检索结果-南通市图书馆

Brucea javanica oil emulsion improves the effect of radiotherapy on esophageal cancer cells by inhibiting cyclin D1-CDK4/6 axis

引用

World Journal of Gastroenterology 2019年第20期25卷 2463-2472页

作者： Zhong-hua Qiu Wei-Wei zhang hong-hua zhang Gui-hua Jiao Department of Neurology Liangshan County People's HospitalJining272600Shandong ProvinceChina Department of Neurology Liangshan County People's HospitalJining272600Shandong ProvinceChina

BACKGROUND Esophageal cancer is one of the most common cancers around the world, and it has high incidence and mortality rates. The conventional therapy for esophageal cancer is radiotherapy, although its effect is highly limited by the resistance of esophageal cancer cells. Thus, strong radiosensitizers can be very crucial during radiotherapy against esophageal cancer. Brucea javanica oil emulsion (BJOE) is a widely used drug against various cancers, such as liver, colon, and ovarian cancer. However, its anti-cancer effect and mechanism and the use of BJOE as a radiosensitizer have not been explored in esophageal cancer. AIM To evaluate the anti-cancer effect and mechanism of BJOE and explore the potential use of BJOE as a radiosensitizer during radiotherapy. METHODS The inhibitory effect of BJOE and its enhancement function with radiation on cell viability were examined with the calculated half-maximal effective concentration and half-maximal lethal concentration. The influence of BJOE on cell migration and invasion were measured with EC109 and JAR cells by wound-healing and transwell assay. Clonogenesis and apoptotic rate, which was measured by Hoechst staining, were investigated to confirm its enhancement function with radiation. To investigate the molecular pathway underlying the effect of BJOE, the expressions of several apoptosis- and cycle-related proteins was detected by western *** lines more than normal cell lines, and it markedly reduced migration and invasion in esophageal cancer cells (EC109 and JAR). Moreover, it promoted cell apoptosis and enhanced the effect of radiotherapy against esophageal cancerous cells. In the viability test, the values of half-maximal effective concentration and half-maximal lethal concentration were reduced. Compared to the control, only around 1/5 colonies formed when using BJOE and radiation together in the clonogenic assay. The apoptotic rate in EC109 was obviously promoted when BJOE was added during radiotherap

关键词： Esophageal cancer Brucea javanica oil emulsion Radiosensitizer Apoptosis Cyclin D1-CDK4/6 axis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Taxonomic Distinctness of Macrofauna as an Ecological Indicator in Laizhou Bay and Adjacent Waters

引用

Journal of Ocean University of China 2010年第4期9卷 350-358页

作者： ZHOU hong hua Er zhang Zhinan College of Marine Life Sciences Ocean University of China Qingdao 266003 P. R. China

In this paper, we assessed the ecological and biodiversity status in the Bohai Sea through a quantitative survey on mac-rofaunal community at 25 stations in Laizhou Bay and adjacent waters in the autumn of *** tested the robustness and effectiveness of taxonomic distinctness as an ecological indictor by analyzing its correlation with species richness and natural environmental variables and by analyzing other ecological indicators (Shannon-Wiener H' and W statistics from Abundance Biomass Comparison curve).Results so obtained indicated that the benthic environment of the study waters in general is not under major impact of anthropogenic disturbance, but some stations in Laizhou Bay and along the coast of the Shandong Peninsula and even in the central Bohai Sea might be moderately disturbed and showed signs of ecological *** taxonomic distinctness measures △+ and Λ+ were independent of sampling effort and natural environment factors and were compliant to other ecological *** application of the taxonomic distinctness indicator to assess marine biodiversity and ecosystem health on a larger regional scale with historical data seems promising.

关键词： Taxonomic distinctness macrofauna ecological indicator biodiversity Laizhou Bay Bohai Sea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spectrofluorimetric Determination of Magnesium (Ⅱ) with 7-(8-Hydroxy-3, 6-Disulfonaphthylazo)-8-Hydroxyquinoline-5-Sulfonic Acid

引用

Wuhan University Journal of Natural Sciences 2001年第4期6卷 831-835页

作者： zhang Xian, Wang hong, zhang hua shan College of Chemisitry and Molecular Science, Wuhan University, Wuhan 430072, China College of Chemistry and Molecular Science Wuhan University Wuhan China

A new fluorescent reagent, 7 (8 hydroxy 3, 6 disulfonaphthylazo) 8 hydroxyquinoline 5 sulfonic acid (HDNHQ) for the determination of magnesium has been developed. It reacted with magnesium to form a 1∶1 fluorescent complex with λ ex / λ em =356/495 nm immediately at room temperature in ammonia ammonium chloride buffer (pH 10.7). A linear relationship was obtained in the magnesium concentration range of 0 160 ng·mL -1 with the detection limit of 0.04 ng·mL -1 . The proposed method was simple, rapid and sensitive. It has been successfully applied to the determination of trace magnesium in blood serum with recoveries of 103.75% and 98.16%, respectively.

