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High molecular weight guar gum assisted settling of fine solids in diluted bitumen:Effect of solvents

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Petroleum Science 2021年第6期18卷 1877-1886页

作者： Camila Santander Jing Liu Xiao-Li Tan Qi Liu hong-bo zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada

As water-based extraction technologies for producing bitumen from oil sands have received increasing environmental concerns,developing non-aqueous extraction(NAE)technique is of both fundamental and practical ***,the relatively high concentration of fine solids trapped in the extracted bitumen presents an obstacle for pipeline transport as well as upgrading and refining *** research attempts to provide a solution to fine solids removal without using synthetic additives or affecting bitumen recovery from NAE ***,naturally hydrophilic additives(i.e.,water and high molecular weight guar gum(HGG)produced from Cyamopsiste tragonolobuosr ***.)were introduced to promote the settling of fine solids suspended in bitumen-solvent solution,and the effects of solvents(i.e.,toluene,cyclohexane and their mixtures)were systematically *** size distribution analyzed by the focused beam reflectance measurements confirmed that the addition of water and HGG could promote the agglomeration and settling of fine solids in all solvents ***,the size range and quantity of the agglomerates vary significantly with the solvent's aromatic *** mixtures demonstrate a superior performance on removing fine solids from bitumen over single ***,in a 3:2 toluene/cyclohexane mixture,the solid content was lowered from 0.66 wt%to 0.09 wt%.

关键词： Non-aquoues extraction Fine solids Guar gum Agglomeration Settling

Optimization of flow uniformity control device for six-stream continuous casting tundish

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Journal of Iron and Steel Research International 2020年第9期27卷 1035-1044页

作者： Xin-gang Ai Dong Han Sheng-li Li hong-bo zeng Hui-ya Li Key Laboratory of Chemical Metallurgy Engineering Liaoning Province University of Science and Technology LiaoningAnshan 114051LiaoningChina

For a multistream tundish,the uniformity among the streams plays a significant role in the quality of molten *** to analyze the uniformity quantitatively and optimize structures of a multistream tundish is an important research content for a multistream tundish.A new approach was proposed to quantify the uniformity among the *** a physical study and a numerical study were carried out to optimize the structure of the diversion hole based on the prototype of a six-stream tundish in a steel *** the basis of average residence time,the uniformity of each flow was considered fully and then the optimal structure of the diversion hole was obtained by means of the comprehensive analysis of temperature field and velocity *** results show that the optimum structural parameters adopted for diversion holes are height of 20 mm,angle of 15°and diameter of 80 mm.

关键词： Multistream tundish Uniformity Diversion hole Physical simulation Numerical simulation

Pre-heating temperature induced flowability and wax deposition characteristics of crude oil adding wax inhibitors

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Petroleum Science 2023年第4期20卷 2468-2478页

作者： bo Yao Hao-Ran Zhu Bao-Dong Yan Chuan-Xian Li Fei Yang Guang-Yu Sun hong-bo zeng College of Pipeline and Civil Engineering China University of PetroleumQingdaoShandong266580People's Republic of China Department of Chemical and Materials Engineering University of AlbertaEdmontonABT6G 1H9Canada School of Petroleum Engineering Changzhou UniversityChangzhouJiangsu213164People's Republic of China China Oil&Gas Pipeline Network Corporation Beijing100020China

This paper investigated the effects of pre-heating treatment temperatures(T_(pre))on the flowability and wax deposition characteristics of a typical waxy crude oil after adding wax *** is found that there is little difference in wax precipitation exothermic characteristics of crude oils at different T_(pre),as well as the wax crystal solubility coefficient in the temperature range of 25-30℃.For the undoped crude oil,the flowability after wax precipitation gets much improved and the wax deposition is alleviated as T_(pre)*** T_(pre)=50℃,the viscosity and wax deposition rate of crude oil adding wax inhibitors are higher than those of the undoped crude *** the T_(pre)increases to 60,70,and 80℃,the flowability of the doped crude oil are largely improved and the wax deposition is suppressed with the T_(pre)increase,but the wax content of wax deposit increases *** is speculated that,on the one hand,the T_(pre)increase helps the dispersion of asphaltenes into smaller sizes,which facilitates the co-crystallization with paraffin waxes and generates more aggregated wax crystal *** weakens the low-temperature gel structure and increases the solid concentration required for the crosslink to form the wax *** the other hand,the decrease in viscosity increases the diffusion rate of wax molecules and accelerates the aging of wax *** experimental results have important guiding significance for the pipeline transportation of doped crude oils.

