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MRE11 lactylation:a linker between Warburg effect and DNA repair

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Life Metabolism 2024年第3期3卷 6-8页

作者： Pingyu Liu hongbin ji Fuming Li Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Institute of Metabolism and Integrative Biology State Key Laboratory of Cell BiologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China School of Life Science and Technology Shanghai Tech UniversityShanghai 200120China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China

Lysine lactylation is a recently discovered post-translational modification with emerging roles in both physiology and disease.A recent study published in Cell shows that lactate-induced lactylation of the homologous recombination(HR)protein meiotic recombination 11 results in HR hyperactivation and chemoresistance in cancer cells,establishing a previously unrecognized link between cellular metabolism and deoxyribonucleic acid(DNA)damage repair and providing new insights into how altered glucose metabolism can impact DNA damage response in cancer.

关键词： metabolism damage establishing

Understanding cachexia and its impact on lung cancer and beyond

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第2期2卷 95-105页

作者： Meiting Yue Zhen Qin Liang Hu hongbin ji State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China

Cancer cachexia is a multifactorial syndrome characterized by loss of body weight secondary to skeletal mus-cle atrophy and adipose tissue *** not only has a significant impact on patients’quality of life but also reduces the effectiveness and tolerability of anticancer therapy,leading to poor clinical *** cancer is a prominent global health concern,and the prevalence of cachexia is high among patients with lung *** this review,we integrate findings from studies of lung cancer and other types of cancer to provide an overview of recent advances in cancer *** focus includes topics such as the clinical criteria for di-agnosis and staging,the function and mechanism of selected mediators,and potential therapeutic strategies for clinical application.A comprehensive summary of current studies will improve our understanding of the mecha-nisms underlying cachexia and contribute to the identification of high-risk patients,the development of effective treatment strategies,and the design of appropriate therapeutic regimens for patients at different disease stages.

关键词： Cancer cachexia Staging systems Mediators Signaling pathways Therapeutic strategies

孟鲁司特钠联合酮替芬治疗小儿喘息性支气管炎的临床效果分析

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中国社区医师 2024年第12期40卷 25-27页

作者：纪洪彬岭泉镇卫生院内科山东临沂276600

目的:分析孟鲁司特钠联合酮替芬治疗小儿喘息性支气管炎的临床效果。方法:选取2020年12月—2022年12月岭泉镇卫生院收治的喘息性支气管炎患儿68例作为研究对象,采用随机数字表法分为对照组与研究组,各34例。对照组给予孟鲁司特钠治疗,... 详细信息

目的:分析孟鲁司特钠联合酮替芬治疗小儿喘息性支气管炎的临床效果。方法:选取2020年12月—2022年12月岭泉镇卫生院收治的喘息性支气管炎患儿68例作为研究对象,采用随机数字表法分为对照组与研究组,各34例。对照组给予孟鲁司特钠治疗,研究组在对照组基础上给予酮替芬治疗。比较两组治疗效果。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P=0.032)。治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组住院时间短于对照组,咳嗽消失时间、肺部干湿啰音消失时间、喘息消失时间早于对照组,差异有统计学意义(P<0.05)。研究组不良反应总发生率低于对照组,差异有统计学意义(P=0.021)。结论:孟鲁司特钠联合酮替芬治疗小儿喘息性支气管炎的效果显著,能够改善患儿免疫功能,加快症状恢复,使其提前出院,且安全性较好,值得临床应用并予以推广。

关键词：孟鲁司特钠酮替芬小儿喘息性支气管炎安全性

稀土La对42CrMo钢碳化物析出特征及摩擦学性能增强机理研究

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摩擦学学报（中英文） 2024年第8期44卷 1032-1042页

作者：吉宏斌王建梅程先华王震宇王强太原科技大学重型机械教育部工程研究中心山西太原030024 上海交通大学机械与动力工程学院上海200240

使用真空熔炼技术制备了稀土42CrMo钢,采用光学显微镜(OM)、扫描电子显微镜(SEM)和能谱仪(EDS)对材料微观组织、拉伸断口、磨损表面和亚表层进行了表征,研究了La对42CrMo钢碳化物析出特征及摩擦学性能增强机理.结果表明:La减小了晶界张... 详细信息

