检索结果-南通市图书馆

Orientation and strain rate dependent tensile behavior of single crystal titanium nanowires by molecular dynamics simulations

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2018年第5期34卷 864-877页

作者： Le Chang Chang-Yu Zhou hong-xi liu Jian Li xiao-Hua He School of Mechanical and Power Engineering Nanjing Tech University Nanjing 211816 China School of Mechanical Engineering Jiangsu University of Science and Technology Zhenjiang 212000 China

Molecular dynamics simulation was employed to study the tensile behavior of single crystal titanium nanowires（NWs）with[112^-0],[1^-100] and[0001]orientations at different strain rates from 10^8s^-1 to 10^11s^-*** strain rates are above 10^10s^-1,the state transformation from HCP structure to amorphous state leads to super plasticity of Ti NWs,which is similar to FCC *** strain rates are below 10^10s^-1,deformation mechanisms of Ti NWs show strong dependence on *** [112^-0] orientated NW.{101^-1} compression twins（CTs）and the frequently activated transformation between CTs and deformation faults lead to higher plasticity than the other two orientated ***,tensile deformation process along [112^-0] orientation is insensitive to strain *** [1^-100] orientated NW,prismaticslip is the main deformation mode at 10^8s^-*** the strain rate increases,more types of dislocations are activated during plastic deformation ***[0001]orientated NW,{101^-2} extension twinning is the main deformation mechanism,inducing the yield stress of [0001] orientated NW,which has the highest strain rate *** number of initial nucleated twins increases while the saturation twin volume fraction decreases nonlinearly with increasing strain rate.

关键词： Molecular dynamics Single crystal titanium nanowires Strain rate Orientation Plastic deformation mechanisms

The data and characteristics of the human milk banks in China's Mainland

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2019年第2期15卷 190-197页

作者： xi-hong liu Shu-Ping Han Qiu-Fen Wei Feng-Ying Zheng Ting Zhang Hui-Min Chen Meng Mao Clinical Nutrition Department of Guangzhou Women and Children Medical Center Guangzhou 510623China Nanjing Maternal and Child Health Center Affiliated of Nanjing Medical University NanjingChina Guangxi Maternal and Child Health Hospital NanningChina The 4th People's Hospital of Shaanxi Province Xi'anChina Shanghai Children's Hospital ShanghaiChina West China Second Hospital of Sichuan University ChengduChina

Background Human milk banks (HMB) have been established for over 100 years in North America and *** study aimed to describe and summarize the operation and characteristics of the HMBs in China's Mainland since the first nonprofit HMB operated in *** Operation of HMB in China's Mainland is based on the standards and guidelines of the Human Milk Banking Association of North America and some countries in Europe and was modified to meet the needs and circumstances in China such as donation only in the local HMB by medical *** reviewed the descriptive data of these 14 HMBs and the clinical characteristics of recipients,the eligible milk donors and the donor milk *** In China's Mainland,from March 2013 to December 2016,14 nonprofit HMBs were developed and operational in public hospitals except one and located in the south,east,north and northwest of China's *** total,2680 eligible donors donated 4608.2 L of breast *** mean age of these donors was 29.4 years with 60.6% receiving college education and 90.6% term delivery.A total of 4678 recipients including preterm infants (n =2990,63.9%),feeding intolerance (n =711,15.2%),maternal illness (n =345,7.4%),serious infection (n =314,6.7%),necrotising enterocolitis (n =244,5.2%),post-surgery (n =38,0.8%) and others (n =36,0.8%).The rate of discarded raw milk was only 4.4% because of hepatitis B and C or cytomegalovirus *** HMB has been developing rapidly in China's *** human milk was used not only for preterm infants but also for other ill *** the sustainability of milk banking needs proper management and more financial support by relative health authorities and the government.

关键词： Breast milk Donor human milk Human milk banking Recipients

Spin-orbit torque efficiency enhancement to tungsten-based SOT-MTJs by interface modification with an ultrathin MgO

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第1期67卷 316-317页

作者： Shiyang LU xiaobai NING hongchao ZHANG Sixi ZHEN xiaofei FAN Danrong xiONG Dapeng ZHU Gefei WANG hong-xi liu Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Science and EngineeringBeihang University Truth Memory Corporation

Spin-orbital torque (SOT) based three-terminal magnetic tunnel junctions (MTJs) have attracted much interest as the next generation magnetic random-access memory (MRAM)key device both in the academy and the industry. This is because SOT-MTJs feature high endurance and fast switching speed, benefiting tremendously from the separation of read/write current paths and less incubation time during the write in contrast to the spin-transfer torque (STT) MTJs [1].

关键词：

同方期刊数据库

Effect of two human growth hormone receptor antagonists on glomerulosclerosis in streptozotocin-induced diabetic rats

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第4期25卷 92-97页

作者： Wei LI, Li-hua ZHU, En-bi WANG, Zeng-can YE, Jun LIN, Li-he GUO1, Fei-hong LUO2, xi-hong liu2, xin FANG2, Shui-xian SHEN2 Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, 2Children’s Hospital ofShanghaiMedical University, Shanghai200031, China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Science Chinese Academy of Sciences Children\'s Hospital of Shanghai Medical University Shanghai 200031 China

