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Advances in surface plasmon resonance for analyzing active components in traditional Chinese medicine

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Journal of Pharmaceutical Analysis 2024年第10期14卷 1397-1406页

作者： Jing Xie Xian-Deng Li Mi Li hong-yan zhu yan Cao Jian Zhang A-Jing Xu Faculty of Pharmacy Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200092China Department of Biochemical Pharmacy School of PharmacySecond Military Medical UniversityShanghai200433China

The surface plasmon resonance(SPR)biosensor technology is a novel optical analysis method for studying intermolecular *** to in-depth research on traditional Chinese medicine(TCM)in recent years,comprehensive and specific identification of components and target interactions has become key yet difficult *** has gradually been used to analyze the active components of TCM owing to its high sensitivity,strong exclusivity,large flux,and real-time monitoring *** review sought to briefly introduce the active components of TCM and the principle of SPR,and provide historical and new insights into the application of SPR in the analysis of the active components of TCM.

关键词： Surface plasmon resonance Traditional Chinese medicine Optical analysis techniques Multi-target molecular mechanism study Biosensor

Pseudothrombus deposition accompanied with minimal change nephrotic syndrome and chronic kidney disease in a patient with Waldenstrom’s macroglobulinemia: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2393-2400页

作者： Mercy Julian Mwamunyi hong-yan zhu Chun Zhang Ya-Pei Yuan Li-Jun Yao Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

BACKGROUND Waldenstr?m’s macroglobulinemia(WM) is a rare lymphoid neoplasia, which can have renal complications. These rarely occur, and most common renal manifestations are mild proteinuria and microscopic hematuria. Herein we describe a case of WM that presented with pseudothrombi depositing in capillaries associated with minimal change nephrotic syndrome and chronic kidney disease(CKD).CASE SUMMARY A 52-year-old man presented with features suggesting nephrotic *** workups were done, and there were elevated serum levels of interleukin-6 and vascular endothelial growth factor(VEGF), capillary pseudothrombus accumulation associated with minimal change nephrotic syndrome, CKD, and WM. Treatment was directed at the patient’s WM with bortezomib, thalidomide, and dexamethasone whereby serum immunoglobulin M(IgM) decreased. The damage of IgM on the kidney was corrected; thus, the patient’s proteinuria and serum creatinine had improved. The patient is still under clinical *** It is essential for clinicians to promptly pay more attention to patients presenting with features of nephrotic syndrome and do extensive workups to come up with a proper therapy strategy.

关键词： Waldenstrom’s macroglobulinemia Pseudothrombi Nephrotic syndrome Chronic kidney disease Case report

TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity

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World Journal of Gastroenterology 2015年第28期21卷 8615-8628页

作者： Bo Yuan Wei-hong Tang Li-Juan Lu Yuan Zhou hong-yan zhu You-Lang Zhou hong-hong Zhang Chuang-Ying Hu Guang-Yin Xu Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Institute of NeuroscienceThe Second Affiliated Hospital Soochow University Department of Pain Management Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

