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Severe inflammatory disorder in trisomy 8 without myelodysplastic syndrome and response to methylprednisolone:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6206-6212页

作者： Fei-Yan Pan Hao-Zhe Fan Shun-hong Zhuang Li-Fei Pan xiang-hong ye hong-Jie Tong Intensive Care Medicine Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000Zhejiang ProvinceChina Department of Clinical Laboratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000Zhejiang ProvinceChina Administration Division Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000Zhejiang ProvinceChina

BACKGROUND Patients with trisomy 8 consistently present with myeloid neoplasms and/or auto-inflammatory syndrome.A possible link between myelodysplastic syndromes(MDS)with trisomy 8(+8-MDS)and inflammatory disorders is well recognized,several cases having been ***,inflammatory disorders in patients without MDS have been largely ***,Behçet's disease is the most common type in+***,inflammatory disorders with pulmonary involvement are less frequent,and no effective treatment has been *** SUMMARY A 27-year-old man with recurrent fever,fatigue for>2 mo,and unconsciousness for 1 day was admitted to our emergency department with a provisional diagnosis of severe *** and imipenem were administered and sputum collected for metagenomic next-generation ***–Barr virus and Mycobacterium kansasii were ***,chromosomal analysis showed duplications on chromosome *** days later,repeat metagenomic next-generation sequencing was performed with blood *** portugal,***,and Candida portugal were detected,and duplications on chromosome 8 *** hematological disease,we aspirated a bone marrow sample from the iliac spine,examination of which showed evidence of *** added fluconazole as further antibiotic *** days later,the patient’s condition had not improved,prompting addition of methylprednisolone as an anti-inflammatory ***,this treatment was effective and the patient eventually *** Severe inflammatory disorders with pulmonary involvement can occur in patients with trisomy *** may be an effective treatment.

关键词： Auto-inflammatory disorder Inflammatory disorder Methylprednisolone Myelodysplastic syndromes Trisomy 8 Case report

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滋阴清肝明目方在白内障围手术期的临床观察

中华中医药杂志 2015年第8期30卷 3027-3029页

作者：许家骏韩锦丹向红叶北京中医药大学东直门医院眼科北京100700

目的:观察白内障围手术期使用滋阴清肝明目方的作用。方法:52例拟行白内障手术患者(52只眼)随机分为治疗组和对照组,每组各26例,其中糖尿病视网膜病变患者各13例。治疗组术前2周至术后1周服用滋阴清肝明目方,比较两组患者术后眼部症状... 详细信息

目的:观察白内障围手术期使用滋阴清肝明目方的作用。方法:52例拟行白内障手术患者(52只眼)随机分为治疗组和对照组,每组各26例,其中糖尿病视网膜病变患者各13例。治疗组术前2周至术后1周服用滋阴清肝明目方,比较两组患者术后眼部症状改善、矫正视力及治愈时间、糖尿病视网膜病变患者黄斑中心凹厚度。结果:治疗组患者术后7d眼部症状改善、矫正视力均优于对照组,差异无统计学意义;治疗组患者治愈所需时间明显优于对照组(P<0.05);糖尿病视网膜病变患者术后3d黄斑中心凹厚度下降,明显优于对照组(P<0.05)。结论:滋阴清肝明目方在白内障围手术期的使用可以减少术后并发症,提高患者视力,缩短术后恢复时间。

关键词：滋阴清肝明目方白内障围手术期临床观察

PFNA-II主钉长度对A1、2型股骨转子间骨折患者临床疗效及安全性的影响

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中国现代医学杂志 2017年第26期27卷 119-122页

作者：朱志军朱剑叶峥刘宏鸣叶向红江苏省泰兴市人民医院江苏泰州225400

目的探讨亚洲型股骨近端防旋髓内钉(PFNA-Ⅱ)主钉长度对A1、2型股骨转子间骨折患者临床疗效及安全性的影响。方法选取2012年4月-2015年4月本院收治急A1、2型股骨转子间骨折患者60例,以随机数字表法分为A组和B组各30例,分别选择240 mm主... 详细信息

