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Metallogenic model of sandstone-hosted copper deposits:a case study from the Paleogene in Jiashi area,northwestern China

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Journal of Palaeogeography 2025年第01期14卷 105-125页

作者： Long-Qing Shi xing-Yue Qu Carlos Zavala Yang Li College of Earth Science and Engineering Shandong University of Science and Technology Geology Department Universidad Nacional del Sur Geología de Cuencas Sedimentarias (GCS) Argentina Institute of Energy Peking University Ordos Research Institute of Energy Peking University Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and Technology

Sandstone-hosted copper deposits,a type of Sediment-Hosted Stratiform Copper (SSC) deposits,are widely distributed *** economically viable deposits of SSC are relatively scarce,they account for approximately 30%of the world's total discovered copper ***,there is still a lack of comprehensive and in-depth research into the depositional and metallogenic models of these *** Jiashi area of the Tarim Basin in northwestern China,known for its economically significant Paleogene SSC deposit,lacks in-depth studies on metallogenic *** address this,field profile observations were conducted to analyze the sedimentary evolution,sequence stratigraphy,and tectonism of the Paleogene strata in the Jiashi *** with elemental geochemical analysis of samples,the provenance of sediment,and the source of metallogenic materials,a robust metallogenic model was *** results reveal the influence of provenance for the origin of Paleogene copper-rich *** evolution played a crucial role in controlling the distribution of copper and sulfur elements,as well as the spatial arrangement of metallogenic ***,nappe movement potentially generated faults,allowing upward movement of basin fluids,which played a crucial role in the formation of copper deposits within sandstone-hosted ***,this study offers a comprehensive analysis of the metallogenic processes involved in sandstone-hosted copper deposits,thereby contributing significant insights to the broader research on SSC deposits worldwide.

关键词： Tarim Basin Paleogene Sandstone-hosted copper deposits Metallogenic material source Metallogenic model

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Exploring the effects of perception factors on evacuation intentions of residents

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Journal of Mountain Science 2025年第2期22卷 592-610页

作者： TANG Lan ZHOU Jiawen ZHOU Langyu xing Huige College of Architecture and Environment Sichuan UniversityChengdu 610065China State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China Institute for Disaster Management and Reconstruction Sichuan University-Hong Kong Polytechnic UniversityChengdu 610207China

The evacuation of people under threat is an effective disaster prevention and mitigation measure in response to flash floods and geological hazards,and it is also an essential element of pre-disaster ***,the effect of the interactions between perception factors on residents'willingness to evacuate is an urgent problem to be ***,this paper introduces risk,stakeholder,and protective action perceptions from the protective action decision model as the main explanatory *** three core perceptions are subdivided into affective risk perception,cognitive risk perception,government perception,other-stakeholder perception,resourcerelated attributes,and hazard-related attributes.A questionnaire survey was conducted from June to July 2023 among residents of mountainous communities in nine villages in three towns in Sichuan Province,China.359 cross-sectional data were analyzed using structural equation modeling to explore the effects of six perception factors on evacuation *** results of the study showed that:(1)affective risk perception,government perception,other-stakeholder perception,and hazard-related attributes all directly and positively influence residents'intentions to evacuate;(2)cognitive risk perception is mediated by stakeholder and protective action perceptions,which indirectly and positively affect residents'intentions to *** on the hypothesized paths,strategies to improve residents'willingness to evacuate are discussed from the perspective of three core perceptions:strengthening disaster risk education,improving residents'cohesion,and building government *** results of this study can provide theoretical support and practical suggestions for emergency management departments to formulate emergency evacuation strategies,which can aid decision-makers in better understanding residents'intentions to evacuate,optimizing evacuation information dissemination pathways,and strengthening disaster risk man

关键词： Disaster prevention and mitigation Evacuation intentions Flash floods and geological hazards Protective action decision model Perception factors Structural equation modeling

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mRNA vaccines for gastrointestinal malignancies:cutting-edge advances and future perspectives

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Science Bulletin 2025年第2期70卷 128-131页

作者： Gang Zhang xing Huang Tingbo Liang Zhejiang Provincial Key Laboratory of Pancreatic Disease Department of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China MOE Joint International Research Laboratory of Pancreatic Diseases Hangzhou 310003China

