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Chinese Chemical Letters 2024年第3期35卷 312-315页

作者： Lijuan He hongxia du Yi Yang Zhihua Guan Jinjin Li Honglin Li Xudong Lin Lili Zhu Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&TechnologyShanghai 200237China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China

Thrombosis remains a major global health concern mainly characterized by high rates of morbidity and *** models serve as an indispensable tool to understand the underlying pathogenesis of thrombosis and assess the efficacy of novel antithrombotic ***,zebrafish has emerged as a valuable model organism for thrombosis ***,the traditional method of studying zebrafish thrombosis requires a laborious and time-consuming procedure,including anesthesia and manual immobilization of *** this study,based on hydrodynamic force,a lateral-immobilization zebrafish microfluidic chip(LIZMC)was designed to evaluate the cardiovascular system of multiple larvae within a single microscope field of ***,coupling with microscope imaging,real-time monitoring of the peripheral blood circulation in the tail of phenylhydrazine(PHZ)-induced zebrafish thrombosis was ***,the reliability of LIZMC for in vivo evaluation of antithrombotic agents in zebrafish was verified using ***,this novel LIZMC-based system can be used for in vivo zebrafish thrombosis studies and rapid screening of antithrombotic agents.

关键词： Microfluidic chip Zebrafish Thrombosis In vivo evaluation Real-time monitor

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燃煤锅炉分布式控制系统设计

现代制造技术与装备 2024年第4期60卷 139-141页

作者：杜红霞山西职业技术学院太原030000

燃煤锅炉是一种重要的能量转换设备,对其燃烧过程的稳定控制是燃料充分燃烧的必要条件。为提高锅炉系统的环保性,采用工控机(Industrial Personal Computer,IPC)与可编程逻辑控制器(Programmable Logic Controller,PLC)相结合的方式,设... 详细信息

燃煤锅炉是一种重要的能量转换设备,对其燃烧过程的稳定控制是燃料充分燃烧的必要条件。为提高锅炉系统的环保性,采用工控机(Industrial Personal Computer,IPC)与可编程逻辑控制器(Programmable Logic Controller,PLC)相结合的方式,设计了燃煤锅炉的分布式控制系统。以给煤量控制为例,阐述了控制方法的设计过程。依据燃煤锅炉的工艺过程,采用WinCC组态软件设计监控系统,以实现锅炉的远程交互控制,提高锅炉运行的安全性和稳定性。

关键词：燃煤锅炉分布式控制系统工控机(IPC) 可编程逻辑控制器(PLC) 监控系统

通腑泻热活血方联合针刺法治疗脑出血后顽固性脑水肿的疗效

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西北药学杂志 2024年第4期39卷 100-106页

作者：尹杰马喜刚杜红霞陇南市第一人民医院重症医学科陇南746000 甘肃省中医药大学附属第三医院麻醉科白银730900 陇南市第一人民医院中医科陇南746000

目的探讨通腑泻热活血方联合针刺法治疗脑出血后顽固性脑水肿的疗效。方法选取脑出血后合并顽固性脑水肿患者72例,随机分为对照组与观察组,每组36例。对照组给予常规治疗,观察组在对照组治疗的基础上给予通腑泻热活血方联合针刺治疗。... 详细信息

目的探讨通腑泻热活血方联合针刺法治疗脑出血后顽固性脑水肿的疗效。方法选取脑出血后合并顽固性脑水肿患者72例,随机分为对照组与观察组,每组36例。对照组给予常规治疗,观察组在对照组治疗的基础上给予通腑泻热活血方联合针刺治疗。分别于治疗前及治疗后3、7、14 d检测2组的颅内压(intracranial pressure,ICP),于治疗前及治疗后7、14 d测量脑水肿体积并评估美国国立卫生院神经功能缺损评分(the National Institutes of Health Neurological Impairment Score,NIHSS)、中医证候(traditional Chinese medicine,TCM)评分,检测血清白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-6(interleukin-6,IL-6)、细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、一氧化氮(nitric oxide,NO)、内皮素-1(endothelin-1,ET-1)、水通道蛋白4(aquaporin 4,AQP4)、S100蛋白(S100 protein,S100β)以及神经元特异性烯醇化酶(neuron-specific enolase,NSE)和脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平。结果治疗3、7、14 d后,2组的ICP均明显降低(P<0.05),且治疗3、7 d后观察组的ICP明显低于对照组(P<0.05);治疗7、14 d后,2组的相对脑水肿体积、绝对脑水肿体积、NIHSS评分及TCM评分均显著降低,且观察组低于对照组(P<0.05)。治疗后,2组的血清IL-1β、IL-6、ICAM-1、MMP-9、ET-1、AQP4、S100β及NSE均降低,NO和BDNF均升高,且观察组的改善幅度优于对照组(P<0.05)。结论通腑泻热活血方联合针刺治疗脑出血后顽固性脑水肿可促进水肿消退,提高临床疗效,促进神经重塑,其机制与抑制神经炎症、保护血管内皮细胞及调节神经损伤相关因子的表达等有关。

