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Conjugate-Gradient Progressive-Iterative Approximation for Loop and Catmull-Clark Subdivision Surface Interpolation

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Journal of Computer Science & Technology 2022年第2期37卷 487-504页

作者： Yusuf Fatihu Hamza hong-wei lin School of Mathematical Science Zhejiang UniversityHangzhou 310027China State Key Laboratory of CAD Sz CG Zhejiang UniversityHangzhou 310058China

Loop and Catmull-Clark are the most famous approximation subdivision schemes,but their limit surfaces do not interpolate the vertices of the given ***-iterative approximation(PIA)is an efficient method for data interpolation and has a wide range of applications in many fields such as subdivision surface fitting,parametric curve and surface fitting among ***,the convergence rate of classical PIA is *** this paper,we present a new and fast PIA format for constructing interpolation subdivision surface that interpolates the vertices of a mesh with arbitrary *** proposed method,named Conjugate-Gradient Progressive-Iterative Approximation(CG-PIA),is based on the Conjugate-Gradient Iterative algorithm and the Progressive Iterative Approximation(PIA)*** method is presented using Loop and Catmull-Clark subdivision ***-PIA preserves the features of the classical PIA method,such as the advantages of both the local and global scheme and resemblance with the given ***,CG-PIA has the following features.1)It has a faster convergence rate compared with the classical PIA and W-PIA.2)CG-PIA avoids the selection of weights compared with W-PIA.3)CG-PIA does not need to modify the subdivision schemes compared with other methods with fairness *** examples for Loop and Catmull-Clark subdivision surfaces are provided in this paper to demonstrate the efficiency and effectiveness of CG-PIA.

关键词： progressive-iterative approximation Loop subdivision Catmull-Clark subdivision conjugate-gradient method

Latest developments in chronic intestinal pseudo-obstruction

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World Journal of Clinical Cases 2020年第23期8卷 5852-5865页

作者： Chang-Zhen Zhu hong-wei Zhao hong-wei lin Feng Wang Yuan-Xin Li Department of Gastrointestinal Surgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Chronic intestinal pseudo-obstruction(CIPO)is a type of intestinal dysfunction presenting as symptoms of intestinal obstruction but without actual mechanical *** extremely low incidence,non-specific clinical symptoms,strong heterogeneity,and no definitive cause in some patients make CIPO very difficult to diagnose *** and gastrointestinal manometry are commonly *** patients have progressive worsening of their symptoms and require intervention,and nutritional assessment and treatment are very important to determine the *** improvements in surgical techniques,small bowel transplantation is a feasible treatment option for patients with advanced CIPO;however,the long-term prognosis for CIPO patients remains ***,the disease is rare and difficult to diagnose,which leads to clinicians’lack of understanding of the disease and results in a high rate of *** review describes the characteristics of CIPO and the latest developments in diagnosis and treatment,in *** goal of our review is to improve clinicians'understanding of CIPO so that the disease is identified quickly and accurately,and treated as early as possible to improve patients’quality of life.

关键词： Chronic intestinal pseudo-obstruction Intestinal obstruction Enteral nutrition Parenteral nutrition Intestinal transplantation

Dynamic Development of Aphelenchoides besseyi on Rice Plant by Artificial Inoculation in the Greenhouse

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Agricultural Sciences in China 2008年第8期7卷 970-976页

作者： LIU wei-hong lin Mao-song LI hong-mei SUN Min-jie Plant Protection College Nanjing Agricultural University Nanjing 210095 P.R.China

