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Moxibustion at ST36 activates peritoneal macrophages in CTX-induced immunosuppression in mouse model via IFN-γ

Traditional Medicine Research 2024年第1期9卷 57-68页

作者： Li Tan Jing Li Nan Cao Zhi-Yu Ye Bin-Yan Mo hong-da chen Jiang Pan Ning Wang Department of Traditional Chinese Medicine Shenzhen Longhua District Central HospitalShenzhen 518110China Department of Acupuncture and moxibustion Massage Rehabilitation The First Hospital of Hunan University of Chinese MedicineChangsha 410021China Department of Traditional Chinese Medicine The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China

Background:To explored whether moxa cone moxibustion can reduce peritoneal inflammation by increasing the content of peritoneal macrophages and B cells via ***:The mice were randomly divided into three groups with six mice in each group:the control group,model group,and moxibustion group,and the model was established in mice using *** the moxibustion group,the mice received moxa cone moxibustion at Zusanli(ST36)for 7 *** of Peritoneal cell were detected by flow cytometry and immunofluorescence,the protein expression level in the peritoneal fluid were measured with mouse cytokine antibody arrays and verified by enzyme linked immuno sorbent assay test,and RNA-Sequencing was used for peritoneal cell RNA ***:Our results showed that moxa cone moxibustion could reduce the loss of large peritoneal macrophages and B1 cells(P<0.05).With the cytokine array analysis and enzyme linked immuno sorbent assay test of peritoneal fluid,we found that IFN‐γwas up-regulated in moxibustion group(P<0.05).There were 169 genes were down-regulated in the model group and up-regulated in the moxibustion group while 19 genes that were up-regulated in the model group and down-regulated in the moxibustion group via *** Encyclopedia of Genes and Genomes pathway analysis of 188 intersect differentially expressed genes were found that the top 3 pathways with the highest enrichment of up-regulated genes included Hematopoietic cell lineage,Inflammatory bowel disease and *** differentially expressed genes visualization protein-protein interaction network shows the top 10 genes including Ifng,Grb2,CCR7,CTLA4,CXCR5,Foxp3,kit,PRF1,CD5 and ***:These findings showed that moxa cone moxibustion can alleviate chemotherapy-induced diarrhea by reducing the loss of large peritoneal macrophages and B1 cells in the peritoneal cavity,possibly through up-regulating inflammatory bowel disease signaling pathway via interfe

关键词： moxibustion IFN-γ cyclophosphamide Zusanli(ST36)

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The effects of BCGs on the statistics of large-separation lensed quasars by clusters

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Research in Astronomy and Astrophysics 2011年第9期11卷 1003-1018页

作者： hong Qi da-Ming chen National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

We study the statistics of large-separation multiply-imaged quasars lensed by clusters of galaxies. In particular, we examine how the observed brightest cluster galaxies （BCGs） affect the predicted numbers of wide-separation lenses. We model the lens as an NFW-profiled dark matter halo with a truncated singular isothermal sphere to represent the BCG in its center. We mainly make predictions for the Sloan Digital Sky Survey Quasar Lens Search （SQLS） sample from the data Release 5 （DRS） in two standard ACDM cosmological models： a model with matter density ΩM = 0.3 and δ8 = 0.9, as is usually adopted in the literature （ACDM1）, and a model suggested by the WMAP seven-year （WMAPT） data with ΩM = 0.266 and δ8 = 0.801. We also study the lensing properties for the WMAP3 cosmology in order to compare with the previous work. We find that BCGs in the centers of clusters significantly enhance the lensing efficiency by a factor of 2 - 3 compared with that of NFW-profiled pure dark matter halos. In addition, the dependence of mass ratios of BCGs to their host halos on the host halo masses reduces the lensing rate by - 20% from assuming a constant ratio as in previous studies, but considering the evolution of this ratio with redshift out to z - 1 would reduce it by - 3%. Moreover, we predict that the numbers of lensed quasars with image separations larger than 10″ in the statistical sample of SQLS from DR5 are 1.22 and 0.47, respectively for ACDM1 and WMAP7 and 0.73 and 0.33 for separations between 10″ and 20″, which are consistent with the only observed cluster lens with such a large separation in the complete SQLS sample.

关键词： cosmological parameters -- cosmology: theory -- galaxies: clusters -- gravitational lensing -- dark matter

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Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020

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Chinese Medical Journal 2021年第7期134卷 783-791页

作者： Wei Cao hong-da chen Yi-Wen Yu Ni Li Wan-Qing chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China.