关键词：通腑泻热活血方针刺脑出血顽固性脑水肿神经重塑

Dynamics of total culturable bacteria and its relationship with methylmercury in the soils of the water level fluctuation zone of the Three Gorges Reservoir

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Chinese Science Bulletin 2014年第24期59卷 2966-2972页

作者： Yuping Xiang hongxia du Hong Shen Cheng Zhang Dingyong Wang Chongqing Key Laboratory of Soil Multi-scale Interfacial Process College of Resources and Environment Southwest University Chongqing Engineering Research Center for Agricultural Non-point Source Pollution Control in the Three Gorges Reservoir Area Chongqing Key Laboratory of Agricultural Resources and Environment

Field investigations were conducted to study the temporal and spatial distribution characteristics of total culturable bacteria(TCB)and its relationship with methylmercury(MeHg)in the soils of the water level fluctuation zone of the Three Gorges *** altitudes(170–180,170–175,165–170 and 160–165 m)in Zhenxi(Site 1),Shibaozhai(Site 2)and Tujing(Site 3),Chongqing,China were chosen as sampling *** indicated that TCB did not have significant difference in the top(0–10 cm)and sub(10–20 cm)soil of the non-inundated area(175–180 m),but showing a significant difference in the water level fluctuation zone(\175 m,suggesting that water level fluctuation had an important effect on ***,TCB in soils of various altitudes of Site 1 and 2had significant difference,while for Site 3,this difference was not *** the difference of TCB in Site 2was much greater than that in Site *** results suggested that there were significant differences for TCB in soils of mainstream and *** addition,TCB in soils of 10–20 cm had significant or highly significant positive correlations with MeHg level(r C 0.762,P B 0.048),thus we assumed that there may be some aerobic microorganisms playing dominant roles in mercury methylation.

关键词：水库水位甲基汞涨落带共培养土壤三峡细菌时空分布特征

Advances in the structure design of substrate materials for zinc anode of aqueous zinc ion batteries

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Green Energy & Environment 2023年第6期8卷 1531-1552页

作者： Sinian Yang hongxia du Yuting Li Xiangsi Wu Bensheng Xiao Zhangxing He Qiaobao Zhang Xianwen Wu School of Chemistry and Chemical Engineering Jishou UniversityJishou416000China School of Chemical Engineering North China University of Science and TechnologyTangshan063009China Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen361005China Key Laboratory of High Performance Ceramics Fibers(Xiamen University) Ministry of EducationXiamen361005China

Aqueous zinc ion batteries(AZIBs) demonstrate tremendous competitiveness and application prospects because of their abundant resources,low cost, high safety, and environmental friendliness. Although the advanced electrochemical energy storage systems based on zinc ion batteries have been greatly developed, many severe problems associated with Zn anode impede its practical application, such as the dendrite formation,hydrogen evolution, corrosion and passivation phenomenon. To address these drawbacks, electrolytes, separators, zinc alloys, interfacial modification and structural design of Zn anode have been employed at present by scientists. Among them, the structural design for zinc anode is relatively mature, which is generally believed to enhance the electroactive surface area of zinc anode, reduce local current density, and promote the uniform distribution of zinc ions on the surface of anode. In order to explore new research directions, it is crucial to systematically summarize the structural design of anode materials. Herein, this review focuses on the challenges in Zn anode, modification strategies and the three-dimensional(3D) structure design of substrate materials for Zn anode including carbon substrate materials, metal substrate materials and other substrate materials. Finally, future directions and perspectives about the Zn anode are presented for developing high-performance AZIBs.

