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Acta Pharmaceutica Sinica B 2024年第1期14卷 273-291页

作者： Duc-Vinh Pham Thi-Kem Nguyen Bao-Loc Nguyen Jong-Oh Kim Jee-Heon Jeong Inho Choi Pil-hoon park Department of Pharmacology Hanoi University of PharmacyHanoi 100000Viet Nam College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541Republic of Korea Research Institute of Cell Culture Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan UniversitySuwon 16419Republic of Korea

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSC).However,it remains unclear what drives the compromised potency of obese *** this study,we examined the involvement of adiponectin,an adipose tissuederived hormone,in obesity-induced impaired therapeutic function of ***-induced obesity leads to a decrease in serum adiponectin,accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSC(ADSC).Interestingly,priming with globular adiponectin(gAcrp)improved the immunomodulatory potential of obese *** effects were also observed in lean *** addition,gAcrp potentiated the therapeutic effectiveness of ADSC in a mouse model of DSS-induced ***,while obesity inhibited the glycolytic capacity of MSC,gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1a *** findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSC against immune-mediated disorders.

关键词： Adiponectin Adipose-derived stromal cells Colitis Glycolytic induction HIF1a Immunomodulation Mesenchymal stromal cells Obesity

Fatal intratumoral hemorrhage in a patient with hepatocellular carcinoma following successful treatment with atezolizumab/bevacizumab:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5177-5183页

作者： Kyeong-hoon park Jeong-Ju Yoo Sang Gyune Kim Young Seok Kim Department of Gastroenterology and Hepatology Soonchunhyang University School of MedicineBucheon 14584South Korea

BACKGROUND Atezolizumab/bevacizumab is emerging as the new standard for advanced hepatocellular carcinoma(HCC),with ongoing real-world implementation to study its *** the use of atezolizumab/bevacizumab increases,various side effects have been reported in clinical practice,most notably increased bleeding caused by *** SUMMARY In this case report,we present a rare and fatal case of intratumoral hemorrhage in a patient with advanced HCC following successful treatment with atezolizumab/bevacizumab.A 63-year-old male diagnosed with HCC initially underwent four cycles of intra-arterial ***,follow-up abdominal computed tomography(CT)revealed disease ***,the treatment plan was modified to atezolizumab/*** the fifth cycle of atezolizumab/bevacizumab,CT showed partial regression of *** week later,he visited the emergency room due to severe abrupt abdominal *** CT revealed focal rupture of HCC in the medial segment inferior portion with active bleeding and a large amount of *** was performed on the same day,and embolization of A4 and A8 branches using lipiodol and gelfoam was *** successful hemostasis,the patient subsequently developed liver failure and *** Atezolizumab/bevacizumab for advanced HCC suggests that intratumoral hemorrhage may be crucial despite good tumor response after immunotherapy,emphasizing the continuous monitoring of this side effect.

关键词： Adverse events Atezolizumab Bevacizumab Complication Hemorrhage Bleeding Hepatocellular carcinoma Case report

Visualization of flow structures inside a conical spouted bed by electrical capacitance volume tomography

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Particuology 2019年第1期17卷 15-25页

作者： hoon Chae park Hang Seok Choi Department of Environmental Engineering Yonsei UniversityWonju 26493Republic of Korea

Electrical capacitance volume tomography (ECVT) was conducted to measure instantaneous gas–solid flow structures in a conical spouted bed. The sensor has 24 electrodes/channels and was used to make three-dimensional measurements of the solid volume fraction. Flow structures in the conical spouted bed were analyzed using quantitative ECVT images. Three-dimensional images of gas–solid flow structures and time-averaged vertical and radial solid volume fraction profiles are presented. Different fluidization regimes in spouted beds were characterized by analyzing pressure fluctuation signals and ECVT images. ECVT was shown to be robust and powerful for the three-dimensional visualization and quantitative measurement of a gas–solid fluidization system.

关键词： Conical spouted bed Electrical capacitance volume tomography Multiphase flow

Design and Demonstration of a Locust-Like Jumping Mechanism for Small-Scale Robots

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Journal of Bionic Engineering 2012年第3期9卷 271-281页

作者： Quoc-Viet Nguyen hoon Cheol park Department of Advanced Technology Fusion Konkuk University Seoul 143-701 Republic of Korea

A jumping mechanism can be an efficient mode of motion for small robots to overcome large obstacles on the ground and rough terrain. In this paper, we present a 7 g prototype of locust-inspired jumping mechanism that uses springs, wire, reduction gears, and a motor as the actuation components. The leg structure and muscles of a locust or grasshopper were mimicked using springs and wire, springs for passive extensor muscles, and a wire as a flexor muscle. A small motor was used to slowly charge the spring through a lever and gear system, and a cam with a special profile was used as a clicking mechanism for quick release of elastic energy stored in the springs to create a sudden kick for a quick jump. Performance analysis and experiments were conducted for comparison and performance estimation of the jumping mechanism prototype. Our prototype could produce standing jumps over obstacles that were about 14 times its own size （approximate to 71 cm） and a jumping distance of 20 times its own size （approximate to 100 cm）.