Gastrointestinal malignancies encompass cancers of the esophagus,stomach,pancreas,liver,gallbladder,biliary tract,colon,and *** to the 2020 global cancer statistics,gastrointestinal malignancies accounted for approximately 26.4%of all new cancer cases and 36.3%of new deaths(Text S1 online)[1–3].The high incidence and mortality of gastrointestinal malignancies pose a tremendous threat to human *** significant strides in the management of advanced and metastatic gastrointestinal malignancies(Text S2 online),they frequently prove incurable,with 5-year survival rates consistently remaining<20%across various affected sites[4,5].Emerging evidence increasingly underscores the promising therapeutic potential of mRNA vaccines in the field of cancer *** vaccines offer several advantages over traditional strategies(Texts S3 and S4 online)[6–8].Here,we discuss the recent progress and future perspectives of m RNA vaccines in gastrointestinal malignancies.

关键词： gastrointestinal vaccines stomach

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A comprehensive review of deactivation and modification of selective catalytic reaction catalysts installed in cement kilns

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Journal of Environmental Sciences 2025年第2期148卷 451-467页

作者： Yang Zheng Yi xing Guoliang Li Jiajia Gao Rui Li Qi Liu Tao Yue School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

After the ultralow emission transformation of coal-fired power plants,cement production became China’s leading industrial emission source of nitrogen *** gas dust contents at the outlet of cement kiln preheaters were as high as 80-100 g/m^(3),and the calcium oxide content in the dust exceeded 60%.Commercial V_(2)O_(5)(-WO3)/TiO_(2) catalysts suitable for coal-fired flue gas suffer from alkaline earth metal Ca poisoning of cement kiln flue *** studies have also identified the poisoning of cement kiln selective catalytic reaction(SCR)catalysts by the heavy metals lead and *** of the poisoning process is the primary basis for analyzing the catalytic *** review summarizes and analyzes the SCR catalytic mechanism and chronicles the research progress concerning this poisoning *** on the catalytic and toxification mechanisms,it can be inferred that improving the anti-poisoning performance of a catalyst enhances its acidity,surface redox performance-active catalytic sites,and shell layer *** data provide support in guiding engineering practice and reducing operating costs of SCR ***,future research directions for SCR denitrification catalysts in the cement industry are *** study provides critical support for the development and optimization of poisoning-resistant SCR denitrification catalysts.

关键词： Cement Flue Gas NH_(3)-SCR CaO Poisoning Mechanism Anti-poisoning Modification

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Optimal investment, retirement, and life insurance with consumption ratcheting and time-inhomogeneous utility

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Science China Mathematics 2025年

作者： Jie xing Jingtang Ma School of Big Data Application and Economics Guizhou University of Finance and Economics School of Mathematics Southwestern University of Finance and Economics

In this paper, we study a portfolio selection problem of an investor with a retirement option, who has possibility to buy life insurance and does not tolerate any decline in consumption. The agent's optimization problem can be viewed as a mixed singular control and optimal stopping problem with time-inhomogeneous utility functions. The closed-form optimal solution is not available in general. We use the dual control method to convert the original problem into two classes of optimal stopping problems in finite and infinite *** show that the optimal consumption strategy and the best retirement time depend on the free-boundary functions which satisfy Fredholm and Volterra integral equations. We derive the closed-form formulas for these two free boundaries for some special cases and develop numerical methods to solve the integral equations of the free boundaries for general cases.

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Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： xing-Yu Chen Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

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Advancements and challenges in esophageal carcinoma prognostic models:A comprehensive review and future directions

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 311-314页

作者： Jia Chen Qi-Chang xing Department of Clinical Pharmacy Xiangtan Central HospitalXiangtan 411100Hunan ProvinceChina The Affiliated Hospital Hunan UniversityChangsha 410082Hunan ProvinceChina

In this article,we comment on the article published by Yu et *** employing LASSO regression and Cox proportional hazard models,the article identified nine significant variables affecting survival,including body mass index,Karnofsky performance status,and tumor-node-metastasis *** firmly concur with Yu et al regarding the vital significance of clinical prediction models(CPMs),including logistic regression and Cox regression for assessment in esophageal carcinoma(EC).However,the nomogram's limitations and the complexities of integrating genetic factors pose *** integration of immunological data with advanced statistics offers new research ***-throughput sequencing and big data,facilitated by machine learning,have revolutionized cancer research but require substantial computational *** future of CPMs in EC depends on leveraging these technologies to improve predictive accuracy and clinical application,addressing the need for larger datasets,patientreported outcomes,and regular updates for clinical relevance.