目的探讨亚洲型股骨近端防旋髓内钉(PFNA-Ⅱ)主钉长度对A1、2型股骨转子间骨折患者临床疗效及安全性的影响。方法选取2012年4月-2015年4月本院收治急A1、2型股骨转子间骨折患者60例,以随机数字表法分为A组和B组各30例,分别选择240 mm主钉和170 mm主钉行PFNA-Ⅱ术式治疗;比较两组患者围手术期临床指标水平、股骨前皮质主钉抵触率、随访Harris髋关节功能评分及术后并发症发生率等。结果 A组患者手术时间为(64.82±11.54)min,显性失血量为(156.34±35.16)ml,隐性失血量为(258.86±51.95)ml,住院时间为(9.76±1.26)d;B组患者手术时间为(45.31±7.89)min,显性失血量为(94.70±17.33)ml,隐性失血量为(176.25±40.71)ml,住院时间为(9.51±1.20)d,经t检验,差异有统计学意义(P0.05);A组患者术后并发症发生率为6.67%(2/30),B组患者术后并发症发生率为3.33%(1/30),经χ~2检验,差异无统计学意义(P>0.05)。结论相较于240 mm主钉,选择170 mm主钉行PFNA-Ⅱ术式治疗A1、2型股骨转子间骨折具有操作简便、微创及术后恢复时间短等优势,且未影响髋关节功能恢复效果和增加术后并发症发生风险。

关键词：亚洲型股骨近端防旋髓内钉主钉长度股骨转子间骨折

Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： xiang-Tian Bai Li-Hui Cao Xu-Yong Chen Jia-Yu Wang Zi-ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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Detection and Estimation of False Data Injection Attacks for Load Frequency Control Systems

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 861-870页

作者： Jun ye xiang Yu Hangzhou Innovation Institute Beihang UniversityHangzhouChina School of Automation Science and Electrical Engineering Beihang UniversityBeijingChina

False data injection attacks(FDIAs)against the load frequency control(LFC)system can lead to unstable operation of power *** this paper,the problems of detecting and estimating the FDIAs for the LFC system in the presence of external disturbances are ***,the LFC system model with FDIAs against frequency and tie-line power measurements is ***,a design procedure for the unknown input observer(UIO)is presented and the residual signal is generated to detect the *** UIO is designed to decouple the effect of the unknown external disturbance on the residual *** that,an attack estimation method based on a robust adaptive observer(RAO)is proposed to estimate the state and the FDIAs *** order to improve the performance of attack estimation,the H¥technique is employed to minimize the effect of external disturbance on estimation errors,and the uniform boundedness of the state and attack estimation errors is proven using Lyapunov stability ***,a two-area interconnected power system is simulated to demonstrate the effectiveness of the proposed attack detection and estimation algorithms.

关键词： External disturbance false data injection attacks load frequency control robust adaptive observer unknown input observer

我国农产品流通效率时空演变、地区差异与收敛性

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经济问题 2025年第1期 100-112页

作者：高国生叶林祥支海兵南京财经大学粮食和物资学院江苏南京210003 南京审计大学金审学院管理学院江苏南京210023 南京财经大学经济学院江苏南京210003

农产品流通效率事关我国粮食安全和全国统一大市场的建成。运用熵值法测度了2011—2022年我国31个省级行政区的农产品流通效率,并使用Moran’s I、Kernel核密度估计、Markov链、Dagum基尼系数和β收敛模型分别分析了我国农产品流通效率... 详细信息

农产品流通效率事关我国粮食安全和全国统一大市场的建成。运用熵值法测度了2011—2022年我国31个省级行政区的农产品流通效率,并使用Moran’s I、Kernel核密度估计、Markov链、Dagum基尼系数和β收敛模型分别分析了我国农产品流通效率的时空演变、地区差异与收敛性情况。结果显示:研究期内我国农产品流通效率存在显著正向空间相关性,“高—高”集聚和“低—低”集聚特征明显;核密度曲线宽度变大呈现右拖尾和高度差明显的双峰形态,表明农产品流通效率逐渐提升,地区内部存在极化趋势;相邻省区市空间滞后水平对本省区市农产品流通效率维持原有状态或向更高水平发展均有较大影响;地区间差异是造成农产品流通效率总体差异显著的主要原因;农产品流通效率存在显著绝对β收敛和条件β收敛。据此,对如何提高农产品流通效率和缩小地区间差距提出了相关政策建议。

关键词：农产品流通效率时空演变空间分布地区差异

Thermodynamic cycle analysis of solid propellant air-turbo-rocket

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航空动力学报 2009年第2期24卷 269-276页

作者： CHEN xiang CHEN Yu-chun TU Qiu-ye ZHANG hong CAI Yuan-hu School of Power and Energy Northwestern Polytechnical University Xi'an 710072 China

Solid propellant air-turbo-rocket(SPATR) is an air-breathing propulsion system.A numerical model of performance and characteristics analysis for SPATR was presented and the corresponding computer program was written according to the operation characteristics of *** influence on the SPATR performance at design point caused by the gas generator exit parameters and compressor pressure ratio had been computed and analyzed in *** off-design performance of SPATR at sea level and high altitude had also been *** performance of thrust and specific impulse for SPATR with different solid propellant had been compared at off-design points,and the off-design performance comparison had been made between fuel-rich and *** computation results indicated that SPATR operates within wide range of Mach number(0~3) and altitude(0~12 km),and SPATR possesses high specific thrust(1 200 N/(kg/s)) and high specific impulse(7 000 N/(kg/s)) when fuel-air ratio of combustor equals fuel-air ratio.

