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Moxibustion enables protective effects on rheumatoid arthritis-induced myocardial injury via transforming growth factor beta1 signaling and metabolic reprogramming

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1190-1199页

作者： WANG Miao ZHU Yan zhao Hui zhao hongfang the Geriatrics Anhui University of Traditional Chinese MedicineHefei 230031China the Geriatrics the Second Hospital Affiliated of Anhui University of Traditional Chinese MedicineHefei 230061China

OBJECTIVE:To examine the effects of moxibustion on myocardial injury and myocardial metabolomics in rats with rheumatoid arthritis(RA)based on the transforming growth factor beta1(TGF-β1)/Smads signaling ***:One hundred rats were treated with saline[normal control(NC)group]or complete Freund’s adjuvant(CFA)by right plantar injection for the RA model group,and the latter were randomly divided into 4 *** wilfordii polyglycoside tablets(雷公藤多苷片,TPT)have anti-inflammatory and are widely used in the clinical treatment of RA,therefore serving as a positive control *** days post injection rats were given TPT tablet(TPT group),acupuncture therapy(APT group),and moxibustion treatment(MOX group)for 15 consecutive days,while NC group and model group were equally grasped and fixed and received normal *** joint swelling scores and arthritis index(AI)were evaluated in each group before the CFA challenge,therapy and after receiving *** ultrastructure was observed by electron ***-linked immunosorbent assay was used to detect cardiac troponin I(cTnI)levels in rat myocardial *** reverse transcription polymerase chain reaction and Western blotting analysis were used to measure the mRNA and protein levels of TGF-βsignaling molecules including TGF-β1,Smad2,Smad3,Smad4,and *** metabolomics was analyzed using gas chromatography-mass ***:Compared with model group,RA model rats receiving TPT,acupuncture,or moxibustion therapy all showed reduced joint swelling scores and AI(all P<0.01)and improved myocardial damage,whereas rats treated with moxibustion were found to be more ***,the expressions of cTnI,TGF-β1,Smad2,Smad3,and Smad4 were found to be elevated in model rat group in contrast to NC rats and were significantly downregulated in TPT,APT and MOX group when compared with model group,while the levels of Smad7 showed the opposite result(all P<0.01).Moreover,

关键词： moxibustion arthritis rheumatoid transforming growth factor beta1 smad proteins signal transduction myocardial injury metabolomics

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China's Criminal Law Reform from the Perspective of the International Covenant on Civil and Political Rights

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The Journal of Human Rights 2017年第2期16卷 181-192页

作者：焦阳 zhao hongfang Department of International Law China Foreign Affairs University

The International Covenant on Civil and Political Rights reflects the world’s perception of human rights, and is of vital importance in the field of international human rights. The Covenant has been signed by Chinese government. Although not ratified yet, it will definitely have an impact on the reform of China’s Criminal Law. Therefore, it is necessary to further change our notion of the criminal law system by defining the boundary between public power and civil rights and developing the view of human rights protection. In terms of the specific system, it is necessary to further reduce the number of crimes punishable by the death penalty and limit the application of the death sentence, improve China’s Criminal Procedural Law to protect the fundamental rights of suspects and defendants in terms of compulsory measures, investigation means and judicial form, and add some charges like enslavement and illegal human experimentation, which are criminalized around the world, so as to be in line with the requirements of international human rights protection.

关键词： International Covenant on Civil and Political Rights death penalty reform criminal procedure international crime

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The “Transcendental” Interpretation of the Concept of a Community with a Shared Future for Mankind: The Convention on the Rights of Persons with Disabilities and Its Implementation in China

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The Journal of Human Rights 2017年第4期16卷 314-326页

作者：谷盛开 zhao hongfang China Society for Human Rights Studies

The concept of a Community with a Shared Future for Mankind provides new theoretical support for the special protection of the rights of persons with disabilities. The Convention on the Rights of Persons with Disabilities is innovative in terms of its purposes and principles, logic and technology, and the actual implementation of the contracting parties, which is unique in the field of international human rights law. It is a "transcendental" interpretation of the concept of a community with a shared future for mankind and enhances the ethical values of international human rights law. The development of the cause of persons with disabilities in China is positively influenced by the values reflected in the concept of a community of shared Future for mankind and meanwhile highlights them, which provides "Chinese experiences" for the international cause of persons with disabilities.

关键词： a community with a shared future for mankind the Convention on the Rights of Persons with Disabilities international human rights law

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The Practice of Elementary Education Right Protection Proposed in International Human Rights Conventions in China——From the Perspective of the Compulsory Education of Migrant Children

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The Journal of Human Rights 2017年第3期16卷 244-255页

作者：徐爽赵晨 zhao hongfang Institute for Human Rights at China University of Political Science and Law

The right to education is a basic human right China has actively implemented the international treaties on the right of migrant children to elementary education and provided institutional support to ensure the implementation of elementary education policy In practice,however,due to factors such as regional differences and fiscal capacity,the problems of equal treatment and a balanced distribution of educational resources remain to be addressed In this regard,this paper suggests solving the problems from the perspectives of enhancing the implementation of international treaties,increasing compulsory education resources,improving the quality of education,and adjusting policies

关键词： migrant children the right to elementary education compulsory education

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Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1159-1174页

作者： Heng Xu hongfang zhao Chunyong Ding Defang Jiang Zijie zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Chemical Biology Research Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Pharm-X center College of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xianlin RoadQixiaNanjing 210023 JiangsuChina University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen-Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor *** clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural *** identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target ***,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising ***,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired *** peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal *** solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with *** derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure *** Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer *** anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer *** downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 *** findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer.