关键词： Predictive model Machine learning Esophageal carcinoma Survival rate Factors

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Bisulfite-mediated base-free decarboxylative carbonylsulfination of alkenes:access toβ-keto sultines

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Science China Chemistry 2025年第2期68卷 622-630页

作者： Yongxin Zhang Pan Zhou Xinyue Ma Xiaoxiao Yang xing Fang Yuxi Wang Chao Shu State Key Laboratory of Green Pesticide Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon ReductionCCNU-uOttawa Joint Research CentreCollege of ChemistryCentral China Normal University(CCNU)Wuhan 430079China Key Laboratory of Functional Molecular Solids Ministry of EducationAnhui Normal UniversityWuhu 241000China

A straightforward three-component decarboxylative cross-coupling ofα-keto acids,alkenes and sodium bisulfite is established for the construction of otherwise challenging-to-accessβ-keto sultine *** reaction involves the photoinduced carbonylsulfination of alkenes and utilizes sodium bisulfite as both a sulfur dioxide surrogate and buffer agent for deprotonation ofα-keto carboxylic *** note,the practical procedure featured broad substrate scope and group tolerance for diverse biologically important molecules under mild and operationally simple conditions,using an organic *** studies indicated that the transformation proceeds an apparent two-pronged radical addition/radical-polar crossover/SO_(2) insertion/ionic cyclization relay process,distinct from traditional alkenes bifunctionalization.

关键词： photoredox catalysis β-keto sultines carbonylsulfination sodium bisulfite radical

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Epigenetic control of plant abiotic stress responses

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Journal of Genetics and Genomics 2025年第2期52卷 129-144页

作者： Lijun Ma Lihe xing Zicong Li Danhua Jiang Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Ministry of Education Key Laboratory of Plant Development and Environmental Adaption Biology School of Life SciencesShandong UniversityQingdaoShandong 266237China Temasek Life Sciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604Republic of Singapore

On top of genetic information,organisms have evolved complex and sophisticated epigenetic regulation to adjust gene expression in response to developmental and environmental *** epigenetic mechanisms include DNA methylation,histone modifications and variants,chromatin remodeling,and chemical modifications of *** control of environmental responses is particularly important for plants,which are sessile and unable to move away from adverse *** enabling plants to rapidly respond to environmental stresses,some stress-induced epigenetic changes can be maintained,providing plants with a pre-adapted state to recurring *** these epigenetic mechanisms offers valuable insights for developing crop varieties with enhanced stress ***,we focus on abiotic stresses and summarize recent progress in characterizing stress-induced epigenetic changes and their regulatory mechanisms and roles in plant abiotic stress resistance.

关键词： Plant EpigeneticslGene expressionlAbiotic stresslEnvironmental memory

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GPU-Enabled Isogometric Topology Optimization with Bezier Element Stiffness Mapping

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1481-1514页

作者： Xuesong Li Shuting Wang Nianmeng Luo Aodi Yang xing Yuan Xianda Xie School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China School of Advanced Manufacturing Nanchang UniversityNanchang330031China

Due to the high-order B-spline basis functions utilized in isogeometric analysis(IGA)and the repeatedly updating global stiffness matrix of topology optimization,Isogeometric topology optimization(ITO)intrinsically suffers from the computationally demanding *** this work,we address the efficiency problem existing in the assembling stiffness matrix and sensitivity analysis using B˙ezier element stiffness *** Element-wise and Interaction-wise parallel computing frameworks for updating the global stiffness matrix are proposed for ITO with B˙ezier element stiffness mapping,which differs from these ones with the traditional Gaussian integrals *** the explicit stiffness computation formula derived from B˙ezier element stiffness mapping possesses a typical parallel structure,the presented GPU-enabled ITO method can greatly accelerate the computation speed while maintaining its high memory efficiency *** examples demonstrate threefold speedup:1)the assembling stiffness matrix is accelerated by 10×maximumly with the proposed GPU strategy;2)the solution efficiency of a sparse linear system is enhanced by up to 30×with Eigen replaced by AMGCL;3)the efficiency of sensitivity analysis is promoted by 100×with GPU ***,the proposed method is a promising way to enhance the numerical efficiency of ITO for both single-patch and multiple-patch design problems.

关键词： Isogeometric analysis topology optimization GPU sparse system solver B˙ezier element stiffness mapping

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