使用真空熔炼技术制备了稀土42CrMo钢,采用光学显微镜(OM)、扫描电子显微镜(SEM)和能谱仪(EDS)对材料微观组织、拉伸断口、磨损表面和亚表层进行了表征,研究了La对42CrMo钢碳化物析出特征及摩擦学性能增强机理.结果表明:La减小了晶界张力和界面能,降低了碳化物沉淀所需成核势垒,提供了形核点,使42CrMo钢具有更小的原奥氏体晶粒和碳化物,原奥氏体和碳化物尺寸减少约46.5%和19.4%.添加La后,42CrMo钢具有更优良的力学和摩擦磨损性能,屈服强度、抗拉强度和断后伸长率比普通钢提升了9.29%、9.48%和25.01%,磨损率降低了36.71%.稀土钢强塑性的提高得益于La对晶粒和碳化物的细化以及碳化物和基体界面柔韧性的提高.摩擦磨损性能的提升是由于碳化物和基体的柔性界面在摩擦磨损过程中起到协调变形作用,减少了微裂纹的形成和碳化物的剥离,使摩擦表面形成的自润滑膜更加致密、完整,不易破坏.此外,La减少了钢中夹杂物,也提高了稀土钢的塑性和摩擦磨损性能.

关键词：稀土La 42CrMo钢碳化物摩擦学性能柔性界面

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内分泌治疗老年前列腺癌的远期生存率预测模型建立与验证

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临床泌尿外科杂志 2024年第3期39卷 192-197页

作者：季宏斌陈先国安徽医科大学第一附属医院东城院区泌尿外科合肥231600

目的:建立并验证老年前列腺癌(prostate cancer,PCa)患者内分泌治疗后5年生存率的预测模型。方法:回顾性分析安徽医科大学第一附属医院东城院区2010年1月—2023年8月治疗的91例老年PCa患者的临床资料。所有患者均接受内分泌治疗。采用... 详细信息

目的:建立并验证老年前列腺癌(prostate cancer,PCa)患者内分泌治疗后5年生存率的预测模型。方法:回顾性分析安徽医科大学第一附属医院东城院区2010年1月—2023年8月治疗的91例老年PCa患者的临床资料。所有患者均接受内分泌治疗。采用单因素分析、LASSO回归及多因素Cox回归分析明确影响5年生存率的独立危险因素。并使用R软件建立5年生存率的Nomogram风险预测模型,采用受试者工作特征(receiver operating characteristic,ROC)曲线及Calibration校准曲线评估模型的区分能力和校准度。并使用Bootstrap法对该模型进行内部验证以评估模型的准确性,决策曲线分析(decision curve analysis,DCA)图对模型进行临床实用性评估。结果:年龄、分化程度、Gleason评分及转移情况是影响老年PCa患者5年生存率的独立影响因子(P<0.05)。建立的预测模型ROC曲线下面积(area under curve,AUC)为0.938,显示良好的区分能力,校准曲线显示预测生存率与实际生存率有良好的一致性。内部验证显示,AUC为0.926,Calibration校准曲线在理想曲线附近。结论:基于年龄、分化程度、Gleason评分及转移情况建立的老年PCa患者内分泌治疗后5年生存率的预测模型具有较好的准确性,可为老年PCa的治疗和预后评估提供一定的指导。

关键词：前列腺癌内分泌治疗总体生存率预测模型

LKB1 in lung cancerigenesis:a serine/threonine kinase as tumor suppressor

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Protein & Cell 2011年第2期2卷 99-107页

作者： Yijun Gao Gaoxiang Ge hongbin ji Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Lung cancer is featured with high mortality,with a 15%five-year survival rate *** alterations,such as loss of function of tumor suppressor genes,frequently contribute to lung cancer initiation,progression and *** kinase B1(LKB1),as a serine/threonine kinase and tumor suppressor,is frequently mutated and inactivated in non-small cell lung cancer(NSCLC).Recent studies have provided strong evidences that LKB1 loss promotes lung cancerigenesis process,especially lung cancer progression and *** review will summarize recent progress on how LKB1 modulates the process of lung cancerigenesis,emphasizing on LKB1 downstream signaling pathways and biological *** will further discuss the potential development of prognostic biomarkers or therapeutic targets in lung cancer clinic based on the molecular alteration associated with deregulated LKB1 signaling.

