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Chinese Chemical Letters 2024年第8期35卷 270-277页

作者： Shulei Hu Yu Zhang xiong Xie Luhan Li Kaixian Chen hong Liu Jiang Wang Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Lingang Laboratoty Shanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China

Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability,increased potency and ***,we present a rapid synthesis method for constructing Trp(C7)-alkene(E)-crosslinked cyclic peptides with potent anti-proliferative activities against cancer cells,through C-H alkenylation and *** report addresses critical challenges associated with the installation and removal of the directing group N-Piv,configuration selectivity of the olefin,and intramolecular ***-tably,this method exhibits mild reaction conditions,traceless removal of the directing group,and high configuration selectivity.

关键词： C-H functionalization Rh(Ⅲ)-catalyzed Alkenylation Cyclic peptides Macrolactamization

外卖智能派单的订单-骑手多目标匹配模型及其适应性算法研究

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管理工程学报 2024年第3期38卷 150-160页

作者：熊浩鄢慧丽海南大学管理学院海南海口570228 海南大学旅游学院海南海口570228

随着外卖业的快速发展,外卖智能派单成为外卖服务的重要形式。然而,目前相关研究侧重于研究外卖配送路径问题,不利于解决外卖智能派单的多目标动态决策中存在的问题。本文从外卖订单-骑手匹配的角度,分析了外卖平台智能派单的五个基本... 详细信息

随着外卖业的快速发展,外卖智能派单成为外卖服务的重要形式。然而,目前相关研究侧重于研究外卖配送路径问题,不利于解决外卖智能派单的多目标动态决策中存在的问题。本文从外卖订单-骑手匹配的角度,分析了外卖平台智能派单的五个基本目标和四个基本约束,构建了多目标的订单-骑手匹配优化模型,进而给出了基于适应性策略的实时优化算法。最后,本文设计了外卖智能派单的仿真实验,对比了骑手-订单数量均衡、骑手供过于求、骑手供不应求等三种情况下的优化情况,验证了基于适应性策略的实时优化算法的优化效果。本研究对外卖平台发展智能派单模式具有较好的理论与实践价值。

关键词：外卖平台智能派单多目标优化实时优化算法订单-骑手匹配

长江上游特有鱼类红唇薄鳅微卫星DNA分离及序列特征分析

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江西农业大学学报 2017年第1期39卷 145-152页

作者：刘红艳熊飞宋丽香江汉大学生命科学学院湖北武汉430056

为筛选出特异性高的红唇薄鳅微卫星位点,采用生物素探针(AC)13杂交和FIASCO磁珠富集法从红唇薄鳅基因组DNA中分离出一批微卫星序列,并对其序列特征进行分析。结果显示,157个单克隆中,阳性克隆为131个,阳性克隆率为83.44%。排除重复序列... 详细信息

为筛选出特异性高的红唇薄鳅微卫星位点,采用生物素探针(AC)13杂交和FIASCO磁珠富集法从红唇薄鳅基因组DNA中分离出一批微卫星序列,并对其序列特征进行分析。结果显示,157个单克隆中,阳性克隆为131个,阳性克隆率为83.44%。排除重复序列后,共得到69条重复类型和重复次数不同微卫星序列,阳性富集率为52.67%。在这些微卫星序列中,共检测到110个微卫星位点,其中90个二碱基重复微卫星位点,14个四碱基重复微卫星位点,6个五碱基重复微卫星位点。二碱基重复中,以AC/TG重复最为丰富(73个位点),四碱基重复中,AAAG重复数目最多(6个位点),只发现了1种五碱基重复TCTTC(6个位点)。微卫星重复次数在6~10次之间最多(65.45%),20次以上的较少(0.91%)。二碱基重复微卫星的变异系数最大(36.52%),四碱基重复类型的变异系数最小(26.75%)。红唇薄鳅微卫星以完美型为主(63.64%),复合型次之(23.63%),非完美型最少(12.73%)。筛选出的这些微卫星位点将对红唇薄鳅及近缘种微卫星分子标记开发和应用提供依据。

关键词：红唇薄鳅微卫星序列特征

Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

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Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-Qin Wu An-An Liu Xu Li Jia-Wei Tu Juan Kong Ling-Ling yang Jian-hong Jia Chuan Wang Bin Hu Zhi-xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

A Semiparametric Additive-multiplicative Rates Model for the Weighted Composite Endpoint of Recurrent and Terminal Events

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Acta Mathematica Sinica,English Series 2024年第4期40卷 985-999页

作者： Yi DENG Qiang xiong Shu Wei LI School of Economics and Statistics Guangzhou UniversityGuangzhou 510006P.R.China

Recurrent event data are commonly encountered in many scientific fields,including biomedical studies,clinical trials and epidemiological surveys,and many statistical methods have been proposed for their *** this paper,we consider to use a weighted composite endpoint of recurrent and terminal events,which is weighted by the severity of each event,to assess the overall effects of covariates on the two types of events.A flexible additive-multiplicative model incorporating both multiplicative and additive effects on the rate function is proposed to analyze such weighted composite event process,and more importantly,the dependence structure among the recurrent and terminal events is left *** the estimation,we construct the unbiased estimating equations by virtue of the inverse probability weighting technique,and the resulting estimators are shown to be consistent and asymptotically normal under some mild regularity *** evaluate the finite-sample performance of the proposed method via simulation studies and apply the proposed method to a set of real data arising from a bladder cancer study.

