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MicroRNA21 Meets Neuronal TLR8: Non-canonical Functions of MicroRNA in Neuropathic Pain

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Neuroscience Bulletin 2019年第5期35卷 949-952页

作者： zhi-hong wang Tong Liu Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow University Suzhou 215021 China College of Life Sciences Yanan University Yanan 716000 China

Toll-like receptors (TLRs) are well-known as patternrecognition receptors in the immune system for recognizing pathogen-associated and damage-associated molecular patterns [1]. TLRs play an essential role in the innate and adaptive immune responses. To date, 10 functional TLRs have been identified in humans (TLR1–TLR10) and 12 in mice (TLR1–TLR9 and TLR11–TLR13)[1]. TLRs are evolutionarily conserved type I transmembrane proteins and comprise an ectodomain characterized by leucine-rich repeats mediating the recognition of ligands, a transmembrane region, and cytosolic Toll-interleukin (IL)-1 receptor domains that activate the downstream signaling pathways [1].

关键词： MicroRNA21 Neuronal TLR8 Neuropathic Pain

COSSET＋： Crowdsourced Missing Value Imputation Optimized by Knowledge Base

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Journal of Computer Science & Technology 2017年第5期32卷 845-857页

作者： hong-zhi wang zhi-Xin Qi Ruo-Xi Shi Jian-Zhong Li hong Gao School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China

Missing value imputation with crowdsourcing is a novel method in data cleaning to capture missing values that could hardly be filled with automatic approaches. However, the time cost and overhead in crowdsourcing are high. Therefore, we have to reduce cost and guarantee the accuracy of crowdsourced imputation. To achieve the optimization goal, we present COSSET+, a crowdsourced framework optimized by knowledge base. We combine the advantages of both knowledge-based filter and crowdsourcing platform to capture missing values. Since the amount of crowd values will affect the cost of COSSET+, we aim to select partial missing values to be crowdsourced. We prove that the crowd value selection problem is an NP-hard problem and develop an approximation algorithm for this problem. Extensive experimental results demonstrate the efficiency and effectiveness of the proposed approaches.

关键词： crowdsourcing missing value imputation knowledge base optimization

EntityManager： Managing Dirty Data Based on Entity Resolution

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Journal of Computer Science & Technology 2017年第3期32卷 644-662页

作者： Xue-Li Liu hong-zhi wang Jian-Zhong Li hong Gao Massive Data Computing Laboratory Harbin Institute of Technology Harbin 150001 China

Data quality is important in many data-driven applications, such as decision making, data analysis, and data mining. Recent studies focus on data cleaning techniques by deleting or repairing the dirty data, which may cause information loss and bring new inconsistencies. To avoid these problems, we propose EntityManager, a general system to manage dirty data without data cleaning. This system takes real-world entity as the basic storage unit and retrieves query results according to the quality requirement of users. The system is able to handle all kinds of inconsistencies recognized by entity resolution. We elaborate the EntityManager system, covering its architecture, data model, and query processing techniques. To process queries efficiently, our system adopts novel indices, similarity operator and query optimization techniques. Finally, we verify the efficiency and effectiveness of this system and present future research challenges.

关键词： dirty data entity resolution uncertain attribute query processing query optimization

FrepJoin:an efficient partition-based algorithm for edit similarity join

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Frontiers of Information Technology & Electronic Engineering 2017年第10期18卷 1499-1510页

作者： Ji-zhou LUO Sheng-fei SHI hong-zhi wang Jian-zhong LI School of Computer Science and Technology Harbin Institute of Technology Guangdong Key Laboratory of Popular High Performance Computers Key Laboratory of Service Computing and Application

String similarity join(SSJ) is essential for many applications where near-duplicate objects need to be found. This paper targets SSJ with edit distance constraints. The existing algorithms usually adopt the filter-andrefine framework. They cannot catch the dissimilarity between string subsets, and do not fully exploit the statistics such as the frequencies of characters. We investigate to develop a partition-based algorithm by using such *** frequency vectors are used to partition datasets into data chunks with dissimilarity between them being caught easily. A novel algorithm is designed to accelerate SSJ via the partitioned data. A new filter is proposed to leverage the statistics to avoid computing edit distances for a noticeable proportion of candidate pairs which survive the existing filters. Our algorithm outperforms alternative methods notably on real datasets.

