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Recent advances in metal-organic frameworks for X-ray detection

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Science China Chemistry 2022年第12期65卷 2338-2350页

作者： hongming chen Jingru chen Menghua Li Minghua You Qiushui chen Meijin Lin Huanghao Yang College of Materials Science and Engineering Fuzhou UniversityFuzhou 350116China College of Chemistry Fuzhou UniversityFuzhou 350116China College of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China

Metal-organic frameworks(MOFs)are a class of fascinating supramolecular crystalline materials that have been widely developed for catalysis,gas storage,illumination,drug delivery/cytoprotection,and so ***,MOFs have been found to have potential applications in X-ray detection due to their high sensitivity,fast response time,high absorption coefficient,and radiation *** this review,we present an overview on the fundamental mechanism of using MOFs for X-ray *** further discuss the recent developments in X-ray detection based on indirect X-ray scintillation and direct X-ray ***,we provide a summary and a perspective on the future of this promising research field.

关键词： metal-organic frameworks scintillation X-ray detection semiconducting

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1,1’-Binaphthol annulated perylene diimides: Aggregation-induced emission enhancement and chirality inversion

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Chinese Chemical Letters 2022年第5期33卷 2473-2476页

作者： Yang Zhang Juejun Wang hongming chen Meijin Lin Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhou 350116China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350116China

Aggregation-induced emission enhancement and aggregation-induced chirality inversion are two individ-ual phenomena for the enantiomerically pure organic dyes in the *** we reported for the first time that these two interesting phenomena could be observed simultaneously in the aggregated states of enantiomerically pure S/R-1,1?-binaphthol annulated perylene diimides,in which two perylene diimides moieties were bridged by S/R-1,1?-binaphthol(BINOL)at the bay *** to the rotat-able C2 axes between two naphthol annulated perylene diimides moieties,both of them display intrinsic behaviors of aggregation-induced emission *** the same time,due to the steric hindrances in the imide and methoxy positions,the neighboring twoπ-systems of these two unique polycyclic aro-matic imides in poor solvents are preferable to adopt a cross-stacking mode and thus form helical X-aggregates of opposite chirality(M/P)with chirality inversion characteristics in their circular dichroism and circularly polarized luminescence spectroscopic studies.

关键词： Perylene diimides 1,1’-Binaphthol Aggregation-induced emission enhancement Chirality inversion

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A low-power,area-efficient all-digital delay-locked loop for DDR3 SDRAM controller

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Science China(Information Sciences) 2014年第12期57卷 176-183页

作者： chen hongming MA Song WANG Liu ZHANG Hao PAN KenYi chenG YuHua Shanghai Research Institute of Microelectronics (SHRIME) Peking University School of Electronics Engineering and Computer Science Peking University

A new low-power,area efficiency all-digital delay-locked loop(ADDLL)circuit is proposed for *** ADDLL can process the input clock frequency ranging from 333 MHz to 800 MHz(DDR3-667/800/1066/1600)by using Phase Detector(PD),Delay Control Delay Line(DCDL),Digital Loop Filter Controller(DLFC)and Delay Generator(DG).To achieve 1.6 Gb/s/pin operation,a novel DCDL scheme is *** DCDL has a small delay with a shunt capacitor based digitally controlled delay element.A splitcontrol thermometer-code generator generates the control voltages used to set a current in the current-starved *** testchip fabricated with a 40-nm CMOS process gives the ADDLL data rate of 667 Mbps–1.6 *** results that show the power consumption is 1.87 m W at 1.1 V with active area is 0.0137mm2.

