检索结果-南通市图书馆

Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第2期17卷 291-298页

作者： tian-Hao Guo Sheng-Wei hong Wen-Jian Zhu Yi-Fan Hui Wen-Li Qiu Yan Wu Xuan Li Fei Ke Liu Li Hai-Bo Cheng Institute of Health and Regimen Jiangsu Open UniversityNanjing 210036Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Pathology Jiangsu Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine)Nanjing 210029Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer *** patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to *** recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including *** present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of *** SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as *** patient has been receiving a combination treatment of Western and Traditional Chinese *** assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its *** patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies *** the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced *** This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.

关键词： Colorectal cancer Colorectal liver metastasis Drug resistance Immunotherapy Anti-programmed death-1 Case report

Rare large sigmoid hamartomatous polyp in an elderly patient with atypical Peutz-Jeghers syndrome:A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2025年第3期17卷 406-414页

作者： Zhe-Sen tian Xiao-Peng Ma hong-Xun Ruan Yang Yang Ya-Lei Zhao Department of Radiotherapy The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Anus and Intestine Surgery The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Anus and Intestine Surgery The Third Hospital of Hebei Medical UniversityShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Peutz-Jeghers(PJ)syndrome(PJS)is a rare autosomal dominant genetic disease characterized by the association of intestinal polyposis,mucosal skin pigmen-tation,and cancer *** patients have a significantly increased risk of malignant tumors in the gastrointestinal tract and extra-gastrointestinal tract,including various epithelial malignant tumors(colorectal cancer,gastric cancer,pancreatic cancer,breast cancer,and ovarian cancer,etc.).PJS is commonly seen in children and adolescents with multiple small intestinal polyps,often causing *** SUMMARY A 62-year-old male presented with intermittent left lower abdominal pain after drinking or consuming cold beverages that was accompanied by occasional *** contrast-enhanced computed tomography indicated an isolated sigmoid colon grape-like ***,the patient underwent la-paroscopic surgery,and the pathological diagnosis was PJ hamartomatous *** was not considered at the initial visit,as the patient was older,and the facial pigmentation was not ***,significant pigmentation was observed in the perineum during digital rectal ***,we observed that the patient exhibited nodular shadows in the adrenal glands computed tomo-graphy images that may be related to ***,we performed the determination of adrenal cortical hormones,but the results were not *** with skin and mucosal pigmentation and laboratory examinations,the patient was diagnosed with *** laparoscopic sigmoid colon resection,the patient's symptoms improved,and no discomfort symptoms were reported in the later *** The age of onset and lesion location of this case are different from those of typical or isolated PJS patients.

关键词： Peutz-Jeghers syndrome Sigmoid colon Large isolated colonic polyp Skin pigmentation Case report

Circular RNA contributes to gastric cancer by targeting Wnt family member 2B as a competing endogenous RNA

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第10期31卷 71-85页

作者： Wei Bai Zong-Liang Guo Jiang-hong Guo Feng Li Peng Bu juan Liu Department of Pathology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina Department of Gastroenterology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina Department of Cell Biology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina Department of Special Needs Medicine Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina

BACKGROUND As a non-coding RNA molecule,circular RNAs(circRNAs)have significant specificity,and existing data suggest a close relationship between them and the prognosis of patients with gastric cancer(GC).However,this mechanism has no evidence *** article explores the functions of hsa_circRNA_102415 in the malignant behavior and potential downstream signaling of GC *** chosen approach is loss of signal and functional *** To investigate and analyze the relationship between hsa_circRNA_102415 and GC and explore its specific *** provide reference for other researchers to develop targeted treatment *** The gene expression omnibus(GEO)database can be used to obtain the microarray dataset *** were analyzed using the GEO2R tool to identify differences in circRNAs between normal and GC *** real-time polymerase chain reaction was used to detect differentially expressed genes in GC tissue samples and adjacent cancer tissue *** cells were transfected with small interfering-hsa_circRNA_104415 and plasmid DNA(pcDNA)-hsa_ircRNA_*** detection methods,such as Transwell and cell counting kit 8,were used to evaluate cellular physiological activities,including cell invasion and *** relationship between Wnt family members 2B,microRNA(miR)-4529-5p,etc.,including argonaute 2-RNA immunoprecipitation and luciferase reporter genes was *** experiments were conducted to analyze and explore the relationship between the malignant behavior of GC cells and hsa_circRNA_*** GEO2R analysis confirmed that hsa_circRNA_102415 had significantly higher expression levels in disease ***_circRNA_102415 and miR-4529-5p showed a negative correlation in disease cells,suggesting that hsa_circRNA_102415 upregulated WNT2B expression in GC cells as a competing endogenous RNA for ***-4529-5p mimic or small interfering-WNT2B reversed the effects of pcDNA-hsa_circRNA_102415 or miR