关键词： String similarity join Edit distance Filter and refine Data partition Combined frequency vectors

O2iJoin： An Efficient Index-Based Algorithm for Overlap Interval Join

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Journal of Computer Science & Technology 2018年第5期33卷 1023-1038页

作者： Ji-Zhou Luo Sheng-Fei Shi Guang Yang hong-zhi wang Jian-Zhong Li School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China Guangdong Key Laboratory of Popular High Performance Computers Key Laboratory of Service Computing and Application Shenzhen 518000 China

Time intervals are often associated with tuples to represent their valid time in temporal relations, where overlap join is crucial for various kinds of queries. Many existing overlap join algorithms use indices based on tree structures such as quad-tree, B＋-tree and interval tree. These algorithms usually have high CPU cost since deep path traversals are unavoidable, which makes them not so competitive as data-partition or plane-sweep based algorithms. This paper proposes an efficient overlap join algorithm based on a new two-layer flat index named as Overlap Interval Inverted Index （i.e., O2i Index）. It uses an array to record the end points of intervals and approximates the nesting structures of intervals via two functions in the first layer, and the second layer uses inverted lists to trace all intervals satisfying the approximated nesting structures. With the help of the new index, the join algorithm only visits the must-be-scanned lists and skips all others. Analyses and experiments on both real and synthetic datasets show that the proposed algorithm is as competitive as the state-of-the-art algorithms.

关键词： overlap interval join temporal relation overlap inverted index join algorithm

Highly Stretchable and Conductive Hybrid Fibers for High-performance Fibrous Electrodes and All-solid-state Supercapacitors

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Chinese Journal of Polymer Science 2020年第5期38卷 531-539,I0007页

作者： Gui-Qing Wu Xin-Yu Yang Jia-Hui Li Nan Sheng Cheng-Yi Hou Yao-Gang Li hong-zhi wang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China School of Materials Science and Engineering Nanyang Technological University639798Singapore

The development of lightweight,flexible,and stretchable energy storage systems is essential for state-of-the-art electronic *** propose a new and broad strategy to fabricate a stretchable and conductive GO/CNTs-TPU fiber electrode by direct wet spinning,from which a flexible fibrous supercapacitor is *** fibrous electrode exhibits a high strength of 11.68 MPa,high conductivity of 342 S/cm,and high specific capacitances(21.8 mF/cm,36.45 F/cm^3,and 95 F/g).The specific capacitance of the assembled all-solid-state hybrid fiber-shaped supercapacitor reaches 14.3 F/cm^*** 5000 charge-discharge cycles,97%of the capacitance of the hybrid supercapacitor is *** high-strength electrochemical electrode materials could be potential candidates for applications in practical and large-scale energy storage systems and textile clothes.

关键词： Graphene Carbon nanotubes Thermoplastic polyurethane Supercapacitor Flexibility

Nomogram for predicting the prognosis of tumor patients with sepsis after gastrointestinal surgery

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1771-1784页

作者： Ren-Xiong Chen Zhou-Qiao Wu Zi-Yu Li hong-zhi wang Jia-Fu Ji ICU Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijing 100142China Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijing 100142China

BACKGROUND There were few studies on the prognosis of tumor patients with sepsis after gastrointestinal surgery and there was no relevant nomogram for predicting the prognosis of these *** To establish a nomogram for predicting the prognosis of tumor patients with sepsis after gastrointestinal surgery in the intensive care unit(ICU).METHODS A total of 303 septic patients after gastrointestinal tumor surgery admitted to the ICU at Peking University Cancer Hospital from January 1, 2013 to December 31, 2020 were analysed retrospectively. The model for predicting the prognosis of septic patients was established by the R software *** The most common infection site of sepsis after gastrointestinal surgery in the ICU was abdominal infection. The 90-d all-cause mortality rate was 10.2% in our study group. In multiple analyses, we found that there were statistically significant differences in tumor type, septic shock, the number of lymphocytes after ICU admission, serum creatinine and total operation times among tumor patients with sepsis after gastrointestinal surgery(P < 0.05). These five variables could be used to establish a nomogram for predicting the prognosis of these septic patients. The nomogram was verified, and the initial C-index was 0.861. After 1000 internal validations of the model, the C-index was 0.876, and the discrimination was good. The correction curve indicated that the actual value was in good agreement with the predicted *** The nomogram based on these five factors(tumor type, septic shock, number of lymphocytes, serum creatinine, and total operation times) could accurately predict the prognosis of tumor patients with sepsis after gastrointestinal surgery.