AIM: To explore the feasibility of human growth hormone (hGH) receptor antagonist in the treatment of end-stage diabetic renal complications. METHODS: Two hGH mutants, hGHA1 (Cys-hGH-del1-4, G120R, K168A, E174A, C182S, del186-191) and hGHA2 (hGH-H21A, G120R, E174A) were expressed in E coli. The IC50 (Mean±SD) values for the mutants for inhibiting 125I-hGH binding to rabbit growth hormone receptor were (65±10) ng for hGHA1, (27±5.6) ng for hGHA2, and (10±0.6) ng for wild type hGH, respectively. RESULTS: After treatment for 12 weeks, the renal histology analysis showed that treatment with hGHA2 at 4 mg/kg body weight daily markedly suppressed glomerulosclerosis in streptozotocin-induced diabetic Sprague-Dawley (SD) rats; hGHA1 at the same dosage slightly increased the renal damage compared with saline; while wild type hGH at 1 U/kg body weight daily severely worsened the glomerulo-sclerosis in diabetic SD rats. CONCLUSION: The data indicated that hGHA2 inhibited the end-stage glomerulosclerosis in diabetic rats, but hGHA1 mildly increased the glomerulosclerosis.

关键词： growth hormone diabetic nephropathies mutation diabetes mellitus

2010版早产儿肠内营养支持建议和早产儿营养需求建议介绍

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华儿科杂志 2010年第9期48卷 711-715页

作者：丁宗一刘喜红北京军区总医院八一儿童医院 100700

《JPediatrGastroenterolNutr》2010年第50卷第1期刊出欧洲儿科胃肠病、肝病和营养学会营养委员会（EuropeanSocietyforPaediatricGastroenterology，HepatologyandNutritionCommitteeonNutrition，ESPGAN）最新颁布的“2010版早产儿肠... 详细信息

关键词：肠内营养支持营养需求早产儿营养学会胃肠病委员会

在线全文

学校读者我要写书评

暂无评论

第19届国际营养大会介绍

中华儿科杂志 2010年第8期48卷 639-640页

作者：丁宗一刘喜红北京军区总医院八一儿童医院 100700

由国际营养科学联盟（International Union of Nutritional Sciences,IUNS）举办的第19届国际营养大会于2009年10月3-9日在泰国首都曼谷召开,136个国家和地区的4 000多名医师、营养学工作者、护士以及有关人员参加了会议.300名专业人士... 详细信息

由国际营养科学联盟（International Union of Nutritional Sciences,IUNS）举办的第19届国际营养大会于2009年10月3-9日在泰国首都曼谷召开,136个国家和地区的4 000多名医师、营养学工作者、护士以及有关人员参加了会议.300名专业人士在各种类型的会议上发言,另有200张壁报交流.这次大会是继2005年在南非召开的18届国际营养大会之后,在亚洲地区召开的一次盛会.

关键词：营养科学国际 2009年专业人士亚洲地区工作者营养学会议

在线全文

学校读者我要写书评

暂无评论

代谢组学在儿科领域中的应用

中华儿科杂志 2010年第6期48卷 442-445页

作者：刘喜红丁宗一北京军区总医院附属八一儿童医院 100700

体是一个复杂的系统,存在于这一系统中的生物分子相互关联、互相依赖.近年来,人们已经意识到牛物学的整体复杂性以及基因构成与环境因素之间的复杂交互作用,而对这些交互作用的理解已经不能单单从基因组学、蛋白质组学或转录组学水平去... 详细信息

体是一个复杂的系统,存在于这一系统中的生物分子相互关联、互相依赖.近年来,人们已经意识到牛物学的整体复杂性以及基因构成与环境因素之间的复杂交互作用,而对这些交互作用的理解已经不能单单从基因组学、蛋白质组学或转录组学水平去揭示.关注生物分子之间途径及网络的动态变化和关系的系统生物学（systems biology）或整体系统生物学（global systems biology）,则通过研究DNA、RNA、蛋白质和代谢物之间的相互作用,整合各种生物信息,从全局反映遗传背景和所处环境对生物个体的作用和影响.代谢组学（metabolomics或metabonomics）是系统生物学重要的组成部分,也是最新的＂omics,组学＂,由Nicholson等[1]1999年提出以来,迅速发展并成为近年来的研究热点,已广泛应用于疾病的早期诊断、药物开发、毒性评价、环境评价、生理学、功能基因组学、个性化治疗、营养学等科学领域.目前代谢组学在临床上的研究尚未大量开展,特别足在儿科领域.现主要从儿科临床研究的角度,对代谢组学做一综述.

关键词：代谢组学儿科应用功能基因组学系统生物学蛋白质组学生物分子交互作用

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li xi liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

在线全文

学校读者我要写书评

暂无评论

染整生产节能节水降耗减排技术

染整技术 2011年第1期33卷 34-40,8页

作者：刘宏喜广东纺织职业技术学院广东佛山528041

印染产业历来是我国出口创汇的支柱产业,同时又是耗能、用水和排污较大的工业部门之一,是影响纺织产品的安全和健康性能、影响生态环境的关键产业,是对未来中国纺织行业可持续发展影响最大的产业之一。染整生产节能节水、降耗减排是一... 详细信息

印染产业历来是我国出口创汇的支柱产业,同时又是耗能、用水和排污较大的工业部门之一,是影响纺织产品的安全和健康性能、影响生态环境的关键产业,是对未来中国纺织行业可持续发展影响最大的产业之一。染整生产节能节水、降耗减排是一项庞大的系统工程,本文主要从绿色生态纺织纤维、印染半制品、染料和助剂以及节能节水、降耗减排的染整设备和染整新技术等几方面进行阐述。

关键词：染整技术节能节水降耗减排