A study was done on the relationship between Aphelenchoides besseyi and the symptoms of small grains and erect panicles. This is an important rice disease in Jiangsu Province, China. A. besseyi was extracted from small grains and erect panicles and cultured artificially, and then inoculated into bud and leaf sheaths of seedlings of two Oryza sativa cultivars, namely Zhendao 2 and Wuyunjing 7 in a greenhouse. The effect on rice growth, in particular the small grains and erect panicles, was revealed by the extent of the disease, seed expansion stages, nematode load, and nematode mortality. In contrast to healthy seedlings, the height, length, and the numbers of spikelets of unhealthy panicles of Zhendao 2 were decreased by 6.7, 16.4, and 13.5%, respectively. Before anthesis, nematodes were attracted to the leaf sheath and apical meristem, nematode load increased by 40%; after anthesis, nematodes occurred in spikelets principally and the number increased by 90.8%. The percentages of infected seeds and nematode load were highest in plump seeds and lowest in empty seeds. Nematode mortality on grain with normal endosperm was lower than seeds with abnormal endosperm. Results indicated that A. besseyi was the pathogen in rice with the symptoms of small grains and erect panicles. Wuyunjing 7 manifests only the small grains and erect panicles symptoms and not the symptoms of leaf white-tip. These symptoms of small grains and erect panicles are new symptom records for the disease caused by A. besseyi on rice.

关键词： Aphelenchoides besseyi small grains and erect panicles nematode distribution seed expansion nematodemortality

Interleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 877-892页

作者： Yan Yan hong-wei lin Zhuo-Nan Zhuang Ming Li Sen Guo Department of Operating Room Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of Gastrointestinal Surgery Beijing Tsinghua Changgung Hospital School of Clinical MedicineTsinghua UniversityBeijing 102200China Department of General Surgery Zouping Traditional Chinese Medicine HospitalZhouping 256200Shandong ProvinceChina Department of General Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Kras mutant colon cancer shows abnormal activation of the nuclear factor kappa-B(NF-κB)pathway,resulting in the proliferation of tumor *** with fluorouracil(5-FU)might not achieve the expected inhibition of proliferation of malignant cells based on the fluorouracil-induced activation of the NF-κB *** To detect whether interleukin(IL)-1 receptor antagonist(IL-1RA)could increase the chemosensitivity to 5-FU by decreasing the activation of the NF-κB pathway and reducing the proliferation of colon cancer *** Western blot analysis was performed to detect the persistent activation of the NF-κB pathway in colon cancer cell *** transcription-polymerase chain reaction was used to detect the IL-1RA-reduced expression levels of IL-6,IL-8,IL-17,IL-21 and TLR4 in colon cancer cell *** used a xenograft nude mouse model to demonstrate the downregulation of the NF-κB pathway by blocking the NF-κB-regulated IL-1αfeedforward loop,which could increase the efficacy of chemotherapeutic agents in inhibiting tumor cell *** IL-1 receptor antagonist could decrease the expression of IL-1αand IL-1βand downregulate the activity of the NF-κB pathway in Kras mutant colon cancer *** with 5-FU combined with IL-1RA could increase the chemosensitivity of the SW620 cell line,and decreased expression of the TAK1/NF-κB and MEK pathways resulted in limited proliferation in the SW620 cell *** Adjuvant chemotherapy with IL-1RA and 5-FU has a stronger effect than single chemotherapeutic ***-1RA combined with fluorouracil could be a potential neoadjuvant chemotherapy in the clinic.

关键词： Colon carcinoma Chemotherapy Nuclear factor kappa-B Interleukin-1 Proliferation Fluorouracil

Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas

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World Journal of Gastroenterology 2020年第37期26卷 5682-5692页

作者： Qin-Fen Chen Xiao-Dong Zhou Dan-hong Fang En-Guang Zhang Chun-Jing lin Xiao-Zhen Feng Na Wang Jian-Sheng Wu Dan Wang wei-hong lin Department of Physical Examination Medical Care Center The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The significance of Helicobacter pylori(***)infection and atrophic gastritis(AG)in the prevalence of colorectal adenomas has been examined in a limited number of ***,these studies reported disputed *** To investigate whether *** infection,AG,and ***-related AG increase the risk of colorectal *** This retrospective cross-sectional study included 6018 health-check *** relevant data for physical examination,laboratory testing,13C-urea breath testing,gastroscopy,colonoscopy and histopathological examination of gastric and colorectal biopsies were *** and multivariate logistic regression analyses were performed to determine the association between ***-related AG and colorectal *** Overall,1012 subjects(16.8%)were diagnosed with colorectal adenomas,of whom 143(2.4%)had advanced *** the enrolled patients,the prevalence of *** infection and AG was observed as 49.5%(2981/6018)and 10.0%(602/6018),*** with *** infection had an elevated risk of colorectal adenomas(adjusted odds ratio[OR]of 1.220,95%confidence interval(CI):1.053-1.413,P=0.008)but no increased risk of advance adenomas(adjusted OR=1.303,95%CI:0.922-1.842,P=0.134).AG was significantly correlated to an increased risk of colorectal adenomas(unadjusted OR=1.668,95%CI:1.352-2.059,P<0.001;adjusted OR=1.237,95%CI:0.988-1.549,P=0.064).*** infection accompanied by AG was significantly associated with an increased risk of adenomas(adjusted OR=1.491,95%CI:1.103-2.015,P=0.009)and advanced adenomas(adjusted OR=1.910,95%CI:1.022-3.572,P=0.043).CONCLUSION ***-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals.

关键词： Helicobacter pylori Gastritis Atrophy Adenomas Colorectal Health-check

Indication to distinguish the burst region of coal gas from seismic data

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Journal of Coal Science & Engineering(China) 2009年第3期15卷 243-247页

作者： CHENG Jian-yuan TANG hong-wei XU lin LI Yan-fang Xi＇an Research Institute China Coal Research Institute Xi＇an 710054 China

The velocity of an over-burst coal seam based on laboratory test results. This seam is about 1/3 compared to a normal coal can be considered as a basis to confirm the area of coal and gas burst by seismic exploration technique. Similarly, the simulation result of the theoretical seismic model shows that there is obvious distinction between over-burst coal and normal coal based on the coal reflection＇s travel-time, energy and frequency. The results from the actual seismic data acquired in the coal and gas over-burst cases is consistent with that of the laboratory and seismic modeling; that is, in the coal and gas burst region, seismic reflection travel time is delayed, seismic amplitude is weakened and seismic frequency is reduced. Therefore, it can be concluded that seismic exploration tech- nique is promising for use in distinguishing coal and gas over-burst regions based on the variation of seismic reflection travel time, amplitude and frequency.

关键词： coal and gas over-burst region seismic data characteristic identification

Attention deficit hyperactivity disorder in children with epilepsy:a multicenter cross-sectional analysis in China

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World Journal of Pediatrics 2024年第10期20卷 1070-1078页

作者： Gang Pan Ying Han Tian-Cheng Wang Zi-Yi Chen Xiang-Qing Wang hong-Bin Sun Yong-hong Liu Qun Wang wei-hong lin Jin-Mei Li Shui-Zhen Zhou Yue-Hua Zhang Department of Neurology Children’s Hospital of Fudan University399 Wan Yuan RoadMinhang DistrictShanghaiChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Neurology Lanzhou University Second HospitalLanzhouChina Department of Neurology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Department of Neurology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Neurology Sichuan Provincial People HospitalChengduChina Department of Neurology Xijing HospitalFourth Military Medical UniversityXi’anChina Department of Neurology Beijing Tiantan HospitalCaptial Medical UniversityBeijingChina Department of Neurology The First Hospital of Jilin UniversityChangchunChina Department of Neurology Sichuan University West China HospitalChengduChina

Background The diagnosis and treatment of attention deficit hyperactivity disorder(ADHD)comorbid with epilepsy have been insufficiently addressed in *** conducted a study in China to investigate the current status,diagnosis,and treatment of ADHD in children to further our understanding of ADHD comorbid with epilepsy,strengthen its management,and improve patients’quality of *** We carried out a multicenter cross-sectional survey of children with epilepsy across China between March 2022 and August *** screened all patients for ADHD and compared various demographic and clinical factors between children with and without ADHD,including gender,age,age at epilepsy onset,duration of epilepsy,seizure types,seizure frequency,presence of epileptiform discharges,and treatment *** objective was to explore any possible associations between these characteristics and the prevalence of *** Overall,395 epilepsy patients aged 6–18 years were *** age at seizure onset and duration of epilepsy ranged from 0.1–18 to 0.5–15 years,*** onset seizures were observed in 212(53.6%)patients,while 293(76.3%)patients had epileptiform interictal electroencephalogram(EEG)*** the 370 patients treated with anti-seizure medications,200(54.1%)had *** 189(47.8%)patients had ADHD,only 31 received treatment for it,with the inattentive subtype being the most *** was more common in children undergoing polytherapy compared to those on ***,poor seizure control and the presence of epileptiform interictal EEG abnormalities may be associated with a higher prevalence of *** While the prevalence of ADHD was higher in children with epilepsy than in normal children,the treatment rate was notably *** highlights the need to give more importance to the diagnosis and treatment of ADHD in children with epilepsy.