关键词：空气涡轮火箭压缩机压力固体推进剂设计方案

Suppression of esophageal cancer cell growth using curcumin,(-)-epigallocatechin-3-gallate and lovastatin

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World Journal of Gastroenterology 2012年第2期18卷 126-135页

作者： Fei ye Gui-hong Zhang Bao-xiang Guan Xiao-Chun Xu Department of Clinical Cancer Prevention The Universityof Texas MD Anderson Cancer Center Houston TX 77030United States Department of Pathology Anhui Medical University Hefei 230032 Anhui ProvinceChina

AIM:To determine the effects of curcumin,(-)-epigallocatechin-3-gallate (EGCG),lovastatin,and their combinations on inhibition of esophageal ***:Esophageal cancer TE-8 and SKGT-4 cell lines were subjected to cell viability methyl thiazolyl tetrazolium and tumor cell invasion assays in vitro and tumor formation and growth in nude mouse xenografts with or without curcumin,EGCG and lovastatin *** expression was detected using immunohistochemistry and Western blotting in tumor cell lines,tumor xenografts and human esophageal cancer tissues,***:These drugs individually or in combinations significantly reduced the viability and invasion capacity of esophageal cancer cells in ***,these three agents reduced the expression of phosphorylated extracellular-signal-regulated kinases (Erk1/2),c-Jun and cyclooxygenase-2 (COX-2),but activated caspase 3 in esophageal cancer *** nude mouse xenograft assay showed that EGCG and the combinations of curcumin,EGCG and lovastatin suppressed esophageal cancer cell growth and reduced the expression of Ki67,phosphorylated Erk1/2 and *** expression of phosphorylated Erk1/2 and COX-2 in esophageal cancer tissue specimens was also analyzed using *** data demonstrated that 77 of 156 (49.4%) tumors expressed phosphorylated Erk1/2 and that 121 of 156 (77.6%) esophageal cancers expressed COX-2 *** particular,phosphorylated Erk1/2 was expressed in 23 of 50 (46%) cases of esophageal squamous cell carcinoma (SCC) and in 54 of 106 (50.9%) cases of adenocarcinoma,while COX-2 was expressed in 39 of 50 (78%) esophageal SCC and in 82 of 106 (77.4%) esophageal ***:The combinations of curcumin,EGCG and lovastatin were able to suppress esophageal cancer cell growth in vitro and in nude mouse xenografts,these drugs also inhibited phosphorylated Erk1/2,c-Jun and COX-2 expression.

关键词： Chemoprevention Curcumin Cyclooxygen-ase-2 (-)-epigallocatechin-3-gallate Esophageal can-cer Statin

Tribological properties of laser cladding TiB_2 particles reinforced Ni-base alloy composite coatings on aluminum alloy

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Rare Metals 2015年第11期34卷 789-796页

作者： Long He ye-Fa Tan Xiao-Long Wang Qi-Feng Jing xiang hong College of Field Engineering PLA University of Science and Technology

To improve the wear resistance of aluminum alloy frictional parts, Ti B2particles reinforced Ni-base alloy composite coatings were prepared on aluminum alloy 7005 by laser cladding. The microstructure and tribological properties of the composite coatings were investigated. The results show that the composite coating contains the phases of Ni Al, Ni3Al, Al3Ni2, TiB2, TiB, TiC, CrB, and *** microhardness is HV0.5855.8, which is 15.4 % higher than that of the Ni-base alloy coating and is 6.7 times as high as that of the aluminum alloy. The friction coefficients of the composite coatings are reduced by 6.8 %–21.6 % and 13.2 %–32.4 % compared with those of the Ni-base alloy coatings and the aluminum alloys, while the wear losses are 27.4 %–43.2 % less than those of the Ni-base alloy coatings and are only 16.5 %–32.7 % of those of the aluminum alloys at different loads. At the light loads ranging from 3 to 6 N, the calculated maximum contact stress is smaller than the elastic limit contact stress. The wear mechanism of the composite coatings is micro-cutting wear, but changes into multi-plastic deformation wear at 9 N due to the higher calculated maximum contact stress than the elastic limit contact stress. As the loads increase to 12 N, the calculated flash temperature rises to 332.1 °*** composite coating experiences multi-plastic deformation wear, micro-brittle fracture wear, and oxidative wear.

关键词： Ti B2 Ni-base alloy Laser cladding Composite coati