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New Explorations on Cannon's Contributions and Generalized Solutions for Uniform Linear Motion Blur Identification

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Journal of Computer Science & Technology 2012年第1期27卷 174-186页

作者： Lu Wang hong-yan zhang Si-Long Peng The National Engineering and Technology Research Center for ASIC Design Institute of AutomationChinese Academy of SciencesBeijing 100190China The Key Laboratory of Complex Systems and Intelligence Science Institute of AutomationChinese Academy of Sciences Beijing 100190China Sino-European Institute of Aviation Engineering Civil Aviation University of ChinaTianjin 300300China

Existing frequency-domain-oriented methods of parameter identification for uniform linear motion blur （ULMB） images usually dealt with special scenarios. For example, blur-kernel directions were horizontal or vertical, or degraded images were of foursquare dimension. This excludes those identification methods from being applied to real images, especially to estimate undersized or oversized blur kernels. Pointing against the limitations of blur-kernel identifications, discrete Fourier transform （DFT）-based blur-kernel estimation methods are proposed in this paper. We analyze in depth the Fourier frequency response of generalized ULMB kernels, demonstrate in detail its related phase form and properties thereof, and put forward the concept of quasi-cepstrum. On this basis, methods of estimating ULMB-kernel parameters using amplitude spectrum and quasi-cepstrum are presented, respectively. The quasi-cepstrum-oriented approach increases the identifiable blur-kernel length, up to a maximum of half the diagonal length of the image. Meanwhile, directing toward the image of undersized ULMB, an improved method based on quasi-cepstrum is presented, which ameliorates the identification quality of undersized ULMB kernels. The quasi-cepstrum-oriented approach popularizes and applies the simulation-experiment- focused DFT theory to the estimation of real ULMB images. Compared against the amplitude-spectrum-oriented method, the quasi-cepstrum-oriented approach is more convenient and robust, with lower identification errors and of better noiseimmunity.

关键词： Fourier amplitude spectrum phase perpendicular relation uniform linear motion blur identification quasicepstrum

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

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Journal of Molecular Cell Biology 2016年第1期8卷 31-43页

作者： Yong Ran Jing zhang Li-Li Liu Zhao-Yi Pan Ying Nie hong-yan zhang yan-Yi Wang Wuhan Institute of Virology State Key Laboratory of VirologyChinese Academy of SciencesWuhan 430072China College of Life Sciences Wuhan UniversityWuhan 430072China

The transcription factors IRF3 and NF-kB are required for the expression of many genes involved in antiviral innate immune response,including type I interferons(IFNs)and proinflammatory *** is well established thatTBK1 isan essential kinase engageddownstream of multiple pattern-recognition receptors(PRRs)to mediate IRF3 phosphorylation and activation,whereas the precise mechanisms of TBK1 activation have not been fully elucidated ***,weidentified tripartite motif 26(TRIM26)as an important regulator for RNAvirus-triggered innate immune *** of TRIM26 impaired virus-triggered IRF3,NF-kB activation,IFN-b induction,and cellular antiviral ***26 was physically associated with TBK1 independent of viral *** an E3 ligase,TRIM26 underwent autoubiquitination upon viral *** TRIM26 subsequently associated with NEMO,thus bridging TBK1–NEMOinteraction,which is critical for the recruitment of TBK1 to the VISA signalsome and activation of *** findings suggest that TRIM26 is an important regulator of innate immune responses against RNA viruses,which functions by bridging TBK1 to NEMO and mediating the activation of TBK1.

关键词： TRIM26 TBK1 NEMO ubiquitination antiviral response

Localization of keratin m RNA and collagen Ⅰm RNAin gastric cancerby in situ hybridization and hybridization electron microscopy

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World Journal of Gastroenterology 1999年第6期5卷 527-530页

作者： SU Chang Qing 1, QIU hong 1 and zhang yan 2 解放军第81医院江苏南京 210002 解放军第81医院江苏南京江苏南京市第二医院江苏南京

INTRODUCTIONImmunohistochemistry and immune electron microscopy were used to determine the keratin and collagen Ⅰ polypeptides expressed in gastric mucosa and gastric cancer. We found that the canceration of gastric epithelia and the infiltration and metastasis of gastric cancer are closely related with cellular skeleton and extracellular matrix[1]. The in situ hybridization (ISH) technique, developed by Gall and Pardue in 1969[2,3], has become an essential tool for detecting the localization of synthesis and abundance of RNA transcripts on tissue sections. With a K6 (Mr 56 000) keratin cDNA probe and a collagen Ⅰα1-chain cDNA probe, the cDNA-mRNA ISH technique was used to study changes of keratin mRNA and collagen Ⅰ mRNA expression in gastric mucosa and gastric cancer.