关键词： all-digital delay-locked loop double-data-rate digitally controlled delay line shunt capacitor thermometer code

Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet:In vitro evaluation and in vivo pharmacokinetics study

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 128-137页

作者： Guangjing Li Yongjun Wang hongming chen Donglei Leng Panqin Ma Yanjie Dong Lifang Gao Zhonggui He School of Pharmacy Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China Kangya of Ningxia Pharmaceuticals Co.Ltd China

One purpose of this study was to develop a paliperidone(PAL)tri-layer ascending release pushepull osmotic pump(TA-PPOP)tablet which could meet the needs of clinical *** another purpose was to investigate whether different coating materials influenced in vivo performance of *** ascending release mechanism of this trilayer delivery system on theory was ***-PPOP was prepared by means of coating with cellulose acetate(CA)or ethyl cellulose(EC).Several important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were *** optimization of formulation and process was conducted by comparing different in vitro release behaviors of *** vitro dissolution studies indicated that both the two formulations of different coating materials were able to deliver PAL at an ascending release rate during the whole 24 h *** in vivo pharmacokinetics study showed that both self-made PPOP tablets with different coating had a good in vitro-in vivo correlation(IVIVC)and were bioequivalent with the brand product,which demonstrated no significant influence of the coating materials on the in vivo release acceleration of TA-PPOP.

关键词： Ascending release Tri-layer osmotic pump Paliperidone Cellulose acetate Pharmacokinetics In vitroein vivo correlation

Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats

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Asian Journal of Pharmaceutical Sciences 2014年第6期9卷 330-335页

作者： Jibin Guan Nana Zhao Yinglei Zhai Chunxia Chu hongming chen Tianhong Zhang Shenyang Pharmaceutical University School of PharmacyNo.103Wenhua RoadShenyang 110016China

To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in *** plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection(UPLC-MS/MS)through a new validated *** pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows:AUC_(0-t) 900.76±186.59 versus 687.08±66.24 ng h/ml,C_(max) 854.54±159.48 versus 610.59±235.99 ng/ml,t_(1/2)2.37±1.99 versus 2.80±2.69 *** relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%.The developed methods could meet the requirements of *** to the solution injection,intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.

关键词： Nitrendipine Submicron emulsion Bioavailability Method validation

Efficient and Fast X-Ray Luminescence in Organic Phosphors Through High-Level Triplet-Singlet Reverse Intersystem Crossing

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CCS Chemistry 2024年第2期6卷 334-341页

作者： Yang Zhang Minghong chen Xiaoze Wang Miao Lin Hongyu Wang Weihong Li Fuhai chen Qing Liao hongming chen Qiushui chen Meijin Lin Huanghao Yang Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhouFujian 350116 New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhouFujian 350108 College of Materials Science and Engineering Fuzhou UniversityFuzhouFujian 350116

Organic scintillators that efficiently generate bright triplet excitons are of critical importance for highperformance X-ray-excited luminescence in radiation ***,the nature of triplet-singlet spinforbidden transitions in these materials often result in long-lived phosphorescence,which is undesirable for ultrafast X-ray detection and *** we demonstrate that the effect of hybridized local and charge-transfer(HLCT)excited states enables organic scintillators to exhibit highly efficient and fast radioluminescence(RL)in response to X-ray *** experimental and theoretical investigation shows that the oxidized 1,8-naphthalimide-phenothiazine dyad(OMNI-PTZ 2)with HLCT-excited states has an enhanced overlap integral of the highest occupied molecular orbital(HOMO)and lowest unoccupied molecular orbital(LUMO)on MNIπ-orbitals,and moderate donor–acceptor electron *** a result,the RL of these crystals exhibits a 61-fold increase and its monoexponential decay lifetime is three orders of magnitude faster compared to its corresponding thermally activated delayed fluorescence(TADF)molecule MNI-PTZ *** further demonstrate the practical utility of the OMNI-PTZ 2(G)in high-performance X-ray detection and imaging,achieving an X-ray dose sensitivity of 97 nGy s−1 and an exceptional spatial resolution of 20 lp/*** study provides a promising molecular design principle for utilizing triplet excitons to develop high-efficiency and fast X-ray scintillators for the development of next-generation flexible and stretchable X-ray imaging detectors.

