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多发骨转移癌联合治疗近期疗效观察

中国肿瘤临床与康复 2006年第1期13卷 54-56页

作者：洪巧银章平年肖必文浙江省肿瘤医院核医学科杭州310022

目的探讨缓解多发骨转移癌疼痛的有效治疗方法。方法190例多发骨转移癌患者,采用153Sm-EDTMP及153Sm-EDTMP加99Tc-MPD方案,观察治疗后1年疼痛缓解情况、病灶修复作用及安全性。结果总的镇痛缓解率为79.5%,病灶修复率31.1%;A、B两组镇痛... 详细信息

目的探讨缓解多发骨转移癌疼痛的有效治疗方法。方法190例多发骨转移癌患者,采用153Sm-EDTMP及153Sm-EDTMP加99Tc-MPD方案,观察治疗后1年疼痛缓解情况、病灶修复作用及安全性。结果总的镇痛缓解率为79.5%,病灶修复率31.1%;A、B两组镇痛缓解率及骨病变修复率分别为56.7%、86.9%和20.0%、35.5%,两组比较差异有显著性(P<0.05)。治疗骨转移的同时其他脏器的转移占13.6%。毒副反应以骨髓抑制为主,全组未见肝肾功能损害。结论采用以放射性核素为主的综合治疗方案,不仅能有效缓解骨疼痛,同时对病灶的修复有一定的治疗价值。建议在治疗骨转移的同时,只要血像正常,身体状况尚好,可以考虑配合其他治疗,以防止其他脏器的转移。

关键词：骨肿瘤/化学疗法转移

Atomistic study of inverse size effect induced by interfacial plasticity in pearlitic multi-principal element alloy

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Rare Metals 2024年第7期43卷 3341-3355页

作者： Chen Yang qiao-Sheng Xia Cun-hong yin Dong-Peng Hua College of Mechanical Engineering Guizhou UniversityGuiyang 550025China Key Laboratory of Advanced Manufacturing Technology Ministry of EducationGuizhou UniversityGuiyang 550025China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi'an 710072China

Owing to the fine nano-laminated structure,the pearlitic multi-principal element alloy(PMPEA) exhibits excellent mechanical and tribological ***,the incomplete understanding of the size effect of its lamella thickness and the unclear understanding of the plasticity-interface interaction mechanism limit further optimization of *** this study,the FeCoNi/Ni_3Ti interface-mediated plastic deformation behavior in PMPEA and the variation of mechanical and tribological properties with lamella thickness within the nanoscale range using molecular dynamics(MD) simulation were *** results indicate that the mechanical and tribological properties of the PMPEA with lamella thicknesses below 10 nm have a significant inverse size effect,i.e.,the smaller the lamella thickness,the weaker the *** is because the plastic carrier-interface interaction mechanism changes from a strengthening mechanism that hinders dislocations to a weakening mechanism that promotes dislocations with the decreases in the lamella thickness,and the weakening effect becomes more pronounced as the lamella thickness decreases and the number of interfaces *** particular,the deformation behavior of Ni_3Ti lamellae changes from crystal-like to amorphous-like with decreasing ***,in the sample with larger lamella thickness,the occurrence of hierarchical slips in the body-centered cubic(BCC) phase due to the multiprincipal elements effect can better alleviate the stress concentration caused by the dislocation accumulation at the interface,so that the phase interface exhibits outstanding load-bearing *** the dislocation pattern in BCC phase shows a firm high-density cell,which makes the substrate exhibit a stable tribological response.

关键词： Multi-principal element alloy Nano-laminated structure Molecular dynamics simulation Nanoindentation and nanoscratch

The pathological role of ferroptosis in ischemia/reperfusion-related injury

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Zoological Research 2020年第3期41卷 220-230页

作者： hong-Fa Yan Qing-Zhang Tuo qiao-Zhi yin Peng Lei Department of Neurology and State Key Laboratory of Biotherapy West China HospitalSichuan Universityand Collaborative Center for BiotherapyChengduSichuan 610041China Chengdu University of Traditional Chinese Medicine ChengduSichuan 610041China

Ischemia/reperfusion(I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore,we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury(IRI) associated cell damage and death.

关键词： Ischemia/reperfusion Ferroptosis Reactive oxygen species Lipid peroxidation Iron

Progress in side-chain thiophene-containing polymers: synthesis, properties and applications

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Science China Chemistry 2015年第11期58卷 1641-1650页

作者： Yali qiao Xiaodong yin Chuanbing Tang Department of Chemistry and Biochemistry University of South Carolina

In contrast to conventional main-chain conjugated polymers, incorporation of electronically active conjugated oligomers into non-conjugated polymer backbones as pendant groups represents a promising alternative strategy to developing novel electroactive polymer materials that are desirable for potential applications in organic electronics. This review focuses on polymers with thiophene in the side chain and summarizes the most important synthetic approaches to these polymers, including direct controlled polymerization techniques(e.g., ATRP, ROMP, and RAFT) as well as post-polymerization modifications. Additionally, various properties and applications of these polymers are discussed.

