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基于主分量分析的相关矢量量化编码算法

计算机辅助设计与图形学学报 2005年第8期17卷 1662-1666页

作者：孙宏伟顾明孙家广清华大学软件学院北京100084

在编码前,首先计算码书中所有码字在主轴上的投影值,然后按照这些投影值从小到大对码字进行排序;在编码过程中,利用邻近图像块的高度相关性和当前输入矢量在主轴上的投影值共同确定相应的码字搜索范围.实验结果表明,与传统穷尽搜索矢量... 详细信息

在编码前,首先计算码书中所有码字在主轴上的投影值,然后按照这些投影值从小到大对码字进行排序;在编码过程中,利用邻近图像块的高度相关性和当前输入矢量在主轴上的投影值共同确定相应的码字搜索范围.实验结果表明,与传统穷尽搜索矢量量化编码法相比,虽然文中算法的编码质量略有下降,但编码速度和压缩效率都有了显著的提高.

关键词：图像编码矢量量化主分量分析相关矢量量化

Spontaneous movement of a retrotransposon generated genic dominant male sterility providing a useful tool for rice breeding

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National Science Review 2023年第9期10卷 204-213页

作者： Conghao Xu Yifeng Xu Zhengji Wang Xiaoyu Zhang Yuying Wu Xinyan Lu hongwei sun Lei Wang Qinglu Zhang Qinghua Zhang Xianghua Li Jinghua Xiao Xu Li Mingfu Zhao Yidan Ouyang Xianbo Huang Qifa Zhang National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Hubei Hongshan LaboratoryHuazhong Agricultural University Ningde Inspection and Testing Centre for Agricultural Product Quality and Safety Fujian Academy of Agricultural Sciences Sanming Institute of Agricultural Sciences

Male sterility in plants provides valuable breeding tools in germplasm innovation and hybrid crop ***,genetic resources for dominant genic male sterility,which hold great promise to facilitate breeding processes,are extremely rare in natural *** we characterized the Sanming Dominant Genic Male Sterility in rice and identified the gene SDGMS using a map-based cloning *** found that spontaneous movement of a 1978-bp long terminal repeat(LTR) retrotransposon into the promoter region of the SDGMS gene activates its expression in anther tapetum,which causes abnormal programmed cell death of tapetal cells resulting in dominant male *** encodes a ribosome inactivating protein showing N-glycosidase *** activation of SD GMS triggers transcription reprogramming of genes responsive to biotic stress leading to a hypersensitive response which causes *** results demonstrate that an ectopic gene activation by transposon movement can give birth to a novel trait which enriches phenotypic diversity with practical utility.

关键词： Oryza sativa dominant male sterility ribosome-inactivating protein retrotransposon

Advanced landfill leachate treatment using a two-stage UASB-SBR system at low temperature

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Journal of Environmental Sciences 2010年第4期22卷 481-485页

作者： hongwei sun,Qing Yang,Yongzhen Peng,Xiaoning Shi,Shuying Wang,Shujun Zhang Key Laboratory of Beijing Water Quality Science and Water Envirocnnment Recovery Engineering,Beijing University of Technology,Beijing 100124,China Key Laboratory of Beijing Water Quality Science and Water Environment Recovery Engineering Beijing University of Technology Beijing 100124 China

A two-stage upflow anaerobic sludge blanket （UASB） and sequencing batch reactor （SBR） system was introduced to treat landfill leachate for advanced removal of COD and nitrogen at low temperature. In order to improve the total nitrogen （TN） removal efficiency and to reduce the COD requirement for denitrification, the raw leachate with recycled SBR nitrification supematant was pumped into the first-stage UASB （UASB1） to achieve simultaneous denitrification and methanogenesis. The results showed that UASB1 played an important role in COD removal and UASB2 and SBR further enhanced the nutrient removal efficiency. When the organic loading rates of UASB1, UASB2 and SBR were 11.95, 1.63 and 1.29 kg COD/（m^***）, respectively, the total COD removal efficiency of the whole system reached 96.7%. The SBR acted as the real undertaker for NH4^＋-N removal due to aerobic nitrification. The system obtained about 99.7% of NH4^＋-N removal efficiency at relatively low temperature （14.9-10.9℃）. More than 98.3% TN was removed through complete denitrification in UASB 1 and SBR. In addition, temperature had a significant effect on the rates of nitrification and denitrification rather than the removal of TN and NH4^＋-N once the complete nitrification and denitrification were achieved.