关键词： Zinc ion battery Structure design of substrate materials Dendrite-free 3D Zn anode

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地埋滴灌不同覆盖对土壤水分变化规律的影响

农业技术与装备 2024年第3期 36-38页

作者：周慧徐红梅赵太平孙杰杜红霞河套学院内蒙古自治区巴彦淖尔015000

为了了解地埋滴灌不同覆盖对土壤水分变化规律的影响,设置玉米生长过程中不同覆盖条件下的地埋滴灌试验区,采集土壤水分数数据,对不同覆盖条件下的土壤水分变化进行分析。结果表明,地埋滴灌不同覆盖对土壤水分变化规律有着显著影响,在... 详细信息

为了了解地埋滴灌不同覆盖对土壤水分变化规律的影响,设置玉米生长过程中不同覆盖条件下的地埋滴灌试验区,采集土壤水分数数据,对不同覆盖条件下的土壤水分变化进行分析。结果表明,地埋滴灌不同覆盖对土壤水分变化规律有着显著影响,在漫灌条件下,不覆膜灌溉均较覆膜灌溉土壤含水量高,玉米拔节期该现象最显著,随着玉米生长的推进,该现象逐渐减弱至消失;在浅埋和深埋滴灌条件下,不覆膜灌溉基本较覆膜灌溉土壤含水量高。该试验漫灌灌溉制度适宜,浅埋滴灌和深埋滴灌灌溉制度需继续优化。

关键词：地埋滴灌不同覆盖土壤水分变化

Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

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Chinese Chemical Letters 2024年第2期35卷 380-385页

作者： du Qiao hongxia Li Weiping Zhu Lili Zhu Danyang Zhao Honglin Li Key Laboratory for Precision & Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116023China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Lingang Lab Shanghai 200031China

Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles ***,the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles.A novel particle separation lab-on-chip(LOC)prototype integrated with microstructures and micropolar arrays is designed and ***,a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is *** effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement accurate prediction of particle *** is found that the separation efficiency of magnetic particles increased from 50.2%to 91.7%and decreased from 88.6%to 85.7%in the range of depth factors from 15µm to 27µm and width factors from 30µm to 60µm,*** particular,the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional ***,the developed LOC prototype was generalized for extension to arbitrary *** work provides a new insight and robust method for the microfluidic separation of magnetic particles.

关键词： Microfluidic Particle separation Synergistic effect Hydrodynamics Magnetic field Numerical calculation

Mechanism of nanoparticle aggregation in gas-liquid microfluidic mixing

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Chinese Chemical Letters 2024年第4期35卷 376-381页

作者： hongxia Li Xiyang Wang du Qiao Jiahao Li Weiping Zhu Honglin Li Key Laboratory for Precision&Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116023China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China

Using gas-liquid segmented micromixers to prepare nanoparticles that have a homogeneous particle size, controllable shape, and monodispersity advantages. Although nanoparticle aggregation within a microfluid has been shown to be affected by the shear effect, the shear effect triggering conditions in gasliquid two-phase flow is unclear and the aggregation behavior of nanoparticles under the shear effect is difficult to predict, resulting in uncontrollable physical and chemical properties of nanoparticle aggregates. In this study, a numerical simulation of nanoparticle aggregation in gas-liquid two-phase flow under the shear effect is performed using the CFD-DEM method. Then, the effects of total flow rate,gas-liquid two-phase flow ratio, and particle volume fraction on particle aggregation were analyzed to achieve control of particle aggregation shape and size. Meanwhile, the triggering mechanism of the shear effect and the mechanism of the shear effect on the aggregation of nanoparticles were clarified. The results show that increasing the total flow rate or decreasing the gas-liquid two-phase flow rate ratio can induce the shear effect, which reduces the particle aggregation size and makes the morphology tend to be spherical. Moreover, increasing the particle volume fraction, and total flow rate or decreasing the gas-liquid two-phase flow rate ratio also increases the number of particle collisions and induce interparticle adhesion. Hence, particle adhesion and the shear effect compete with each other and together affect particle aggregation.

