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The Messenger RNA and Long Non-coding RNA Expression Profiles in Ectopic and Eutopic Endometrium Provide Novel Insights into Endometriosis

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Reproductive and Developmental Medicine 2019年第1期3卷 11-17页

作者： Song-Ping Liu Xin Tian hong-yan cui Qiong Zhang Ke-Qin Hua Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200090China Department of Obstetrics and Gynecology Zhenjiang Maternal and Child Health HospitalZhenjiang 212001China

Objective:To establish the messenger RNA(mRNA)and long non-coding RNA(lncRNA)expression profiles in ectopic and eutopic endometrium and provide novel insights into ***:The mRNA and lncRNA expression profiles were tested using high-throughput sequencing technology in ectopic and eutopic endometrium with endometriosis and normal endometrium without *** potential targeted lncRNAs were annotated by analyzing the correlation between lncRNA and mRNA expression to better understand the pathogenesis of ***:In ectopic compared with normal endometrium,a total of 2,188 mRNAs and 1,200 lncRNAs were differentially expressed with a fold-change(FC)≥*** eutopic compared with normal endometrium,a total of 2,324 mRNAs and 695 lncRNAs were differentially expressed with an FC≥*** ectopic compared with eutopic endometrium,a total of 2,223 mRNAs and 511 lncRNAs were differentially expressed with an FC≥*** analysis indicated that the differentially expressed mRNAs were enriched in the biological processes and signaling pathways involved in *** addition,we constructed a gene coexpression network based on the dysregulated lncRNAs in both ectopic endometrium and eutopic endometrium,combined with their coexpressed mRNAs to simulate the complex ***:This study describes the first-to-integrate analysis of the differential expression profiles of mRNAs and lncRNAs,including analyses between ectopic and normal endometrium,eutopic and normal endometrium,and ectopic and eutopic endometrium,which provides new insights to investigate the pathogenesis of endometriosis and explore novel diagnostic biomarkers and therapeutic targets.

关键词： Endometriosis Gene Profile Long Non-coding RNA Messenger RNA RNA Sequencing

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A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： Linlin Sun Zihui Wang Shukun cui Ziquan yan Weiping Hu Qingchun Meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks

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Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： hongqiang yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao yang Jia Li Xiaojin Han yan cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui hong Wei Quan Xinyu Qiao Chun cui Chenmeng Qiao Weijiang Zhao yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Synthetic control of chiral pore surfaces in covalent organic frameworks for enantioselective separation of chiral drugs

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Science China Chemistry 2025年

作者： Shiguo Fu Xiaofeng Zhang Kaixuan Wang Linfeng Chen Fan Xia Yong cui yan Liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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Molecular characterization and phylogenetic analysis of membrane protein genes of porcine epidemic diarrhea virus isolates in China

Molecular characterization and phylogenetic analysis of memb...

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中国畜牧兽医学会畜牧兽医生物技术学分会暨中国免疫学会兽医免疫分会第七次研讨会

作者： CHEN Jian-Fei,SUN Dong-Bo, WANG Cheng-Bao,Shi hong-yan, cui Xiao-Chen, LIU Sheng-Wang, Qiu Hua-Ji,Feng Li

Six porcine epidemic diarrhea viruses (PEDVs) were isolated from the fecal samples of piglets infected with PEDV in 2006 in China. The membrane (M) protein genes of six PEDV isolates were amplified by reverse transcriptase-poly- merase chain reaction (RT-PCR), then cloned, sequenced, and compared with each other as well as those ten PEDV reference strains. The M protein genes of six Chinese PEDV isolates consisted of 692 nucleotides containing a single open reading frame (ORF) of 681 nucleotides, which encoded a 226aa-long peptide. The conserved intergenic motif (ATAAAC), as previously rec- ognized in Br1/87, was found in the 5 nucleotides upstream of the initiator ATG of M protein genes of six Chinese PEDV iso- lates. The hexamer motif was also found in CV777, JMe2, LZC, and QH. The M protein of six isolates had three main trans- membrane domains (aa208, aa435, aa757). The M protein of one isolate, CH/IMT/06, had one potential glycosylation site, but those of the other five isolates had two. The glycosylation sequence Asn-Phe-Thr was highly conserved in the M pro- teins of six PEDV isolates. The six PEDV isolates showed nucleotide sequence homology between 98.8 and 100 % and deduced amino acid sequence homology between 98.2 and 100 % with each other. The nucleotide and amino acid identity of M protein genes between the six PEDV isolates and ten reference PEDV strains varied from 97.2 to 99.4 % and 96.9 to 100 %, respec- tively. On the basis of the phylogenetic relationship of M protein genes, six Chinese PEDV isolates composed of a separate clus- ter including one Chinese strain JS-2004-02, however, not including the Chinese strain LJB/03. These results demonstrated that there was a new genotype of PEDV prevailing in China.