关键词： Attention deficit hyperactivity disorder Children China Epilepsy Electroencephalogram

Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus

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Chinese Medical Journal 2016年第20期129卷 2508-2509页

作者： Xin-Yue Zhang Jin-Bei Yu Dan Yang Chun-Tao Han wei-hong lin Department of Neurology Neuroscience CenterFirst Hospital of Jilin UniversityChangchunJilin 130021China

To the Editor：The term myoclonus refers to a form of fast,transient,lightning-like muscle twitch that originates in the nervous *** is usually a manifestation of neurological dysfunction or intractable epilepsy and is clinically divided into cortical myoclonus,spinal myoclonus,physiological myoclonus,*** is also categorized as epileptic myoclonus or nonepileptic *** myoclonic epilepsy （JME） is the most common form of epileptic myoclonus,while frontal lobe epilepsy （FLE） with myoclonus is relatively *** clinical manifestations of these two forms of epilepsy include shock-like muscle activity appearing in the upper limbs or involving the shoulder and arms together,with irregular and arrhythmic clonus in the morning after waking up that typically results in an involuntary hurtling of objects held in the *** is hard to make a distinction between the two conditions ***,we report a case of FLE with myoclonus to provide clues to distinguish between the two.

关键词：表单肌阵挛肌阵挛性癫痫幼年型四肢休克胰岛素癫痫癫痫额叶

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine,fasudil,imatinib,and caspofungin as potential treatments for lethal COVID-19

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Cellular & Molecular Immunology 2023年第4期20卷 351-364页

作者： in Xia Lun-zhi Yuan Ya-hong Hu Jun-yi Liu Guo-sheng Hu Ruo-yao Qi Tian-ying Zhang Hua-long Xiong Zao-zao Zheng hong-wei lin Jia-mo Zhang Chao Yu Ming Zhou Jian Ma Tong Cheng Ri-rong Chen Yi Guan Ning-shao Xia Wen Liu State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiang’an South RoadXiamenFujian 361102China Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical SciencesXiamen UniversityXiang’an South RoadXiamenFujian 361102China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiang’an South RoadXiamenFujian 361102China State Key Laboratory of Emerging Infectious Diseases School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina.

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019(COVID-19)severity and ***,drugs that are effective against inflammation to treat lethal COVID-19 are still urgently ***,we constructed a SARS-CoV-2 spike protein-specific CAR,and human T cells infected with this CAR(SARS-CoV-2-S CAR-T)and stimulated with spike protein mimicked the T-cell responses seen in COVID-19 patients,causing cytokine storm and displaying a distinct memory,exhausted,and regulatory T-cell ***1 remarkably augmented cytokine release in SARS-CoV-2-S CAR-T cells when they were in *** on this"two-cell"(CAR-T and THP1 cells)model,we screened an FDA-approved drug library and found that felodipine,fasudil,imatinib,and caspofungin were effective in suppressing the release of cytokines,which was likely due to their ability to suppress the NF-kB pathway in ***,fasudi,imatinib,and caspofungin were further demonstrated,although to different extents,to attenuate lethal inflammation,ameliorate severe pneumonia,and prevent mortality in a SARS-CoV-2-infected Syrian hamster model,which were also linked to their suppressive role in *** summary,we established a SARS-CoV-2-specific CAR-T-cell model that can be utilized as a tool for anti-inflammatory drug screening in a fast and high-throughput *** drugs identified herein have great potential for early treatment to prevent COVID-19 patients from cytokine storm-induced lethality in the clinic because they are safe,inexpensive,and easily accessible for immediateuseinmostcountries.

关键词： COVID-19 SARS-CoV-2 CAR-T anti-inflammation NF-kB pathway