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Androgen actions on endothelium functions and cardiovascular diseases

Journal of Geriatric Cardiology 2016年第2期13卷 183-196页

作者： Jing-Jing CAI Juan WEN wei-hong jiang Jian LIN Yuan hong Yuan-Shan ZHU Department of Cardiology of the Third Xiangya Hospital Central South University Changsha China The Center of Clinical Pharmacology of the Third Xiangya Hospital Central South University Changsha China Department of Medicine/Endocrinology Weill Cornell Medical College NY USA Department of Clinical Pharmacology Xiangya Hospital Central South University Changsha China

The roles of androgens on cardiovascular physiology and pathophysiology are controversial as both beneficial and detrimental effects have been reported. Although the reasons for this discrepancy are unclear, multiple factors such as genetic and epigenetic variation, sex-specificity, hormone interactions, drug preparation and route of administration may contribute. Recently, growing evidence suggests that androgens exhibit beneficial effects on cardiovascular function though the mechanism remains to be elucidated. Endothelial cells （ECs） which line the interior surface of blood vessels are distributed throughout the circulatory system, and play a crucial role in cardiovascular function. Endothelial progenitor cells （EPCs） are considered an indispensable element for the reconstitution and maintenance of an intact endothelial layer. Endothelial dysfunction is regarded as an initiating step in development of atherosclerosis and cardiovascular diseases. The modulation of endothelial functions by androgens through either genornic or nongenomic signal pathways is one possible mechanism by which androgens act on the cardiovascular system. Obtaining insight into the mechanisms by which androgens affect EC and EPC functions will allow us to determine whether androgens possess beneficial effects on the cardiovascular system. This in turn may be critical in the prevention and therapy of cardiovascular diseases. This article seeks to review recent progress in androgen regulation of endothelial function, the sex-specificity of androgen actions, and its clinical applications in the cardiovascular system.

关键词： Androgen Cardiovascular diseases Endothelial cells Endothelium Estrogen

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Micro-porous TiO2 thin films grown on surface of Ti substrate

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 178-181页

作者： WU Xiao-hong QIN wei jiang Zhao-hua HU Xin-guo Li Qing-fen Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China School of Mechanics and Electronics Engineering Harbin Engineering University Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China School of Mechanics and Electronics EngineeringHarbin Engineering University Harbin 150001 China

Microporous titanium dioxide thin films have been grown on titanium plates by the micro-plasma oxidation method with different current densities (4, 6, 10 and 14 A/dm2). X-ray diffraction, scanning electronic microscopy and UV-Vis spectrophotometry were used to characterize the films. It is found that the films grown are microporous and consist of crystalline titanium dioxide. The micropore size and the content of anatase and rutile TiO2 phase increase with the applied voltage. The relatively higher degradation efficiency for rhodamine B is obtained in the film produced with a current density of 10 A/dm2.

关键词： micro-plasma oxidation TiO2 thin film photo-catalytic activity rhodamine B

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Elevated Arsenic Exposure Is Associated with an Increased Risk of Chronic Hepatitis B Virus Infection： NHANES （2003-2014） in U.S. Adults

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Current Medical Science 2018年第4期38卷 610-617页

作者： wei-hua ZHANG Jiao HUANG Mei FENG Ye-qing TONG Xu-hua GUAN hong-wei jiang Sheng wei Department of Epidemiology and Biostatistics Key Laboratory of Environment and Health of Ministry of Education School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Preventive Medicine School of Medicine Ningbo University Ningbo 315211 China Institute of Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and Prevention Wuhan 430079 China

Studies concerning the association between arsenic exposure and hepatitis B virus （HBV） infection have been lacking. The present study aimed to examine the association between total urinary arsenic （TUA） and infection ofHBV. A total of 5186 participants from National Health and Nutrition Examination Survey （NHANES） 2003-2014 were included in the analysis. We used logistic regression to evaluate the association. We defined two measures of TUA. TUA1 was the sum of arsenous acid, arsenicacid, monomethylarsonic acid and dimethylarsenic acid. TUA2 was defined as TUA minus arsenobetaine and arsenocholine. The results showed that the weighted overall prevalence of HBV infection was 6.08%. For NHANES 2003-2014, the medians （interquartile range） of TUA1 and TUA2 were 5.60 μg/L （3.97-8.09 μg/L） and 4.91 μg/L （2.36-9.11 μg/L）, respectively. Comparing the highest quartile to the lowest quartile after multivariable adjustment showed that the odds ratios （ORs） and 95% confidence intervals （CIs） for TUA1 and TUA2 were 2.44 （1.40-4.27） and 2.84 （1.60-5.05）, respectively. In conclusion, elevated urinary arsenic was associated with the risk of HBV infection. Further studies, especially prospective studies, are needed to confirm the causal relationship between arsenic exposure and HBV infection.

