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EZH2-dependent myelination following sciatic nerve injury

Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi Xu Tianyi Huang Ying wang Siyuan Xu Yiting wang Wencong wang Zhiping wang hongkui wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects

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Bioactive Materials 2024年第1期31卷 563-577页

作者： Shanshan wang hongkui wang Panjian Lu Leilei Gong Xiaosong Gu Meiyuan Li Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu226001PR China Department of Obstetrics and Gynecology Affiliated Hospital of Nantong UniversityNantongJiangsu226001PR China

Decellularized extracellular matrix(dECM),with its distinct biological properties,has gained significant attention as a natural *** its potentials,we successfully developed a three-dimensional matrix-based oriented nerve graft by encapsulating a fibrous scaffold with multilayered conformationally intact and biologically active human bone marrow mesenchymal stem cell-derived decellularized extracellular matrix(hBMSC-dECM).Convincingly,the hBMSC-dECM group exhibited comparable functional recoveries to the autograft group by postoperative week *** the comprehensive analysis,the molecular regulations in the hBMSC-dECM group were more intricate and nuanced compared to the autograft ***,both groups displayed similar molecular regulatory processes in terms of vascularization and extracellular ***,the hBMSC-dECM group demonstrated sustained high levels of regulation in axon and myelin regeneration at week 12,while the immunomodulation returned to the normal levels after peaking at week ***,our findings illustrated the satisfactory construction of a cell-matrixed nerve graft that established a microenvironment conducive to nerve regeneration,and elucidated the distinct molecular regulation patterns and characteristics associated with different repair modes.

关键词： Decellularization Extracellular matrix hBMSC Peripheral nerve regeneration Tissue engineering

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Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration

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Research 2020年第1期2020卷 373-390页

作者： Guicai Li Qi Han Panjian Lu Liling Zhang Yuezhou Zhang Shiyu Chen Ping Zhang Luzhong Zhang Wenguo Cui hongkui wang Hongbo Zhang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Nantong University226001 NantongChina Co-Innovation Center of Neuroregeneration Nantong University226001 NantongChina Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)&Xi’an Institute of Biomedical Materials and Engineering(IBME)Northwestern Polytechnical University127 West Youyi RoadXi’an 710072China Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai 200025China Pharmaceutical Sciences Laboratory and Turku Bioscience Centre Åbo Akademi University20520 TurkuFinland

Biofunctionalization of artificial nerve implants by incorporation of specific bioactive factors has greatly enhanced the success of grafting procedures for peripheral nerve ***,most studies on novel biofunctionalized implants have emphasized the promotion of neuronal and axonal repair over vascularization,a process critical for long-term functional *** constructed a dual-biofunctionalized chitosan/collagen composite scaffold with Ile-Lys-Val-Ala-Val(IKVAV)and vascular endothelial growth factor(VEGF)by combining solution blending,in situ lyophilization,and surface *** of VEGF and IKVAV on the scaffolds was confirmed both qualitatively by staining and quantitatively by *** single-and dual-biofunctionalized scaffolds were compared for the promotion of endothelial cell(EC)and Schwann cell(SC)proliferation as well as the induction of angiogenic and neuroregeneration-associated genes by these cells in *** efficacy of these scaffolds for vascularization was evaluated by implantation in chicken embryos,while functional repair capacity in vivo was assessed in rats subjected to a 10mm sciatic nerve ***-biofunctionalized scaffolds supported robust EC and SC proliferation and upregulated the expression levels of multiple genes and proteins related to neuroregeneration and ***-biofunctionalized scaffolds demonstrated superior vascularization induction in embryos and greater promotion of vascularization,myelination,and functional recovery in *** findings support the clinical potential of VEGF/IKVAV dual-biofunctionalized chitosan/collagen composite scaffolds for facilitating peripheral nerve regeneration,making it an attractive candidate for repairing critical nerve *** study may provide a critical experimental and theoretical basis for the development and design of new artificial nerve implants with excellent biological performance.

关键词： functional promotion Dual

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Chitosan/PLGA-based tissue engineered nerve grafts with SKP-SC-EVs enhance sciatic nerve regeneration in dogs through miR-30b-5p-mediated regulation of axon growth

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Bioactive Materials 2024年第10期40卷 378-395页

作者： Miaomei Yu Mi Shen Daiyue Chen Yan Li Qiang Zhou Chunyan Deng Xinyang Zhou Qi Zhang Qianru He hongkui wang Meng Cong Haiyan Shi Xiaosong Gu Songlin Zhou Fei Ding Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu226001China Clinical Medical Research Center The Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu213003China Department of Pathophysiology School of MedicineNantong UniversityNantongJiangsu226001China

