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Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

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Chinese Chemical Letters 2024年第2期35卷 305-310页

作者： Hongda zhu Kai Ma Rui Ruan Chaobo Yang Aqin Yan Jing Li Qi Yu hongmei Sun Mingxing Liu hongmei Zheng Jing Gao Xiaofang Guan zhu Dai Yao Sun Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province) Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of TechnologyWuhan 430068China Hubei Cancer Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079China National Key Laboratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhan 430079China Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science Ministry of EducationQingdao University of Science and TechnologyQingdao 266000China

Immune checkpoint inhibitors(ICIs)therapy targeting programmed cell death ligand 1(PD-L1)and programmed death protein 1(PD-1)had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer(TNBC).However,the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of immunotherapy.Herein,the immunomodulator epigallocatechin gallate palmitate(PEGCG)and the immunoadjuvant metformin(MET)self-assembled into tumor-targeted micelles via hydrogen bond and electrostatic interaction,which encapsulated the therapeutic agents doxorubicin(DOX)-loaded PEGCG-MET micelles(PMD)and combined with ICIs(anti-PD-1 antibody)as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive microenvironment.The results presented that PMD integrated chemotherapy and immunotherapy to enhance antitumor efficacy in vitro and in vivo,compared with DOX or anti-PD-1 antibody for the therapy of TNBC.PMD micelles might be a potential candidate,which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.

关键词： Immunotherapy Tumor-targeted Self-assembled micelles Metformin Reducing PD-L1 expression TNBC

Accurate Quantification of Pure Thiacloprid with Mass Balance and Quantitative H-NMR

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Journal of Analysis and Testing 2024年第1期8卷 1-8页

作者： Mengling Tu Wei Zhang Yunxiao zhu Wen Ma Xiao Li Shukun Zhou hongmei Li Xianjiang Li Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation Division of Metrology in ChemistryNational Institute of MetrologyBeijing 100029China State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and EnvironmentChina University of PetroleumBeijing 102249China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Thiacloprid is the first-generation neonicotinoid insecticide,which is widely used in modern agriculture.Reference materials are essential for sound measurement and traceability of results in chemical analysis.Pure thiacloprid was comprehensively assessed by two orthonormal methods:mass balance(MB) and quantitative nuclear magnetic resonance spectroscopy(qNMR).From MB,its mass fraction value was 998.4 mg/g with the subtraction of structurally related impurities(99.87%),inorganic impurities(0.006 mg/g),water(0.33 mg/g),and volatile organic solvent(0 mg/g).To guarantee sufficient separation of structurally related purity,peak purity of thiacloprid was evaluated by five points of UV spectra.From the qNMR of hydrogen,its mass fraction value was 995.7 mg/g which was traced to the internal standard(methyl sulfone).Finally,the certified value was assigned to 997 mg/g,together with an expanded uncertainty of 3 mg/g(k=2).This high-purity thiacloprid can be applied to routine monitoring in agriculture and the food fields.

关键词： Mass balance Quantitative nuclear magnetic resonance spectroscopy Reference material Thiacloprid

Distributed Application Addressing in 6G Network

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China Communications 2024年第4期21卷 193-207页

作者： Liu Jie Chen Sibo Liu Yuqin Mo Zhiwei Lin Yilin zhu hongmei He Yufeng China Telecom Research Institute Guangzhou 510632China

To ensure the extreme performances of the new 6G services,applications will be deployed at deep edge,resulting in a serious challenge of distributed application addressing.This paper traces back the latest development of mobile network application addressing,analyzes two novel addressing methods in carrier network,and puts forward a 6G endogenous application addressing scheme by integrating some of their essence into the 6G network architecture,combining the new 6G capabilities of computing&network convergence,endogenous intelligence,and communication-sensing integration.This paper further illustrates how that the proposed method works in 6G networks and gives preliminary experimental verification.