关键词： arsenic exposure hepatitis B infection National Health and Nutrition Examination Survey

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Genome-wide identification of imprinted genes in pigs and their different imprinting status compared with other mammals

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Zoological Research 2020年第6期41卷 721-725页

作者： Yin-Qiao Wu Heng Zhao Ying-Ju Li Saber Khederzadeh hong-jiang wei Zhong-Yin Zhou Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution and Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province Yunnan Agricultural UniversityKunmingYunnan 650201China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

DEAR EDITOR,Genomic imprinting often results in parent-of-origin specific differential expression of maternally and paternally inherited alleles and plays an essential role in mammalian development and *** genomic imprinting has primarily been studied in mice and humans,with only limited information available for *** systematically characterize this phenomenon and evaluate imprinting status between different species,we investigated imprinted genes on a genome-wide scale in pig brain tissues.

关键词： imprinting imprint primarily

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Optimization of sgRNA expression strategy to generate multiplex gene-edited pigs

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Zoological Research 2022年第6期43卷 1005-1008页

作者： Ju-Qing Zhang Jian-Xiong Guo Xiao-Jie Wu Yu Wang wei Yue Zhuo-Hui Li wei Wang Xin-Fang wei Xiao-Long Wu Qiao-Yan Shen An-Min Lei hong-jiang wei Jin-Lian Hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F University State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural University College of Animal Sciences&Technology Northwest A&F University National Institute of Biological Sciences

DEAR EDITOR,The use of CRISPR/Cas9 technology to breed polygenicmodified animals with desired traits holds great promise in agriculture and biomedicine. However, as most studies are based on human and mouse models, whether different single guide RNA(sg RNA) expression strategies affect multiplex gene-editing efficiency in domestic animals remains elusive.

关键词： CRISPR/Cas9 holds desired

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An AES Study of Initial Oxidation of Ce-La Alloy at Room Temperature and Low Oxygen Pressure

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Journal of Rare Earths 2004年第Z1期22卷 18-21页

作者： Yang jiangrong Wang Xiaolin Xiao hong Zhou wei jiang Chunli Lu Lei China Academy of Engineering Physics Mianyang 621900 China China Academy of Engineering Physics Mianyang 621900 China China Academy of Engineering Physics Mianyang 621900 China China Academy of Engineering Physics Mianyang 621900 China China Academy of Engineering Physics Mianyang 621900 China China Academy of Engineering Physics Mianyang 621900 China

Auger Electron Spectroscopy was used to characterize the initial stages of the oxidation of Ce-5% La alloy in an oxygen atmosphere at low pressure( ～ 10-6 Pa) and room temperature after the surface is cleaned by Ar+ ion *** is shown that exposure of clean cerium to oxygen causes the appearance and development of three new Auger peaks at 97,662 and 676 eV, which steadily grow during oxidation of *** oxygen dose less than 20 L,a semi-protective layer of oxide forms on the surface of cerium and its growth follows a logarithmic *** further exposure of oxygen, the oxide film grown in the previous stage becomes thicker and the uptake of oxygen reaches saturation at oxygen exposure of 25 L,and the oxide film mainly consists of Ce2O3.

关键词： Auger electron spectroscopy oxidation Ce-La alloy rare earths

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Research progress of artesunate in diabetes and its complications

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Traditional Medicine Research 2023年第5期8卷 44-51页

作者： Yuan-Hui Guo Lu-Lu Chen Ying LI Jia-Jia Duan Chuan-Xin Liu hong-wei jiang Endocrine and Metabolic Disease Center First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyMedical Key Laboratory of Hereditary Rare Diseases of HenanLuoyang Sub-center of National Clinical Research Center for Metabolic DiseasesLuoyang 471003China College of Clinical Medicine of Henan University of Science and Technology Department of Pharmacy First Affiliated Hospital of Henan University of Science and TechnologyLuoyang 471003China College of Clinical Medicine of Henan University of Science and Technology Laboratory Department of the First Affiliated Hospital of Henan University of Science and TechnologyLuoyang 471003China

Diabetes is a metabolic disease characterized by abnormally elevated blood glucose *** hyperglycemia leads to diabetic nephropathy,diabetic retinopathy,diabetes with periodontal disease and other diabetic *** diseases have become the main causes of disability and death in diabetic *** is well known as an antimalarial drug for controlling malaria *** studies have shown that artesunate improves diabetes and its complications by protecting islet cells,improving glucose and lipid metabolism,anti-inflammatory and immune *** on the research status in recent years,this paper focuses on the mechanism of artesunate in diabetes and its complications,to provide a theoretical basis for future diabetes research.

