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Development and Validation of a Carbohydrate Metabolism-related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients

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当代医学科学（英文） 2024年第4期44卷 771-788页

作者： hong-xiang huang Pei-yuan Zhong Ping LI Su-juan PENG Xin-jing DING xiang-lian CAI Jin-hong CHEN Xie ZHU Zhi-hui LU Xing-yu TAO Yang-yang LIU Li CHEN Department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Oncology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Objective:The activities and products of carbohydrate metabolism are involved in key processes of ***,its relationship with hepatocellular carcinoma(HCC)is ***:The cancer genome atlas(TCGA)-HCC and ICGC-LIRI-JP datasets were acquired via public *** expressed genes(DEGs)between HCC and control samples in the TCGA-HCC dataset were identified and overlapped with 355 carbohydrate metabolism-related genes(CRGs)to obtain differentially expressed CRGs(DE-CRGs).Then,univariate Cox and least absolute shrinkage and selection operator(LASSO)analyses were applied to identify risk model genes,and HCC samples were divided into high/low-risk groups according to the median risk ***,gene set enrichment analysis(GSEA)was performed on the risk model *** sensitivity of the risk model to immunotherapy and chemotherapy was also ***:A total of 8 risk model genes,namely,G6PD,PFKFB4,ACAT1,ALDH2,ACYP1,OGDHL,ACADS,and TKTL1,were ***,the risk score,cancer status,age,and pathologic T stage were strongly associated with the prognosis of HCC *** the stromal score and immune score had significant negative/positive correlations with the risk score,reflecting the important role of the risk model in immunotherapy ***,the stromal and immune scores had significant negative/positive correlations with risk scores,reflecting the important role of the risk model in immunotherapy ***,we found that high-/low-risk patients were more sensitive to 102 drugs,suggesting that the risk model exhibited sensitivity to chemotherapy *** results of the experiments in HCC tissue samples validated the expression of the risk model ***:Through bioinformatic analysis,we constructed a carbohydrate metabolism-related risk model for HCC,contributing to the prognosis prediction and treatment of HCC patients.

关键词： bioinformatics carbohydrate metabolism hepatocellular carcinoma the cancer genome atlas

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Fabrication and luminescent properties of Eu(BMPPA)3BPy complex and its functionalized silica nanocomposites

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Chinese Chemical Letters 2016年第10期27卷 1602-1606页

作者： hong-xiang huang Wen-Li He xiang-Hai Sheng wen-Jie wu Department of Macromolecular Science and State Key Laboratory of Molecular Engineering of Polymers Shanghai 200433China Department of Chemistry Fudan UniversityShanghai 200423China

Luminescent silica nanocomposites functionalized with a Eu-complex have been prepared and characterized. The europium complex is composed of 2,2＇-bipyridyl （BPy） and 2-（4-bromomethyl）- phenylpropionic acid （BMPPA）, which contains highly active benzyl bromide substituents and can covalently bind with poly（4-vinylpyridine）（P4VP）-modified silica nanoparticles （nanoSiO2P4VP） to form nanoSiO2P4VPEuBIy composites. Microscopic images revealed that the nanoSiO2P4VPEuBPy composites easily formed aggregates, due to an inter-particle binding caused by the benzyl bromide among the composites. The as-prepared nanocomposites showed the typical emissions of Eu（III） ions at the wavelengths from 580 nm to 750 nm designated to the SDo- 7Fn transitions. Time-resolved fluorescence decay measurements revealed that the emission lifetime was approximately 0.204 ms and 0.5？6 ms for the nanoSiO2EuBPy composites, a little shorter than that in the Eu（BMPPA）3BPy complex.

关键词： Eu-complexNanocompositesSilica nanoparticlesFluorescence

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Total synthesis of glypetelotine

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Chinese Chemical Letters 2009年第6期20卷 643-644页

作者： xiang hong huang Xu Feng Lin Su Qin Chen Yan Guang Wang College of Biology and Environmental Engineering Zhejiang Shuren University Hangzhou 310015 PR China Department of Chemistry Zhejiang University Hangzhou 310027 PR China College of Chemical and Material Engineering Wenzhou University Wenzhou 325027 PR China

A total synthesis of glypetelotine, the first sulphur-containing indole alkaloid from the leaf extracts of Glycosmis petelotii collected in the north of Vietnam, was described from indole through 6 steps. The structure of the glypetelotine was confirmed by IR, 1H NMR, 13C NMR and MS analysis. The spectral data of synthetic compound was identical with those of natural compound.