关键词： keratin collagen in situ hybridization nucleic acid stomach neoplasms mRNA

Genomic organization and sequence dynamics of the AvrPiz-t locus in Magnaporthe oryzae

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第6期13卷 452-464页

作者： Ping LI Bin BAI hong-yan zhang Heng ZHOU Bo ZHOU State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control Institute of Virology and BiotechnologyZhejiang Academy qf Agricultural SciencesHangzhou 310021China Institute of Biotechnology Zhejiang UniversityHangzhou 310058China

Plants utilize multiple layers of defense mechanisms to fight against the invasion of diverse *** R gene mediates resistance,in most cases,dependent on the co-existence of its cognate pathogen-derived avirulence (Avr) *** rice blast R gene Piz-t corresponds in gene-for-gene fashion to the Magnaporthe oryzae Avr gene *** this study,we determined and compared the genomic sequences surrounding the AvrPiz-t gene in both avirulent and virulent isolates,designating as AvrPiz-t-ZB15 and avrPiz-t-70-15 regions,*** sequence of the AvrPiz-t-ZB15 region is 120966 bp whereas avrPiz-t-70-15 is 146292 bp in *** extreme sequence similarity and good synteny in gene order and content along with the absence of two predicted genes in the avrPiz-t-70-15 region were observed in the predicted protein-coding regions in the AvrPiz-t ***,frequent presence/absence and highly dynamic organization of transposable elements (TEs) were identified,representing the major variation of the AvrPiz-t locus between different ***,TEs constitute 27.3% and 43.2% of the genomic contents of the AvrPiz-t-ZB15 and avrPiz-t-70-15 regions,respectively,indicating that TEs contribute largely to the organization and evolution of AvrPiz-t *** findings of this study suggest that *** could benefit in an evolutionary sense from the presence of active TEs in genes conferring avirulence and provide an ability to rapidly change and thus to overcome host R genes.

关键词： Magnaporthe oryzae Synteny Transposon complex Dynamics Recombination

Isolation and Identification of Virus dsRNA from Strawberry Plants

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Agricultural Sciences in China 2007年第1期6卷 86-93页

作者： LI He DAI hong-yan zhang Zhi-hong GAO Xiu-yan DU Guo-dong zhang Xin-yu College of Horticulture Shenyang Agricultural University Shenyang 110161 P.R.China

The analysis of virus genome is based on nucleic acid isolation. The aims of this study were to develop a method for isolation and identification of virus double-stranded ribonucleic acid （dsRNA） and to elucidate the nucleotide sequences of strawberry virus. Using the modified method, virus dsRNA was extracted from strawberry virus indicator plants and cultivated strawberry plants and detected using agarose gel electrophoresis with ethidium bromide staining and reverse transcription-polymerase chain reaction （RT-PCR）. The quantity of virus dsRNA varied among strawberry cultivars. The quantity of dsRNA from in vitro plantlets was higher than that from the young leaves of field plants. For the field-grown plants, there was more dsRNA in the young leaves. Virus dsRNA extracted from strawberry plants was resistant to deoxyribonuclease Ⅰ （DNase Ⅰ）, but evidently, it became resistant to ribonuclease A （RNase A） only in the presence of 0.5 M NaCl. Its bands in agarose gel could be readily recycled using an agarose gel DNA purification kit. With RT-PCR, the segments of both strawberry mottle virus and Strawberry mild yellow edge virus genomes were amplified by using the virus dsRNA recycled from gel or treated with DNase Ⅰ /RNase A as templates. The system developed for dsRNA isolation and identification in strawberry plants laid a sound foundation for the work on genome analysis of strawberry virus isolates in China.

关键词： dsRNA virus strawberry isolation RT-PCR

SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5

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Virologica Sinica 2021年第2期36卷 231-240页

作者： Dong-Peng Wang hong-yan zhang Bo-Wei Liao Zhen Tong Zhi-Sheng Xu yan-Yi Wang yan yang Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

During virus infection,RIG-I-like receptors(RLRs)recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling,leading to activation of transcription factors NF-κB and IRF3,which collaborate to induce type I interferons(IFNs).IFNs further induce expression of hundreds of IFN-stimulated genes(ISGs)that suppress viral replication and facilitate the adaptive immune *** production of IFNs is implicated in various immune *** we identified Signal Recognition Particle 54(SRP54)as a negative regulator of RLRs-induced antiviral *** of SRP54 inhibited RNA virus-triggered induction of IFN-b and increased viral replication,whereas knockdown of SRP54 had opposite ***,SRP54 interacted with both RIG-I and MDA5 and impaired their association with *** findings demonstrate that SRP54 acts as a negative regulator of RLRs-mediated innate immune response by disrupting the recruitment of VISA to RIG-I/MDA5.