关键词： Tumor Surgery Sepsis Gastrointestinal Nomogram

Middle Devonian ostracods from Jiwozhai patch reef(Dushan,Guizhou Province,South China):Biostratigraphic and palaeoecological implication

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Journal of Palaeogeography 2024年第3期13卷 581-593页

作者： Jun-Jun Song Jia-Yuan Huang Wen Guo Kun Liang Yu-Cong Sun zhi-hong wang Wen-Kun Qie State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina Hubei Key Laboratory of Paleontology and Geological Environment Evolution Wuhan Center of China Geological SurveyWuhan 430205Hubei ProvinceChina University of Chinese Academy of Sciences NanjingNanjing 211135Jiangsu ProvinceChina

The Middle Devonian ostracods from the Jiwozhai patch reef in Dushan, Guizhou Province, South China were described for the first time in this study. Twenty-nine species belonging to 20 genera were identified and figured, including a new species named wangshangkia jiwozhaiensis sp. nov. The ostracod fauna in the Jiwozhai patch reef represents a Givetian age. The ostracod assemblage belongs to the smooth-podocopid association, which is also ecologically equivalent to the Eifelian Mega-Assemblage Ⅲ. This association is indicative of shallow open-marine environments. The Jiwozhai patch reef fauna is primarily comprised of suspension feeders, including filter-feeding ostracods, corals, brachiopods and bryozoans. Ostracods from the Jiwozhai patch reef were compared to the ostracod faunas from Laurentia-Baltica at generic level, which reveals limited faunal exchanges between South China and Laurentia-Baltica during the Middle Devonian.

关键词： Ostracods Givetian Jiwozhai patch reef Dushan Palaeoecology

Dynamic changes and surveillance function of prion protein expression in gastric cancer drug resistance

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World Journal of Gastroenterology 2011年第35期17卷 3986-3993页

作者： Ji-Heng wang Jing-Ping Du Ying-Hai Zhang Xiao-Jun Zhao Ru-Ying Fan zhi-hong wang Zi-Tao Wu Ying Han Department of Gastroenterology Beijing Army General Hospital Beijing 100700 China Department of General Surgery Jiamusi University Medical College Jiamusi 154004 Heilongjiang Province China

AIM:To explore the dynamic changes of prion protein (PrPc) in the process of gastric cancer drug resistance and the role of PrPc expression in the prognosis of gastric cancer patients receiving ***:A series of gastric cancer cell lines resistant to different concentrations of adriamycin was established,and the expression of PrPc,Bcl-2 and Bax was detected in these *** was determined using Annexin V *** blotting and immunohisto-chemistry were performed to detect the expression of PrPc in patients receiving chemotherapy and to explore the role of PrPc expression in predicting the chemosensitivity and the outcome of gastric cancer patients receiving ***-up was performed for 2 ***:PrPc expression was increased with the increase in drug ***-2,together with PrPc,increased the level of anti-apoptosis of cancer *** PrPc expression predicted the enhanced level of anti-apoptosis and resistance to anticancer *** expression could be used as a marker for predicting the efficacy of chemotherapy and the prognosis of gastric *** PrPc expression predicted both poor chemosensitivity and a low 2-year survival ***,low PrPc expression predicted favorable chemosensitivity and a relatively high 2-year survival ***:PrPc expression is associated with histological types and differentiation of gastric cancer cells;The PrPc expression level might be a valuable marker in predicting the efficacy of chemotherapy and the prognosis of gastric cancer patients receiving chemotherapy.

关键词： Prion protein Gastric cancer Drug resistance Chemotherapy Apoptosis