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Long-term efficacy,safety and biocompatibility of a novel sirolimus eluting iron bioresorbable scaffold in a porcine model

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Bioactive Materials 2024年第9期39卷 135-146页

作者： Ya-Nan Gao hong-tao yang Zi-Feng Qiu Feng Qi Qian-hong Lu Jian-Feng Zheng Zi-Wei Xi Xin Wang Li Li Gui Zhang De-Yuan Zhang Yu-Die Lu Hai-Ping Qi hong Qiu Run-Lin Gao Yu-Feng Zheng Department of Cardio-Metabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Coronary Artery Disease CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials Animal Experimental CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Engineering Medicine Beihang UniversityBeijingChina R&D Center Biotyx Medical(Shenzhen)Co.Ltd.ShenzhenChina Department of Cardiology Fuwai Yunnan HospitalChinese Academy of Medical SciencesAffiliated Cardiovascular Hospital of Kunming Medical UniversityKunmingChina Peking University Health Science Center BeijingChina Department of Cardiology Beijing Tsinghua Changgung HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseasesBeijingChina School of Materials Science and Engineering Peking UniversityBeijingChina

Iron is considered as an attractive alternative material for bioresorbable scaffolds(BRS).The sirolimus eluting iron bioresorbable scaffold(IBS),developed by Biotyx Medical(Shenzhen,China),is the only iron-based BRS with an ultrathin-wall *** study aims to investigate the long-term efficacy,safety,biocompatibility,and lumen changes during the biodegradation process of the IBS in a porcine model.A total of 90 IBSs and 70 cobaltchromium everolimus eluting stents(EES)were randomly implanted into nonatherosclerotic coronary artery of healthy mini *** multimodality assessments including coronary angiography,optical coherence tomography,micro-computed tomography,magnetic resonance imaging,real-time polymerase chain reaction(PCR),and histopathological evaluations,were performed at different time *** was no statistical difference in area stenosis between IBS group and EES group at 6 months,1year,2 years and 5 *** the scaffolded vessels narrowed at 9 months,expansive remodeling with increased mean lumen area was found at 3 and 5 *** IBS struts remained intact at 6 months,and the corrosion was detectable at 9 *** 5 years,the iron struts were completely degraded and absorbed in situ,without in-scaffold restenosis or thrombosis,lumen collapse,aneurysm formation,and chronic *** local or systemic toxicity and abnormal histopathologic manifestation were found in all *** from real-time PCR indicated that no sign of iron overload was reported in scaffolded ***,the IBS shows comparable efficacy,safety,and biocompatibility with EES,and late lumen enlargement is considered as a unique feature in the IBS-implanted vessels.

关键词： Bioresorbable scaffold Sirolimus eluting iron bioresorbable scaffold Preclinical study Completely bioresorbable Late lumen enlargement

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Construction of Greenbelt and Sustainable Development in Harbin City

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Journal of Northeast Agricultural University(English Edition) 2011年第3期18卷 71-74页

作者： PANG Songling hong Li yang tao CHE Daidi College of Horticulture Northeast Agricultural University Harbin 150000 China

Through analyzing the current urban greenbelt construction and relative issues during the development in northeastern parts in Harbin of China, some feasible solutions were proposed. In order to improve the urban ecological environment and upgrading the constructive level of the urban greenbelt along with the sustainable development in the future, the paper provided some solutions in details

关键词： urban greenbelt construction problem and solution sustainable development

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Research progress on non-drug treatment of diabetic kidney disease

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TMR Non-Drug Therapy 2021年第3期4卷 1-7页

作者： Bei-Liang Miao Li Yu Jing Li hong-tao yang First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Diabetic kidney disease is one of the most serious and common chronic complications of diabetes and one of the leading causes of death in diabetic *** the case of diabetic kidney disease,sustained proteinuria is irreversible until it develops into end-stage renal *** treatment of diabetic kidney disease is relatively *** and more evidences into the effectiveness and safety that related non-drug treatments not only have the characteristics of simple operation and high safety,but also can improve the clinical symptoms of patients with diabetic kidney disease,reduce laboratory indicators,and delay disease *** article summarizes the recent literature on non-drug treatment of diabetic kidney disease such as exercise therapy,acupuncture therapy,acupoint application,auricular acupoint pressing pill therapy,moxibustion therapy,in order to provide reference for clinical treatment.