AIM:To investigate the roles of toll-like receptor 4(TLR4) and nuclear factor(NF)-κB on cystathionine βsynthetase(CBS) expression and visceral hypersensitivity in ***:This study used 1-7-wk-old male SpragueDawley *** blot analysis was employed to measure the expression of TLR4,NF-kB and the endogenous hydrogen sulfide-producing enzyme CBS in colon dorsal root ganglia(DRG) from control and "irritable bowel syndrome" rats induced by neonatal colonic inflammation(NCI).Colon-specific DRG neurons were labeled with Dil and acutely dissociated to measure excitability with patch-clamp *** was employed to determine the co-expression of TLR4,NF-kB and CBS in Dil-labeled DRG ***:NCI significantly upregulated the expression of TLR4 in colon-related DRGs(0.34 ± 0.12 vs 0.72 ±0.02 for the control and NCI groups,respectively,P <0.05).Intrathecal administration of the TLR4-selective inhibitor CLI-095 significantly enhanced the colorectal distention threshold of NCI ***-095 treatment also markedly reversed the hyperexcitability of colonspecific DRG neurons and reduced the expression of CBS(1.7 ± 0.1 vs 1.1 ± 0.04,p < 0.05) and of the NF-kB subunit p65(0.8 ± 0.1 vs 0.5 ± 0.1,P< 0.05).Furthermore,the NF-KB-selective inhibitor pyrrolidine dithiocarbamate(PDTC) significantly reduced the upregulation of CBS(1.0 ± 0.1 vs 0.6 ± 0.1,P< 0.05)and attenuated visceral hypersensitivity in the NCI *** vitro,incubation of cultured DRG neurons with the TLR4 agonist lipopolysaccharide significantly enhanced the expression of p65(control vs 8 h:0.9 ± 0.1 vs1.3 ± 0.1;control vs 12 h:0.9 ± 0.1 vs 1.3 ± 0.1,P< 0.05;control vs 24 h:0.9 ± 0.1 vs 1.6 ± 0.1,P <0.01) and CBS(control vs 12 h:1.0 ± 0.1 vs 2.2 ±0.4;control vs 24 h:1.0 ± 0.1 vs 2.6 ± 0.1,P< 0.05),whereas the inhibition of p65 via pre-incubation with PDTC significantly reversed the upregulation of CBS expression(1.2 ± 0.1 vs 0.6 ± 0.0,P< 0.01).CONCLUSION:Our results suggest that the

关键词： Irritable bowel syndrome Dorsal rootganglion Visceral hypersensitivity Hydrogen sulfide Toll-like receptors Nuclear factor-kappa B

Adjuvant radiotherapy for gallbladder cancer:A dosimetric comparison of conformal radiotherapy and intensity-modulated radiotherapy

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World Journal of Gastroenterology 2011年第3期17卷 397-402页

作者： Xiao-Nan Sun Qi Wang Ben-Xing Gu yan-hong zhu Jian-Bin Hu Guo-Zhi Shi Shu Zheng Department of Radiation Oncology of SirRun Run Shaw Hospital Sir Run Run Shaw Institute of ClinicalMedicine of Zhejiang University Zhejiang University School ofMedicine Hangzhou 310016 Zhejiang Province China Cancer Institute (Key Laboratory of Cancer Prevention and Intervention Ministry of Education Key Laboratory ofMolecular Biology in Medical Sciences Zhejiang Province China)The Second Affiliated Hospital Zhejiang University School ofMedicine Hangzhou 310009 Zhejiang Province China

AIM: To assess the efficacy and toxicity of conformal radiotherapy (CRT) and compare with intensity-modulated radiotherapy (IMRT) in the treatment of gallbladder cancer. METHODS: Between November 2003 and January 2010, 20 patients with gallbladder cancer were treated with CRT with or without chemotherapy after surgical resection. Preliminary survival data were collected and examined using both Kaplan-Meier and actuarial analysis. Demographic and treatment parameters were collected. All patients were planned to receive 46-56 Gy in 1.8 or 2.0 Gy per fraction. CRT planning was compared with IMRT. RESULTS: The most common reported acute toxicities requiring medication (Radiation Therapy Oncology Group, Radiation Therapy Oncology Group Grade 2) were nausea (10/20 patients) and diarrhea (3/20). There were no treatment-related deaths. Compared with CRT planning, IMRT significantly reduced the volume of right kidney receiving > 20 Gy and the volume of liver receiving > 30 Gy. IMRT has a negligible impact on the volume of left kidney receiving > 20 Gy. The 95% of prescribed dose for a planning tumor volume using either 3D CRT or IMRT planning were 84.0% ± 6.7%, 82.9% ± 6.1%, respectively (P > 0.05). CONCLUSION: IMRT achieves similar excellent target coverage as compared with CRT planning, while reducing the mean liver dose and volume above threshold dose. IMRT offers better sparing of the right kidney compared with CRT planning, with a significantly lower mean dose and volume above threshold dose.