Background:Cancer is one of the leading causes of death globally,but its burden is not *** 2020 has newly updated the estimates of cancer *** study summarizes the most recent changing profiles of cancer burden worldwide and in China and compares the cancer data of China with those of other ***:We conducted a descriptive secondary analysis of the GLOBOCAN 2020 *** depict the changing global profile of the leading cancer types in 2020 compared with 2018,we extracted the numbers of cases and deaths in 2018 from GLOBOCAN *** also obtained cancer incidence and mortality from the 2015 National Cancer Registry Report in China when sorting the leading cancer types by new cases and *** the leading cancer types according to sex in China,we summarized the estimated numbers of incidence and mortality,and calculated China’s percentage of the global new cases and ***:Breast cancer displaced lung cancer to become the most leading diagnosed cancer worldwide in ***,liver,stomach,breast,and colon cancers were the top five leading causes of cancer-related death,among which liver cancer changed from the third-highest cancer mortality in 2018 to the second-highest in *** accounted for 24%of newly diagnosed cases and 30%of the cancer-related deaths worldwide in *** the 185 countries included in the database,China’s age-standardized incidence rate(204.8 per 100,000)ranked 65th and the age-standardized mortality rate(129.4 per 100,000)ranked *** two rates were above the global *** cancer remained the most common cancer type and the leading cause of cancer death in ***,breast cancer became the most frequent cancer type among women if the incidence was stratified by *** of colorectal cancer and breast cancer increased *** leading causes of cancer death varied minimally in ranking from 2015 to 2020 in *** cancers,including stomach,colorectal,liver,and es

关键词： Cancer incidence Cancer mortality Changing profile China GLOBOCAN 2020 Worldwide

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Single fundamental mode photonic crystal VCSEL with high power and low threshold current optimized by modal loss analysis

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Chinese Physics B 2017年第1期26卷 200-207页

作者： Yi-Yang Xie Qiang Kan chen Xu Kun Xu hong-da chen Key Laboratory of Optoelectronics Technology (Ministry of Education) Beijing University of Technology Beijing 100124 China State Key Laboratory of Integrated Optoelectronics Institute of Semiconductor Chinese Academy of Sciences Beijing 100083 China Zhengzhou University of Aeronautics Zhengzhou 450046 China

The characteristics of the photonic crystal vertical cavity surface emitting lasers（PhC-VCSELs） were investigated by using the full vector finite-difference time-domain（FDTD） method through the transverse mode loss analysis. PhC-VCSELs with different photonic crystal structures were analyzed theoretically and experimentally. Through combining the dual mode confinement of oxide aperture and seven-point-defect photonic crystal structure, the PhC-VCSELs with low threshold current of 0.9 mA and maximum output power of 3.1 mW operating in single fundamental mode were demonstrated. Mode loss analysis method was proven as a reliable and useful way to analyze and optimize the PhC-VCSELs.

关键词： vertical cavity surface emitting lasers single fundamental mode mode loss

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Divergent detection rates of fecal immunochemical test and questionnaire-based risk assessment for detecting proximal and distal advanced colorectal adenomas

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Chinese Medical Journal 2021年第5期134卷 605-607页

作者： hong-da chen Ming Lu Yu-Han Zhang Min dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

To the Editor:Fecal immunochemical tests(FTTs)are immunoassays that are designed to detect human hemoglobin to indicate the occurrence of colonic neopla-sia,which have been widely used in global colorectal cancer(CRC)screening *** diagnostic studies demonstrated that strong gradient in site-specific sensitivity existed with typically higher rate for advanced adenoma located in distal colon/rectum than that in the proximal parts,which may be explained by the colonic transition time affecting the degradation of hemoglobin,and the shape of adenoma(pedunculated,flat,and sessile)in different anatomic regions.

关键词： adenoma colorectal proximal

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Colorectal cancer incidence and mortality:the current status,temporal trends and their attributable risk factors in 60 countries in 2000–2019

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Chinese Medical Journal 2021年第16期134卷 1941-1951页

作者： Bin Lu Na Li chen-Yu Luo Jie Cai Ming Lu Yu-Han Zhang hong-da chen Min dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cancer Prevention Hunan Cancer HospitalChangshaHunan 410006China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China.

