a robust watermarking algorithm against the most harmful attacks,like volumetric scaling,histogram equalization,and non-conventional watermarking attacks like the Denoising Convolution Neural Network(DnCNN),which must be considered in watermarking algorithm design due to its rising role in the state-of-the-art *** DnCNN is initialized and trained using watermarked image samples created by our proposed Covert and Severe Attacks Resistant Watermarking Algorithm(CSRWA)to prove its *** this algorithm to satisfy the robustness and imperceptibility tradeoff,implementing the Dither Modulation(DM)algorithm is boosted by utilizing the Just Noticeable Distortion(JND)principle to get an improved performance in this ***,luminance,inter and intra-block contrast are used to adjust the JND values.

关键词： Covert attack digital watermarking DnCNN JND perceptual model robustness

Enhancing the Robustness of Visual Object Tracking via Style Transfer

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Computers, Materials & Continua 2022年第1期70卷 981-997页

作者： Abdollah Amirkhani Amir hossein Barshooi Amir ebrahimi School of Automotive Engineering Iran University of Science and TechnologyTehran16846-13114Iran School of Electrical Engineering and Computing The University of NewcastleCallaghan2308Australia

The performance and accuracy of computer vision systems are affected by noise in different *** numerous solutions and algorithms have been presented for dealing with every type of noise,a comprehensive technique that can cover all the diverse noises and mitigate their damaging effects on the performance and precision of various systems is still *** this paper,we have focused on the stability and robustness of one computer vision branch(i.e.,visual object tracking).We have demonstrated that,without imposing a heavy computational load on a model or changing its algorithms,the drop in the performance and accuracy of a system when it is exposed to an unseen noise-laden test dataset can be prevented by simply applying the style transfer technique on the train dataset and training the model with a combination of these and the original untrained *** verify our proposed approach,it is applied on a generic object tracker by using regression *** method’s validity is confirmed by testing it on an exclusive benchmark comprising 50 image sequences,with each sequence containing 15 types of noise at five different intensity *** OPE curves obtained show a 40%increase in the robustness of the proposed object tracker against noise,compared to the other trackers considered.

关键词： Style transfer visual object tracking robustness corruption

Investigation on the homogenization treatment and element segregation on the microstructure of a γ/γ′-cobalt-based superalloy

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International Journal of Minerals,Metallurgy and Materials 2019年第2期26卷 222-233页

作者： Saeed Aliakbari Sani hossein Arabi Shahram Kheirandish Golamreza ebrahimi School of Materials and Metallurgical Engineering Iran University of Science and Technology ((IUST)) School of Materials and Metallurgical Engineering Iran University of Science and Technology (IUST) Materials and Polymers Engineering Department Faculty of Engineering Hakim Sabzevari University

The aim of the present study was to investigate the effect of element segregation on the microstructure and γ′ phase in a γ/γ′ cobalt-based superalloy. Several samples were prepared from a cast alloy and homogenized at 1300°C for different times, with a maximum of 24 h. A microstructural study of the cast alloy using wavelength-dispersive spectroscopic analysis revealed that elements such as Al, Ti, and Ni segregated mostly within interdendritic regions, whereas W atoms were segregated within dendrite cores. With an increase in homogenization time, segregation decreased and the initial dendritic structure was eliminated. Field-emission scanning electron microscopy micrographs showed that the γ′ phases in the cores and interdendritic regions of the as-cast alloy were 392 and 124 nm, respectively. The size difference of γ′ was found to be due to the different segregation behaviors of constituent elements during solidification. After homogenization, particularly after 16 h, segregation decreased; thus, the size, chemical composition, and hardness of the precipitated γ′ phase was mostly uniform throughout the samples.

关键词： superalloy segregation homogenization microstructure γ′phase

Mechanical Properties of Al/BN Nanocomposites Fabricated by Planetary Ball Milling and Conventional Hot Extrusion

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Acta Metallurgica Sinica(English Letters) 2018年第3期31卷 245-253页

作者： Reza Gostariani Ramin ebrahimi Mohsen Asadi Asadabad Mohammad hossein Paydar Department of Materials Science and Engineering School of Engineering Shiraz University Materials and Nuclear Fuel Research School Nuclear Science and Technology Research InstituteTehran Iran

In this study,Al matrix nanocomposites containing 1,2 and 4 wt% nano-boron nitride were fabricated by mechanical milling and hot *** mechanical properties of all extruded samples were ***,the morphology and microstructure of the milled composite powders were characterized using two types of electron *** results showed that a high fraction of the boron nitride nanoparticles dissolved and formed a solid solution in Al matrix during the milling *** the process of solid solution formation,the work hardening rate of the composite powders *** led to a morphological change in the composite powders and resulted in equiaxed *** powder particle size also decreased after the milling *** increasing boron nitride content within a range of 0--4 wt% in the hot extruded samples,tensile stress increased from 212 to 333 *** hardness of the nanocomposite samples including 1,2 and 4 wt% boron nitride improved approximately 55,70 and 90% in comparison with pure Al,respectively.

关键词： Al/BN nanocomposite Planetary ball milling Hot extrusion Mechanical properties Microstructure

Spatiotemporal clustering of cutaneous leishmaniasis in Fars province,Iran

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 862-869页

作者： Marjan Zare Abbas Rezaianzadeh Hamidreza Tabatabaee Mohsen Aliakbarpoor hossein Faramarzi Mostafa ebrahimi Department of Epidemiology School of HealthShiraz University of Medical SciencesShirazIran Department of Social Medicine School of HealthShiraz University of Medical SciencesShirazIran

Objective: To assess the spatiotemporal trait of cutaneous leishmaniasis(CL) in Fars province, ***: Spatiotemporal cluster analysis was conducted retrospectively to find spatiotemporal clusters of CL cases. Time-series data were recorded from 29 201 cases in Fars province, Iran from 2010 to 2015, which were used to verify if the cases were distributed randomly over time and place. Then, subgroup analysis was applied to find significant sub-clusters within large clusters. Spatiotemporal permutation scans statistics in addition to subgroup analysis were implemented using Sa TScan ***: This study resulted in statistically significant spatiotemporal clusters of CL(P < 0.05). The most likely cluster contained 350 cases from 1 July 2010 to 30 November2010. Besides, 5 secondary clusters were detected in different periods of time. Finally,statistically significant sub-clusters were found within the three large clusters(P < 0.05).Conclusions: Transmission of CL followed spatiotemporal pattern in Fars province,Iran. This can have an important effect on future studies on prediction and prevention of CL.

关键词： Cutaneous leishmaniasis Scan statistics Spatiotemporal clustering Clusters within a cluster