关键词： Porcine epidemic diarrhea virus M protein genes Transmembrane domains Glycosylation site Phylogenetic relationship Genotype

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第一性原理研究Mn和Cu掺杂六钛酸钾(K_2Ti_6O_(13))的电子结构和光学性质

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物理学报 2018年第6期67卷 195-202页

作者：戚玉敏陈恒利金朋路洪艳崔春翔河北工业大学材料科学与工程学院天津300130 淮北师范大学物理与电子信息学院淮北235000

六钛酸钾(K_2Ti_6O_(13))是宽带隙半导体光催化材料,只能响应波长较短的紫外光.为了使K_2Ti_6O_(13)对可见光响应,本文采用第一性原理方法,研究过渡金属Mn和Cu掺杂改性后K_2Ti_6O_(13)的电子结构和光学性质.计算结果表明:Mn,Cu掺杂后K_2... 详细信息

六钛酸钾(K_2Ti_6O_(13))是宽带隙半导体光催化材料,只能响应波长较短的紫外光.为了使K_2Ti_6O_(13)对可见光响应,本文采用第一性原理方法,研究过渡金属Mn和Cu掺杂改性后K_2Ti_6O_(13)的电子结构和光学性质.计算结果表明:Mn,Cu掺杂后K_2Ti_6O_(13)禁带中出现了杂质能级,这些杂质能级由O 2p和Ti 3d与Mn 3d或Cu 3d态杂化而成.对于Mn掺杂的K_2Ti_6O_(13),其带隙值变小,位于能带中间的杂质能级可作为电子跃迁的桥梁,从而实现了对可见光的吸收.对于Cu掺杂的K_2Ti_6O_(13),其带隙值虽略有增大,但是若考虑将与价带相连的杂质能级,带隙值将大大减小,且此杂质能级可抑制光生载流子的复合,使得掺杂后K_2Ti_6O_(13)吸收带边红移至可见光区并在可见光范围内吸收强度明显增强.总的而言,Mn,Cu的掺杂实现了钛酸钾对可见光的吸收,同时Cu掺杂的效果要优于Mn掺杂的效果.研究结果对K_2Ti_6O_(13)在光催化领域上的应用具有重要的意义.

关键词：第一性原理掺杂电子结构红移

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扶正化瘀方影响转化生长因子β1/Smad信号通路的抗肝纤维化作用机制

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中西医结合学报 2012年第5期10卷 561-568页

作者：王清兰陶艳艳沈丽崔红燕刘成海上海中医药大学曙光医院上海中医药大学肝病研究所上海201203 上海市中医临床重点实验室上海201203 上海中医药大学肝肾疾病病证教育部重点实验室上海201203

目的:探讨扶正化瘀方影响转化生长因子β1(transforming growth factor-β1,TGF-β1)/Smad信号转导的抗肝纤维化作用机制。方法:本研究分体内实验和体外实验两部分。在体内实验中,37只雄性Wistar大鼠分为正常组(5只)、模型组(18只)和扶... 详细信息