Extracellular vesicles from skin-derived precursor Schwann cells(SKP-SC-EVs)promote neurite outgrowth in culture and enhance peripheral nerve regeneration in *** study aimed at expanding the application of SKPSC-EVs in nerve grafting by creating a chitosan/PLGA-based,SKP-SC-EVs-containing tissue engineered nerve graft(TENG)to bridge a 40-mm long sciatic nerve defect in ***-SC-EVs contained in TENGs significantly accelerated the recovery of hind limb motor and electrophysiological functions,supported the outgrowth and myelination of regenerated axons,and alleviated the denervation-induced atrophy of target muscles in *** clarify the underlying molecular mechanism,we observed that SKP-SC-EVs were rich in a variety of miRNAs linked to the axon growth of neurons,and miR-30b-5p was the most important among *** further noted that miR-30b-5p contained within SKP-SC-EVs exerted nerve regeneration-promoting effects by targeting the Sin3a/HDAC complex and activating the phosphorylation of ERK,STAT3 or *** findings suggested that SKP-SC-EVs-incorporating TENGs represent a novel type of bioactive material with potential application for peripheral nerve repair in the clinic.

关键词： Peripheral nerve regeneration Skin-derived precursor Schwann cells Extracellular vesicles Tissue engineered nerve graft miR-30b-5p Sin3a/HDAC complex

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Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect

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Bioactive Materials 2024年第3期33卷 572-590页

作者： Chengbin Xue Hui Zhu hongkui wang Yaxian wang Xi Xu Songlin Zhou Dong Liu Yahong Zhao Tianmei Qian Qi Guo Jin He Kairong Zhang Yun Gu Leilei Gong Jian Yang Sheng Yi Bin Yu Yongjun wang Yan Liu Yumin Yang Fei Ding Xiaosong Gu Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Research Center of Clinical MedicineAffiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNantong UniversityNantongJS226001PR China Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJS226001PR China Department of Hand Surgery China-Japan Union HospitalJilin UniversityChangchunPR China Medical School of Nantong University NantongJS226001PR China

A central question in neural tissue engineering is how the tissue-engineered nerve(TEN)translates detailed transcriptional signals associated with peripheral nerve regeneration into meaningful biological ***,we report a skin-derived precursor-induced Schwann cell(SKP-SC)-mediated chitosan/silk fibroin-fabricated tissue-engineered nerve graft(SKP-SCs-TEN)that can promote sciatic nerve regeneration and functional restoration nearly to the levels achieved by autologous nerve grafts according to behavioral,histological,and electrophysiological *** achieving better effect of neuroregeneration,this is the first time to jointly apply a dynamic perfusion bioreactor and the ascorbic acid to stimulate the SKP-SCs secretion of extracellular matrix(ECM).To overcome the limitation of traditional tissue-engineered nerve grafts,jointly utilizing SKP-SCs and their ECM components were motivated by the thought of prolongating the effect of support cells and their bioactive cues that promote peripheral nerve *** further explore the regulatory model of gene expression and the related molecular mechanisms involved in tissue engineering-aided peripheral nerve regeneration,we performed a cDNA microarray analysis of gene expression profiling,a comprehensive bioinformatics analysis and a validation study on the grafted segments and dorsal root ganglia tissues.A wealth of transcriptomic and bioinformatics data has revealed complex molecular networks and orchestrated functional regulation that may be responsible for the effects of SKP-SCs-TEN on promoting peripheral nerve *** work provides new insights into transcriptomic features and patterns of molecular regulation in nerve functional recovery aided by SKP-SCs-TEN that sheds light on the broader possibilities for novel repair strategies of peripheral nerve injury.

关键词： SKP-SCs-TEN Transcriptomic feature Reconstruction of regenerative microenvironment Molecular regulation Molecular regenerative-medicine

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Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats

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Neural Regeneration Research 2014年第14期9卷 1386-1388页

作者： Xiaoyang Chen Yifei Yin Tingting Zhang Yahong Zhao Yumin Yang Xiaomei Yu hongkui wang Department of Doppler Ultrasound Affiliated Hospital of Nantong University Jiangsu Key Laboratory of Neuroregeneration Nantong University School of Biology and Basic Medical Sciences Soochow University

The repair of peripheral nerve injuries with autologous nerve remains the gold standard （wang et al., 2005; Yao et al., 2010; Deal et al., 2012; Kriebel et al., 2014; Liu et al., 2014; Tamaki et al., 2014; Yu et al., 2014; Zhu and Lou, 2014）. With advances in tissue engineering and biomaterials, tissue-engineered nerve conduits with various biomaterials and structures, such as collagen and chitosan nerve conduits, have already been used in the clinic as alternatives to autologous nerve in the repair of peripheral nerve injury （wang et al., 2012; Svizenska et al., 2013; Eppenberger et al., 2014; Gu et al., 2014; Koudehi et al., 2014; MoyaDiaz et al., 2014; Novajra et al., 2014; Okamoto et al., 2014; Shea et al., 2014; Singh et al., 2014; Tamaki et al., 2014; Yu et al., 2014）. Therefore, new simple and effective methods

关键词： Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats

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The dynamic change and regulation of IGF-1 on axonal regeneration after sciatic nerve transaction

The dynamic change and regulation of IGF-1 on axonal regener...