关键词： Hydroxy 3 6 disulfonaphthylazo) 8 hydroxyquinoline 5 sulfonic acid magnesium spectrofluorimetry blood serum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk Assessment of Nitrogen Discharge from a Coastal Watershed

引用

Pedosphere 2007年第4期17卷 467-474页

作者： CHEN Neng-Wang hong hua-Sheng zhang Luo-Ping CAO Wen-Zhi State Key Laboratory of Marine Environmental Science Environmental Science Research Center Xiamen University Xiamen 361005 （China）.

Probabilistic risk assessment （PRA） uses probability theory to quantify the probability of occurrence of an event. In this study, PRA was conducted for the discharge of excess nitrogen （N） from an agricultural （Jiulong River） watershed in Southeast China. Using fault tree analysis, a type of PRA, the probability of occurrence of excess N discharge into the river during a runoff event was evaluated both qualitatively and quantitatively. Land use maps, soil maps, fertilizer use records, and expert opinions were used to determine probabilities of individual events within the fault tree and to calculate the overall probability of excess N discharge during a runoff event. Qualitative analysis showed that the risk of excess N discharge was mainly related to crop and livestock practices in the watershed. Proper management of tillage, fertilizer, and manure was necessary to control N releases. Quantitative assessment results indicated that alternative practices including reduction of fertilization, installation of vegetative strip buffer around the pig farms, and installation of more riparian buffers along the Jiulong River could reduce the likelihood of N discharge through runoff.

关键词： N discharge probabilistic risk assessment runoff watershed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism of local solidification time variations with melt rate during vacuum arc remelting process of 8Cr4Mo4V high-strength steel

引用

Journal of Iron and Steel Research International 2024年第2期31卷 377-388页

作者： Tao Pan hong-chun Zhu Zhou-hua Jiang hua-bing Li Rui zhang Hao Feng School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

A 2D axisymmetric numerical model was established to investigate the variations of molten pool with different melt rates during the vacuum arc remelting of 8Cr4Mo4V high-strength steel,and the ingot growth was simulated by dynamic mesh *** results show that as the ingot grows,the molten pool profile changes from shallow and flat to V-shaped,and both the molten pool depth and the mushy width ***,the variation of both the molten pool shape and the mushy width melt rate is clarified by the thermal equilibrium *** melt rate increases,both the molten pool depth and the mushy width *** is caused by the increment in sensible heat stored in the ingot due to the limitation of the cooling capacity of the *** nonlinear increment in sensible heat leads to a nonlinear increase in the mushy *** addition,as melt rate increases,the local solidification time(LST)of ingot decreases obviously at first and then *** melt rate is controlled in a suitable range,LST is the lowest and the secondary dendrite arm spacing of the ingot is the smallest,which can effectively improve the compactness degree of 8Cr4Mo4V high-strength steel.

关键词： 8Cr4Mo4V high-strength steel Vacuum arc remelting process Melt rate Molten pool Local solidification time

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimized cardiac resynchronization therapy in patients with congestive heart failure

引用

Chinese Medical Journal 2007年第7期120卷 605-607页

作者： NIU hong-xia hua Wei zhang Shu SUN Xin CHEN Ke-ping WANG Fang-zheng CHEN Xin Center of Arrhythmia Diagnosis and Treatment Fuwai Hospital and Cardiovascular Institute Chinese Academy and Medical Sciences ＆ Peking Union Medical College Beijing 100037 China

Heart failure was a major and increasing public health problem, with an almost ＂epidemic＂ increase in the number of patients. Despite recent advances in pharmacotherapy, the prognosis remains poor. Cardiac resynchronization therapy （CRT）, by pacing right and left ventricles, has been proved to improve symptoms and reduce mortality for heart failure patients with cardiac dyssynchrony, However, 20% to 30% of patients did not respond to CRT. The good cardiac synchronicity before CRT and the remaining atrioventficular, inter- and intra-ventricular dyssynchrony after CRT may explain the non-response. New echocardiographic techniques, and in particular tissue Doppler imaging （TDI） analysis, has been proved to be a helpful tool in evaluating cardiac dyssynchrony, as well as in assessing the degree of cardiac resynchronization after biventricular device implantation. So, in this study, we optimized the pacing parameters to determine whether echo-guided optimizing of AV/VV delays would enhance the effect of CRT on cardiac function and synchronicity.