关键词： biomimetics locust jumping mechanism passive tibia extensor muscle

Generation of Control Moments in an Insect-like Tailless Flapping-wing Micro Air Vehicle by Changing the Stroke-plane Angle

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Journal of Bionic Engineering 2016年第3期13卷 449-457页

作者： Hoang Vu Phan hoon Cheol park Artificial Muscle Research Center Konkuk University Seoul 143-701 South Korea Deptment of Advanced Technology Fusion Konkuk University Seoul 143-701 South Korea

We propose a control moment generator to control the attitude of an insect-like tailless Flapping-wing Micro Air Vehicle （FW-MAV）, where the flapping wings simultaneously produce the flight force and control moments. The generator tilts the stroke plane of each wing independently to direct the resultant aerodynamic force in the desired direction to ultimately generate pitch and yaw moments. A roll moment is produced by an additional mechanism that shifts the trailing edge, which changes the wing rotation angles of the two flapping wings and produces an asymmetric thrust. Images of the flapping wings are captured with a high-speed camera and clearly show that the FW-MAV can independently change the stroke planes of its two wings. The measured force and moment data prove that the control moment generator produces reasonable pitch and yaw moments by tilting the stroke plane and realizes a roll moment by shifting the position of the trailing edge at the wing root.

关键词： insect-like Flapping-wing Micro Air Vehicle (FW-MAV) control mechanism stroke plane beetle flight

Influence of Center of Gravity Location on Flight Dynamic Stability in a Hovering Tailless FW-MAV: Lateral Motion

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Journal of Bionic Engineering 2020年第1期17卷 148-160页

作者： Loan Thi Kim Au hoon Cheol park Department of Smart Vehicle Engineering and Artificial Muscle Research Center Konkuk UniversitySeoul 05029Korea

This paper reports the effect of the Center of Gravity(CG)position on lateral flight dynamic stability of hovering KUBeetle,a tailless FW-MAV,providing further insights on the effects of asymmetries in body mass distribution and wing *** the current study,the standard linearized equations of motion were applied as in the previous work on longitudinal dynamic *** stability derivatives were acquired using the computational fluid dynamic methods via the commercial software of ANSYS *** exists a stable region for CG between 2.6%and 3.5%of the mean chord below the wing pivot point,in which the lateral motion of hovering KUBeetle is passively *** CG below the stable region,because of an unstable oscillatory mode,the lateral motion of the FW-MAV is unstable but can be stabilized using rolling rate *** CG above the stable region,because of a divergence mode,the system remains unstable even with the rolling rate *** with other works on an FW-MAV based on a quasi-steady aerodynamic model and on insect showed similar characteristics for flapping *** is also interesting to note that the asymmetries in body mass and wing kinematics can enlarge the stable region of the system by a non-zero Ixz which approaches the root square of√IxIz,a negative LrNp,and a positive Ix2(Ir+Np).Combining the current result with that of the previous work on longitudinal motion,the most beneficial region of the CG for full 6-DOF flight dynamic stability of hovering KUBeetle was suggested.

关键词： FW-MAV center of gravity flight dynamic stability lateral motion asymmetry computational fluid dynamics bioinspired flight

Influence of Center of Gravity Location on Flight Dynamic Stability in a Hovering Tailless FW-MAV:Longitudinal Motion

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Journal of Bionic Engineering 2019年第1期16卷 130-144页

作者： Loan Thi Kim Au hoon Cheol park Department of Smart Vehicle Engineering and Artificial Muscle Research Center Konkuk UniversitySeou105029Korea

The influence of Center of Gravity(CG)location on longitudinal dynamic stability of hovering KUBeetle,a tailless Flapping-Wing Micro Air Vehicle(FW-MAV),is reported in this *** rigid-body approximation was assumed,allowing application of the standard equations of motion used for fixed-wing *** each considered location of CG,stability derivatives were obtained using the computational fluid dynamics method via the commercial software of ANSYS *** dynamic stability was studied using technique of eigenvalue *** exists a narrow stable region for CG between 23%-24%of mean chord above the wing pivot point,where the longitudinal hovering of KUBeetle is passively *** CG is located below the stable region,the analysis identifies two subsidence modes and one unstable oscillatory mode,which makes the hovering of KUBeetle ***,it can be stabilized using pitching rate *** CG is located above the stable region,the system yields one stable oscillatory mode,one subsidence mode,and one divergence *** of the divergence mode,the system remains unstable even with the angular rate *** results share similar characteristics to another FW-MAV and *** study may provide a reference for FW-MAV developers.