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中国解剖学会2019年年会

作者： Hui Zhu Chengbin Xue hongkui wang Xiaodong Cai Yongjun wang Xiaosong Gu Research Center of Clinical Medicine Affiliated Hospital of Nantong University Key Laboratory of Neuroregeneration Ministry of Education and Jiangsu ProvinceCo-innovation Center of NeuroregenerationNantong University

＜正＞To figure out the effect on the intrinsic capability of axonal growth and regulation of regeneration microenvironment are crucial for clinical therapies when suffering peripheral nerve injuries （PNIs）.The present work focused on the role of miR-129 in regulation of Insulin-like growth factor-1（IGF-1） signaling after sciatic nerve *** showed IGF-1 increased in proximal nerve stump following

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基于失真传递的时域自适应量化算法

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浙江大学学报（理学版） 2017年第1期44卷 57-63页

作者：殷海兵王鸿奎王忠霄中国计量大学信息工程学院浙江杭州310018

码率控制是视频编码器中的关键模块,其算法直接决定编码器率失真性能.视频编码帧间预测导致的编码失真会在时域产生传递效应,考虑该传递效应是优化码率控制算法性能的关键.宏块树码率控制是一种典型的时域量化控制算法,核心是根据编码... 详细信息

码率控制是视频编码器中的关键模块,其算法直接决定编码器率失真性能.视频编码帧间预测导致的编码失真会在时域产生传递效应,考虑该传递效应是优化码率控制算法性能的关键.宏块树码率控制是一种典型的时域量化控制算法,核心是根据编码单元失真传递量(相对传递代价ρ)自适应地调整量化参数(偏移量δ),合适的δ-ρ映射关系是宏块树量化控制算法的核心.宏块树算法采用基于经验的δ-ρ模型,对不同视频序列的普适性有待改进,模型准确度和精度也需进一步优化.针对上述问题,将竞争决策方法用于探索最优δ-ρ映射关系,提出了一种率失真性能优化的失真时域传递自适应量化δ-ρ模型,以改进时域自适应量化算法.实验结果表明,信噪比BD-PSNR较原模型提升了0.14dB以上,SSIM性能提升了0.29dB.算法能更好地控制码率时域分配,降低失真时域传递恶化.

关键词：视频编码码率控制率失真优化失真传递竞争决策

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国内外电力体制改革研究

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电网与清洁能源 2017年第8期33卷 44-48页

作者：李敏王洪奎广东电网有限责任公司阳江供电局广东阳江529500 中电联(北京)科技发展有限公司北京100055

为了解决能源危机,环境污染等一系列问题,促进新能源开发利用,英美等过率先进行了电力体制改革。通过分析国外电改的政策及取得的成就,结合我国新电改的政策和方向,给出现行新电改面临的机遇和挑战。分析结果表明:国外电改在取得较成绩... 详细信息

为了解决能源危机,环境污染等一系列问题,促进新能源开发利用,英美等过率先进行了电力体制改革。通过分析国外电改的政策及取得的成就,结合我国新电改的政策和方向,给出现行新电改面临的机遇和挑战。分析结果表明:国外电改在取得较成绩的同时,也暴露了一些问题,不同的电改适合不同的国家;尽管各国发展特点不同,但共同的趋势是向低碳环保方向发展;中国电力改革发展之路,必须充分尊重自己本身的情况和基本国情。

关键词：能源危机电力体制改革 9号文能源互联网

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犊牦牛腹泻发生原因及防治

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畜牧兽医科学（电子版） 2020年第15期 61-62页

作者：王宏奎青海省大通种牛场西宁810102

青海地区地处高原地带,因其特殊的地形和气候原因,牦牛是当地农牧民群众的主要经济来源和致富手段。但由于受到气候条件等多方面不良因素的影响,牦牛犊牛出生后易出现腹泻疾病,影响犊牛正常生长发育。该文主要论述牦牛犊牛腹泻发生的原... 详细信息

青海地区地处高原地带,因其特殊的地形和气候原因,牦牛是当地农牧民群众的主要经济来源和致富手段。但由于受到气候条件等多方面不良因素的影响,牦牛犊牛出生后易出现腹泻疾病,影响犊牛正常生长发育。该文主要论述牦牛犊牛腹泻发生的原因及具体的防治措施。

关键词：牦牛犊牛腹泻原因防治措施

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