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Increased Oxygen Evolution Activity in pH-Universal Electrocatalyst: Urea-Modified NiFeCoCN Medium-Entropy Alloy

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Chinese Journal of Chemistry 2023年第23期41卷 3290-3298页

作者： hongwei lv Zhiguo Ye Feng Pei Xinyuan Peng Juntong Huang Duosheng Li Zhong Jin School of Material Science and Engineering Nanchang Hangkong University696#FengHeNan RoadNanchangJiangxi330063 China State Grid Jiangxi Electric Power Research Institute NanchangJiangxi330096 China MOE Key Laboratory of Mesoscopic Chemistry MOE Key Laboratory of High Performance Polymer Materials and TechnologyJiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210023 China

The kinetic process of a slow oxygen evolution reaction (OER) always constrains the efficiency of overall water electrolysis for H2 *** particular,nonprecious metal electrodes for the OER have difficulty in possessing excellent electrocatalytic activity and stability in pH-universal media *** this work,urea is first used as a pore-forming agent and active C/N source to fabricate a nanoporous NiFeCoCN medium-entropy alloy (MEA) by high-temperature sintering based on the nanoscale Kirkendall *** NiFeCoCN MEA achieves an overpotential of 432 mV at a current density of 10 mA·cm^(-2) and a lower Tafel slope of 52.4 mV·dec^(-1) compared to the IrO_(2)/Ti electrode (58.6 mV·dec^(-1)) in a 0.5 mol/L H_(2)SO_(4) *** a 1 mol/L KOH solution,the NiFeCoCN MEA obtains an overpotential of 175 mV for 10 mA·cm^(-2) and a Tafel slope of 40.8 mV·dec^(-1),which is better than IrO_(2)/Ni *** work proves a novel strategy to design and prepare nanoporous MEA materials with desirable C/N species,which provides promising prospects for the industrial production of H2 energy.

关键词： Oxygen evolution reaction Medium-entropy alloy Urea Electrocatalytic activity Stability

Weak and Strong Convergence of Self Adaptive Inertial Subgradient Extragradient Algorithms for Solving Variational Inequality Problems

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Journal of Harbin Institute of Technology(New Series) 2024年第2期31卷 38-49页

作者： Yao Li hongwei Liu Jiamin lv School of Mathematics and Statistics Xidian UniversityXi'an710126China

Many solutions of variational inequalities have been proposed,among which the subgradient extragradient method has obvious *** different algorithms are given for solving variational inequality problem in this *** problem we study is defined in a real Hilbert space and has L-Lipschitz and pseudomonotone *** new algorithms adopt inertial technology and non-monotonic step size rule,and their convergence can still be proved when the value of L is not given in ***,some numerical results are designed to demonstrate the computational efficiency of our two new algorithms.

关键词： variational inequality inertial method non-monotonic step size rule Lipschitz continuity pseudomonotone mapping

贝伐珠单抗联合安罗替尼治疗非小细胞肺癌的临床疗效及对免疫状态的影响

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哈尔滨医药 2024年第1期44卷 41-44页

作者：丁妍华门帅张江霞张旭张善存刘璐吕宏伟肖正红南阳南石医院临床药学河南南阳473000

目的观察贝伐珠单抗联合安罗替尼治疗非小细胞肺癌的临床效果,并分析其对免疫状态的影响。方法采用前瞻性随机对照研究,选取非小细胞肺癌患者作为研究对象,采用随机数字表法将患者分为观察组与对照组。对照组采用安罗替尼治疗,观察组实... 详细信息