目的:探讨扶正化瘀方影响转化生长因子β1(transforming growth factor-β1,TGF-β1)/Smad信号转导的抗肝纤维化作用机制。方法:本研究分体内实验和体外实验两部分。在体内实验中,37只雄性Wistar大鼠分为正常组(5只)、模型组(18只)和扶正化瘀方组(14只)。模型组和扶正化瘀组大鼠采用二甲基亚硝胺(dimethylnitrosamine,DMN)腹腔注射复制大鼠肝纤维化模型。灌胃治疗4周后,采用盐酸水解法检测肝组织中羟脯氨酸(hydroxyproline,Hyp)含量,蛋白质印迹法分析肝组织中TGF-β1、TGF-β1Ⅰ型受体(TGF-β1 type Ⅰ receptor,TβR-Ⅰ)、Smad2、Smad3及磷酸化Smad2/3蛋白的表达。体外实验采用培养4d的原代大鼠肝星状细胞(hepatic stellate cell,HSC),分为对照组、TGF-β1组、10%扶正化瘀方药物血清组及TβR-Ⅰ胞内激酶抑制剂(SB-431542)组。后3组用2.5ng/mLTGF-β1刺激24h后,对照组及TGF-β1组加10%正常大鼠血清,10%扶正化瘀方药物血清组加10%服用扶正化瘀方的大鼠血清,SB-431542组加10%正常大鼠血清及10μmol/LSB-431542。共孵育24h后,免疫荧光染色检测HSC中α平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)和Smad3蛋白的表达,蛋白质印迹法分析HSC中α-SMA蛋白的表达。结果:体内实验发现,扶正化瘀方可明显降低纤维化肝组织中异常升高的Hyp含量及TGF-β1、TβR-Ⅰ、磷酸化Smad2/3蛋白的表达。体外研究发现,正常HSC中α-SMA、TβR-Ⅰ表达较低,TGF-β1刺激可显著上调其表达;扶正化瘀方药物血清共孵育后,可明显抑制TGF-β1诱导的HSC中α-SMA的表达;正常HSCSmad3主要表达在细胞质中,细胞核中表达较低,TGF-β1可显著刺激Smad3向细胞核转移,扶正化瘀方药物血清可明显抑制TGF-β1诱导的Smad3核转位。结论:扶正化瘀方可下调纤维化大鼠肝脏及HSC中的TGF-β1/Smad病理信号转导通路,这可能是扶正化瘀方抗肝纤维化的部分作用机制。

关键词：中草药肝纤维化肝星状细胞转化生长因子β1 Smad蛋白质类,受体调节性大鼠

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基于微博的时空事件识别研究

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计算机科学 2016年第10期43卷 214-219页

作者：郑喆君金蓓弘崔艳玲中国科学院软件研究所北京100190 中国科学院大学北京100190

微博是一种社交网络服务,它主要基于用户的关注关系进行信息分享和传播,具有时效性强、传播迅速等特点。将微博看成是反映城市动态的一类感知器,从识别微博的主题入手,检测微博中反映的时空事件。为此,首先提出了一种用于分析微博主题... 详细信息

微博是一种社交网络服务,它主要基于用户的关注关系进行信息分享和传播,具有时效性强、传播迅速等特点。将微博看成是反映城市动态的一类感知器,从识别微博的主题入手,检测微博中反映的时空事件。为此,首先提出了一种用于分析微博主题的主题模型ST-LDA,并应用该模型将具有语义相似性、时空聚集性的微博归属于同一主题下;然后给出了从主题中检测时空事件的方法。基于真实的新浪微博数据进行实验,结果表明此方法比基于LDA的方法、基于TimeLDA的方法在事件识别上有更高的查全率和查准率。

关键词：微博时空事件主题模型

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全平面上无限级Dirichlet级数的增长性

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数学的实践与认识 2016年第21期46卷 268-274页

作者：周凤麟徐洪焱崔永琴景德镇陶瓷大学信息工程学院江西景德镇333403

利用Knopp-Kojima的方法研究在全平面上收敛的无限级Dirichlet级数的增长性,主要是讨论了Dirichlet级数的βU级与下βU级,应用型函数的方法及牛顿多边形,获得了关于βU级增长性的几个定理.

关键词： Dirichlet级数牛顿多边形增长性

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