关键词： Diabetic kidney disease External therapy Modern rehabilitation treatment methods Traditional non-drug therapy Acupuncture

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Influence of astragalus polysaccharide on kidney status and fibrosis indices of a ratmodel of streptozotocin-induced diabetic nephropathy

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Traditional Medicine Research 2018年第4期3卷 173-180页

作者： Yue Ji Xue-Rou Yan hong-tao yang Kang yang Qing-Yun Zhao Shou-Ci Hu Qi-Hang Su Tianjin University of Traditional Chinese Medicine Tianjin China The First Teaching Hospital of Tianjin Universityof Traditional Chinese Medicine Tianjin China

Object： To examine the effect of astragalus polysaccharide （APS） on kidney status and fibrosis indices of rats withdiabetic nephropathy. Methods： 72 male rats were randomly divided into three groups： negative control group （NC, n =24）; diabetic nephropathy model group （DNM, n = 24）; and diabetic nephropathy model with APS group （DNM ＋ APS,n = 24）. Rats of the DNM and DNM ＋ APS groups were subjected to both unilateral nephrectomy and administeredstreptozotocin （STZ） injection （65 mg/kg）. DNM ＋ APS group rats were administered 50 IU/kg/d APS by subcutaneousinjection from the first week after operation until death. The NC and DNM group rats were subcutaneously injected withan identical volume of physiological saline. At weeks 3, 8, and 13 after the operation, 6 rats from each group wererandomly sacrificed and blood was collected to measure serum creatinine and blood urea nitrogen. On the day beforesacrifice, the rats were placed in a metabolic cage for 24 h to collect urine. At week 14 after the operation, 6 rats fromeach group were randomly selected to measure body weight and kidney index. Blood was collected to measure bloodglucose. The kidneys were harvested to detect pathological changes by hematoxylin and eosin staining. Results：Histological assessment of DNM rats suggested damage symptoms as evidenced by hyperplasia of the glomerularmesangial matrix, atrophia of the kidney tubules, and thickening of the basement membrane. In contrast, STZ-induceddiabetic nephropathy rats treated with APS （50 IU/kg/d） showed significantly improved histological results, suggestingthat APS has beneficial effect on renal tissues in STZ-induced DNM rats. Our results also indicated that APS relievedrenal injury and effectively improved body weight in DNM rats. The ratio of kidney weight to body weight was reducedand the early stage of renal function damage was improved after APS treatment. In the later stages of the disease, the 24h urinary protein significantly decreased. Moreover, AP

关键词： Diabetic Nephropathy Astragalus polysaccharide Renal index Fibrosis TGF-β1 α-SMA

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中生代砂岩细观结构对强度和能量耗散的影响

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煤炭学报 2017年第2期42卷 452-459页

作者：赵永川刘洪磊杨天鸿徐涛李杨侯宪港秦涛东北大学资源与土木工程学院岩石破裂与失稳研究所辽宁沈阳110819 东北大学深部金属矿山安全开采教育部重点实验室辽宁沈阳110819

对取自东北部和西部侏罗白垩系煤矿中粒砂岩进行镜下观察,对比其矿物颗粒,胶结成分和结晶程度上的异同点,进行了三轴压缩试验和循环加载声发射试验,分析东北部和西部砂岩的强度和能量耗散特征,并用Kaiser效应和加卸载响应比理论研究了... 详细信息

对取自东北部和西部侏罗白垩系煤矿中粒砂岩进行镜下观察,对比其矿物颗粒,胶结成分和结晶程度上的异同点,进行了三轴压缩试验和循环加载声发射试验,分析东北部和西部砂岩的强度和能量耗散特征,并用Kaiser效应和加卸载响应比理论研究了循环加载中的声发射规律。试验表明:以钙质胶结为主的东北部砂岩在Mohr-Coulomb准则下承载能力高于以钙泥质胶结为主的西部砂岩,随着压力的增大,耗散能所占比例呈现迅速降低、稳定、缓慢升高的趋势,且同等应力水平下东北部砂岩耗散能低于西部砂岩,Kaiser效应往往出现在低应力的弹性阶段,且在东北部砂岩中出现的频率和持续阶段要高于西部砂岩,加卸载响应比则出现急剧降低、缓慢平稳下降的趋势,在强度峰值点达到最小值,且东北部砂岩的加卸载响应比低于西部砂岩。东北部和西部砂岩的胶结物中泥质含量和重结晶成岩程度是产生上述力学性质和能量耗散特征差异的根本原因。

关键词：细观结构能量耗散声发射 Kaiser效应加卸载响应比

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CKD4期患者营养状态与肠道黏膜免疫屏障的关系及中药结肠透析干预的疗效

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世界华人消化杂志 2017年第10期25卷 940-945页

作者：郝娜杨洪涛天津中医药大学第一附属医院肾病科天津市300382

目的探讨慢性肾脏病(chronic kidney disease,CKD)相关营养不良与肠黏膜免疫屏障功能的相关性,观察中药结肠透析的治疗效果.方法本研究通过MQSGA量表评价患者营养状态,通过检测CKD患者粪便slg A含量来研究其的肠黏膜免疫屏障功能,评价... 详细信息