关键词： liver kinase B1 lung cancer tumor suppressor

Lung stem cells in regeneration and tumorigenesis

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Journal of Genetics and Genomics 2021年第4期48卷 268-276页

作者： Yuting Chen Yun Xue Yujuan jin hongbin ji State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Pulmonary Hospital Tongji UniversityShanghai 200092China

Adult lung is a highly quiescent organ,with extremely low cell turnover ***,emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various *** regeneration mainly depends on the proliferation of regionally distributed pulmonary stem cells that re-enter the cell *** lineage-tracing approaches help to track the lung epithelial differentiation and/or de-differentiation path,and single-cell transcriptomic technique reveals the essential molecular signaling involved in lung *** of the molecular signaling that balances quiescence and self-renewal leads to the transformation of lung stem cells,and thus promotes lung cancer ***,different subtypes of lung cancer share common cells of origin and the pathological transition among various subtypes is responsible for drug resistance in the *** this review,we summarize the recent understanding of lung stem cells in regeneration and tumorigenesis as well as related molecular mechanisms,with the hope to provide helpful insights for clinical treatments of respiratory diseases.

关键词： Lung stem cells Lung cancer Regeneration Tumorigenesis Pathological transition

Evolution from genetics to phenotype： reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance

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Protein & Cell 2017年第3期8卷 178-190页

作者： Yingjiao Xue Shenda Hou hongbin ji Xiangkun Han Key Laboratory of Systems Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Innovation Center for Cell Signaling Network Shanghai Institutes for Biological Sciences Chinese Academy of Sciences_ Shanghai 200031 China CAS Center for Excellence in Molecular Cell Science Institute of Biochemistry and Cell Biology Shanghai Institutes forBiological Sciences Chinese Academy of Sciences Shanghai 200031 China School of Life Science and Technology Shanghai Tech University Shanghai 200120 China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China

Lung cancer is the leading cause of cancer-related deaths worldwide. Targeted therapy is beneficial in most cases, but the development of drug resistance stands as an obstacle to good prognosis. Multiple mechanisms were explored such as genetic alterations, activation of bypass signaling, and phenotypic transition. These intrinsic and/or extrinsic dynamic regulations facilitate tumor cell survival in meeting the demands of signaling under different stimulus. This review introduces lung cancer plasticity and heterogeneity and their correlation with drug resistance. While cancer plasticity and heterogeneity play an essential role in the development of drug resistance, the manipulation of them may bring some inspirations to cancer prognosis and treatment. That is to say, lung cancer plasticity and heterogeneity present us with not only challenges but also opportunities.

关键词： lung cancer plasticity heterogeneity drugresistance phenotypic transition

基于SCD模型的智能变电站接线图自动生成系统

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自动化与仪表 2024年第3期39卷 137-141页

作者：陈艳吉宏斌高婷婷国网江苏省电力有限公司扬州供电分公司扬州225009

该文设计智能变电站接线图自动生成系统,降低配置信息理解难度。框架中包括基础层获取变电站配置SCD文件,数据转换层进行处理,数据传输层通过PCIE总线发送到业务层。接线图生成模块分析SCD文件确定IED节点间拓扑关系,计算边权值。采用... 详细信息

该文设计智能变电站接线图自动生成系统,降低配置信息理解难度。框架中包括基础层获取变电站配置SCD文件,数据转换层进行处理,数据传输层通过PCIE总线发送到业务层。接线图生成模块分析SCD文件确定IED节点间拓扑关系,计算边权值。采用图聚类算法完成节点分组,多任务并行运算生成接线图,可视化呈现给用户。实验结果表明系统能快速生成清晰合理的接线图。

关键词： SCD模型智能变电站接线图数据转换并行运算图聚类