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Chinese Journal of Structural Chemistry 2007年第2期26卷 172-176页

作者： MO Wen-Yan HE hong-wu College of Chemistry Central China Normal University Wuhan 430079 China

The title compound, 3-[2-（4-fluoro-phenyl）-ethyl]-5-methyl-4-hydroxyl-4-methyl- 7-methylsulfanyl-3,4-dihydro-pyrido[4,3-d]pyrimidine-8-carbonitrile, has been prepared and detemined by single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 6.8754（8）, b = 10.2617（12）, c = 13.3491（16） A, α = 93.163（2）, β = 96.704（2）, γ = 102.421（2）°, V= 910.35（19）A^3, Z= 2, Mr= 370.44, Dc= 1.351 g/cm^3,μ = 0.203 mm^-1,F（000） = 388, the final R = 0.0573 and wR = 0.1497. X-ray analysis reveals that the pyridine and pyrimidine rings are almost coplanar.

关键词： pyrido[4,3-d]pyrimidine synthesis crystal structure biological activities

Changes in underflow solid fraction and yield stress in paste thickeners by circulation

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International Journal of Minerals,Metallurgy and Materials 2021年第3期28卷 349-357页

作者： hong Li Ai-xiang wu hong-Jiang Wang Hui Chen Liu-Hua Yang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Shandong Taikai Power Electronic Co. Ltd.Taian 271000China

The trouble-free and efficient operation of paste thickeners requires an optimal design and the cooperation of each *** underflow discharging is suspended,alleviating the vast torque that the remaining solids within the thickeners may place on rakes mainly lies in the circulation *** mechanism of this unit was analyzed,and a mathematical model was developed to describe the changes in underflow solid content and yield *** key parameters of the circulation unit,namely,the height and flow rate,were varied to test its performance in the experiments with a self-designed laboratorial thickening *** show that the circulation unit is valid in reducing underflow solid fraction and yield stress to a reasonable extent,and the model could be used to describe its efficiency at different heights and flow rates.A suitable design and application of the circulation unit contributes to a cost-effective operation of paste thickeners.

关键词： paste thickener circulation unit solids content yield stress rake failure

An extended Galerkin analysis for elliptic problems

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Science China Mathematics 2021年第9期64卷 2141-2158页

作者： Qingguo hong Shuonan wu Jinchao Xu Department of Mathematics Pennsylvania State UniversityUniversity ParkPA16802USA School of Mathematical Sciences Peking UniversityBeijing100871China

A general analysis framework is presented in this paper for many different types of finite element methods(including various discontinuous Galerkin methods).For the second-order elliptic equation-div(α▽u)=f,this framework employs four different discretization variables,u_(h),p_(h),u_(h)and p_(h),where u_(h)and p_(h)are for approximation of u and p=-α▽u inside each element,and u_(h)and p_(h)are for approximation of the residual of u and p·n on the boundary of each *** resulting 4-field discretization is proved to satisfy two types of inf-sup conditions that are uniform with respect to all discretization and penalization *** a result,many existing finite element and discontinuous Galerkin methods can be analyzed using this general framework by making appropriate choices of discretization spaces and penalization parameters.

关键词： finite element method extended Galerkin analysis unified study

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu wu Zhongjie Zhu hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

Structure and function of neuropeptide F in insects

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Journal of Integrative Agriculture 2020年第6期19卷 1429-1438页

作者： CUI hong-ying ZHAO Zhang-wu Department of Entomology/MOA Key Lab of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193P.R.China

In sect n europeptides are a group of brain n euro-regulatory factors,which plays very important roles in growth and developme nt,molting and metamorphosis,as well as mating and *** neuropeptide F(NPF),a multi-functional neuropeptide,is one of neuropeptides identified in numerous insect species,which plays important roles in feeding,metabolism,courtship,reproduction,aggression,ethanol sensitivity,locomotor circadian rhythms,learning and stress *** roles of NPF are implemented through NPF receptors(NPFR).The NPFR1,a G protein-coupled receptor with 7 transmembrane domai ns,is one of these receptors and is found to be imports nt for NPF *** NPF usually is con sisted of around 36-40 amino acid residues,but the short neuropeptide F(sNPF)consisted of 7-16 amino acid residues have also been found in some *** this review,the structure and function of both NPF and sNPF in in sects are discussed.