关键词： heart failure dysynchrony cardiac resynchronization therapy atrioventricular delay interventricular delay tissue Doppler imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

引用

World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-hua zhang Zhi-hua Xu Shuang-Shuang Ni hong-Xia Luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrodynamic Characteristics of Undular Tidal Bores in the Qiantang River Based on Field Observations

引用

China Ocean Engineering 2024年第3期38卷 505-518页

作者： zhang Shu-yu PAN Cun-hong zhang Shen-yang LI Ruo-hua CHENG Wenlong XIE Dong-feng Zhejiang Tongji Vocational College of Science and Technology Hangzhou 311231China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310020China

Understanding the undular tidal bores in the Qiantang River is essential for effective river management and *** breaking tidal bores have been studied extensively, reports on undular tidal bores in the Qiantang Riverremain limited. Furthermore, observed data on undular tidal bores fulfilling the requirements of short measurementtime intervals, and spring, medium, and neap tide coverage, and providing detailed data for the global vertical stratificationof flow velocity are quite limited. Based on field observations at Qige in the Qiantang estuary, we analyzedthe characteristics of undular tidal bores. The results showed that the flooding amplitude (a) of the first wave isalways larger than its ebbing amplitude (b). Moreover, the vertical distribution of the maximum flood velocity exhibitesthree shapes, influenced by the tidal range, while that of the maximum ebb velocity exhibites a single shape. Duringthe initial phase of the flood tide in the spring and medium tides, the upper water body experiences multiple oscillatingchanges along the flow direction, corresponding to the alternating process of the crest and trough of the tide levelupon the arrival of the tidal bore. The tidal range is a crucial parameter in tidal bore hydrodynamics. By establishingthe relationship between hydrodynamic parameters and tidal range, other hydrodynamic parameters, such as the tidalbore height, maximum flood depth–averaged velocity, maximum flood stratified velocity at the measurement points,and duration of the flood tide current, can be effectively predicted, thereby providing an important reference for rivermanagement and maintenance.

关键词： tidal bores Qiantang Estuary tidal bore height tidal bore velocity propagation speed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On the Pathwise Uniqueness of Solutions of One-dimensional Reflected Stochastic Differential Equations with Jumps

引用

Acta Mathematicae Applicatae Sinica 2024年第1期40卷 149-163页

作者： hua zhang School of Statistics and Data Science&Key Laboratory of Data Science in Finance and Economics Jiangxi University of Finance and EconomicsNanchang330013China

In this paper, we are concerned with the problem of the pathwise uniqueness of one-dimensional reflected stochastic differential equations with jumps under the assumption of non-Lipschitz continuous coefficients whose... 详细信息

关键词： reflected diffusion processes with jumps pathwise uniqueness local time Meyer It?'s formula

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strong light–matter interactions based on excitons and the abnormal all-dielectric anapole mode with both large field enhancement and low loss

引用

Photonics Research 2024年第4期12卷 854-864页

作者： YAN-HUI DENG YU-WEI LU HOU-JIAO zhang Zhong-hong SHI zhang-KAI ZHOU XUE-hua WANG State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Quantum Science Center of Guangdong–hong Kong–Macao Greater Bay Area(Guangdong) Shenzhen 518045China

The room temperature strong coupling between the photonic modes of micro/nanocavities and quantum emitters(QEs) can bring about promising advantages for fundamental and applied *** the electric fields(EFs) by using plasmonic modes and reducing their losses by applying dielectric nanocavities are widely employed approaches to achieve room temperature strong ***,ideal photonic modes with both large EFs and low loss have been ***,we propose the abnormal anapole mode (AAM),showing both a strong EF enhancement of~70-fold (comparable to plasmonic modes) and a low loss of 34 meV,which is much smaller than previous records of isolated all-dielectric *** realizing strong coupling,we further show that by replacing the normal anapole mode with the AAM,the lasing threshold of the AAM-coupled QEs can be reduced by one order of magnitude,implying a vital step toward on-chip integration of nanophotonic devices.

关键词： dielectric mode coupling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：