关键词： Sulphur-containing alkaloid Glypetelotine Total synthesis Indole

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Decoupled water electrolysis:Flexible strategy for pure hydrogen production with small voltage inputs

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Journal of Energy Chemistry 2024年第7期94卷 340-356页

作者： Kexin Zhou Jiahui huang Daili xiang Aijiao Deng Jialei Du hong Liu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongUniversity of JinanJinan 250022ShandongChina State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongChina Zhengzhou Vocational College of Industrial Safety Zhengzhou 451192HenanChina

Hydrogen gas is widely regarded as an ideal green energy carrier and a potential alternative to fossil fuels for coping with the aggravating energy crisis and environmental ***,the vast majority of the world's hydrogen is produced by reforming fossil fuels;however,this hydrogen-making technology is not sustainable or environmentally friendly because ofits high energy consumption and large carbon ***-driven water splitting(2H_(2)0-2H_(2)+0_(2))becomes an extensively studied scheme for sustain-able hydrogen *** water electrolysis requires an input voltage higher than 1.23 V and forms a gas mixture of H_(2)/O_(2),which results in high electricity consumption,potential safety hazards,and harmful reactive oxygen *** virtue of the auxiliary redox mediators(RMs)as the robust H^(+)/e^(-)reservoir,decoupled electrolysis splits water at a much lower potential and evolves O_(2)(H_(2)O+RMS_(ox)-O_(2)+H-RMS_(red))and H_(2)(H-RMS_(red)-H_(2)+RMS_(ox))at separate times,rates,and spaces,thus pro-ducing the puretarget hydrogen gas *** electrolysis has accelerated the development ofwater electrolysis technology for H_(2) ***,itis still lack of a comprehensive and in-depth review in this field based on different types of *** review highlights the basic principles and critical progress of this emerging water electrolysis mode over the past *** representative examples are then dis-played in detail according to the differences in the *** rational choice and design of RMs have also been ***,novel applications of decoupled water splitting are briefly discussed,including the manufacture of valuable chemicals,Cl_(2) production,pollutant degradation,and other half-reactions in artificial ***,thekey characteristics and disadvantages of each type of mediator are sum-marized in *** addition,we present an outlook for future directions in decoupled

关键词： Hydrogen production Conventional water splitting Decoupled water splitting Redox mediators Biomimetics

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A Review of Type 1 and Type 2 Intraductal Papillary Neoplasms of the Bile Duct

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Current Medical Science 2024年第3期44卷 485-493页

作者： Xia-hui huang Tian-xiang CHEN hong-liang LIU Ming-wen huang Department of General Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang330006China

Intraductal papillary neoplasm of the bile duct(IPNB)is a heterogeneous disease similar to intraductal papillary mucinous neoplasm of the *** lesions have been recognized as one of the three major precancerous lesions in the biliary tract since *** 2018,Japanese and Korean pathologists reached a consensus,classifying IPNBs into type l and type 2 *** are more prevalent in male patients in East Asia and are closely related to diseases such as cholelithiasis and *** a molecular genetic perspective,IPNBs exhibit early genetic variations,and different molecular pathways may be involved in the tumorigenesis of type 1 and type 2 *** histological subtypes of IPNBs include gastric,intestinal,pancreaticobiliary,or oncocytic subtypes,but type 1 IPNBs typically exhibit more regular and well-organized histological features than type 2 IPNBs and are more commonly found in the intrahepatic bile ducts with abundant *** to the rarity of these lesions and the absence of specific clinical and laboratory features,imaging is crucial for the preoperative diagnosis of IPNB,with local bile duct dilation and growth along the bile ducts being the main imaging *** resection remains the optimal treatment for IPNBs,but negative bile duct margins and the removal of lymph nodes in the hepatic hilum significantly improve the postoperative survival rates for patients with IPNBs.

关键词： intraductal papillary neoplasm of the bile duct subclassification neoplasms precancerous tissue prognosis

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Angiosperm-wide analysis of fruit and ovary evolution aided by a new nuclear phylogeny supports association of the same ovary type with both dry and fleshy fruits

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Journal of Integrative Plant Biology 2024年第2期66卷 228-251页

作者： Yezi xiang Taikui Zhang Yiyong Zhao hongjin Dong hongyi Chen Yi Hu Chien-Hsun huang Jun xiang hong Ma State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity and Ecological EngineeringInstitute of Plant BiologyCenter of Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Biology Howard Hughes Medical InstituteDuke UniversityDurhamNC 27708USA Department of Biology the Eberly College of Scienceand the Huck Institutes of the Life Sciencesthe Pennsylvania State UniversityUniversity ParkPA 16802USA Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization College of Biology and Agricultural ResourcesHuanggang Normal UniversityHuanggang 438000China