关键词： neuropeptide NPF sNPF NPFR1 insects

Searching for critical slip surfaces of slopes using stress fields by numerical manifold method

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1313-1325页

作者： Yongtao Yang Wenan wu hong Zheng State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing100124China

This study first reviews the numerical manifold method(NMM)which possesses some advantages over the traditional limit equilibrium methods(LEMs)in calculating the factors of safety(Fs)of the ***,with regard to a trial slip surface(TSS),associated stress fields reproduced by NMM as well as the enhanced limit equilibrium method are combined to compute *** order to search for the potential critical slip surface(CSS),the MAX-MIN ant colony optimization algorithm(MMACOA),one of the best performing algorithms for some optimization problems,is *** to obtain Fs in conjunction with the potential CSS are ***,the proposed numerical model and traditional methods are compared with stability analysis of three typical *** numerical results show that Fs and CSSs of the slopes can be accurately calculated with the proposed model.

关键词： Enhanced limit method Ant colony algorithm Numerical manifold method(NMM) Slope stability

Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： Feng He Sitong Chen Ruili Zhou Hanyu Diao Yangyang Han Xiaodong wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

Shaking table test for reinforcement of soil slope with multiple sliding surfaces by reinforced double-row anti-slide piles

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Journal of Mountain Science 2022年第5期19卷 1419-1436页

作者： wu hong-gang PAI Li-fang Northwest Research Institute Co. Ltd of China Railway Engineering CorporationLanzhou 730000China China Academy of Railway Sciences Beijing 100081China

Despite the continuous advancements of engineering construction in high-intensity areas,many engineering landslides are still manufactured with huge thrust force,and double-row piles are effective to control such large *** this study,large shaking table test were performed to test and obtain multi-attribute seismic data such as feature image,acceleration,and dynamic soil *** the feature image processing analysis,the deformation characteristics for the slope reinforced by double-row piles were *** analyzing the acceleration and the dynamic soil pressure time domain,the spatial dynamic response characteristics were *** Fast Fourier Transform and half-power bandwidth,the damping ratio of acceleration and dynamic soil pressure was *** that,the Seism Signal was used to calculate the spectral displacement of the accelerations to obtain the regional differences of spectral *** results showed that the overall deformation mechanism of the slope originates from tension failure in the soil *** platform at the back of the slope was caused by seismic subsidence,and the peak acceleration ratio was positively correlated with the relative pile *** dynamic soil pressure of the front row piles showed an inverted"K"-shaped distribution,but that of the back row piles showed an"S"-shaped *** predominant frequency of acceleration was 2.16 Hz,and the main frequency band was 0.7-6.87 Hz;for dynamic soil pressure,the two parameters became 1.15 Hz and 0.5-6.59 Hz,*** conclusion,dynamic soil pressure was more sensitive to dampening effects than ***,compared to acceleration,dynamic soil pressure exhibited larger loss factors and lower resonance ***,back row pile heads were highly sensitive to spectral displacement compared to front row pile *** findings may be of reference value for future seismic designs of double-row piles.

关键词： Double row anti-slide piles multislide surface landslide Shaking table test Acceleration Dynamic soil pressure Dynamic response characteristic

An advanced higher-order theory for laminated composite plates with general lamination angles

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Acta Mechanica Sinica 2011年第5期27卷 720-729页

作者： Zhen wu hong Zhu Wan-Ji Chen Key Laboratory of Liaoning Province forComposite Structural Analysis of Aerocraft and Simulation Shenyang Aerospace University 110136 Shenyang China

This paper proposes a higher-order shear deformation theory to predict the bending response of the laminated composite and sandwich plates with general lamination *** proposed theory a priori satisfies the continuity conditions of transverse shear stresses at ***,the number of unknown variables is independent of the number of *** first derivatives of transverse displacements have been taken out from the inplane displacement fields,so that the C 0 shape functions are only required during its finite element *** to C 0 continuity requirements,the proposed model can be conveniently extended for implementation in commercial finite element *** verify the proposed theory,the fournode C 0 quadrilateral element is employed for the interpolation of all the displacement parameters defined at each nodal point on the composite *** results show that following the proposed theory,simple C 0 finite elements could accurately predict the interlaminar stresses of laminated composite and sandwich plates directly from a constitutive equation,which has caused difficulty for the other global higher order theories.

关键词： Laminated and sandwich composites Higherorder theory C 0 continuity requirement Transverse shear stress