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VisComposer: A Visual Programmable Composition Environment for Information Visualization

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Visual Informatics 2018年第1期2卷 71-81页

作者： honghui mei Wei Chen Yuxin Ma Huihua Guan Wanqi Hu State Key Lab of CAD&CG Zhejiang UniversityHangzhouChina

As the amount of data being collected has increased,the need for tools that can enable the visual exploration of data has also *** has led to the development of a variety of widely used programming frameworks for information ***,such frameworks demand comprehensive visualization and coding skills and require users to develop visualization from *** alternative is to create interactive visualization design environments that require lttle to no ***,these tools only supports a small portion of visual *** present a programmable integrated development environment(IDE),VisComposer,that supports the development of expressive visualization using a drag and-drop visual ***-Composer exposes the programmability by customizing desired components within a modular-ized visualization composition pipeline,effectively balancing the capability gap between expert coders and visualization *** implemented system empowers users to compose compre-bensive visualizations with real-time preview and optimization features,and supports prototyp-ing,sharing and reuse of the effects by means of an intuitive visual *** program-ming and textual programming integrated in our system allow users to compose more complex visual effects while retaining the simplicity of *** demonstrate the performance of VisCom-poser with a variety of examples and an informal user evaluation.

关键词： Information Visualization Visualization authoring Interactive development environment

DataV:Data Visualization on large high-resolution displays

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Visual Informatics 2020年第3期4卷 12-23页

作者： honghui mei Huihua Guan Chengye Xin Xiao Wen Wei Chen Alibaba Group China State Key Lab of CAD&CG Zhejiang UniversityChina Joint Institute of Frontier Technologies Alibaba-Zhejiang UniversityChina

In recent years,the technology and applications of visualizations on large high-resolution displays(LHDs)have received widespread attention because of its perceptual benefits and improved produc***,existing work on LHD visualization lacks both comprehensive guidance for design requirements and tools developed for its specific usage *** this paper,we present the scenarios,design,and implementation of DataV,a Software-as-a-Service(SaaS)visual deployment tool that enables rapid construction and cross-platform publishing of interactive visualization on *** framework can support rich components for the high-performance rendering of multisource heterogeneous *** provides a full-fledged toolchain to help the user efficiently specify layout and *** present its accessibility and impressive visual effects with examples and comparison with Tableau,Power BI,VisComposer,and *** also report the performance of using DataV for 3D map rendering by comparing it with ***.

关键词： Information visualization Large high-resolution displays Interactive design Software-as-a-service

COVID-19 data visualization public welfare activity

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Visual Informatics 2020年第3期4卷 51-54页

作者： Yiting Wang Ting Wang Ying Cui honghui mei Xiao Wen Jinzhi Lu Wei Chen Alicloud China State Key Laboratory of CAD&CG Zhejiang UniversityChina

The coronavirus disease 2019(COVID-19)pandemic started in early *** the beginning of February,a public welfare activity in epidemic data visualization,jointly launched by China Computer Federation(CCF)(CCF)CAD&CG Technical Committee,Alibaba Cloud Tianchi(Alibaba Cloud Tianch),JiqiZhixin(JiqiZhixin),Alibaba Cloud DataV(Alibaba Cloud DataV),and DataWhale(DataWhale),was launched with the theme‘‘Fighting the Epidemic with One Mind and Talents like Tianchi.’’Developers in general are expected to focus on several demand scenarios,such as epidemic situation display,epidemic popular science,trend prediction,material-supply situation,and rework and return situation of employees from all sectors and areas,to discover the relationship between complex heterogeneous multi-source data,develop various upbeat works and present useful information to the public in a coherent *** entry works take the form of data visualization and are divided into two categories:popular science publicity and application *** popular science publicity category includes works for the public,focused on epidemic situation display,epidemic popular science publicity,epidemic prevention and control,and *** application scenario category consists of the works of frontline officers,which can provide anti-epidemic workers with effective data tools for efficient and intuitive epidemic analysis;offer reliable,understandable,and easily transmitted information for disease prevention;and assist governments,enterprises,and institutions in the fight against COVID-19.

关键词： return Developer prevention

ECharts: A declarative framework for rapid construction of web-based visualization

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Visual Informatics 2018年第2期2卷 136-146页

作者： Deqing Li honghui mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen Baidu Inc. China State Key Lab of CAD&CG Zhejiang UniversityChina

While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based *** this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive *** motivation is driven by three goals:easy-touse,rich built-in interactions,and high *** kernel of ECharts is a suite of declarative visual design language that customizes built-in chart *** underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of *** report the design,implementation,and applications of ECharts with a diverse variety of *** compare the utility and performance of ECharts with ***,HighCharts,and *** of the experiments demonstrate the efficiency and scalability of our *** the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the *** is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab.