关键词： Gallbladder cancers Adjuvant treatment Surgery Radiation therapy

The association of Serum Klotho with the prevalence of cardiovascular disease and prognosis in general population:results from the National Health and Nutrition Examination Survey 2007-2016

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Journal of Geriatric Cardiology 2024年第11期21卷 1034-1046页

作者： Yi-Ting CAI Shu-Ying QI Shu-Yuan QI Rong XU hong-yan zhu Guang-Yao ZHAI Department of Cardiovascular Medicine Capital Medical UniversityBeijingChina

Background Previous studies have extensively investigated traditional predictors of cardiovascular disease(CVD)development,progression,and ***,the influence of novel indicators such as Klotho,on CVD prevalence and prognosis in the general population remains *** This was an observational study that utilized cross-sectional and longitudinal methods to examine the general population in the National Health and Nutrition Examination Survey(NHANES)*** participants were divided into four groups according to the Klotho *** outcome was CVD[coronary artery disease(CAD),congestive heart failure,and stroke],secondary outcomes were all-cause mortality and cardiovascular ***-weighted binary logistic regression analysis was used to analyze the association between Klotho and the prevalence of primary outcome,and the restricted cubic spline(RCS)curve was used to further analyze the nonlinear *** analyses were conducted to investigate the association between Klotho values and CVD prevalence using survey-weighted binary logistic *** incidence of the secondary outcomes among four groups was assessed through Kaplan-Meier survival ***,the relationship between Klotho values and secondary endpoints was explored using survey-weighted Cox proportional hazards regression across various patient *** A total of 12,146 participants(56.8±10.7 years,48.5%male)were included in our *** total incidence of CVD was 9.9%(n=1201),of which 4.7%(n=574)were CAD,3.7%(n=454)were congestive heart failure,and 4.1%(n=497)were *** logistics regression analysis showed that higher Klotho quartiles were associated with the decreased prevalence of CVD[Quartile 4 *** 1:odds ratio(OR)(95%CI):0.77(0.64-0.93),P=0.006]and congestive heart failure[Quartile 4 *** 1:0.75(0.56-0.99),P=0.048],However,no significant associations were found between Klotho levels and the ou

关键词： Klotho prevalence cardiovascular

Preparation of 2D square-like Bi2S3-BiOCl heterostructures with enhanced visible light-driven photocatalytic performance for dye pollutant degradation

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Water Science and Engineering 2017年第4期10卷 334-339页

作者： Jing-jing Xu Jing-wen yang Pu Zhang Quan Yuan yan-hong zhu Yu Wang Miao-miao Wu Zheng-mei Wang Min-dong Chen Collaborative Innovation Center of Atmospheric Environment and Equipment Technology School of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China Jiangsu Engineering Technology Research Center of Environmental Cleaning Materials Nanjing University of Information Science and TechnologyNanjing 210044China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Nanjing University of Information Science and TechnologyNanjing 210044China

A series of Bi2 S3-BiOCI composites with two-dimensional(2 D) square-like structures were prepared via a two-step anion exchange route.X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), and diffuse reflectance spectra(DRS)were used to investigate the properties of the as-prepared Bi_2 S_3-BiOCI heterostructures. The coupling of BiOCl and Bi_2 S_3 induced enhanced photoabsorption efficiency and bandgap narrowing. A reactive brilliant red X-3 B dye was used as a contaminant to test the photocatalytic activity of the obtained Bi_2 S_3-BiOCl samples under visible light irradiation. The sample Bi_2 S_3-BiOCl with a mass ratio of 8:4 exhibited the highest photodegradation efficiency, which was six times higher than that of pure BiOCl. In addition, a mechanism for the enhancement of photocatalytic activity is proposed.