关键词： center of gravity hovering longitudinal dynamic stability computational fluid dynamics flapping wings bioinspired flight

Reliable beacon transmission based MAC protocol for LR-WPANs over WLAN interferences

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第6期15卷 470-481页

作者： Ji-hoon park Byung-Seo KIM ITO Business Division Nongshim Data System Department of Computer and Information Communications Engineering Hongik University

The use of IEEE 802.15.4 standard based application systems has been rapidly increasing, for example, in medical services, sensor networks, public safety systems, and home automation systems. However, issues arise from the fact that IEEE 802.15.4 standard based low rate wireless personal area networks(LR-WPANs) use the same frequency bands as wireless local area networks(WLANs), and they interfere with each other. Based on past research on this issue, the interference has a more serious impact on LR-WPANs' performance than on WLANs' performance. In this paper we propose a method to improve LR-WPANs' performance while coexisting with WLANs, which is called the reliable beacon transmission based medium access control(MAC) protocol. Since the reliability of a beacon frame is important, in this method, only the beacon frame is transmitted in interference-free channels, and the data packets are transmitted in interfered channels instead of abandoning the channels altogether. This method increases the reliability of beacon frames as well as overall channel utilizations. The effectiveness of the proposed method was evaluated through extensive simulations, and this paper proves that this method improves the performance of IEEE 802.15.4 based wireless sensor networks(WSNs) over WLANs' interferences.

关键词： Low rate wireless personal area network(LR-WPAN) Interference Wireless local area network(WLAN) Beacon

Thrust Analysis of a Fish Robot Actuated by Piezoceramic Composite Actuators

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Journal of Bionic Engineering 2011年第2期8卷 158-164页

作者： Quang Sang Nguyen hoon Cheol park Doyoung Byun Biomimetics and bltelligent Microsystems Laboratory Department of Advanced Technology Fusion Konkuk University Seoul 143-701 South Korea Department of Advanced Technology Fusion Konkuk University Seoul 143-701 South Korea Department of Aerospace Engineering Konkuk University Seoul 143-701 South Korea

In this work, a three-dimensional （3D） Computational Fluid Dynamics （CFD） model was built to simulate the tail fin motion of a fish robot actuated by a piezoceramic composite actuator, and to determine the maximum thrust tail-beat frequency. A simulation of the tail fin at a tail-beat frequency was performed to confirm measured thrust data from a previous study. The computed and measured thrusts were in good agreement. A series of thrust simulations were conducted for various tail-beat frequencies to confirm the maximum thrust frequency that was obtained from thrust measurements in the previous study. The largest thrust was calculated at a tail-beat frequency of 3.7 Hz and vortices around the tail were fully separated. The calculated maximum thrust tail-beat frequency was in good agreement with the measured frequency. Flow characteristics during tail fin motion were examined to explain why the largest thrust occurred at this particular tail-beat frequency.

关键词： fish robot CFD LIPCA thrust measurement thrust analysis composite actuator vortex shedding

Design and Demonstration of Insect Mimicking Foldable Artificial Wing Using Four-Bar Linkage Systems

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Journal of Bionic Engineering 2014年第3期11卷 449-458页

作者： Quang-Tri Truong Byoma Wing Argyoganendro hoon Cheol park Laboratory of Applied Mechanics Faculty of Applied Science HCMUT Ho Chi Minh City 740-128 Vietnam Biomimetics and Intelligent Microsystem Laboratory Konkuk University Seoul 143-701 Korea Department of Advanced Technology Fusion Konkuk University Seoul 143-701 Korea Artificial Muscle Research Center Konkuk University Seoul 143-701 Korea

In this work, we develop an artificial foldable wing that mimics the hind wing of a beetle （Allomyrina dichotoma）. In real flight, the beetle unfolds forewings and hind wings, and maintains the unfolded configuration unless it is exhausted. The artificial wing has to be able to maintain a fully unfolded configuration while flapping at a desirable flapping frequency. The artificial foldable hind wing developed in this work is based on two four-bar linkages which adapt the behaviors of the beetle＇s hind wing. The four-bar-linkages are designed to mimic rotational motion of the wing base and the vein folding/unfolding motion of the beetle＇s hind wing. The behavior of the artificial wings, which are installed in a flapping-wing system, is observed using a high-speed camera. The observation shows that the wing could maintain a fully unfolded configuration during flapping motion. A series of thrust measurements are also conducted to estimate the force generated by the flapping-wing system with foldable artificial wings. Although the artificial foldable wings give added burden to the flapping-wing system because of its weight, the thrust measurement results show that the flapping-wing system could still generate reasonable thrust.

关键词： beetle's hind wing folding/unfolding motion flapping-wing system foldable wing four-bar linkage configuration thrust measurement