关键词： colorectal cancer nude

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Review of Poverty Alleviation Work in Rural Areas in China and Its Future Prospects

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The Journal of Human Rights 2017年第3期16卷 205-220页

作者：李云龙 zhao hongfang the International Strategic Institute at the CPC Central Party School the China Society for Human Rights Studies

Since the launched of reform and opening up,the Chinese government has made great efforts and provided a lot of funds to promote poverty alleviation and development in rural areas China has made great achievements in the cause of poverty alleviation and these have been recognized by the international community The infrastructure in poverty-stricken areas has also been continuously improved,and industrial activities have been encouraged in poverty-stricken areas to help promote self-reliance As a result of the government's actions the poor rural population has been greatly reduced,and rural people's living standards have been greatly improved Since the 18^(th) National Congress of the Communist Party of China,the central government has put forward a strategy of accurate poverty alleviation,implemented poverty alleviation projects in areas where poverty has stubbornly persisted and enhanced its efforts to finally eliminate poverty Under the vigorous leadership of the CPC,China is expected to achieve the goal of eliminating absolute poverty nationwide ahead of schedule

关键词： development-oriented poverty alleviation human rights poverty alleviation poor rural population

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Electric stimulation and decimeter wave therapy improve the recovery of injured sciatic nerves

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Neural Regeneration Research 2013年第21期8卷 1974-1984页

作者： Feng zhao Wei He Yingze Zhang Dehu Tian hongfang zhao Kunlun Yu Jiangbo Bai Department of Orthopedics the First Hospital of Hebei Medical University Department of Hand Surgery the Third Hospital of Hebei Medical University

Drug treatment, electric stimulation and decimeter wave therapy have been shown to promote the repair and regeneration of the peripheral nerves at the injured site. This study prepared a Mackinnon’s model of rat sciatic nerve compression. Electric stimulation was given immediately after neurolysis, and decimeter wave radiation was performed at 1 and 12 weeks post-operation. Histological observation revealed that intraoperative electric stimulation and decimeter wave therapy could improve the local blood circulation of repaired sites, alleviate hypoxia of compressed nerves, and lessen adhesion of compressed nerves, thereby decreasing the formation of new entrapments and enhancing compressed nerve regeneration through an improved microenvironment for regeneration. Immunohistochemical staining results revealed that intraoperative electric stimulation and decimeter wave could promote the expression of S-100 protein. Motor nerve conduction velocity and amplitude, the number and diameter of myelinated nerve fibers, and sciatic functional index were significantly increased in the treated rats. These results verified that intraoperative electric stimulation and decimeter wave therapy contributed to the regeneration and the recovery of the functions in the compressed nerves.

关键词： neural regeneration peripheral nerve injury physical therapy electric stimulation sciatic nerve compression Schwann cells functional recovery neuroregeneration

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最新法律法規

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中国法律（中英文版） 2015年第4期 144-148,I0001页

作者： zhao hongfang

中华人民共和国国务院颁布系列行政法规《国务院关於取消非行政许可审批事项的决定》（2015年5月10日国发[2015]27号发布）《国务院关於修改〈中国公民往来台湾地区管理办法〉的决定》（015年6月14日中华人民共和国国务院令第661号公布... 详细信息

中华人民共和国国务院颁布系列行政法规《国务院关於取消非行政许可审批事项的决定》（2015年5月10日国发[2015]27号发布）《国务院关於修改〈中国公民往来台湾地区管理办法〉的决定》（015年6月14日中华人民共和国国务院令第661号公布自2015年7月1日起施行）

关键词：中华人民共和国国务院令法律法规行政许可审批事项行政法规台湾地区中国公民

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司法部副部長趙大程就《關於完善法律援助制度的意見》答記者問

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中国法律（中英文版） 2015年第4期 74-80页

作者： zhao hongfang

近期，中央全面深化改革领导小组第十二次会议审议通过了《关於完善法律援助制度的意见》（以下简称《意见》）。中共中央办公厅、国务院办公厅印发了《意见》。日前，司法部副部长赵大程就《意见》有关问题回答了记者提问。

关键词：法律援助制度副部长司法部答记者问中共中央办公厅国务院办公厅记者提问审议

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資訊&數據

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中国法律（中英文版） 2014年第4期 58-59,118-121页

作者： zhao hongfang

中共中央政治局委员、中央政法委书记孟建柱近日在司法体制改革试点工作座谈会上强调，要把思想和行动统一到习近平总书记系列重要讲话精神和中央关於深化司法体制改革的决策部署上来，牢固树立改革大局观，把注重顶层设计与鼓励基层探... 详细信息

中共中央政治局委员、中央政法委书记孟建柱近日在司法体制改革试点工作座谈会上强调，要把思想和行动统一到习近平总书记系列重要讲话精神和中央关於深化司法体制改革的决策部署上来，牢固树立改革大局观，把注重顶层设计与鼓励基层探索结合好，凝聚共识、攻坚克难，紮实推进司法体制改革，走出一条具有中国社会主义特色、符合司法规律的改革之路。

关键词：中央政治局委员改革试点工作司法体制改革中国社会主义特色资讯政法委书记决策部署顶层设计

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