目的探讨慢性肾脏病(chronic kidney disease,CKD)相关营养不良与肠黏膜免疫屏障功能的相关性,观察中药结肠透析的治疗效果.方法本研究通过MQSGA量表评价患者营养状态,通过检测CKD患者粪便slg A含量来研究其的肠黏膜免疫屏障功能,评价其相关性;将284例CKD4期患者分为治疗组(口服中药汤剂+自愿接受中药结肠透析治疗)和对照组(仅口服辨证中药汤剂组),观察治疗前后中医症状积分及临床化验指标,初步分析天津中医药大学第一附属医院中药结肠透析应用成效.结果研究显示CKD4期患者存在肠道黏膜免疫屏障功能障碍,肠道slgA水平作为黏膜免疫屏障功能的评价指标与患者营养状态评分呈负向相关的关系,随白蛋白、血红蛋白水平降低而升高,相关系数r=-0.533(P<0.05),与血肌酐、尿素氮水平呈正相关,相关系数r=0.486(P<0.05),随中医证候积分减低而降低,相关系数r=0.419(P<0.05).中医证候积分较高(即症状明显)患者,其营养状态评分与slgA表达量呈线性相关,相关系数r=-0.823(P<0.05),提示营养状态与肠道黏膜免疫屏障功能明显相关,且随肾脏病进展相关性逐步增加.结论本研究证实可以通过研究肠道内slgA水平来评估肠黏膜免疫屏障功能.中药结肠透析可通过改善CKD4期患者肠黏膜免疫屏障功能,改善患者的营养状况,从而改善预后,提高患者生存质量,延缓CKD进展.

关键词：营养不良肠道黏膜免疫屏障中药结肠透析

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Metformin and depression: A protocol for systematic review and meta-analysis

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Psychosomatic Medicine Research 2022年第4期4卷 24-28页

作者： Jin Lin Yue Ji Jin-Hua Si Xu-Ran Liu Zhi-Wang Feng hong-tao yang Li Shen Department of Psychosomatic First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin300381China Graduate School Tianjin University of Traditional Chinese MedicineTianjin301617China Library Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Pediatrics First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300381China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin300381China.

Introduction:Metformin(MET)has been shown in animal models and diabetic patients with depression to have antidepressant *** is gaining attraction as a treatment for depression;nevertheless,a comprehensive review and evaluation are *** primary objective of this review article is to evaluate metformin's effectiveness and safety in the treatment of *** and analysis:From inception,a wide-ranging survey of the literature will be conducted to categorize possibly suitable studies from online databanks such as the Wan-Fang Database,Chinese Scientific Journal Database(VIP database),Chinese Biomedical Literature Database(CBM),China National Knowledge Infrastructure(CNKI),Traditional Chinese Medicine databases,the Web of Science,EMBASE,PubMed,and the Cochrane Central Register of Controlled Trials(CENTRAL).For this search,no linguistic constraints will be *** randomized controlled trials will be considered,and each study's bias risk will be assessed using the Cochrane Risk of Bias *** primary outcome measures will be self-rating scales or clinician-rated *** remission and quality-of-life indices will be secondary *** evidence quality for each study will be assessed by grading the review process,development,and *** and dissemination:The primary data will not be collected in this review;therefore,no ethical consent is *** results of this methodical review will be available in a peer-reviewed scientific publication and will be made freely *** registration number CRD42021286394 Strengths and limitations of this study:This protocol will ensures that the methodologies and processes employed are transparent,allows for peer review,and avoids the risk of bias and ***-analyses will not be used as a method of quantitative *** review study will map the literature on randomized controlled trials of metformin for depression treatment,assess the scope and s

关键词： Metformin Depression Antidepressant effects

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Stimulated Raman Scattering in Nanorod Silicon Carbide Films

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Semiconductor Photonics and Technology 2002年第1期8卷 32-36页

作者： ZHANG hong tao, XU Zhong yang (Dept. of Electronics Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, CHN) Dept. of Electronics Science and Technology Huazhong University of Science and Technology Wuhan 430074

When the film is excited by a very low excitation energy, thespontaneous Raman scattering emerges. The intensity of Ramanscattering is proportional to the Excitation power below thethreshold excitation. When the excited power reaches the Excitationthreshold, the intensity of Stokes light strongly *** an anti- Stokes light at 495 nm and multiple order butsmall Stokes peaks occur. The intensity of Stokes light is muchlarger than that of anti-Stokes.

关键词： Nanosructured film silicon carbide stimulated raman scattering opticalproperty

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Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： yang-Gang Luo Mei Wu hong-Guang Chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy

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RBF网络在线建模方法在热误差实时补偿技术中的应用

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上海交通大学学报 2009年第5期43卷 807-810页

作者：张宏韬杨建国上海交通大学机械与动力工程学院上海200240

应用径向基(RBF)神经网络模型的学习性能,对一台数控加工中心的主轴温度与主轴径向热误差关系分别进行离线建模与在线建模对比研究,并将2种建模方法用于实例分析.结果表明,RBF神经网络模型能够反映数控机床的热特性,准确实时预报机床热... 详细信息

应用径向基(RBF)神经网络模型的学习性能,对一台数控加工中心的主轴温度与主轴径向热误差关系分别进行离线建模与在线建模对比研究,并将2种建模方法用于实例分析.结果表明,RBF神经网络模型能够反映数控机床的热特性,准确实时预报机床热误差.当工况发生较大变化时,在线建模能够及时补充系统信息,更好地反映机床系统热性能,从而精确预报机床的热误差,提高了误差补偿效果.

关键词：热误差实时补偿在线建模神经网络

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