Background:Globally,colorectal cancer(CRC)imposes a substantial burden on healthcare systems and confers considerable medical *** aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of ***:We used data from the GLOBOCAN database to estimate CRC incidence and mortality worldwide in 2020 and their association with the human development index(HDI).Trends of age-standardized rates of incidence and mortality in 60 countries(2000–2019)were evaluated by Joinpoint regression analysis using data of Global Burden of Disease *** association between exposure to country-level lifestyle,metabolic and socioeconomic factors obtained from the World Health Organization Global Health Observatory and World Bank dataBank data and CRC incidence and mortality was determined by multivariable linear ***:CRC incidence and mortality varied greatly in the 60 selected countries,and much higher incidence and mortality were observed in countries with higher HDIs,and vice *** 2000 to 2019,significant increases of incidence and mortality were observed for 33 countries(average annual percent changes[AAPCs],0.24–3.82)and 18 countries(AAPCs,0.41–2.22),respectively.A stronger increase in incidence was observed among males(AAPCs,0.36–4.54)and individuals<50 years(AAPCs,0.56–3.86).Notably,15 countries showed significant decreases in both incidence(AAPCs,0.24 to2.19)and mortality(AAPCs,0.84 to2.74).A significant increase of incidence among individuals<50 years was observed in 30 countries(AAPCs,0.28–3.62).Countries with higher incidence were more likely to have a higher prevalence of alcohol drinking,higher level of cholesterol level,higher level of unemployment,and a poorer healthcare ***:Some high-HDI countries showed decreasing trends in CRC incidence and mortality,whereas developing countries that previously had low disease burden showed significantly increas

关键词： Colorectal cancer burden Trend Incidence Mortality Risk factor GLOBOCAN Global Burden of Disease

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Head-to-head comparison of the test performance of selfadministered qualitative vs. laboratory-based quantitative fecal immunochemical tests in detecting colorectal neoplasm

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Chinese Medical Journal 2021年第11期134卷 1335-1344页

作者： Ming Lu Yu-Han Zhang Bin Lu Jie Cai cheng-cheng Liu hong-da chen Min dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Background:Fecal immunochemical tests(FITs)are the most widely used non-invasive tests in colorectal cancer(CRC)***,evidence about the direct comparison of the test performance of the self-administered qualitative a laboratory-based quantitative FITs in a CRC screening setting is ***:Based on a CRC screening trial(TARGET-C),we included 3144 pre-colonoscopy fecal samples,including 24 CRCs,230 advanced adenomas,622 non-advanced adenomas,and 2268 participants without significant findings at *** selfadministered qualitative FITs(Pupu tube)with positivity thresholds of 8.0,14.4,or 20.8 mg hemoglobin(Hb)/g preset by the manufacturer and one laboratory-based quantitative FIT(OC-Sensor)with a positivity threshold of 20 mg Hb/g recommended by the manufacturer were tested by trained staff in the central *** diagnostic performance of the FITs for detecting colorectal neoplasms was compared in the different scenarios using the preset and adjusted thresholds(for the quantitative FIT).Results:At the thresholds preset by the manufacturers,apart from the qualitative FIT-3,significantly higher sensitivities for detecting advanced adenoma were observed for the qualitative FIT-1(33.9%[95%CI:28.7–39.4%])and qualitative FIT-2(22.2%[95%CI:17.7–27.2%])compared to the quantitative FIT(11.7%[95%CI:8.4–15.8%]),while at a cost of significantly lower ***,such difference was not observed for detecting *** scenarios of adjusting the positivity thresholds of the quantitative FIT to yield comparable specificity or comparable positivity rate to the three qualitative FITs accordingly,there were no significant differences in terms of sensitivity,specificity,positive/negative predictive values and positive/negative likelihood ratios for detecting CRC or advanced adenoma between the two types of FITs,which was further evidenced in ROC ***:Although the self-administered qualitative and the laboratory-based quantitat

关键词： Fecal immunochemical test Test performance Colorectal neoplasm Screening

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Risk factors for gastric cancer:a large-scale,population-based case-control study

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Chinese Medical Journal 2021年第16期134卷 1952-1958页

作者： Rui Zhang He Li Ni Li Ju-Fang Shi Jiang Li hong-da chen Yi-Wen Yu Chao Qin Jian-Song Ren Wan-Qing chen Jie He Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and ImplementBeijing 100021China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China.