目的观察贝伐珠单抗联合安罗替尼治疗非小细胞肺癌的临床效果,并分析其对免疫状态的影响。方法采用前瞻性随机对照研究,选取非小细胞肺癌患者作为研究对象,采用随机数字表法将患者分为观察组与对照组。对照组采用安罗替尼治疗,观察组实施安罗替尼联合贝伐珠单抗治疗。比较两组患者临床疗效、T淋巴亚群水平(CD4+、CD3+、CD8+、CD4+/CD8+)、血管内皮生长因子(VEGF)水平、卡氏功能(KPS)评分、肿瘤标志物水平[血清癌胚抗原(CEA)、糖类抗原199(CA199)、CA125]、生存期及用药不良反应。结果治疗前,两组患者各个指标比较,差异无统计学意义(P>0.05)。治疗后,观察组患者疾病控制率(DCR)、客观缓解率(ORR)、CD4+、CD3+、CD4+/CD8+、KPS评分明显高于对照组(P0.05)。结论贝伐珠单抗联合安罗替尼可改善非小细胞肺癌患者免疫功能及状态,延长生存期,降低肿瘤标志物与VEGF表达水平,具有良好的临床效果。

关键词：贝伐珠单抗安罗替尼非小细胞肺癌生存期肿瘤标志物

Two-Dimensional Tunable and Temperature-Insensitive Lyot Filter for FM-to-AM Compensation

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Photonic Sensors 2021年第3期11卷 325-333页

作者： Mengqiu Fan Xiaocheng Tian Dandan Zhou Jiatian Wei Handing Xia hongwei lv Hao Zhao Dangpeng Xu Wanguo Zheng Laser Fusion Research Center China Academy of Engineering PhysicsMianyang621900China Graduate School of China Academy of Engineering Physics Beijing100088China No.34 Institute of China Electronics Technology Group Corporation Guilin541004China

Utilizing polarization maintaining photonic crystal fiber(PM-PCF)with the low temperature coefficient of birefringence,a two-dimensional tunable and temperature-insensitive Lyot filter aiming to compensate the frequency modulation to amplitude modulation(FM-to-AM)conversion in high power laser facility is *** Jones matrix is applied to analyze the relationship between optical characteristics of the filter and physical parameters(including amplitude ratio,phase delay,and susceptibility of the birefringence to temperature)of the polarization optical *** the transmission peak wavelength and extinction ratio of the spectral transmission are able to be changed simultaneously,hence,it shows more efficient FM-to-AM compensation ***,the transmission peak shift is about 18pm/°C with the PM-PCF configuration,which is about two orders of magnitude less than the normal polarization maintaining fiber(PMF)*** demonstrated filter presents a practical application potential in large scale laser driven facility.

关键词： Laser fusion optical fiber devices frequency modulation birefringence optical filters

MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition

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Science China(Life Sciences) 2017年第11期60卷 1203-1213页

作者： guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang international cooperation laboratory on signal transduction eastern hepatobiliary surgery institutesecond military medical universityShanghai 200438China national center for liver cancer Shanghai 201805China state key laboratory of oncogenes and related genes shanghai cancer institute renji hospitalshanghai jiaotong university school of medicineShanghai 200127China

MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection ***, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target.

关键词： hepatocellular carcinoma(HCC) MXR7 metastasis epithelial-mesenchymal transition(EMT)

热稳定单原子催化剂的理性构筑:从原子级结构到实际应用

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Chinese Journal of Catalysis 2022年第1期43卷 71-91页

作者：吕宏伟国文馨陈敏周煌吴宇恩中国科学技术大学化学系能源材料化学协同创新中心合肥微尺度物理科学国家实验室安徽合肥230026 洁净能源国家实验室(筹) 辽宁大连116023

80%以上的工业生产过程涉及催化,如化工生产、能源转换、制药和废物处理等等.催化剂的使用显著提高了生产效率,降低了生产成本,为国民经济、地球环境和人类文明的可持续发展做出了很大贡献.为了满足日益增长的生产需求和最大的经济效益... 详细信息