关键词： landfill leachate two-stage UASB-SBR advanced nitrogen removal low temperature nitrification denitrification

Simulated Microgravity can Promote the Apoptosis and Change Inflammatory State of Kupffer Cells

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Biomedical and Environmental Sciences 2024年第10期37卷 1117-1127页

作者： Jun Ge Fei Liu Hongyun Nie Yuan Yue Kaige Liu Haiguan Lin Hao Li Tao Zhang Hongfeng Yan Bingxin Xu hongwei sun Jianwu Yang Shaoyan Si Jinlian Zhou Yan Cui Clinical laboratory the Ninth Medical Center of the PLA General HospitalBeijing 100101China Department of General Surgery Fuyang Affiliated Hospital of Anhui Medical UniversityFuyang 236000AnhuiChina Department of General Surgery the 306th Hospital of PLA-Peking University Teaching HospitalBeijing 100101China Department of Disease Control and Prevention the Ninth Medical Center of PLA General HospitalBeijing 100101China Department of General Surgery PLA Medical CollegeBeijing 100101China Department of General Surgery the Ninth Medical Center of PLA General HospitalBeijing 100101China Special Medical Laboratory the Ninth Medical Center of PLA General HospitalBeijing 100101China Department of Pathology the Ninth Medical Center of PLA General HospitalBeijing 100101China

Objective In this study,we analyzed the transcriptome sequences of Kupffer cells exposed to simulated microgravity for 3 d and conducted biological experiments to determine how microgravity initiates apoptosis in Kupffer *** Rotary cell culture system was used to construct a simulated microgravity *** and KEGG analyses were conducted using the DAVID *** was performed using the R *** STRING database was used to conduct PPI *** was used to measure the IL1B,TNFA,CASP3,CASP9,and BCL2L11 mRNA *** Blotting was performed to detect the level of proteins CASP3 and CASP *** cytometry was used to detect apoptosis and mitochondrial membrane *** electron microscopy was used to detect changes in the ultrastructure of Kupffer *** Transcriptome Sequencing indicated that simulated microgravity affected apoptosis and the inflammatory state of Kupffer *** microgravity improved the CASP3,CASP9,and BCL2L11 expressions in Kupffer ***-V/PI and JC-1 assays showed that simulated microgravity promoted apoptosis in Kupffer *** microgravity causes M1 polarization in Kupffer *** Our study found that simulated microgravity facilitated the apoptosis of Kupffer cells through the mitochondrial pathway and activated Kupffer cells into M1 polarization,which can secrete TNFA to promote apoptosis.

关键词： Microgravity Apoptosis Kupffer cell Polarization

A Process Simulation-Based Method for Engineering Change Management

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Transactions of Nanjing University of Aeronautics and Astronautics 2021年第1期38卷 173-180页

作者： YIN Leilei ZHU Haihua sun hongwei LIAO Liangchuang School of Automation Nanjing Institute of TechnologyNanjing 211167P.R.China College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China Jiangsu Automation Research Institute Lianyungang 222006P.R.China

Engineering change management is a special form of problem solving where many rules must be followed to satisfy the requirements of product *** engineering change has great influence on the cycle and the cost of product development,it is necessary to anticipate design changes(DCs)in advance and estimate the influence effectively.A process simulation-based method for engineering change management is proposed incorporating multiple assessment ***,the change propagation model is established,which includes the formulation of change propagation influence,assessment score of DC *** the optimization process of DC solution is introduced based on ant colony optimization(ACO),and an optimization algorithm is detailed to acquire the optimal DC solution ***,a case study of belt conveyor platform is implemented to validate the proposed *** results show that changed requirement of product can be satisfied by multiple DC solutions and the optimal one can be acquired according to the unique characteristics of each solution.

关键词： change propagation simulation ant colony algorithm design change solution

Effective and precise adenine base editing n mouse zygotes

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Protein & Cell 2018年第9期9卷 808-813页

作者： Puping Liang hongwei sun Xiya Zhang Xiaowei Xie Jinran Zhang Yaofu Bai Xueling Ouyang Shengyao Zhi Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang Key Laboratory of Gene Engineering of the Ministry of Education Guangzhou Key Laboratory of Healthy Aging Research and SYSU-BCM Joint Research Center School of Life Sciences Sun Yat-sen University Guangzhou 510275 China Key Laboratory of Reproductive Medicine of Guangdong Province School of Life Sciences and the First Affiliated Hospital Sun Yatsen University Guangzhou 510275 China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Verna and Marrs Mclean Department of Biochemistry and Molecular Biology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA

Dear Editor, Many human genetic diseases are caused by pathogenic single nucleotide mutations. Animal models are often used to study these diseases where the pathogenic point mutations are created and/or corrected through gene editing （e.g., the CRISPP-JCas9 system）（Komor et al., 2017; Liang et al., 2017）. CRISPR/Cas9-mediated gene editing depends on DNA double-strand breaks （DSBs）, which can be of low efficiency and lead to indels and off-target cleavage （Kim et al., 2016）. We and others have shown that base editors （BEs） may represent an attractive alternative for disease mouse model generation （Liang et al., 2017; Kim et al., 2017）. Compared to CRISPR/ Cas9, cytidine base editors （CBEs） can generate C·G to T·A mutations in mouse zygotes without activating DSB repair pathways （Liang et al., 2017; Kim et al., 2017; Komor et al., 2016）. In addition, CBEs showed much lower off-targets than CRISPR]Cas9 （Kim et al., 2017）, making the editing process potentially safer and more controllable. Recently, adenine base editors （ABEs） that were developed from the tRNA- specific adenosine deaminase （TADA） of Escherichia coli were also reported （Gaudelli et al., 2017）. As a RNA-guided programmable adenine deaminase, ABE can catalyze the conversion of A to I. Following DNA replication, base I is replaced by G, resulting in A·T to G·C conversion （Gaudelli et al., 2017; Hu et al., 2018）. The development of ABEs has clearly expanded the editing capacity and application of BEs. Here, we tested whether ABEs could effectively generate disease mouse models, and found high efficiency by ABEs in producing edited mouse zygotes and mice with single-nucleotide substitutions.