关键词： organic scintillators X-ray imaging hybridized local and charge transfer excited state triplet-singlet reverse intersystem crossing high exciton utilization

Development and validation of a rapid and sensitive UHPLCeMS/MS method for the determination of paliperidone in beagle dog plasma

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Asian Journal of Pharmaceutical Sciences 2014年第5期9卷 286-292页

作者： hongming chen Longshan Zhao Guangjing Li Donglei Leng Panqin Ma Lijin Tong Tianhong Zhang Shenyang Pharmaceutical University No.103Wenhua RoadShenyang 110016China Kangya of Ningxia Pharmaceutical Co. Ltd.No.6High and New Technology Industrial Development ZoneYinchuan 750002China

In order to evaluate the pharmacokinetic profile of paliperidone extended-release tablets in vivo,a simple and rapid ultra-high performance liquid chromatographyetandem mass spectrometry(UHPLCeMS/MS)method was developed and validated for the determination of paliperidone in beagle dog *** and diazepam(internal standard)were extracted from plasma samples with diethyl ether,and then separated on a C_(18) column(2.1×50 mm,2.6 mm)under gradient elution with methanol-0.1%formic acid at a flow rate of 0.3 ml/*** compounds were detected using a triple-quadrupole mass spectrometer equipped with an electrospray ionization(ESI)*** validated method was linear over the concentration range of 1.00-1000.00 ng/ml and the lower limit of quantitation was 1.00 ng/*** intra-day and inter-day precision values were not more than 15%(relative standard deviation<20%at low levels),while the accuracy was within±10%of nominal *** validated UHPLC-MS/MS method was successfully applied to an oral pharmacokinetic study of paliperidone extended-release tablets in a beagle dog.

关键词： Paliperidone Dog plasma UHPLC-MS/MS Pharmacokinetics

Generic Interpretable Reaction Condition Predictions with Open Reaction Condition Datasets and Unsupervised Learning of Reaction Center

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Research 2024年第2期2023卷 773-794页

作者： Xiaorui Wang Chang-Yu Hsieh Xiaodan Yin Jike Wang Yuquan Li Yafeng Deng Dejun Jiang Zhenxing Wu Hongyan Du hongming chen Yun Li Huanxiang Liu Yuwei Wang Pei Luo Tingjun Hou Xiaojun Yao Dr.Neher's Biophysics Laboratory for lnnovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao999078China innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Faculty of Applied Sciences Macao Polytechnic UniversityMacao999078China College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou730000China Carbon Silicon AI Technology Co. LtdHangzhouZhejiang 310018China Center of Chemistry and Chemical Biology Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510530China College of Pharmacy Shaanxi University of Chinese MedicineXianyangShaanxi712044China

Effective synthesis planning powered by deep learning(DL)can significantly accelerate the discovery of new drugs and ***,most DL-assisted synthesis planning methods offer either none or very limited capability to recommend suitable reaction conditions(RCs)for their reaction ***,the prediction of RCs with a DL framework is hindered by several factors,including:(a)lack of a standardized dataset for benchmarking,(b)lack of a general prediction model with powerful representation,and(c)lack of *** address these issues,we first created 2 standardized RC datasets covering a broad range of reaction classes and then proposed a powerful and interpretable Transformer-based RC predictor named *** careful design of the model architecture,pretraining method,and training strategy,Parrot improved the overall top-3 prediction accuracy on catalysis,solvents,and other reagents by as much as 13.44%,compared to the best previous model on a newly curated ***,the mean absolute error of the predicted temperatures was reduced by about 4℃.Furthermore,Parrot manifests strong generalization capacity with superior cross-chemical-space prediction *** analysis indicates that Parrot effectively captures crucial chemical information and exhibits a high level of interpretability in the prediction of *** proposed model Parrot exemplifies how modern neural network architecture when appropriately pretrained can be versatile in making reliable,generalizable,and interpretable recommendation for RCs even when the underlying training dataset may still be limited in diversity.

关键词： versatile absolute generalization

Tightly-coupled Lidar-inertial Odometry and Mapping in Real Time

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Tightly-coupled Lidar-inertial Odometry and Mapping in Real ...