Fruit functions in seed protection and dispersal and belongs to many dry and fleshy types,yet their evolutionary pattern remains unclear in part due to uncertainties in the phylogenetic relationships among several orders and *** we used nuclear genes of 502 angiosperm species representing 231 families to reconstruct a well supported phylogeny,with resolved relationships for orders and families with previously uncertain *** this phylogeny as a framework,molecular dating supports a Triassic origin of the crown angiosperms,followed by the emergence of most orders in the Jurassic and Cretaceous and their rise to ecological dominance during the Cretaceous Terrestrial *** robust phylogeny allowed an examination of the evolutionary pattern of fruit and ovary types,revealing a trend of parallel carpel fusions during early diversifications in eudicots,monocots,and ***,taxa in the same order or family with the same ovary type can develop either dry or fleshy fruits with strong correlations between specific types of dry and fleshy fruits;such associations of ovary,dry and fleshy fruits define several ovaryfruit"modules"each found in multiple *** of the frequent modules has an ovary containing multiple ovules,capsules and berries,and another with an ovary having one or two ovules,achenes(or other single-seeded dry fruits)and *** new perspective of relationships among fruit types highlights the closeness of specific dry and fleshy fruit types,such as capsule and berry,that develop from the same ovary type and belong to the same module relative to dry and fleshy fruits of other modules(such as achenes and drupes).Further analyses of gene families containing known genes for ovary and fruit development identified phylogenetic nodes with multiple gene duplications,supporting a possible role of whole-genome duplications,in combination with climate changes and animal behaviors,in angiosperm fruit and ovary diversificat

关键词： angiosperm fruit evolution MADS-box molecular clock nuclear phylogeny ovary and fruit developmental genes

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On Hamiltonian Property of Cayley Digraphs

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 547-556页

作者： Fang DUAN Qiong-xiang huang School of Mathematics Science Xinjiang Normal UniversityUrumqi 830017China College of Mathematics and Systems Science Xinjiang UniversityUrumqi 830017China

Let G be a finite group generated by S and C(G,S) the Cayley digraphs of G with connection set *** this paper,we give some sufficient conditions for the existence of hamiltonian circuit in C(G,S),where G=Zm×H is a semiproduct of Zmby a subgroup H of *** particular,if m is a prime,then the Cayley digraph of G has a hamiltonian circuit unless G=Zm×*** addition,we introduce a new digraph operation,called φ-semiproduct of Γ1by Γ2and denoted by Γ1×Γ_φΓ2,in terms of mapping φ:V(Γ2)→{1,-1}.Furthermore we prove that C(Zm,{a})×_φ C(H,S) is also a Cayley digraph if φ is a homomorphism from H to{1,-1} ≤ Zm~*,which produces some classes of Cayley digraphs that have hamiltonian circuits.

关键词： Cayley digraphs hamiltonian circuit external semidirect product

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Preparation and properties of poly(ethylene glycol)-bpoly( 3-acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 395-410页

作者： Yichuan hong Haojie YU Li WANG xiang CHEN Di SHEN Yu WANG Shuning REN Yudi huang Jian YANG State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose *** designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of ***(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer ***-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic *** patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the *** insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good *** results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.

关键词： Diabetes Hyaluronic acid Phenylboronic acid(PBA) Glucose responsive hydrogel Microneedles

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Lifetime-tunable circularly polarized luminescent system based on triplet-to-singlet Förster resonance energy transfer

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Science China Chemistry 2024年第9期67卷 2918-2922页

作者： Zhenyi He Zizhao huang xiang Ma Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Circularly polarized luminescence(CPL)materials have received widespread attention due to their remarkable performance and broad ***,current CPL material research primarily focuses on tunable color,intensity,and *** CPL with adjustable lifetime remains a significant ***,a series of CPL polymeric materials with tunable lifetime were obtained by employing phosphorescent terephthalic acid and chiral organic small molecule R/S-BNAF(a luminescent binaphthol derivative)to copolymerize with acrylamide in different *** was verified that this performance results from the different energy transfer efficiency between luminophores with varying ratios of the monomers for *** strategy to realize CPL with tunable lifetime by modulating the energy transfer efficiency will provide a new perspective to broaden the applications of CPL materials.

关键词： circularly polarized luminescence tunable lifetime Förster resonance energy transfer room temperature phosphorescence

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Redox-Active Dihydrophenazine-Based Macrocycle:Synthesis,Conformation-Adaptive Behavior and Host-Guest Complexation with Tetracyanoquinodimethane

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Chinese Journal of Chemistry 2024年第16期42卷 1895-1900页

作者： Qiong-Yan hong Bin huang Meng-xiang Wu Lin Xu Xiao-Li Zhao Xueliang Shi Hai-Bo Yang Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular&Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal University3663 N.Zhongshan RoadShanghai 200062China

A novel macrocycle based on conformation-adaptive and electron-rich dihydrophenazine was designed and *** the one hand,the macrocycle showed host-guest interactions with tetracyanoquinodimethane(TCNQ)driving by charge transfer interaction between ***,host-guest complexation was accompanied by fluorescence quenching and conformational change of the *** the other hand,the oxidation of the macrocycle resulted in its diradical cation analogue and induced the release of the guest molecule TCNQ,thereby accomplishing reversible binding ***,this work wellillustrates the chemical and structural versatility of dihydrophenazine in the synthesis of macrocycles and their host-guest chemistry.

关键词： Dihydrophenazine Macrocycle Conformational adaptation Redox-active Host-guest interactions Charge transfer interaction Organic radical Supramolecular chemistry

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