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复合锂基润滑脂制备反应的密度泛函理论

石油学报（石油加工） 2010年第4期26卷 571-575页

作者：刘磊孙洪伟中国石化石油化工科学研究院北京100083

采用传统方法制备了复合锂基润滑脂,通过红外光谱对其进行分析。采用密度泛函理论研究了复合锂基润滑脂的制备反应,并用B3LYP/6-31+G方法计算了制备反应的反应物、产物的总能量,用B3LYP/6-31+G*方法计算了制备反应的反应物、中间体、过... 详细信息

采用传统方法制备了复合锂基润滑脂,通过红外光谱对其进行分析。采用密度泛函理论研究了复合锂基润滑脂的制备反应,并用B3LYP/6-31+G方法计算了制备反应的反应物、产物的总能量,用B3LYP/6-31+G*方法计算了制备反应的反应物、中间体、过渡态和产物的总能量与零点振动能。结果表明,在复合锂基润滑脂制备中,氢氧化锂与12-羟基硬脂酸、氢氧化锂与癸二酸的反应均为放热反应,活化能均较低,中间体处于势能面的最低点,过渡态比反应物的能量要低。

关键词：复合锂基润滑脂密度泛函理论(DFT) 反应机理

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墨子、鲁班工匠形象的分化与转换

民族艺术 2019年第6期 84-92页

作者：孙洪伟齐鲁工业大学艺术设计学院

作为先秦时期的著名工匠,《墨子》中墨子与鲁班同台竞技的故事家喻户晓。从工匠传承的角度来看,二人都源于"工商食官"的周代工匠体系,都是从"执艺事以谏"的传统中走出,但是却在新的社会环境中产生分化。鲁班以"艺"傍身,走向了民间、市场... 详细信息

作为先秦时期的著名工匠,《墨子》中墨子与鲁班同台竞技的故事家喻户晓。从工匠传承的角度来看,二人都源于"工商食官"的周代工匠体系,都是从"执艺事以谏"的传统中走出,但是却在新的社会环境中产生分化。鲁班以"艺"傍身,走向了民间、市场;而墨子却坚持了"谏"的传统,并进一步将其学术化、体系化,最终成为墨家思想的核心内容之一。因此,在二人最初的竞技中,与其说是墨子战胜了鲁班,不如说是墨家学派的话语战胜了鲁班。然而在历史的发展中,儒家最终突出百家重围,成为中国传统文化的主流。在儒家话语的规训下,墨子的形象不断被异化,变成一个不知礼乐的苦行僧的模样,甚至是一个"供人捧腹"的怪老头。而鲁班则逐渐摆脱《墨子》的影响,先是通过众多文本中的"故事",被塑造成一个有情义、有血肉,技艺高超的工匠形象;进而又通过一系列文本中的"神迹"被神化,并最终成为工匠崇拜的对象。借此,鲁班与墨子的形象,实现了戏剧化的反转。

关键词：墨子鲁班工匠形象工匠历史设计文本

乡土与禽言:当代北爱尔兰诗人迈克·郎利诗歌中的禽鸟书写

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当代外国文学 2022年第3期43卷 59-69页

作者：孙红卫南京大学外国语学院

当代北爱尔兰诗人迈克·郎利常以禽鸟起兴,描绘乡土自然,省思诗人志业,或探索禽言鸟语,与叶芝、乔伊斯以及同代爱尔兰作家作品中的禽鸟意象相呼应,形成了一种交相唱和的禽鸟诗学。本文引入文化地理学与语言哲学的相关论述,探讨禽鸟诗在... 详细信息

当代北爱尔兰诗人迈克·郎利常以禽鸟起兴,描绘乡土自然,省思诗人志业,或探索禽言鸟语,与叶芝、乔伊斯以及同代爱尔兰作家作品中的禽鸟意象相呼应,形成了一种交相唱和的禽鸟诗学。本文引入文化地理学与语言哲学的相关论述,探讨禽鸟诗在郎利诗歌之中呈现的特殊图景,指出禽鸟诗不只是单纯的文人兴味或风物书写,而且以隐微的方式与北爱尔兰政治动乱的社会背景相关联,融汇了地理、诗艺、语言等重要主题,在其轻盈、灵动的表象之下隐藏着严肃的社会关切与关于语言表达的思考。

关键词：迈克·朗利诗歌禽鸟乡土禽言