关键词： Microfluidic Gas-liquid segmented micromixer Nanoparticle aggregation Shear effect Numerical calculation

生长期施用GA_(4+7)对黄冠梨贮藏过程中挥发性有机化合物的变化影响

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齐鲁工业大学学报 2024年第1期38卷 19-29页

作者：郑欣欣颜朦朦陈子雷杜红霞杨亲正张文君齐鲁工业大学(山东省科学院)生物工程学院山东济南250353 山东省农业科学院农产品质量标准与检测技术研究所山东济南250100

为了研究生长期赤霉素4+7(GA_(4+7))的施用对梨果贮藏期香气品质的影响,采用顶空固相微萃取(HS-SPME)结合全二维气相色谱/飞行时间质谱(GC×GC/TOFMS)进行分析。经分析发现在对照组和GA_(4+7)处理组中均检测到酯、烯烃、醇、醛、酮、烷... 详细信息

为了研究生长期赤霉素4+7(GA_(4+7))的施用对梨果贮藏期香气品质的影响,采用顶空固相微萃取(HS-SPME)结合全二维气相色谱/飞行时间质谱(GC×GC/TOFMS)进行分析。经分析发现在对照组和GA_(4+7)处理组中均检测到酯、烯烃、醇、醛、酮、烷烃、芳烃和硫化物8大类挥发性物质,其中,酯类、醇类、醛类和烯烃是主要的挥发性香气成分。在贮藏当天,GA_(4+7)处理组的挥发性物质总质量浓度和数量最高,是对照组的1.72倍,然而在贮藏50 d后,GA_(4+7)处理组中挥发性物质的质量浓度和数量便迅速下降。此外,主成分分析和热图分析表明,贮藏过程中GA_(4+7)处理组与对照组之间的香气变化有显著差异。进一步的香韵分析表明,GA_(4+7)处理可以增加果实贮藏当天的果味香型质量分数占比,但会降低贮藏期梨果的果味香型。上述研究全面阐明了在生长期施用GA_(4+7)对梨果实贮藏期间挥发性成分的影响,为梨贮藏期的确定和生产管理提供了重要的理论支持。

关键词：黄冠梨植物生长调节剂挥发性有机化合物全二维气相色谱质谱/飞行时间质谱香韵分析

Response Surface Optimized Extraction of Flavonoids from Cacumen platycladi and Antioxidant Activities In vitro

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Medicinal Plant 2018年第5期9卷 5-9,12页

作者： hongxia du Xiang WANG Yanxiu LIU Xuan YU School of Chemical Engineering and Materials Science Nanjing Polytechnic Institute

[Objectives]To explore the optimal extraction process and the antioxidant activity of flavonoidsof Cacumen platycladi. [Methods]FCPwas obtained from C. platycladi by a new set extraction process of microwave-assisted extraction,freeze thawing,superfine crushingand freeze drying technology and purification. On the basis of single-factor tests,the quadratic regression parasitism model was established by the extraction amount of total flavonoids with microwave power,alcohol concentration,and liquid-to-solid ratio through the response surface methodology. [Results] The optimal extraction conditions were microwave power of 757 W,alcohol concentration of 69%,liquid-to-solid ratio of21∶ 1,with the optimal extraction yield of 15. 302 9 mg/g. Under the real conditions( microwave power of 800 W,alcohol concentration of69%,liquid-to-solid ratio of 21∶ 1) in our laboratory,the maximum yield of total flavonoids was 15. 9 mg/g,the results fitwell with the prediction of quadratic regression parasitism model. The good antioxidant activity has been determined byscavenging effect of FCP on 1,1-diphenyl-2-picrylhydrazyl( DPPH) radical and superoxide anion free radical with the scavenging yield of 70. 2% and 68. 8% respectively. [Conclusions]All results established a good foundation for furtherdevelopment of C. platycladi products.

关键词： Flavonoids of Cacumen platycladi Response surface methodology Extraction Optimization Antioxidant activity