关键词： application addressing CNC(Computing&Network Convergence) DNS(Domain Name System) ICN(Information-Centric Network) 6G

Rational design and synthesis of cerium dioxide-based nanocomposites

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Nano Research 2023年第3期16卷 3622-3640页

作者： Haiyan An Liangliang Liu Nan Song hongmei zhu Yu Tang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China School of Pharmacy Lanzhou UniversityLanzhou 730000China

Cerium dioxide(CeO_(2))-based nanocomposites,as a branch of nanocomposites,are always constructed from CeO_(2)combining with other constituents,which exhibit enhanced performance and excellent stability due to their inherent synergistic systems.The modulation of morphology,size,and types of doping of active metals can be achieved by designing the structures,which providing the opportunity to construct diverse CeO_(2)-based nanocomposites.The optimization of the structure enables the design of new multifunctional CeO_(2)-based nanocomposites for various applications such as the field of catalysis.In this minireview,we describe the recent development of the nanocomposites based on noble metal-,transition metal-,and metal-organic framework(MOF)-CeO_(2),which are synthesized through various scientific and rational methods.Meanwhile,the design,synthesis,and basic working principles for CeO_(2)-based nanocomposites are also elucidated.In addition,some examples of their catalytic applications such as electrocatalysis,photocatalysis,and thermocatalysis are also discussed.Finally,the structure-activity relationship in guiding the design and synthesis of CeO_(2)-based nanocomposites is summarized and prospected.

关键词： CeO_(2) nanocomposites synthetic strategy catalysis

Microbially-mediated formation of Ca-Fe carbonates during dissimilatory ferrihydrite reduction:Implications for the origin of sedimentary ankerite

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Science China Earth Sciences 2024年第1期67卷 208-221页

作者： Deng LIU Jinpeng CAO Shanshan YANG Yating YIN Pengcong WANG Dominic PAPINEAU hongmei WANG Xuan QIU Genming LUO Zongmin zhu Fengping WANG State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China School of Environmental Studies China University of GeosciencesWuhan 430074China London Centre for Nanotechnology University College LondonLondon WC1H 0AHUK Department of Earth Sciences University College LondonLondon WC1E 6BTUK Center for Planetary Sciences University College London and Birkbeck College LondonLondon WC1E 6BTUK State Key Laboratory of Microbial Metabolism State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The origin of sedimentary dolomite has become a long-standing problem in the Earth Sciences.Some carbonate minerals like ankerite have the same crystal structure as dolomite,hence their genesis may provide clues to help solving the dolomite problem.The purpose of this study was to probe whether microbial activity can be involved in the formation of ankerite.Bio-carbonation experiments associated with microbial iron reduction were performed in batch systems with various concentrations of Ca^(2+)(0–20 mmol/L),with a marine iron-reducing bacterium Shewanella piezotolerans WP3 as the reaction mediator,and with lactate and ferrihydrite as the respective electron donor and acceptor.Our biomineralization data showed that Ca-amendments expedited microbially-mediated ferrihydrite reduction by enhancing the adhesion between WP3 cells and ferrihydrite particles.After bioreduction,siderite occurred as the principal secondary mineral in the Ca-free systems.Instead,Ca-Fe carbonates were formed when Ca^(2+)ions were present.The CaCO_(3) content of microbially-induced Ca-Fe carbonates was positively correlated with the initial Ca2+concentration.The Ca-Fe carbonate phase produced in the 20 mmol/L Ca-amended biosystems had a chemical formula of Ca_(0.8)Fe_(1.2)(CO_(3))_(2),which is close to the theoretical composition of ankerite.This ankeritelike phase was nanometric in size and spherical,Ca-Fe disordered,and structurally defective.Our simulated diagenesis experiments further demonstrated that the resulting ankerite-like phase could be converted into ordered ankerite under hydrothermal conditions.We introduced the term“proto-ankerite”to define the Ca-Fe phases that possess near-ankerite stoichiometry but disordered cation arrangement.On the basis of the present study,we proposed herein that microbial activity is an important contributor to the genesis of sedimentary ankerite by providing the metastable Ca-Fe carbonate precursors.