关键词： Information visualization Web-based visualization

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联邦学习可视化:挑战与框架

计算机辅助设计与图形学学报 2020年第4期32卷 513-519页

作者：潘如晟韩东明潘嘉铖周舒悦魏雅婷梅鸿辉陈为浙江大学CAD&CG国家重点实验室杭州310058 之江实验室杭州310000

联邦学习是一种保证数据隐私安全的分布式机器学习方案.与传统的机器学习的可解释性问题类似,如何对联邦学习进行解释是一个新的挑战.文中面向联邦学习方法的分布式与隐私安全性的特性,探讨联邦学习的可视化框架设计.传统的可视化任务... 详细信息

联邦学习是一种保证数据隐私安全的分布式机器学习方案.与传统的机器学习的可解释性问题类似,如何对联邦学习进行解释是一个新的挑战.文中面向联邦学习方法的分布式与隐私安全性的特性,探讨联邦学习的可视化框架设计.传统的可视化任务需要使用大量的数据,而联邦学习的隐私性决定了其无法获取用户数据.因此,可用的数据主要来自服务器端的训练过程,包括服务器端模型参数和用户训练状态.基于对联邦学习可解释性的挑战的分析,文中综合考虑用户、服务器端和联邦学习模型3个方面设计可视化框架,其包括经典联邦学习模型、数据中心、数据处理和可视分析4个模块.最后,介绍并分析了2个已有的可视化案例,对未来通用的联邦学习可视分析方法提出了展望.

关键词：联邦学习可解释机器学习数据隐私异常检测

The Effect of Beta-Amyloid on Neurons and the Influence of Glucocorticoid and Age on Such Effect

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第3期22卷 250-252页

作者：陈红辉孙圣刚梅元武刘昌勤刘安求童萼塘 Department of Geriatrics Wuhan Psychiatric Hospital. Department of Neurology Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

To explore the relationship between β amyloid (Aβ) and the pathogenesis of Al zheimer disease (AD), after injection of β amyloid into the rat brain, the apo ptosis of nerve cells and acetylcholine (Ach) content in rat hippocampus were ex amined by employing TUNEL technique and base hydroxylamine colorimetry respectiv ely. The influence of age and glucocorticoid on the neurotoxic effect of Aβ was also analyzed. Aβ peptide could strongly induce the apoptosis of neurons in hi ppocampus, cortex and striate body ( P <0.05 or P <0.01). In addition, the senility and glucocorticoid pre treatment could enhance the toxic effect of Aβ( P <0.05 or P <0.01). It is concluded that Aβ may play an important role in the pathogenesis of Alzheimer disease via its induction of apoptosis of neur ons and by decreasing the content of the Ach.

关键词： Alzheimer disease β amyloid glucocorticoid acetylcholine

Etomidate protects retinal ganglion cells from hydrogen peroxide-induced injury via Nrf2/HO-1 pathway

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1606-1613页

作者： Xuan Zhao De-Gang Fan Xin-Chao Zhang Si-Wei You Fang Kuang Ming-mei Wu Department of Histology and Embryology School of Basic Medical SciencesXi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Neurobiology the Basic Medical Science Academythe Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina College of Life Sciences Northwestern UniversityXi’an 710069Shaanxi ProvinceChina

AIM:To determine whether etomidate(ET)has a protective effect on retinal ganglion cells(RGCs)injured with hydrogen peroxide(H_(2)O_(2))and to explore the potential mechanism underlying the antioxidative stress effect of ***:Cultured RGCs were identified by double immunofluorescent labeling of microtubule-associated protein 2 and *** injury model of H_(2)O_(2)-induced RGCs oxidative stress was established in *** were pretreated with different concentrations of ET(1,5,and 10μmol/L)for 4h,followed by further exposure to H_(2)O_(2)at 1000μmol/*** counting kit 8 and Annexin V/propidium iodide assays were applied to detect the viabilities and apoptosis rates of the RGCs at 12,24,and 48h after H_(2)O_(2)*** levels of nitric oxide,malondialdehyde,and glutathione in culture media were measured at these time *** reverse transcription polymerase chain reaction(qRT-PCR)and Western blot were performed to observe the effects of ET on the messenger RNA and protein expression of inducible nitric oxide synthase(iNOS),nuclear factor erythroid 2-related factor 2(Nrf2),heme oxygenase 1(HO-1),glutathione peroxidase 1 and the level of conjugated acrolein in RGCs at 12,24,and 48h after H_(2)O_(2)stimulation and in the retina at 12h after optic nerve transection(ONT).RESULTS:The applications of 5 and 10μmol/L of ET significantly increased the viability of *** from qRT-PCR indicated a decrease in the expression of iNOS and an increase in the expressions of Nrf2 and HO-1 in ETpretreated RGCs at 12,24 and 48h after H_(2)O_(2)stimulation,as well as in ET-treated retinas at 12h after *** blot analysis revealed a decrease in the expression of iNOS and levels of conjugated acrolein,along with an increase in the expressions of Nrf2 and HO-1 in ET-pretreated RGCs in vitro and ET-treated retinas in ***:ET is a neuroprotective agent in primary cultured RGCs injured by H_(2)O_(2).The effect of ET is dosedependent with the