关键词： Additive-multiplicative rates model estimating equation recurrent events terminal event weighted composite endpoint

Study on the preparation and fretting behavior of bonded oriented MoS_(2)solid lubricant coating

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Friction 2024年第11期12卷 2505-2518页

作者： Liangliang xiong Mengxue WU Xiaoqiang FAN Minhao ZHU Key Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Tribology Research Institute School of Mechanical EngineeringSouthwest Jiaotong UniversityChengdu 610031China

The bonded MoS_(2)solid lubricant coating is an effective measure to mitigate the fretting wear of AISI 1045 *** this work,the amino functionalized MoS_(2)was protonated with acetic acid to make the MoS_(2)positively *** directional arrangement of protonated MoS2 in the coating was achieved by electrophoretic deposition under the electric field *** bonded directionally aligned MoS_(2)solid lubricant coating showed high adaptability to various loads and excellent lubrication performance under all three working *** a load of 10 N,the friction coefficient and wear volume of the coating with 5 wt%protonated MoS_(2)decreased by 20.0%and 37.2%compared to the pure epoxy coating,respectively,and by 0.07%and 16.8%than the randomly arranged MoS_(2)sample,*** remarkable lubricating properties of MoS_(2)with directional alignment were attributed to its effective load-bearing and mechanical support,barrier effect on longitudinal extension of cracks,and the formation of a continuous and uniform transfer film.

关键词： bonded solid lubricant coating MoS_(2) fretting oriented alignment

Artificial intelligence in the anterior segment of eye diseases

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1743-1751页

作者： Yao-hong Liu Lin-Yu Li Si-Jia Liu Li-xiong Gao Yong Tang Zhao-Hui Li Zi Ye School of Medicine Nankai UniversityTianjin 300071China Medical School of Chinese PLA Beijing 100039China Department of Ophthalmology Chinese PLA General HospitalBeijing 100039China Chinese PLA General Hospital Medicine Innovation Research Department Beijing 100039China

Ophthalmology is a subject that highly depends on imaging *** intelligence(AI)technology has great potential in medical imaging analysis,including image diagnosis,classification,grading,guiding treatment and evaluating *** combination of the two can realize mass screening of grass-roots eye health,making it possible to seek medical treatment in the mode of“first treatment at the grass-roots level,two-way referral,emergency and slow treatment,and linkage between the upper and lower levels”.On the basis of summarizing the AI technology carried out by scholars and their teams all over the world in the field of ophthalmology,quite a lot of studies have confirmed that machine learning can assist in diagnosis,grading,providing optimal treatment plans and evaluating prognosis in corneal and conjunctival diseases,ametropia,lens diseases,glaucoma,iris diseases,*** paper systematically shows the application and progress of AI technology in common anterior segment ocular diseases,the current limitations,and prospects for the future.

关键词： artificial intelligence anterior segment ocular disease ametropia glaucoma

A review on WO_(3)-based composite photocatalysts:synthesis,catalytic mechanism and diversified applications

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Rare Metals 2024年第8期43卷 3441-3459页

作者： Xue Zhang Zi-Qi Zhang yan-Dong Sun Xiao-Jia Ma Feng-Xian Jin Fang-Yuan Zhang Wei-Guang Han Bo-xiong Shen Sheng-Qi Guo College of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Department of Food and Chemical Engineering Liuzhou Institute of TechnologyLiuzhou 545616China

Photocatalysis as an emerging "green" energy conversion technology has attracted domestic and international *** technology uses semiconductor photocatalysts to convert solar energy into directly usable chemical energy,showing great potential for application in environmental pollutant purification and clean energy production,with broad development *** many semiconductor materials,tungsten trioxide(WO_(3)) is favored by researchers in the field of photocatalysis because of its good visible light response and excellent valence band hole oxidation ***,a large number of photocatalysts based on WO_(3),in particular W03-based composite photocatalysts,have been reported,and their applications cover a wide range of *** order to promote the development of WO_(3)-based photocatalysts and provide a reference for colleagues,we present a systematic summary of the applications and research progress of W03-based composites in the field of photocatalysis in recent *** from the structural properties of WO_(3)itself,this article summarizes the preparation methods and structure-activity relationships of WO_(3)-based composite ***,it introduces the current application status of existing WO_(3)-based composite photocatalysts in CO_(2) reduction,hydrogen production,nitrogen fixation,and pollutant ***,the development prospects were analyzed.

关键词： WO_(3)-based composite photocatalysts Intrinsic characteristic Preparation method Reaction mechanism Applications

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2024年

作者： Chen xiong hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical College Fudan University Department of Breast Surgery Fudan University Shanghai Cancer Center Fudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer Center Fudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences Fudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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