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Solution set calculation of the Sun-perturbed optimal two-impulse trans-lunar orbits using continuation theory

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Astrodynamics 2020年第1期4卷 75-86页

作者： Bo-yong He hong-xin shen State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an710043China

The solution set of the Sun-perturbed optimal two-impulse trans-lunar orbit is helpful for overall optimization of the lunar exploration mission.A model for computing the two-impulse trans-lunar orbit,which strictly satisfies the boundary constraints,is *** solution set is computed first with a circular restricted three-body model using a generalized local gradient optimization algorithm and the strategy of design variable initial *** taking the solution set of a circular restricted three-body model as the initial values of the design variables,the Sun-perturbed solution set is calculated based on the dynamic model continuation theory and traversal search methodology.A comparative analysis shows that the fuel cost may be reduced to some extent by considering the Sun’s perturbation and choosing an appropriate transfer ***,there are several optimal two-impulse trans-lunar methods for supporting a lunar mission to select a scenario with a certain ground measurement and to control the time cost.A fitted linear dependence relationship between the Sun’s befitting phase and the trans-lunar duration could thus provide a reference to select a low-fuel-cost trans-lunar injection window in an engineering project.

关键词： trans-lunar orbit optimization optimal solution set continuation theory Sun-perturbed

Spanning tree trajectory optimization in the galaxy space

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Astrodynamics 2021年第1期5卷 27-37页

作者： Tian-Jiao Zhang Dietmar Wolz hong-xin shen Ya-Zhong Luo State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an 710043China University of Jena Jena 07737Germany National University of Defense Technology Changsha 410073China

The 10th edition of the Global Trajectory Optimization Competition considered the problem of the galaxy settlement wherein competitors from all over the world were expected to design the trajectories of different settler vessels to maximize the given multi-faceted merit *** synthesis methods used by the winning team,led jointly by the National University of Defense Technology(NUDT)and Xi’an Satellite Control Center(XSCC),are described along with a greedy search method and the improved solution obtained by University of ***,we presented a layout-first topology-second approach that allows an efficient settlement tree search guided by the pre-specified ideal spatial *** also explained how the problem of constructing settlement trees can be modeled as the widely studied minimum spanning tree ***,University of Jena explored the possibility that a greedy search can generate even better settlement trees,based on the same initial conditions,when compared to that of the winning solution.

关键词： trajectory optimization Settlers of the Galaxy minimum spanning tree ant colony optimization greedy search

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun shen xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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甲烷超声速燃烧过程的数值模拟

推进技术 2002年第1期23卷 63-66,83页

作者：刘宏杜新沈月阳雷麦芳王发民中国科学院力学研究所北京100080

提出了一种CH4 O2 在超声速气流中燃烧的 6方程化学反应模型 ,并且用在超声速高温空气中横向喷射的二维流场进行了数值模拟验证。特别模拟了不同来流条件和壁面条件对燃烧效率的影响及CH4 和空气中的氧气混合燃烧的过程。数值方法采用... 详细信息

提出了一种CH4 O2 在超声速气流中燃烧的 6方程化学反应模型 ,并且用在超声速高温空气中横向喷射的二维流场进行了数值模拟验证。特别模拟了不同来流条件和壁面条件对燃烧效率的影响及CH4 和空气中的氧气混合燃烧的过程。数值方法采用二阶精度的Harten Yee隐式TVD格式 ,计算结果表明 6方程反应模型能较好地反映CH4 O2

关键词：超音速冲压喷气发动机超音速燃烧甲烷数值仿真

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen shen Liu Junshan Zhou hongdong Zhao Ye hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

艾宾浩斯记忆法在老年慢性阻塞性肺疾病患者健康教育中应用

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护理实践与研究 2017年第5期14卷 153-155页

作者：单萍承红沈鑫江苏省常州市第二人民医院20病区老年科常州市213003

目的:探讨艾宾浩斯记忆法在老年慢性阻塞性肺疾病综合健康教育中的应用效果。方法:选取2014年8月~2015年8月我院收治的老年慢性阻塞性肺疾病患者62例作为对照组,实施常规健康教育;选取2015年9月~2016年9月我院收治的老年慢性阻塞性肺疾... 详细信息

目的:探讨艾宾浩斯记忆法在老年慢性阻塞性肺疾病综合健康教育中的应用效果。方法:选取2014年8月~2015年8月我院收治的老年慢性阻塞性肺疾病患者62例作为对照组,实施常规健康教育;选取2015年9月~2016年9月我院收治的老年慢性阻塞性肺疾病患者62例作为观察组,根据艾宾浩斯记忆法实施综合健康教育。比较两组患者干预前后肺功能指标、运动能力和自我效能感评分。结果:观察组干预后FEV_1、FEV_1/FVC、MVV和PEFR高于对照组(P<0.05)。干预后运动能力分级优于对照组(P<0.05),自我效能感评分高于对照组(P<0.05)。结论:艾宾浩斯记忆法在老年慢性阻塞性肺疾病综合健康教育中效果显著,可明显改善患者肺功能,提高运动能力和自我效能感,值得推广。

关键词：艾宾浩斯记忆法老年慢性阻塞性肺疾病综合健康教育肺功能运动能力自我效能

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： shengyang Zhou Ting Li Wei Zhang Jian Wu Hui hong Wei Quan xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian Zhu Kangli shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan xin Cao Liang Chen Qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu shen Hudie Wei hongyu Chen Guoqiang Ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector