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World Journal of Gastroenterology 2005年第38期11卷 5926-5930页

作者： hong-wei shen Shun-Liang Gao Yu-Lian Wu Shu-You Peng Department of Surgery 2^nd Affiliated Hospital of Medical CollegeZhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To characterize the expression and genomic amplification of decoy receptor 3 （DcR3） in hepatocellular carcinoma （HCC） and to evaluate the role of DcR3 in apoptosis.METHODS： We examined 48 cases of HCC for DcR3 expression by RT-PCR and DcR3 gene amplification by quantitative genomic PCR. DcR3 protein was detected by immunohistochemistry. Terminal deoxynucleotidyl transferase-mediated dUTP digoxigenin nick and labeling （TUNEL） was used to identify the apoptosis cells in tissues. Primary hepatoma cell culture and MTT test were used to evaluate the protection against FasL- and chemicalinduced apoptosis by DcR3 expression. RESULTS： DcR3 mRNA overexpression was detected in 60% HCC （29/48） patients. The occurrence of HCC was not associated with amplification of the gene. One sample base substitution was found in three sites as a sequence in Genbank. The expression of DcR3 in HCC was associated with the apoptotic index （0.067±0.04 vs 0.209±0.12, P〈0. 01）, size of mass, stage, and infiltration or metastasis （41.2% vs71.0%, 40% vs75%, 51.8% vs84.6%, P〈0. 05）. DcR3 expression could protect hepatoma cells against apoptosis induced by FasL, but not by chemicals. CONCLUSION： These data suggest that in addition to gene amplification there may be another mechanism underlying DcR3 overexpression. The effect of overexpression of DcR3 on the apoptosis of cancer cells may have direct therapeutic implications for the management of HCC.

关键词： DcR3 Hepatocellular carcinoma Apoptosis

Task-specific Part Discovery for Fine-grained Few-shot Classification

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Machine Intelligence Research 2024年第5期21卷 954-965页

作者： Yongxian wei Xiu-shen wei School of Computer Science and Technology Nanjing University of Science and TechnologyNanjing210094China

Localizing discriminative object parts(e.g.,bird head)is crucial for fine-grained classification tasks,especially for the more challenging fine-grained few-shot *** work always relies on the learned object parts in a unified manner,where they attend the same object parts(even with common attention weights)for different few-shot episodic *** this paper,we propose that it should adaptively capture the task-specific object parts that require attention for each few-shot task,since the parts that can distinguish different tasks are naturally *** for a few-shot task,after obtaining part-level deep features,we learn a task-specific part-based dictionary for both aligning and reweighting part features in an ***,part-level categorical prototypes are generated based on the part features of support data,which are later employed by calculating distances to classify query data for *** retain the discriminative ability of the part-level representations(i.e.,part features and part prototypes),we design an optimal transport solution that also utilizes query data in a transductive way to optimize the aforementioned distance calculation for the final *** experiments on five fine-grained benchmarks show the superiority of our method,especially for the 1-shot setting,gaining 0.12%,8.56%and 5.87%improvements over state-of-the-art methods on CUB,Stanford Dogs,and Stanford Cars,respectively.

关键词： Fine-grained image recognition few-shot learning transductive learning visual dictionary part feature discovery

Wireless multisite sensing systems for continuous physiological monitoring

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Science China Materials 2024年第6期67卷 2045-2047页

作者： Ruilai wei Qilin Hua Guozhen shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Institute of Flexible Electronics Beijing Institute of TechnologyBeijing 102488China

Respiratory diseases rank as the third leading cause of adult mortality[1],while cardiopulmonary and gastrointestinal issues are the primary cause of death within the first five years of a child’s life[2].The monitoring of cardiac,respiratory,and gastrointestinal sounds plays a vital role in routine care,as alterations or absence of these body sounds can serve as indicators of underlying diseases.

关键词： routine continuous monitoring

Intervention of CT Localization plus TCM Therapy on Prolapse of Lumbar Intervertebral Disc

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Journal of Acupuncture and Tuina Science 2003年第4期1卷 53-55页

作者： LUO Zhi-hong shen wei-na Tuina Department of Ruijin Hospital Shanghai 200025 China

Purpose To observe the curative effect of interventional therapy by CT localization combined traditional Chinese medicine on prolapse of lumbar intervertebral *** The inpatients of lumbar intervertegroup and control group. Interventional therapy by CT localization combined TCM was used in the treatment group while in the control group TCM therapy was taken only. The treatment lasted for 10 days in both *** The curative effect was 94.3% in the treatment group while 76.8% in the control one (Phong (1968-), male, attending physicianTranslator: shen wei-na

关键词： Tomography X-Ray Computed Intervertebral Disk Displacement Lumbar Vertebrae Tuina Massage

Novel Adaptive Memory Event-Triggered-Based Fuzzy Robust Control for Nonlinear Networked Systems via the Differential Evolution Algorithm

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1836-1848页

作者： wei Qian Yanmin Wu Bo shen School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo 454000China College of Information Science and Technology Donghua UniversityShanghai 201620China

This article mainly investigates the fuzzy optimization robust control issue for nonlinear networked systems characterized by the interval type-2(IT2)fuzzy technique under a differential evolution *** provide a more reasonable utilization of the constrained communication channel,a novel adaptive memory event-triggered(AMET)mechanism is developed,where two event-triggered thresholds can be dynamically adjusted in the light of the current system information and the transmitted historical *** conditions with less conservative design of the fuzzy imperfect premise matching(IPM)controller are presented by introducing the Wirtinger-based integral inequality,the information of membership functions(MFs)and slack ***,under the IPM policy,a new MFs intelligent optimization technique that takes advantage of the differential evolution algorithm is first provided for IT2 TakagiSugeno(T-S)fuzzy systems to update the fuzzy controller MFs in real-time and achieve a better system control ***,simulation results demonstrate that the proposed control scheme can obtain better system performance in the case of using fewer communication resources.

关键词： Adaptive memory event-triggered(AMET) differential evolution algorithm fuzzy optimization robust control interval type-2(IT2)fuzzy technique.

Auto-parametric resonance of a continuous-beam-bridge model under two-point periodic excitation:an experimental investigation and stability analysis

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 445-454页

作者： Li Yuchun shen Chao Liu wei Li Dong Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this *** auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on *** parametric vibration equation is established for the test model using the finite-element *** auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent *** effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test *** with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental *** a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric *** with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed.

关键词： auto-parametric resonance continuous beam bridge model two-point excitation experimental investigation stability analysis vibration of Volgograd Bridge

Transient Stability Analysis and Design of VSGs with Different DC-Link Voltage Controllers

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 593-604页

作者： Chao shen wei Gu Wanxing sheng Keyan Liu School of Electrical Engineering Southeast UniversityNanjingChina Power Distribution Research Department China Electric Power Research InstituteBeijing 100192China

Virtual synchronous control has been widely studied for the advantages of emulating inertia for voltage source converters (VSCs). A constant dc-link voltage is usually assumed in existing literature to estimate transient stability of virtual synchronous generators (VSGs). However, actual power supply in the dc-side of VSGs is limited and different dc-link voltage controllers are needed to achieve power balance between DC side and AC side. Addition of dc-link voltage controller has great influence on transient behavior of VSGs, which has not been investigated by previous research. To fill this gap, this paper gives insights into the effect of dc-link voltage dynamics on transient stability of VSGs. First, two typical kinds of VSGs with dc-link voltage controllers are introduced. Then, mathematical models considering dc-link dynamics are established and the effect of dc-link voltage controllers on transient synchronization stability of VSGs is revealed through equal area criterion (EAC). It is found that dc-link voltage controller would reduce stability margin of VSGs and design-oriented transient stability analysis is carried out quantitively using critical clearing time (CCT). Finally, simulation results are given to validate correctness of theoretical analysis.