关键词： Artesunate diabetes diabetic complications islet cells glycolipid metabolism anti-inflammatory immunoregulation

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The research of test sample development

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微计算机信息 2009年第30期25卷 33-34,3页

作者： ZHANG hong-wei jiang Xiu-feng China Great Wall Industry Corporation

The model and requirements of ISO for software test are studied and *** types of software defects and the common modes are also studied.A software defect model is built based on the test cases.A typical test sample is... 详细信息

关键词：软件测试样本测试 ISO 软件缺陷

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Catheter ablation of atrial fibrillation in a patient with dextrocardia： what is the challenge？

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Chinese Medical Journal 2010年第17期123卷 2478-2479页

作者： WANG Xin-hua SHI Hai-feng HAN Bing TAN hong-wei jiang wei-feng LIU Xu Department of Cardiology Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200030 China

Catheter ablation has been an established strategy for treating paroxysmal atrial fibrillation （AF）.Pulmonaryvein isolation is the predominant approach of catheter ablation. This procedure is characterized as transseptal catheterization and point-by-point ablation around the ipsilateral pulmonary veins （PVs）. Although catheter ablation can be safely performed in a heart with normal structures, it may be challenging to be performed in a dextrocardia.

关键词： atrial fibrillation catheter ablation structures strategy approach heart PVs

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Corrosion resistance of in-situ growth of nano-sized Mg（OH）2 on micro-arc oxidized magnesium alloy AZ31—Influence of EDTA

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Journal of Materials Science & Technology 2019年第6期35卷 1088-1098页

作者： Chang-Yang Li Xiao-Li Fan Rong-Chang Zeng Lan-Yue Cui Shuo-Qi Li Fen Zhang Qing-Kun He M. Bobby Kannan hong-wei (George) jiang Dong-Chu Chen Shao-Kang Guan College of Materials Science and Engineering Shandong University of Science and Technology Qingdao 266590 China Biomaterials and Engineering Materials (BEM) Laboratory College of Science Technology and Engineering James Cook University Townsville 4811Australia School of Engineering RMIT University Carlton 3053 VIC Australia School of Materials Science and Energy Engineering Foshan University Foshan 528000 China School of Materials Science and Engineering Zhengzhou University Zhengzhou 450002 China

One of the major obstacles for the clinical use of biodegradable magnesium(Mg)-based materials is their high corrosion rate. Micro-arc oxidation(MAO) coatings on Mg alloys provide mild corrosion protection owing to their porous structure. Hence, in this study a dense Mg(OH)2 film was fabricated on MAO-coated Mg alloy AZ31 in an alkaline electrolyte containing ethylenediamine tetraacetic acid disodium(EDTA-2 Na) to reinforce the protection. Surface morphology, chemical composition and growth process of the MAO/Mg(OH)2 hybrid coating were examined using field-emission scanning electron microscopy, energy dispersive X-ray spectrometer, X-ray diffraction, X-ray photoelectron spectroscopy and Fourier transform infrared spectrophotometer. Corrosion resistance of the coatings was evaluated via potentiodynamic polarization curves and hydrogen evolution tests. Results manifested that the Mg(OH)2 coating possesses a porous nano-sized structure and completely seals the micro-pores and micro-cracks of the MAO *** intermetallic compound of AlMn phase in the substrate plays a key role in the growth of Mg(OH)2 film. The current density of Mg(OH)2-MAO composite coating decreases three orders of magnitude in comparison with that of bare substrate, indicating excellent corrosion resistance. The Mg(OH)2-MAO composite coating is beneficial to the formation of calcium phosphate corrosion products on the surface of Mg alloy AZ31, demonstrating a great promise for orthopaedic applications.

关键词： Magnesium alloys Micro-arc oxidation Magnesium hydroxide Coatings Biomaterials

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