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Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients

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World Journal of Gastroenterology 2010年第15期16卷 1896-1900页

作者： Kazuhisa Okada Masahiko Inamori Kento Imajyo Hideyuki Chiba Takashi Nonaka Tadahiko Shiba Takashi Sakaguchi Kazuhiko Atsukawa Hisao Takahashi Etsuo hoshino Atsushi Nakajima Department of Gastroenterology and Hepatology Hiratsuka City Hospital Gastroenterology Division Yokohama City University School of Medicine Division of Endoscopy Cancer Institute Hospital of Japanese Foundation for Cancer Research

AIM:To clarify the gender differences about the clini-cal features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese ***: There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatmentduring the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both ***: A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk fac-tor, and the time to diagnosis as having LDA-associat-ed peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050). CONCLUSION: We demonstrated gender differences about the clinical features and risk factors of LDA-asso-ciated peptic ulcer. Special attention should be paid to aged female patients taking LDA.

关键词： Low-dose aspirin Gender Peptic ulcer

NORTH WESTERN PACIFIC TROPICAL CYCLONE ENSEMBLE FORECAST PROJECT

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Tropical Cyclone Research and Review 2014年第3期3卷 193-201页

作者： MUNEHIKO YAMAGUCHI TETSUO NAKAZAWA SHUNSUKE hoshino Meteorological Research Institute of the Japan Meteorological Agency TsukubaJapan World Meteorological Organization GenevaSwitzerland Aerological Observatory Japan Meteorological AgencyTsukubaJapan

The WMO/TCP and WWRP launched the North Western Pacific Tropical Cyclone Ensemble Forecast Project(NWP-TCEFP) in 2009 to explore the utility of ensemble forecasts, including multi-model ensemble forecasts of TCs, and to promote such products for operational TC forecasting. Operational global mediumrange ensembles, which have been exchanged in real-time in a CXML format under the initiative of the WMO GIFS-TIGGE Working Group, have been used to create ensemble products of TC tracks that were used by the Typhoon Committee Members and forecasters participating in the SWFDP in Southeast Asia through a password-protected website developed and maintained by the JMA. In some cases many or all of the ensembles have simultaneously predicted small or large ensemble spreads in TC tracks. The implication is that multi-model ensemble products provide forecasters with additional information on forecast certainty or uncertainty and thus increase the level of confidence in the forecasts. Another important outcome of the project was the responses to surveys conducted by the WMO/TCP and WWRP and also by the WMO GIFS-TIGGE Working Group. The responses confirmed that ESCAP/WMO Typhoon Committee Members have routinely accessed the website and have recognized the usefulness of the ensemble products available on the website for operational TC forecasting.

关键词： tropical cyclone ensemble forecasting THORPEX TIGGE

Outcomes of endoscopic endonasal dacryocysto-rhinostomy for intractable lacrimal dacryostenosis and associated factors

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1471-1475页

作者： Tohru Tanigawa Hirokazu Sasaki Hiroshi Nonoyama Yuichiro Horibe Kunihiro Nishimura Tetsuro hoshino Tetsuya Ogawa Kenta Murotani Hiromi Ueda Masahiro Kaneda Department of Otolaryngology Aichi Medical University Department of Otolaryngology Tono Kosei Hospital Division of Biostatistics Clinical Research CenterAichi Medical University Department of Ophthalmology Tono Kosei Hospital

AIM：To examine the effects of patient age,canalicular obstruction,mode of anesthesia,and duration of nasolacrimal intubation on the outcomes of endoscopic endonasal dacryocystorhinostomy（DCR）. METHODS： Totally 56 eyes of 46 patients with prolonged epiphora underwent minimally invasive endoscopic endonasal DCR.A successful surgical outcome was defined as a significant improvement in symptoms,adequate water passage from the puncta to the nasal cavity,and patency of the DCR *** outcomes were assessed at least 6mo after ***＇s exact test was used to discuss the factors,and then the logistic regression analysis was made by SAS9.4 ***： The overall success rate was 75.0%,and complete resolution was observed in 27 *** success rate was higher for patients with ≥6mo intubation than for those with 〈6mo ***,there were no significant differences in outcomes between groups stratified by age（〈65 or ≥65y）,presence or absence of canalicular obstruction,mode of anesthesia（local or general）,and use or nonuse of a radiowave *** patient developed subcutaneous emphysema around the eye and nose and one developed subcutaneous hemorrhage after surgery. CONCLUSION： Endoscopic endonasal DCR can be considered safe and minimally invasive with reasonable success rates,particularly when the duration of nasolacrimal intubation is ≥6mo.