关键词： Competing endogenous RNA Wnt family member 2B MicroRNA-4529-5p Circular RNAs Gastric cancer

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-Jie Wang Yu Yu tian Xia Xue-Min Zhang Ai-Ling Li Tao Zhou hong Cai Tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

科研团队学:提高科技创新资源配置效率的新探索

在线全文

学校读者我要写书评

暂无评论

西安交通大学学报(社会科学版) 2025年第1期45卷 152-161页

作者：梅红朱钰田佳琦西安交通大学公共政策与管理学院陕西西安710049 宁波市乡村振兴促进中心浙江宁波315000

“有组织科研”背景下,科研团队建设已成为推动科技创新、实现国家科技战略目标的重要抓手。科研团队学作为一门国际上新兴的交叉学科,其核心是对科研团队从事研究探索活动的特点和有效性开展研究。阐释了科研团队学提出的时代背景以及... 详细信息

“有组织科研”背景下,科研团队建设已成为推动科技创新、实现国家科技战略目标的重要抓手。科研团队学作为一门国际上新兴的交叉学科,其核心是对科研团队从事研究探索活动的特点和有效性开展研究。阐释了科研团队学提出的时代背景以及当前科研团队发展的现实问题。运用隐含狄利克雷分布主题建模方法梳理了2006—2022年Web of Science上的692篇文献,凝练分析国际学术研究概况,从科研团队合作动机及协调发展、成员多样性与互动、跨学科协同环境、科研团队有效性等关键研究领域进行学术领域分析和价值阐释。从科研团队分层分类治理体系存在的“难点”、面向科技创新前沿的有组织科研探索存在的“卡点”以及支持系统推进创新突破的生态环境存在的“断点”等方面分析了中国发展科研团队学研究的迫切性。据此提出深入挖掘并分析科研团队资源禀赋特征、关注“有组织科研”的政策设计、营建科研团队成长的良好生态环境等研究展望。

关键词：科研团队学有组织科研科技创新资源配置团队合作跨学科协同环境

维普期刊数据库博看期刊

同方期刊数据库

Flexible Gradient Poly(ether-ester)from the Copolymerization of Epoxides and c-Caprolactone Mediated by a Hetero-bimetallic Complex

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2021年第8期39卷 1013-1019,I0007页

作者： Wei-Min Ren hong-juan Gao tian-Jun Yue State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

Copolymerization is a commonly employed method for optimizing the properties of polymer *** ether segments into polyesters main chain to obtain polyether-polyester copolymers is an effective strategy to realize the integration of multiple properties of polyester and polyether,and to develop more high-performance,multi-purpose polymer ***,the synthesis of poly(ether-ester)s is accessible by employing the biphenyl-linked heterodinuclear salen Cr-AI complex in the presence of PPNCI for the copolymerization of epoxides and£-caprolactone(CL).Monitoring the copolymerization process reveals that catalyst 1 exhibited good performance for the copolymerization of epoxides and CL,affording copolymers with a gradient sequence *** dynamic thermomechanical analysis(DMA)study indicates the obtained poly(ether-ester)s possess enhanced flexibility compared with the block copolymers or blend of PPO and PCL homopolymers with the same *** study provides a theoretical basis for the preparation of high-performance polymer materials.