关键词： Pre-heating treatment Wax inhibitor Flowability Wax deposition Waxy crude oil

Exploring the mechanisms of calcium carbonate deposition on various substrates with implications for effective anti-scaling material selection

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Petroleum Science 2024年第4期21卷 2870-2880页

作者： Lu Gong Fei-Yi Wu Ming-Fei Pan Jun Huang Hao Zhang Jing-Li Luo hong-bo zeng College of Science China University of PetroleumBeijing102249China Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of PetroleumBeijing102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of PetroleumBeijing102249China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada Key Laboratory of High Efficiency and Clean Mechanical Manufacture(Ministry of Education) School of Mechanical EngineeringShandong University

The unexpected scaling phenomena have resulted in significant damages to the oil and gas industries,leading to issues such as heat exchanger failures and pipeline *** is of practical and fundamental importance to understand the scaling mechanisms and develop efficient anti-scaling ***,the underlying surface interaction mechanisms of scalants(e.g.,calcite)with various substrates are still not fully *** this work,the colloidal probe atomic force microscopy(AFM)technique has been applied to directly quantify the surface forces between calcite particles and different metallic substrates,including carbon steel(CR1018),low alloy steel(4140),stainless steel(SS304)and tungsten carbide,under different water chemistries(i.e.,salinity and pH).Measured force profiles revealed that the attractive van der Waals(VDW)interaction contributed to the attachment of the calcium carbonate particles on substrate surfaces,while the repulsive electric double layer(EDL)interactions could inhibit the attachment *** salinity and acidic p H conditions of aqueous solutions could weaken the EDL repulsion and promote the attachment *** adhesion of calcite particles with CR1018 and4140 substrates was much stronger than that with SS304 and tungsten carbide *** bulk scaling tests in aqueous solutions from an industrial oil production process showed that much more severe scaling behaviors of calcite was detected on CR1018 and 4140 than those on SS304 and tungsten carbide,which agreed with surface force measurement ***,high salinity and acidic p H can significantly enhance the scaling *** work provides fundamental insights into the scaling mechanisms of calcite at the nanoscale with practical implications for the selection of suitable antiscaling materials in petroleum industries.

关键词： Scaling phenomenon Metallic substrates Surface forces Bulk scaling tests

原发性开角型青光眼视盘周围血管密度变化的研究

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国际眼科杂志 2019年第12期19卷 2036-2040页

作者：刘勇郭毅曾洪波中国湖北省洪湖市人民医院眼科

目的:比较原发性开角型青光眼患者(POAG)与正常人视盘周围血管密度(VD)的差异,并评价视盘周围VD在POAG中的诊断价值。方法:连续纳入2018-03/12期间在我院初诊的POAG患者60例。同时纳入60例年龄、性别匹配的正常志愿者作为对照。采用光... 详细信息

目的:比较原发性开角型青光眼患者(POAG)与正常人视盘周围血管密度(VD)的差异,并评价视盘周围VD在POAG中的诊断价值。方法:连续纳入2018-03/12期间在我院初诊的POAG患者60例。同时纳入60例年龄、性别匹配的正常志愿者作为对照。采用光相干断层扫描血流成像(OCTA)技术检测并比较POAG患者及正常人视盘周围VD。采用受试者工作特征曲线(ROC)及ROC曲线下面积(AUC)评价视盘周围VD诊断POAG的效能。结果:与正常人相比,POAG患者视盘周围平均VD降低(P<0.001)。POAG患者视盘周围上方、下方的VD分别为52.38%±5.31%以及52.58%±5.32%。而对照组分别为58.43%±4.11%以及58.36%±3.40%(P<0.001)。多元线性回归分析结果显示杯盘比以及POAG诊断与视盘周围平均VD呈独立相关。ROC及AUC分析结果提示视盘周围平均VD的AUC值为0.808(95%CI:0.730~0.887)。结论:POAG患者视盘周围VD明显变小,变小的视盘周围VD与POAG诊断存在显著相关性。视盘周围VD可作为其它常规诊断青光眼的补充手段。