关键词： dacryocystorhinostomy endoscopy,, intubation epiphora

Dual-radical-based molecular anisotropy and synergy effect of semi-conductivity and valence tautomerization in a photoswitchable coordination polymer

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National Science Review 2023年第6期10卷 200-214页

作者： Jing-Wei Dai Yu-Qin Li Zhao-Yang Li Hai-Tao Zhang Carmen Herrmann Shohei Kumagai Marko Damjanovi? Markus Enders Hiroyuki Nojiri Masakazu Morimoto Norihisa hoshino Tomoyuki Akutagawa Masahiro Yamashita State Key Laboratory of Medicinal Chemical Biology Nankai University School of Materials Science and Engineering Nankai University Institute of Inorganic and Applied Chemistry University of Hamburg Department of Chemistry Graduate School of Science Tohoku University Institute of Inorganic Chemistry University of Heidelberg Institute for Materials Research Tohoku University Department of Chemistry Rikkyo University Institute of Multidisciplinary Research for Advanced Materials (IMRAM) Tohoku University

Organic radicals are widely used as linkers or ligands to synthesize molecular magnetic ***,studies regarding the molecular anisotropies of radical-based magnetic materials and their multifunctionalities are ***,a photoisomerizable diarylethene ligand was used to form{[CoⅢ(3,5-DTSQ·-)(3,5-DTCat2-)]2(6F-DAE-py2)}·3CH3CN·H2O(o-1·3CH3CN·H2O,6F-DAE-py2=1,2-bis(2-methyl-5-(4-pyridyl)-3-thienyl)perfluorocyclopentene),a valence-tautomeric(VT) coordination *** directly observed dual radicals for a single crystal using high-field/-frequency(～13.3 T and～360 GHz) electron paramagnetic resonance(EPR) spectroscopy along the c-axis,which was further confirmed by angle-dependent Q-band EPR ***,a conductive anomaly close to the VT transition temperature was observed only when probes were attached at the ab plane of the single crystal,indicative of synergy between valence tautomerism and *** anisotropy studies and density functional theory(DFT) calculations revealed that this synergy is due to electron transfer associated with valence *** study presents the first example of dual-radical-based molecular anisotropy and charge-transfer-induced conductive anisotropy in a photoswitchable coordination polymer.

关键词： valence tautomerization charge transfer photo switching diradical coordination polymer

Internal Microanatomy and Zoological Affinity of the Early Cambrian Olivooides

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Acta Geologica Sinica(English Edition) 2016年第1期90卷 38-65页

作者： Han Jian LI Guoxiang KUBOTA Shin OU Qiang TOSHINO Sho WANG Xing YANG Xiaoguang UESUGI Kentaro MASATO hoshino SASAKI Osamu KANO Harumasa SATO Tomohiko KOMIYA Tsuyoshi Early Life Institute and Department of Geology and State Key Laboratory of Continental Dynamics Northwest University229 Taibai RoadXi'an 710069China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Seto Marine Biological Laboratory Field Science Education and Research CenterKyoto UniversityShirahamaNishimuroWakayama 649-2211Japan Early Life Evolution Laboratory School of Earth Sciences and ResourcesChina.University of GeosciencesBeijing 100083China Graduate School of Fisheries Sciences Kitasato University1-15-1 KitasatoSagamiharaKanagawa 252-0373Japan Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 Kouto Sayo-choSayo-gunHyogoJapan Tohoku University Museum Tohoku University6-3 AobaAramakiAoba-kuSendaiJapan Department of Earth Science and Astronomy Graduate School of Arts and SciencesThe University of TokyoTokyo 153-8902Japan

The early Cambrian pentamerous microfossil Olivooides/Punctatus in South China, which is characterized by a diagnostic stellate tubular apex, has been well-known for its almost complete development sequence that can be confidently traced from embryos and hatched juveniles, to conical adults. However, its zoological affinity remains highly controversial. Here we describe the internal microanatomic structures of the soft-body inside the peridermal theca of Olivooides multisulcatus Qian, 1977, including interradial pairs of tentacles, adradial and perradial frenula, perradial oral marginal lappets and twins of perradial gastric saccule-like humps as well as a circular velarium with striated coronal muscles. Particularly, one specimen shows bifurcated velarial canals along the bell aperture. Both the components of the soft-body and the external theca （or cyst） are arranged in perfect pentaradial symmetry. These characteristics are more compatible with those of living cubomedusans and co-occurring Cambrian athecate embryonic cubozoans. Concerning the presence of peridermal theca, Olivooides most likely represents an extinct thecate stem-group cubomedusae but devoid of both perradial eyes and specialized pedalia. The well-grown soft body inside the peridermal tube displays a set of mixed features of both polyp and medusa.