Background:Early detection of gastric cancer(GC)has been the topic of major efforts in *** study aimed to explore the risk factors associated with GC and to provide evidence for the selection of a high-risk population of ***:Based on the cancer screening cohort of the National Cancer Screening Program in Urban China,GC patients diagnosed by endoscopy and pathological examinations constituted the case group,and controls were 1:3 matched by sex and age(±5 years)*** variables were selected by univariable analysis of factors such as body mass index(BMI),dietary habits,lifestyle,stomach disease history,and family history of GC;and multivariable logistic regression was used to analyze the influencing factors of GC and to calculate the odds ratio(OR)of related factors and its 95%confidence interval(CI).Results:A total of 215 GC cases and 645 matched healthy controls were included in the final analysis,with a median age of 61 years for the case and control *** analysis showed that high educational level(above primary school)(OR=0.362,95%CI=0.219–0.599,P<0.001),overweight/obesity(BMI≥24 kg/m2;OR=0.489,95%CI=0.329–0.726,P<0.001),cigarette smoking(OR=3.069,95%CI=1.700–5.540,P<0.001),alcohol consumption(OR=1.661,95%CI=1.028–2.683,P=0.038),history of stomach disease(OR=6.917,95%CI=4.594–10.416,P<0.001),and family history of GC in first-degree relatives(OR=4.291,95%CI=1.661–11.084,P=0.003)were significantly correlated with the occurrence of *** analyses by age and gender indicated that GC risk was still increased in the presence of a history of stomach disease.A history of chronic gastritis,gastric ulcer,or gastric polyposis was positively associated with GC,with adjusted ORs of 4.155(95%CI=2.711–6.368),1.839(95%CI=1.028–3.288),and 2.752(95%CI=1.197–6.326).Conclusions:Subjects who smoke,drink,with history of stomach disease and family history of GC in first-degree relatives are the high-risk populations for ***,attention shou

关键词： Risk factors Gastric cancer Case-control study Cancer screening

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Regulating ion transport behaviors toward dendrite-free potassium metal batteries:recent advances and perspectives

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Rare Metals 2024年第4期43卷 1435-1460页

作者： Lu-Kang Zhao Xuan-Wen Gao Tian-Zhen Ren da Wang da-Wei Wang Zhao-Meng Liu hong chen Wen-Bin Luo School of Metallurgy Northeastern UniversityShenyang110819China School of Chemical Engineering The University of New South WalesSydneyNSW2052Australia

With abundant potassium resources and high capacity,potassium metal batteries(PMBs)present a compelling option for the next generation of energy storage ***,PMBs suffer from an unstable anode interface caused by uncontrolled dendrite growth,which results in unsatisfactory cyclability and safety *** investigations suggest that significant progress has been made in enhancing the interfacial stability of *** various effective strategies for stabilizing interfaces can ultimately be attributed to the regulation of the sluggish ion transfer kinetics and irregular deposition,i.e.,the arrangement of ion transport behaviors at the *** modulation of ions transport rate and ions deposition directions makes it possible to obtain a dendrite-free and smooth deposition ***,the influencing factors and action mechanism of K^(+)interface transport behaviors are discussed to understand the nature of material design for constructing stable anode interfaces,including regulating the solvation and desolvation structures,accelerating K^(+)transport kinetics and controlling K^(+)deposition *** addition,the deficiencies and prospects of the research on electrolyte,separators and designed electrode involved in the manufacturing and testing and ion transport process of PMBs are *** review is expected to provide some possible directions for constructing dendrite-free interfaces in advanced PMBs-related research and offer significant insights for prospective experimental research and commercial applications.

关键词： Ion transport rate Ion transport direction Interface Potassium metal batteries Dendrites growth

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Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441

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Research 2024年第1期2023卷 181-197页

作者： Wen-Juan Lin Wen-Pu Shi Wan-Yi Ge Liang-Liang chen Wei-hong Guo Peng Shang da-Chuan Yin Key Laboratory for Space Bioscience and Biotechnology School of Life SciencesNorthwestern Polytechnical University127 Youyixi RoadXi'an 710072ShaanxiPR China

The biological effects of magnetic fields(MFs)have been a controversial ***,in recent years,there has been increasing evidence that MFs do affect biological ***,the physical mechanism remains ***,we show that MFs(16 T)reduce apoptosis in cell lines by inhibiting liquid–liquid phase separation(LLPS)of Tau-441,suggesting that the MF effect on LLPS may be one of the mechanisms for understanding the“mysterious”magnetobiological *** LLPS of Tau-441 occurred in the cytoplasm after induction with *** phase-separated droplets of Tau-441 recruited hexokinase(HK),resulting in a decrease in the amount of free HK in the *** cells,HK and Bax compete to bind to the voltage-dependent anion channel(VdaC I)on the mitochondrial membrane.A decrease in the number of free HK molecules increased the chance of Bax binding to VdaC I,leading to increased Bax-mediated *** the presence of a static MF,LLPS was marked inhibited and HK recruitment was reduced,resulting in an increased probability of HK binding to VdaC I and a decreased probability of Bax binding to VdaC I,thus reducing Bax-mediated *** findings revealed a new physical mechanism for understanding magnetobiological effects from the perspective of *** addition,these results show the potential applications of physical environments,such as MFs in this study,in the treatment of LLPS-related diseases.

关键词： inhibited Apoptosis finding

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