80%以上的工业生产过程涉及催化,如化工生产、能源转换、制药和废物处理等等.催化剂的使用显著提高了生产效率,降低了生产成本,为国民经济、地球环境和人类文明的可持续发展做出了很大贡献.为了满足日益增长的生产需求和最大的经济效益,开发高效、稳定、低成本的新型催化剂已成为当务之急.金属中心负载在载体上的负载型金属催化剂因其较好的催化活性和相对较低的金属用量而受到广泛关注.研究发现,负载型结构可增强传热和传质并增加活性金属中心的分散度,从而影响催化性能.此外,负载金属的颗粒尺寸对催化剂的性能有很大影响.迄今为止,科学家们一直在通过减小金属颗粒尺寸和提高原子利用效率来提高催化剂的活性.原子级尺寸的颗粒通常表现出与大尺寸颗粒显着不同的物理和化学性质,而当活性位点的尺寸缩小到单个原子时,单原子催化剂的概念应运而生.对于单原子催化剂,金属原子中心通过配位被载体中的缺陷锚定,从而调整金属原子的电子云分布.这种配位调整使得单原子催化剂拥有与传统催化剂不同的性能.作为催化领域的新前沿,单原子催化剂已经在许多催化反应中表现出前所未有的活性和选择性.然而,许多报道的单原子催化剂在高温环境或长期催化应用中容易受到奥斯特瓦尔德熟化过程的影响,从而导致催化剂烧结和失活.而烧结的原因在于金属原子和载体之间较弱的相互作用.失活催化剂的再生和回收将大大增加工业生产的时间和经济成本.因此,开发具有优异热稳定性的单原子催化剂以满足工业需求是十分必要的.本综述首先总结了近年来关于热稳定型单原子催化剂合成方法的基础研究,并从原子尺度上分析了这些方法所构建的金属中心的结构形态和配位环境.此外,结合近些年的研究中新的表征技术与理论计算手段解释了热稳定性的来源.重点讨论了热稳定单原子催化剂的实际催化应用.分析了热稳定单原子催化剂在热催化应用中的独特作用机理、并尝试为确定催化过程中真正的活性中心以及通过原子级调控手段进行高活性热稳定单原子催化剂的合成提供理论指导.最后总结了热稳定单原子催化剂发展的主要问题,并简要分析了单原子催化领域的研究挑战和发展前景.

关键词：热稳定性单原子催化剂烧结与失活合成方法热催化应用

3'-Sialyllactose regulates glucose and lipid metabolic disorders via the gut–liver axis in mice fed a high-fat die

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Food Science and Human Wellness 2024年

作者： Wei Zhang Meizhen Zhu Kelsang Dekyi Linxi Zheng Yichen Zhang Youping lv Dongbei Guo Xiaoxuan Chen Lili Pan Xinyue Wang hongwei Li State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine Laboratory School of Public Health Xiamen University State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Innovation Platform for Industry-Education Integration in Vaccine Research Xiamen University Department of Nutrition Zhongshan Hospital (Xiamen) Fudan University Xiamen Clinical Research Center for Cancer Therapy

Recent research has indicated that sialic acid， such as free sialic acid (N-acetylneuraminic acid， Neu5Ac) and bound sialic acid (3'-sialyllactose， 3'-SL)， can ameliorate disorders associated with glycolipid metabolism， although the underlying mechanisms have yet to be determined. We examined the effects of 3'-SL on glycolipid metabolism in mice fed a high-fat diet. Male C57BL/6J mice were divided into six groups: two model control groups (normal and high-fat diets) and four intervention groups [Neu5Ac， and low-，moderate-， and high-dose 3'-SL]. After 8 weeks of continuous gavage intervention， mice in the 3'-SL intervention groups had lower body weight and total fat content; reduced fasting blood glucose， triglycerides， low-density lipoproteins and oxidized-low-density lipoproteins; and increased high-density lipoproteins，but no dosage-dependent of 3'-SL intervention was found， 3’-SL＿M intervention as optimal for further exploration. 3'-SL intervention could increase respiratory exchange ratio， energy expenditure， and amount of exercise performed. 3'-SL increased the colonic abundances of Akkermansia， Lactobacillus， and Bacteroides， and reduced those of Erysipelatoclostridium， Faecalibaculum， and Aldercreutzia. Changes were also observed in colonic metabolites， and liver gene transcript and metabolites， which were mainly enriched in bile secretion， taurine and hypotaurine metabolism， and insulin resistance. Additionally， 3'-SL was observed to regulate genes associated with physiological rhythms， including clock， per2， cry1， and bhihe41. Collectively， our findings indicate that 3'-SL can contribute to the prevention and control of disorders associated with glucose and lipid metabolism caused by high-fat diets. Compared with Neu5Ac， 3'-SL intervention can ameliorate intestinal flora disorders， enhance bile acid circulation， increase tissue energy expenditure， and reduce lipid synthesis， thereby promoting lipid-lowering effects mediated via the liver–gut axis， and can a