关键词： etomidate retinal ganglion cell neuroprotection hydrogen peroxide-induced injury nuclear factor erythroid 2-related factor 2 heme oxygenase 1

基于LightGBM模型的中国成人吸烟行为研究

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现代信息科技 2024年第7期8卷 128-135,140页

作者：刘忠华卢鑫梅文强赵旻胡彬彬张轲殷红慧中国烟草总公司云南省公司云南昆明650011 云南省烟草农业科学研究院云南昆明650031 云南省烟草质量监督检测站云南昆明650032 云南省烟草公司文山州公司云南文山663099

采用2018年世界卫生组织在中国开展的成人烟草调查数据,对成人吸烟行为影响因素进行探究。首先对原始数据做数据清洗,包括剔除无关变量、组合新变量等步骤。其次结合卡方检验、方差分析以及最大互信息数对处理后的数据集进行特征选择。... 详细信息

采用2018年世界卫生组织在中国开展的成人烟草调查数据,对成人吸烟行为影响因素进行探究。首先对原始数据做数据清洗,包括剔除无关变量、组合新变量等步骤。其次结合卡方检验、方差分析以及最大互信息数对处理后的数据集进行特征选择。再次基于XGBoost、LightGBM算法进行建模,对影响成人吸烟行为的因素进行排序和分析。最后基于表现较好的LightGBM模型进行变量组合建模,进一步挖掘吸烟者特征。经建模分析,识别得出成人性别、烟草环境、增税态度、低焦油烟认知、学历、年龄重要性由强至弱对吸烟行为产生影响。

关键词： LightGBM XGBoost 吸烟行为

Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor

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Science China(Life Sciences) 2022年第4期65卷 718-730页

作者： Shuming Yin Lie Ma Tingting Shao mei Zhang Yuting Guan Liren Wang Yaqiang Hu Xi Chen honghui Han Nan Shen Wenjuan Qiu Hongquan Geng Yongguo Yu Shichang Li Weishi Yu Mingyao Liu Dali Li Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai200241China Bioray Laboratories Inc. Shanghai200241China Xinhua Hospital Shanghai Jiao Tong University School of MedicineShanghai200092China College of Physical Education and Health East China Normal UniversityShanghai200241China Key Laboratory of Adolescent Health Assessment and Exercise Intervention Ministry of EducationCollege of Physical Education and HealthEast China Normal UniversityShanghai200241China CIPHER GENE LLC Beijing100089China

Genome editing through adeno-associated viral(AAV) vectors is a promising gene therapy strategy for various diseases,especially genetic disorders. However, homologous recombination(HR) efficiency is extremely low in adult animal models. We assumed that increasing AAV transduction efficiency could increase genome editing activity, especially HR efficiency, for in vivo gene therapy. Firstly, a mouse phenylketonuria(PKU) model carrying a pathogenic R408W mutation in phenylalanine hydroxylase(Pah) was generated. Through co-delivery of the general AAV receptor(AAVR), we found that AAVR could dramatically increase AAV transduction efficiency in vitro and in vivo. Furthermore, co-delivery of SaCas9/sgRNA/donor templates with AAVR via AAV8 vectors increased indel rate over 2-fold and HR rate over 15-fold for the correction of the single mutation in Pah;mice. Moreover, AAVR co-injection successfully increased the site-specific insertion rate of a 1.4 kb Pah cDNA by 11-fold, bringing the HR rate up to 7.3% without detectable global off-target effects. Insertion of Pah cDNA significantly decreased the Phe level and ameliorated PKU symptoms. This study demonstrates a novel strategy to dramatically increase AAV transduction which substantially enhanced in vivo genome editing efficiency in adult animal models, showing clinical potential for both conventional and genome editing-based gene therapy.

关键词： CRISPR/Cas9 gene therapy adeno-associated virus(AAV) AAVR Pah PKU