关键词： Photocatalysis Bi2S3 BiOCl Visible light Heterostructure

Tetracyclic triterpenoids isolated from semi-mangrove plant Hibiscus tiliaceus

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Chinese Chemical Letters 2013年第12期24卷 1080-1082页

作者： Can-Ling Cheng Zhong-Zhao Wang Ping-Lin Li Xing-Wang Zhang Rong-Cui Wu hong-yan zhu Xu-Li Tang Guo-Qiang Li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of China College of Chemistry and Chemical Engineering Ocean University of China

A continuing phytochemical study on the semi-mangrove plant Hibiscus tiliaceus yielded two new tetracyclic triterpenoids （3β,24S）-19（10→9）-abeo-8α,9β,10α-eupha-5,25（26）-dien-3,24-diol （tiliacol A, 1 ）, and （3β,23Z）-19（10→9）-abeo-8α,9β,10α-tircalla-5,23-dien-3,25-diol （tiliacol B, 3）, together with one known analog （2）. Their structures were elucidated on the basis of extensive spectral analyses （MS, IR, 1D NMR and 2D NMR） and comparison with literature compounds. Compound 2 showed potent cytotoxicity against both P388 and HeLa cells with ICon values of 11.2 μmol/L and 11.5 μmol/L, resoectively.

关键词： Semi-mangrove Hibiscus tiliaceus (Malvaceae) Triterpenoid Cytotoxicity

Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang zhu Chenxi Ding Zhe Sui hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

Inhibition of connective tissue growth factor overexpression decreases growth of hepatocellular carcinoma cells in vitro and in vivo

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Chinese Medical Journal 2011年第22期124卷 3794-3799页

作者： JIA Xiao-qin CHENG Hai-qing LI hong zhu yan LI Yu-hua FENG Zhen-qing ZHANG Jian-ping Department of Pathology School of Medicine Yangzhou University Yangzhou Jiangsu 225500 China

Background We have previously found that connective tissue growth factor （CTGF） is highly expressed in a rat model of liver cancer. Here, we examined expression of CTGF in human hepatocellular carcinoma （HCC） cells and its effect on celt growth. Methods Real-time PCR was used to observe expression of CTGF in human HCC cell lines HepG2, SMMC-7721, MHCC-97H and LO2. siRNA for the CTGFgene was designed, synthesized and cloned into a PIk0.1-GFP-SP6 vector to construct a lentivirus-mediated shRNA/CTGF. CTGF mRNA and protein expression in HepG2 cells treated by CTGF-specific shRNA was evaluated by real-time PCR and Western blotting. 3-（4,5-dimethylthiazol-2-yl）- 2,5-diphenyltetrazolium bromide （MTT） assay was utilized to evaluate the growth effect, and a colony formation assay was used for observing clonogenic growth. In vivo, tumor cell proliferation was evaluated in a nude mouse model of xenotransplantation. Statistical significance was determined by t test for comparison between two groups, or analysis of variance （ANOVA） for multiple groups. Results Immunohistochemical staining of CTGF was seen in 35 of 40 HCC samples （87.5%）. CTGF was overexpressed 5-fold in 20 HCC tissues, compared with surrounding non-tumor liver tissue. CTGF mRNA level was 5-8-fold higher in HepG2, SMMC-7721 and MHCC-97H than in LO2 cells. This indicated that the inhibition rate of cell growth was 43% after knockdown of CTGF expression （P 〈0.05）. Soft agar colony formation assay showed that siRNA mediated knockdown of CTGF inhibited colony formation in soft agar of HepG2 cells （P 〈0.05）. The volume of tumors from CTGF-shRNA-expressing cells only accounted for 35% of the tumors from the scrambled control-infected HepG2 cells （P 〈0.05）. Conclusions CTGF was overexpressed in human HCC cells and downregulation of CTGF inhibited HCC growth in vitro and in vivo. Knockdown of CTGFmay be a potential therapeutic strategy for treatment of HCC.

关键词： hepatocellular carcinoma connective tissue growth factor siRNA cell proliferation