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电化学介导的氧化羧化及二氧化碳还原羧化制备羧酸的研究进展

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有机化学 2024年第3期44卷 780-808页

作者：吕帅朱钢国姚金忠周宏伟浙江师范大学化学与材料科学学院浙江金华321004 嘉兴学院生物与化学工程学院浙江嘉兴314001

作为常见的一类重要化合物,羧酸被广泛应用于医药、农药和聚合物等领域,因此,探究高效且温和的羧酸合成方法具有重要意义.电化学合成羧酸因其环境友好、条件温和等优点,引起人们广泛关注.根据反应机理不同,主要从电化学氧化羧化、电化... 详细信息

作为常见的一类重要化合物,羧酸被广泛应用于医药、农药和聚合物等领域,因此,探究高效且温和的羧酸合成方法具有重要意义.电化学合成羧酸因其环境友好、条件温和等优点,引起人们广泛关注.根据反应机理不同,主要从电化学氧化羧化、电化学二氧化碳还原羧化两方面出发,对电化学合成羧酸这一领域近年来的相关研究做了综述.

关键词：电化学羧酸氧化羧化还原羧化二氧化碳

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选区激光熔化Al-Si-Mg-Zr合金的组织和力学性能

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稀有金属材料与工程 2023年第3期52卷 1087-1093页

作者：吕洪伟张志杰罗金杰耿遥祥鞠洪博喻利花许俊华江苏科技大学材料科学与工程学院江苏镇江212003 昆山国力电子科技股份有限公司江苏昆山215333

针对选区激光熔化(SLM)高Mg含量AlSiMg3合金成形性差的缺点,通过Zr进行合金化,研究了工艺参数对SLM成形高Mg含量Al-Si-Mg-Zr合金的成形性及时效处理对合金组织和力学性能的影响。结果表明,SLM成形Al-Si-Mg-Zr合金的熔池边界处形成了大... 详细信息

针对选区激光熔化(SLM)高Mg含量AlSiMg3合金成形性差的缺点,通过Zr进行合金化,研究了工艺参数对SLM成形高Mg含量Al-Si-Mg-Zr合金的成形性及时效处理对合金组织和力学性能的影响。结果表明,SLM成形Al-Si-Mg-Zr合金的熔池边界处形成了大量的细小等轴晶,从而有效地避免了样品在成形过程中裂纹的产生,增加了样品的SLM成形性,不同激光功率和激光扫描速度下获得样品的孔隙率均低于0.3%。拉伸测试结果表明,成形态样品的屈服强度(YS)为(426±8)MPa,极限抗拉强度(UTS)为(464±12)MPa。经165℃时效处理后,由于α-Al晶粒内部纳米强化相的增多,样品的强度增加明显,时效样品的最大YS和UTS分别为(482±11)MPa和(522±10)MPa。本研究获得SLM成形Al-Si-Mg-Zr样品的强度高于目前商用的SLM成形Al-Si-Mg合金。

关键词：选区激光熔化成分优化 Al-Si-Mg-Zr合金显微组织力学性能