关键词： Lactone Epoxide Copolymerization Poly(ether-ester)copolymer Dynamic mechanical analysis

A Bayesian expectation maximization algorithm for state estimation of intelligent vehicles considering data loss and noise uncertainty

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2025年第2期68卷 257-268页

作者： Yan WANG Feng tian Jianqiang WANG Keqiang LI Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

Sideslip angle,yaw rate,and vehicle velocity are essential for intelligent vehicle *** these vehicle states are not measured directly,some Kalman-based approaches have been developed to estimate these states using in-vehicle ***,the existing studies seldom account for the influence of sensor data loss on estimation *** addition,the process and measurement noise change during the estimation process because of the various driving *** address these problems,an expectation-maximization robust extended Kalman filter(EMREKF)is ***,a robust extended Kalman filter(REKF)is developed to deal with the impact of missing ***,an improved expectation maximization(EM)algorithm that considers data loss is presented to update the noise parameter of the REKF ***,the improved EM is fused with the REKF to form the EMREKF to estimate vehicle *** experimental results demonstrate that the EMREKF outperforms EKF,REKF,and maximum correntropy criterion EKF for various degrees of data loss and the proposed algorithm has a strong adaptive ability to different driving conditions.

关键词： intelligent vehicles state estimation expectation maximization method robust extended Kalman filter

同方期刊数据库

Vision Transformer for Extracting Tropical Cyclone Intensity from Satellite Images

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2025年第1期42卷 79-93页

作者： Ye tian Wen ZHOU Paxson KYCHEUNG Zhenchen LIU Low-Carbon and Climate Impact Research Centre School of Energy and EnvironmentCity University of Hong KongSARChina Key Laboratory of Polar Atmosphere-ocean-ice System for Weather and Climate Ministry of Education&Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric SciencesFudan UniversityShanghai 200433China

Tropical cyclone(TC)intensity estimation is a fundamental aspect of TC monitoring and *** learning models have recently been employed to estimate TC intensity from satellite images and yield precise *** work proposes the ViT-TC model based on the Vision Transformer(ViT)*** images of TCs,including infrared(IR),water vapor(WV),and passive microwave(PMW),are used as inputs for intensity *** indicate that combining IR,WV,and PMW as inputs yields more accurate estimations than other channel *** ensemble mean technique is applied to enhance the model's estimations,reducing the root-mean-square error to 9.32 kt(knots,1 kt≈0.51 m s^(-1))and the mean absolute error to 6.49 kt,which outperforms traditional methods and is comparable to existing deep learning *** model assigns high attention weights to areas with high PMW,indicating that PMW magnitude is essential information for the model's *** model also allocates significance to the cloud-cover region,suggesting that the model utilizes the whole TC cloud structure and TC eye to determine TC intensity.

关键词： Vision Transformer tropical cyclones intensity estimation deep learning

Ship detection based on improved SDD algorithm

在线全文

学校读者我要写书评

暂无评论

Instrumentation 2025年

作者： hong-cheng Chu tian-hu Wang Qian-nian Miao Ze-ran Chen Rong Wang Wen-jie Li Tao Huang School of Electrical Information Engineering Jiangsu University of Technology Changzhou High-tech Technology Innovation and Entrepreneurship Service Center Technical Development Department CRRC Nanjing Puzhen Rolling Stock Co. Ltd.

To address the issue of inadequate detection performance for small and mediumsized densely packed vessels in ship target detection, this paper proposes an improved Single Shot Multibox Detector(SSD) model to achieve more accurate detection. The algorithm redesigns the anchor boxes to fit the ship target detection dataset better and integrates the Squeeze-and-Excitation(SE) module into the Visual Geometry Group(VGG)network to enhance the channel features of the input feature maps. Additionally, the network's ability to perceive and represent important features is further enhanced by introducing the Convolutional Block Attention Module(CBAM), which is responsible for channel and spatial attention mechanisms. Finally, the feature pyramid module is employed to fuse six layers of features from the original network, thereby improving the SSD network's capability to detect small and occluded densely packed vessel targets. The experimental results show that the model's target recognition ability for fishing vessels improved from 58.07% to 65.87%; for patrol boats, the ability increased from 94.6% to 96.03%; and for inflatable boats, it rose from 72.08% to 74.93%. The overall mean Average Precision(mAP) also increased from the original model's 80.04% to 81.22%. Additionally, by clustering prior boxes, more suitable prior boxes for vessel detection were obtained, enhancing the model's perception capabilities for both large and small vessels.

关键词：