关键词： Embryos periderm cnidarians cubozoan early Cambrian Kuanchuanpu Formation

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铝阳极氧化的极限厚度

轻金属 1989年第6期 59-64页

作者： Shigeo hoshino Shigeomi Matsumoto 周建生

一、绪言作为装饰或防腐底层的铝阳极氧化膜的厚度一般为3～10微米。另一方面,硬质阳极氧化的膜厚从20～100微米。过去不应用厚度超过100微米的氧化膜,因而对这种膜的研究很少。但是近来的发展指出,有时需要应用比以往更厚的氧化膜。

关键词：铝阳极氧化氧化膜极限厚度

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Benchmark Integral Cross Sections for Electron Impact Excitation of the n=2 States in Helium

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Plasma Science and Technology 2010年第3期12卷 348-352页

作者： M.hoshino H.KATO D.SUZUKI H.TANAKA I.BRAY D.V.FURSA S.J.BUCKMAN O.INGLFSSON M.J.BRUNGER Department of Physics Sophia University Centre for Antimatter-Matter Studies Curtin University of Technology Centre for Antimatter-Matter Studies Australian National University Department of Chemistry University of IcelandScience Institute Centre for Antimatter-Matter Studies Flinders University

In this paper, we present integral cross sections （ICS） for electron impact excitation of the n = 2 levels in helium in the impact energy range of 23.5 eV to 35 eV. The ICS of each final state, 2^3S, 2^1S, 2^3P and 2^1P, has been determined by integration of the angular differential cross sections （DCS） over all of 0° to 180°, where those DCS were obtained from both our previous experiments and the extrapolation using the convergent close coupling calculation. The present experimental ICS for the optically allowed 21P transition state are also compared with those obtained from the BE f-scaling method. Very good agreement between the experimental and BE f-scaled 21P ICSs is generally found in the measured impact energy region.

关键词： low energy electron impact electronic excitations helium

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Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume ”

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World Journal of Hepatology 2013年第10期5卷 596-600页

作者： Takashi hoshino Hitoshi Takagi Atsushi Naganuma Eri Koitabashi Sanae Uehara Naomi Sakamoto Tomohiro Kudo Ken Sato Satoru Kakizaki Department of Gastroenterology Takasaki General Center Hospital Department of Medicine and Molecular Science Gunma University Graduate School of Medi-cine

MK615, a compound extracted from the Japanese apricot "Prunus mume " has been reported to have in vitro anti-tumor activities against several cancer cell lines,including hepatocellular carcinoma(HCC). However, the clinical effects and feasibility of administering MK615for patients with HCC were unknown. We experienced a case with advanced HCC for which MK615 was effective against both lymph node and pulmonary metastases. A 60-year-old female underwent surgical resection of a 9 cm HCC in the right lobe. The pathological diagnosis was moderately differentiated HCC with vascular invasion. The HCC recurred in the liver 8 mo after the surgery. Radiofrequency ablation and transarterial infusion chemotherapy were performed, but the recurrence was not controlled. One year after the intrahepatic recurrence, pulmonary and lymph metastasis *** was administered, but was not ***, MK615 was administered as a final alternative therapy after informed consent was obtained from the patient. Three months later, her alpha-fetoprotein level decrease and both the lymph node and pulmonary metastases decreased in size. The patient has survived for more than 17 mo after the MK615 administration, and was in good condition. Although further investigations are necessary to clarify its safety and efficacy in humans, MK615 may be useful for the treatment of HCC,without serious adverse effects.

关键词： MK615 Hepatocellular carcinoma Japanese apricot Prunus mume

Efficacy of Cognitive Remediation in Schizophrenia: A Short Review of Its Variable Effects According to Cognitive Domain

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Open Journal of Psychiatry 2015年第2期5卷 170-176页

作者： Akihiko Katsumi Hiroshi hoshino Satoshi Fujimoto Shin-Ichi Niwa Katsumi Clinic Niigata Japan Department of Neuropsychiatry School of Medicine Fukushima Medical University Fukushima Japan Department of Psychiatry Aizu Medical Center Fukushima Medical University Fukushima Japan

Cognitive impairment is a symptom of schizophrenia and strongly associated with impaired social function. In recent years, cognitive interventions (cognitive remediation therapies) have been implemented and their results have also been reported. Intervention studies have been conducted using a variety of methods that differ in terms of terminology, approach, and targeted cognitive domains. In this study, we examined trends in recent cognitive remediation research conducted subsequent to the meta-analyses of McGurk et al. (2007) and Wykes et al. (2011). We identified studies conducted between 2009 and 2013 to examine computer-assisted cognitive remediation and collated and analyzed the literature describing their major results and trends. Our results indicated improved cognitive performance subsequent to cognitive remediation therapy using computer programs. We found promising outcomes, particularly in reasoning and problem solving, verbal learning and memory, verbal working memory, and attention and vigilance, which replicated the findings of Wykes et al. (2011).

关键词： Schizophrenia Cognitive Deficit Cognitive Remediation Variance Cognitive Domain