关键词： non-conjugated polymer thiophene controlled polymerization post-polymerization modification organic electronics

Locally advanced undifferentiated carcinoma with osteoclast-like giant cells of the pancreas

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World Journal of Gastroenterology 2015年第2期21卷 694-698页

作者： hong-qiao Gao yin-Mo Yang Yan Zhuang Ping Liu Department of General Surgery Peking University First Hospital Department of Pathology Peking University First Hospital

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas(UCOGCP) is an unusual pancreatic neoplasm that represents < 1% of all pancreatic malignancies. Moreover, the giant cells of UCOGCP morphologically resemble the benign giant cells of bone tumors. Due to the rarity of this tumor type, the histogenesis and biologic behavior of UCOGCP remain controversial. Here, we report a case of UCOGCP that exhibited an invasive growth pattern involving infiltration of the adjacent bowel loop and portal vein,as well as superior mesenteric vein thrombosis. The patient underwent a distal pancreatectomy with splenectomy and partial colectomy, followed by four cycles of gemcitabine chemotherapy. No evidence of recurrence was detected after ten years. In addition to this case, clinical information on other UCOGCP cases reported in the English literature is summarized.

关键词： Undifferentiated carcinoma with osteoclastlike gia

Brain-inspired Intelligent Robotics:Theoretical Analysis and Systematic Application

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Machine Intelligence Research 2023年第1期20卷 1-18页

作者： hong qiao Ya-Xiong Wu Shan-Lin Zhong Pei-Jie yin Jia-Hao Chen The State Key Laboratory of Management and Control for Complex System Institute of AutomationChineseAcademyof SciencesBeijing100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Chinese Academy of Science Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

Traditional joint-link robots have been widely used in production lines because of their high precision for single *** the development of the manufacturing and service industries,the requirement for the comprehensive performance of robotics is *** types of bio-inspired robotics have been investigated to realize human-like motion control and manipulation.A study route from inner mechanisms to external structures is proposed to imitate humans and animals *** this idea,a brain-inspired intelligent robotic system is constructed that contains visual cognition,decision-making,motion control,and musculoskeletal *** paper reviews cutting-edge research in brain-inspired visual cognition,decision-making,motion control,and musculoskeletal *** software systems and a corresponding hardware system are established,aiming at the verification and applications of next-generationbrain-inspired musculoskeletal robots.

关键词： Brain-inspired intelligent robot software and hardware decision making muscle control cognitive intelligence.

Strong photoluminescence of Cs_4PbBr_6 crystals: a long mystery story

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Science Bulletin 2018年第9期63卷 525-526页

作者： qiao Zhang Yadong yin Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University Department of Chemistry University of California

Halide perovskite nanocrystals(NCs)with a general composition of ABX_3(A=MA,FA or Cs;B=Pb,Sn;and X=Br,I,Cl)have been widely studied for photovoltaic ***,halide perovskites NCs based light-emitting diodes(LEDs)have also attracted significant attention because they have been regarded as the next-generation display technology[1].However,we

关键词：光致发光稳定性问题故事晶体显示技术卤化物新材料二极管

Precipitation Behavior and Its Strengthening Effect of X100 Pipeline Steel

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Journal of Iron and Steel Research International 2010年第11期17卷 73-78页

作者： NIU Tao KANG Yong-lin GU hong-wei yin Yu-qun qiao Ming-liang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China Nanjing Iron and Steel Co Ltd Nanjing 210035 Jiangsu China

Using TEM （transmisson electron microscopy）, electron diffraction, EDX （energy dispersive X-ray） analysis and physicochemical phase analysis, the morphology, crystal structure, size distribution and chemical composition of precipitates in the microstructure of high strength Nb-microalloyed Xl00 pipeline steel were investigated, and the strengthening effect of precipitation was quantitatively calculated with Ashhy-Orowan correction model. The precipitates obtained in X100 pipeline steel can be divided into two kinds：＂complex＂ and ＂single＂ particles by morphology. The EDX analysis of ＂single＂ precipitates reveals that the chemical composition matches well with particle dimensions, especially the Nb to Ti ratio regularly decreases with the increase of particle size. The yield strength increments in the way of precipitation strengthening of X100 pipeline steel reached about 52 MPa, suggesting that the precipitation strengthening is not the dominative strengthening mechanism for X100 pipeline steel.

关键词： X100 pipeline steel carbonitride precipitation behavior strengthening effect

Dissemination of scientific information to fight against COVID-19:Academic journals' role

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Asian Pacific Journal of Tropical Medicine 2021年第12期14卷 525-527页

作者： qiao Zhang yin Pan Editorial Office of Asian Pacific Journal of Tropical Medicine Hainan Medical UniversityHaikou 571199China

In December 2019,the unprecedented newly emerging coronavirus disease 2019(COVID-19)was first *** March 2020,the World Health Organization(WHO)declared the disease a pandemic,which posed a severe challenge for the *** the beginning of the outbreak,the origin of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is the causative agent of COVID-19,mode of transmission,prevention and control,diagnosis and treatment all remained ***’s worse,the disease spread rapidly and *** whole world was in *** across the globe had to make quick decisions to defeat the virus under high ***,academia,researchers and public health infrastructures around the world were not well-prepared for such a pandemic,and academic journals were also faced with the enormous task of rapidly communicating research findings on COVID-19 while maintaining scientific vigor and integrity of the published *** dissemination of the most up-to-date scientific discoveries is of great importance in the current COVID-19 pandemic;thus,the global scientific publication community has adapted to expedite the publication of important and time-sensitive COVID-19 studies.

关键词： prevention diagnosis adapted