关键词： DC-link voltage dynamics equal area criterion(eac) transient synchronization stability virtual synchronous generator(VSG)

Coupled simulation of fluid-particle interaction for large complex granules:A resolved CFD-DEM method for modelling the airflow in a vertical fixed bed of irregular sinter particles

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Particuology 2024年第7期90卷 292-306页

作者： Chengzhi Li Yu Zhang Jiahe shen wei Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan 430063China Centre for Bulk Solids and Particulate Technologies The University of NewcastleCallaghan NSW 2308Australia

A resolved CFD-DEM method is proposed to simulate the fluid-particle interaction for large complex *** airflow in a vertical sinter fixed bed is numerically studied using this *** multi-sphere clumped method is used to create irregular sinter particles in *** immersed boundary method and dynamic cell refinement are applied to describe the fluid flow around particles with higher resolution,by which the fluid-particle interaction can be simulated more *** simulation results presented the packing voidage distributions and the airflow fields in the sinter beds of different single and mixed particle size *** bed pressure drops were simulated and the results were compared with the corresponding experimental *** good agreement indicated that the proposed resolved CFD-DEM method is an effective tool to model the fluid-particle interaction for irregular large granules in the gas-solid multi-phase systems.

关键词： Resolved CFD-DEM method Irregular sinter particles Multi-sphere clumped method Immersed boundary method Dynamic cell refinement

Microstructure and magnetocaloric properties of melt-extracted SmGdDyCoAl high-entropy amorphous microwires

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Rare Metals 2024年第3期43卷 1234-1242页

作者： Shi-Jie wei hong-Xian shen Lun-Yong Zhang Lin Luo Xin-Xing Tang Jian-Fei Sun Xiao-Qing Li School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China Applied Materials Physics Department of Materials Science and EngineeringKTH-Royal Institute of Technology10044StockholmSweden

This paper presents a systematic investigation of the microstructure and magnetocaloric properties of melt-extracted Sm_(20)Gd_(20)Dy_(20)Co_(20)Al_(20)high-entropy *** fabricated wires exhibited an amorphous structure,and the temperature interval of the undercooled liquid AT was 45 *** microwires underwent a second-order magnetic transition from a ferromagnetic to a paramagnetic state near the Curie temperature(T_(C)=52 K),The maximum magnetic entropy change(-ΔS_M^(max)),the relative cooling power and the refrigeration capacity reached 6.34 J·kg^(-1)·K^(-1).422.09 J·kg^(-1)and 332.94 J·kg^(-1),respectively,under a magnetic field change of 5 *** addition,the temperature-averaged entropy changes with two temperature lifts(3 and 10 K)were 6.32 and 6.27 J·kg^(-1)·K^(-1),*** good magnetocalorie performance highlights the significant potential for the Sm_(20)Gd_(20)Dy_(20)Co_(20)Al_(20)microwires to be used as magnetic refrigerant materials in low-temperature region *** work will serve as a valuable reference for future investigations on low-temperature high-entropy magnetocaloric materials.

关键词： Melt-extraction High-entropy amorphous microwires Magnetocaloric effect Magnetic refrigeration

Protein tyrosine phosphatase non-receptor Ⅱ:A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3913-3931页

作者： Hui-Yuan Li Yi-Ming Jing Xue shen Ming-Yue Tang hong-hong shen Xin-wei Li Zi-Shu Wang Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina

BACKGROUND The incidence of primary liver cancer is increasing year by *** 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of *** is the most common primary liver *** has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese *** onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when ***,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of *** tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further *** To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in *** The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and *** value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological ***,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical *** The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC *** Encyclopedia of Ge

关键词： Protein tyrosine phosphatase non-receptor 2 Hepatocellular carcinoma Immune evasion Biomarker Immunotherapy Prognosis