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Communications on Applied Mathematics and Computation 2021年第1期3卷 123-135页

作者： xiao-Xia Guo hong-xiao wu School of Mathematical Science Ocean University of ChinaQingdao 266100Shandong ProvinceChina

In this paper,we study the nonlinear matrix equation X-A^(H)X^(-1)A=Q,where A,Q∈C^(n×n),Q is a Hermitian positive definite matrix and X∈C^(n×n)is an unknown *** prove that the equation always has a unique Hermitian positive definite *** present two structure-preserving-doubling like algorithms to find the Hermitian positive definite solution of the equation,and the convergence theories are ***,we show the effectiveness of the algorithms by numerical experiments.

关键词： Positive definite solution Structure-preserving-doubling like algorithm Convergence Numerical experiment

On the Origin and Numerical Range of Bounded Operators

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Acta Mathematica Sinica,English Series 2019年第10期35卷 1715-1722页

作者： xiao hong wu Jun Jie HUANG ALATANCANG School of Mathematical Sciences Inner Mongolia UniversityHohhot 010021P.R.China Department of Mathematics Hohhot Minzu CollegeHohhot 010051P.R.China

Numerical range has an important applications on spectrum distribution of operators. In this paper, we devoted to characterizing operators whose numerical range contains the origin. Some necessary and sufficient conditions are given by operator decomposition technique and constructive methods. Furthermore, the closeness of the numerical range of a given operator is also investigated.

关键词： Bounded linear operator numerical range origin

Thermal stability of nanocrystalline layer prepared by surface mechanical attrition in 0Cr18Ni9Ti stainless steel

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中国有色金属学会会刊：英文版 2004年第z1期14卷 210-214页

作者： WANG hong-bin wu xiao-chun XU Ling-yun School of Materials Science and Engineering Shanghai University Shanghai 200072 China School of Materials Science and Engineering Shanghai University Shanghai 200072 China School of Materials Science and Engineering Shanghai University Shanghai 200072 China

By means of surface mechanical attrition (SMA), a nanostructured surface layer was formed on a 0Cr18Ni9Ti austenite stainless steel plate. A strain-induced martensite transformation was observed during SMA treatment, and a single magnetic martensite phase layer with thickness of about 30 μm was gotten. The grain growth and phase transformations in the nanocrystalline layer are investigated during heating. The grain growth exponent for nanocrystalline polycrystalline steel is estimated. The kinetics mechanism governing the grain growth in the nanocrystalline layer is discussed. The martensite in the surface layer is quite stable and the temperature at which the reverse transformation of martensite to austenite starts during heating is about 500 ℃.

关键词： grain growth phase transformation surface mechanical attrition surface nanocrystalline layer

Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus

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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： hong-xiao wu xiao-Yan Ding Ya-Wen Xu Ming-Hua Yu xiao-Mi Li Na Deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment *** To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with *** From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan *** were distributed to either the PTL or TACE/Lenvatinib(TL)*** median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary *** Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)*** a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),***,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)*** were no treatment-related deaths or differences in adverse events in either *** A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

Current Status and Prospect of Stent Placement for May-Thurner Syndrome

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Current Medical Science 2021年第6期41卷 1178-1186页

作者： Qin LIU Fang LIU Ping LÜ hong-xiao wu Pin YE Yun YOU Zhong YAO Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Nuclear Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Donnelly Centre for Cellular and Biomolecular Research University of TorontoTorontoOntario M5S 2E8Canada

Stent implantation has been proven to be safe and has become the first-line intervention for May-Thumer syndrome(MTS),with satisfactory mid-term patency rates and clinical *** research has demonstrated that catheter-directed thrombolysis is the preferred strategy when MTS is combined with deep vein thrombosis after self-expanding stent ***,the stent used for the venous system was developed based on the experience obtained in the treatment of arterial ***,relatively common corresponding complications may come along later,which include stent displacement,deformation,and *** measures such as adopting a stent with a larger diameter,improving stent flexibility,and increasing stent strength have been employed in order to prevent these *** ideal venous stent is presently being evaluated and will be introduced in detail in this review.

关键词： May-Thumer syndrome deep vein thrombosis post-thrombotic syndromes stent stent placement

Nkx2-1:a novel tumor biomarker of lung cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 855-866页

作者： LiYANG Min LIN Wen-jing RUAN Liang-liang DONG En-guo CHEN xiao-hong wu Ke-jing YING Department of Respiratory Medicine the First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006 China Department of Radiology the Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005 China Key Laboratory of Biotherapy of Zhejiang Province Department of Respiratory Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

关键词： Nkx2-1 TTF-1 Lung cancer Biomarker Diagnosis Prognosis Therapy

Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第11期21卷 911-920页

作者： xiao-hong wu Jing-wen FANG Yin-qiong HUANG Xue-feng BAI Yong ZHUANG xiao-yu CHEN Xia-hong LIN Department of Endocrinology the Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000China Department of Endocrinology the First Hospital of QuanzhouQuanzhou 362000China

Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients without DPN(NDPN group)and 30 patients with DPN(DPN group),and 30 healthy participants(normal group)were *** coherence tomography(OCT)was used to measure the four quadrants and the overall average RNFL thickness of the optic *** receiver operator characteristic curve was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for ***:The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average((101.07±12.40)μm vs.(111.07±6.99)μm and(109.25±6.90)μm),superior quadrant((123.00±19.04)μm vs.(138.93±14.16)μm and(134.47±14.34)μm),and inferior quadrant((129.37±17.50)μm vs.(143.60±12.22)μm and(144.48±14.10)μm),and the differences were statistically *** diagnostic efficiencies of the overall average,superior quadrant,and inferior quadrant RNFL thicknesses,and a combined index of superior and inferior quadrant RNFL thicknesses were similar,and the AUCs were 0.739(95%confidence interval(CI)0.635–0.826),0.683(95%CI 0.576–0.778),0.755(95%CI 0.652–0.840),and 0.773(95%CI 0.672–0.854),*** diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%.Conclusions:The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.

关键词： Type 2 diabetes Peripheral neuropathy Retinal nerve fiber layer thickness Optical coherence tomography Diagnosis

Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients

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Chinese Medical Journal 2012年第22期125卷 4014-4017页

作者： FAN xiao-hong wu Chi-hong WANG Li-fen ZHENG Ying-ying YAO Ying LU Hai-ying XU xiao-yuan WEI Lai Peking Univ Hosp 1 Dept Infect Dis Beijing 100034 Peoples R China Peking Univ Hosp 1 Dept Nephrol Beijing 100034 Peoples R China Peking Univ Peoples Hosp Inst Hepatol Beijing 100044 Peoples R China

Background Mixed cryoglobulinemia （MC） is one of the most common and severe symptoms in chronic hepatitis C patients. The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin. Methods This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin. Serum cryoglobulin was detected by cryoprecipitation prior to treatment. Serum hepatitis C virus （HCV） RNA levels were checked before treatment, during the fourth and 12th week of treatment, and during the 24th week after cessation of treatment. The genotype of HCV was determined at baseline. Logistic regression analysis was used to assess the factors associated with sustained virological response. Results Twenty-five patients were with MC （43.9%）. Twenty-four weeks after cessation of antiviral treatment, sustained virological response achievement in MC~ patients was significantly lower than that in MC- patients （32.0% vs. 75.0%, P=-0.001）. Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC （odds ratio： 6.375; 95% Ch 1.998-20.343, P=0.002） was negatively associated with sustained virological response achievement. Conclusion MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin.

关键词： hepatitis C cryoglobulinemia virological response

Expression and significance of hypoxia-inducible factor-1αand glucose transporter-1

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Expression and significance of hypoxia-inducible factor-1αa...

Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells

全国耳鼻咽喉头颈外科中青年学术会议

作者： Shui-hong Zhou xiao-hong wu hong-Tian Yao Department of Otolaryngology The First Affiliated HospitalCollege of MedicineZhejiang University Department of Otolaryngology The Peoples Hospital of Deqing CountyZhejiang Province The Cooperative Hospital of The First Affiliated Hospital College of MedicineZhejiang University

Malignant cells show increased glucose uptake in vitro and in *** process is thought to be mediated by glucose transporters(GLUTs).Hypoxia-inducible factor-1α(HIF-1α) may upregulate GLUT-1 expression. Little is know...

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World Journal of Gastroenterology 2007年第24期13卷 3342-3349页

作者： xiao-hong wu Cui-Ping Liu Kuan-Feng Xu xiao-Dong Mao Jian Zhu Jing-Jing Jiang Dai Cui Mei Zhang Yu Xu Chao Liu Department of Endocrinology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM: To study the capacity of bone marrow mesenchymal stem cells (BM-MSCs) trans-differentiating into islet-like cells and to observe the effect of portal vein transplantation of islet-like cells in the treatment of streptozotocin-induced diabetic rat. METHODS: BM-MSCs were isolated from SD rats and induced to differentiate into islet-like cells under defined conditions. Differentiation was evaluated with electron microscopy, RT-PCR, immunofluorescence and flow cytometry. insulin release after glucose challenge was tested with ELiSA. Then allogeneic islet-like cells were transplanted into diabetic rats via portal vein. Blood glucose levels were monitored and islet hormones were detected in the liver and pancreas of the recipient by immunohistochemistry. RESULTS: BM-MSCs were spheroid adherent monolayers with high CD90, CD29 and very low CD45 expression. Typical islet-like cells clusters were formed after induction. Electron microscopy revealed that secretory granules were densely packed within the cytoplasm of the differentiated cells. The spheroid cells expressed islet related genes and hormones. The insulin-positive cells accounted for 19.8% and mean fluorescence intensity increased by 2.6 fold after induction. The cells secreted a small amount of insulin that was increased 1.5 fold after glucose challenge. After transplantation, islet-like cells could locate in the liver expressing islet hormones and lower the glucose levels of diabetic rats during d 6 to d ***: Rat BM-MSCs could be transdifferentiated into islet-like cells in vitro . Portal vein transplantation of islet-like cells could alleviate the hyperglycemia of diabetic rats.

关键词： Bone marrow mesenchymal stem cells Trans-differentiation Islet Insulin Transplantation