关键词： Ankerite Proto-ankerite Microbial iron reduction Dolomite problem Mineral transformation

On Positively Complete Einstein Square Metrics

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Acta Mathematica Sinica,English Series 2023年

作者： Zhongmin SHEN hongmei zhu College of Mathematics and Information Science Henan Normal University Department of Mathematical Sciences Indiana University-Purdue University

The well-known Berwald square metric is a positively complete and projectively flat Finsler metric with vanishing flag curvature. In this paper, we study a positively complete square metric on a manifold. We show a rigidity result that if the Ricci curvature is constant, then it must be isometric to the Berwald square metric. This is not true without assumption on the completeness of the metric.

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Leaching kinetics of fluorine during the aluminum removal from spent Li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie Li Jianxin zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and Lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent Li-ion battery cathode materials.In this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent Li-ion batteries(LIBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery process.The mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this study.The leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/mol.While,the leaching of F was attributed to the dissolution of LiPF6and decomposition of PVDF,and the kinetics associated was described by Avrami model.The interaction of Al and F is advantageous to realize the defluoridation to some degree.It is expected that our investigation will provide theoretical support for the large-scale recycling of spent LIBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics

Electron beam lithography on nonplanar and irregular surfaces

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Microsystems & Nanoengineering 2024年第2期10卷 1-23页

作者： Chenxu zhu Huseyin Ekinci Aixi Pan Bo Cui Xiaoli zhu Department of Electrical and Computer Engineering and Waterloo Institute for Nanotechnology(WIN) University of WaterlooWaterlooONCanada

E-beam lithography is a powerful tool for generating nanostructures and fabricating nanodevices with fine features approaching a few nanometers in size.However,alternative approaches to conventional spin coating and development processes are required to optimize the lithography procedure on irregular surfaces.In this review,we summarize the state of the art in nanofabrication on irregular substrates using e-beam lithography.To overcome these challenges,unconventional methods have been developed.For instance,polymeric and nonpolymeric materials can be sprayed or evaporated to form uniform layers of electron-sensitive materials on irregular substrates.Moreover,chemical bonds can be applied to help form polymer brushes or self-assembled monolayers on these surfaces.In addition,thermal oxides can serve as resists,as the etching rate in solution changes after e-beam exposure.Furthermore,e-beam lithography tools can be combined with cryostages,evaporation systems,and metal deposition chambers for sample development and lift-off while maintaining low temperatures.Metallic nanopyramids can be fabricated on an AFM tip by utilizing ice as a positive resistor.Additionally,Ti/Au caps can be patterned around a carbon nanotube.Moreover,3D nanostructures can be formed on irregular surfaces by exposing layers of anisole on organic ice surfaces with a focused e-beam.These advances in e-beam lithography on irregular substrates,including uniform film coating,instrumentation improvement,and new pattern transferring method development,substantially extend its capabilities in the fabrication and application of nanoscale structures.

关键词： lithography beam coating

Wood of trees:Cellular structure,molecular formation,and genetic engineering

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Journal of Integrative Plant Biology 2024年第3期66卷 443-467页

作者： Yingying zhu Laigeng Li State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China

Wood is an invaluable asset to human society due to its renewable nature,making it suitable for both sustainable energy production and material manufacturing.Additionally,wood derived from forest trees plays a crucial role in sequestering a significant portion of the carbon dioxide fixed during photosynthesis by terrestrial plants.Nevertheless,with the expansion of the global population and ongoing industrialization,forest coverage has been substantially decreased,resulting in significant challenges for wood production and supply.Wood production practices have changed away from natural forests toward plantation forests.Thus,understanding the underlying genetic mechanisms of wood formation is the foundation for developing high-quality,fast-growing plantation trees.Breeding ideal forest trees for wood production using genetic technologies has attracted the interest of many.Tremendous studies have been carried out in recent years on the molecular,genetic,and cell-biological mechanisms of wood formation,and considerable progress and findings have been achieved.These studies and findings indicate enormous possibilities and prospects for tree improvement.This review will outline and assess the cellular and molecular mechanisms of wood formation,as well as studies on genetically improving forest trees,and address future development prospects.

关键词： cambium cell wall Populus wood formation xylem