关键词： TypeⅠinterferons(IFNs) SRP54 RLRs-induced signaling RIG-I/MDA5 and VISA interactions

Flexible carbon fiber-based composites for electromagnetic interference shielding

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Rare Metals 2022年第11期41卷 3612-3629页

作者： hong-yan zhang Jin-Yao Li Ying Pan Yi-Fan Liu Nasir Mahmood Xian Jian School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China RMIT University School of EngineeringMelbourneVic3001Australia

With the rapid development of electronic information technology,the waste electromagnetic radiation generated by the wireless and various other electronic devices has caused serious harm to human *** development of high-efficiency flexible electromagnetic interference(EMI)shielding materials has become one of the most effective ways to mitigate the increasingly serious problem of electromagnetic *** carbon fiber composites possess most of the physical requirements needed for EMI shielding applications,including high electrical conductivity,large specific surface area,light weight,flexibility,porous structure,and adjustable physical and chemical properties,and various morphology of carbon fibers-based composites applied *** this review,the primary EMI shielding mechanism of carbonfiber-based materials is *** carbon fiber suffers from a low absorption efficiency when used for EMI shielding by itself,it is usually combined with additional EMI filling ***,the methods of adding EMI filler materials to the carbon fiber framework and the influence of different fillers on the EMI shielding performance are also *** addition,the novel structural designs of flexible carbon fiber-based EMI shielding materials,including fiber orientation,core-shell structure,and multilayer heterostructure,are summarized in terms of their classification,which includes composites with metal,polymer,nano-carbon,and *** review concludes with a brief discussion of the challenges,research directions,and future prospects of carbon-fiber-based EMI shielding materials.

关键词： Carbon fibers Electromagnetic interference shielding Flexible Composites

Banking of perinatal mesenchymal stem/stromal cells for stem cellbased personalized medicine over lifetime:Matters arising

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World Journal of Stem Cells 2023年第4期15卷 105-119页

作者： Cheng-Hai Li Jing Zhao hong-yan zhang Bin Wang Stem Cell Program of Clinical Research Center People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Clinical Laboratory People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Pharmacy Fuwai Central China Cardiovascular HospitalZhengzhou 450000Henan ProvinceChina Department of Neurosurgery People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina

Mesenchymal stromal/stem cells(MSCs)are currently applied in regenerative medicine and tissue *** clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for *** derived from either human adult or perinatal tissues have their own unique advantages in their medical ***,clinical studies are conducted by using of cultured MSCs after thawing or short-term cryopreserved-then-thawed MSCs prior to administration for the treatment of a wide range of diseases and medical ***,cryogenically banking perinatal MSCs for potential personalized medicine for later use in lifetime has raised growing interest in China as well as in many other ***,this has led to questions regarding the availability,stability,consistency,multipotency,and therapeutic efficiency of the potential perinatal MSC-derived therapeutic products after longterm *** opinion review does not minimize any therapeutic benefit of perinatal MSCs in many diseases after short-term *** article mainly describes what is known about banking perinatal MSCs in China and,importantly,it is to recognize the limitation and uncertainty of the perinatal MSCs stored in cryobanks for stem cell medical treatments in whole *** article also provides several recommendations for banking of perinatal MSCs for potentially future personalized medicine,albeit it is impossible to anticipate whether the donor will benefit from banked MSCs during her/his lifetime.

关键词： Mesenchymal stromal/stem cells Adult mesenchymal stromal/stem cells Perinatal mesenchymal stromal/stem cells Perinatal tissue Stem cell bank Personalized medicine

Synthesis and Characterization of Dual Acidic Ionic Liquids

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Chinese Chemical Letters 2005年第12期16卷 1563-1565页

作者： Xiao Hua WANG Guo hong TAO Zi yan zhang Yuan KOU State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871

Novel ionic liquids with dual acidity, of which the cation contains Brφnsted acidity and anions contain Lewis acidity were synthesized. These ionic liquids obtained were identified by NMR, FF-IR, SDT and FAB-MS. Thei... 详细信息

关键词： Ionic liquids functional dual acidity synthesis characterization