关键词：原发性开角型青光眼视网膜神经纤维层厚度神经节细胞复合体

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特发性黄斑前膜手术前后脉络膜厚度分析

国际眼科杂志 2019年第4期19卷 667-670页

作者：曾洪波蒋珺迪王鲜中国贵州省毕节市第一人民医院眼科 551700 贵州医科大学附属医院眼科中国贵州省贵阳市550004

目的:研究特发性黄斑前膜手术前后膜脉络膜厚度的变化及视功能与脉络膜厚度的关系。方法:选取2016-01/2017-12于我院接受手术治疗的特发性黄斑前膜患者30例30眼进行临床研究,排除手术禁忌,采用25G玻璃体切割系统行标准三切口经睫状体平... 详细信息

目的:研究特发性黄斑前膜手术前后膜脉络膜厚度的变化及视功能与脉络膜厚度的关系。方法:选取2016-01/2017-12于我院接受手术治疗的特发性黄斑前膜患者30例30眼进行临床研究,排除手术禁忌,采用25G玻璃体切割系统行标准三切口经睫状体平坦部玻璃体切除术联合剥除黄斑前膜及内界膜,观察术前、术后1wk,1、3mo患者的BCVA、黄斑中心凹脉络膜厚度,分析BCVA与脉络膜厚度的相关性。结果:术前的BCVA显著低于术后3mo(P=0.011),术后3mo BCVA与术前BCVA显著相关(r=0.610,P<0.01),术前术后不同时间的脉络膜厚度无差异(P=0.999)。手术前后BCVA与手术前后脉络膜厚度无线性相关关系。结论:特发性黄斑前膜手术前后脉络膜厚度无明显变化,患者视功能与脉络膜厚度也无明显相关性。

关键词：黄斑前膜脉络膜厚度最佳矫正视力

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen bo zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

JAK2-STAT3基因多态性对真菌性角膜溃疡患者伏立康唑血药浓度的影响

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国际眼科杂志 2016年第12期16卷 2204-2208页

作者：彭璟李爽乐曾洪波邓应平四川大学华西医院眼科中国四川省成都市610041 中国四川省自贡市第一人民医院眼科 643000

目的:探讨蛋白酪氨酸激酶2/信号转导子与激活子3(Janus kinase signal transducers 2 and activator of transcription 3,JAK2/STAT3)基因多态性对真菌性角膜溃疡患者伏立康唑血药浓度的影响。方法:选取2012-03/2015-02间我院诊治的56... 详细信息

目的:探讨蛋白酪氨酸激酶2/信号转导子与激活子3(Janus kinase signal transducers 2 and activator of transcription 3,JAK2/STAT3)基因多态性对真菌性角膜溃疡患者伏立康唑血药浓度的影响。方法:选取2012-03/2015-02间我院诊治的56例56眼真菌性角膜溃疡患者为研究对象,采用高效液相色谱-荧光检测法测定每位患者伏立康唑的血药浓度,同时利用聚合酶链式反应-限制性片段长度多态性方法(PCRRFLP)分别进行JAK2/STAT3基因型分析。结果:将所有患者以中位标准化伏立康唑血药浓度为分界值,分为高血药浓度组(35例,62%)和低血药浓度组(21例,38%);高、低血药浓度组患者在男性比例、身高、体质量、千克体质量日剂量和不良反应发生情况方面的比较无显著统计学差别(P>0.05);高血药浓度组的中位谷浓度和中位标准化血药浓度都显著高于低血药浓度组(P<0.05);高血药浓度组患者伏立康唑的有效率也优于低血药浓度组(P<0.05);在JAK2-STAT3基因7个多态位点分型中,高血药浓度组患者JAK2 rs10119004位点GG和GA等位基因、STAT3 rs12948909位点TT等位基因与低血药浓度组比较,差异均有统计学意义(P<0.05)。结论:JAK2-STAT3基因多态性对伏立康唑血药浓度和临床疗效均有明显影响,提示药物遗传学研究对伏立康唑的临床合理用药有重要指导意义。

关键词：真菌性角膜溃疡伏立康唑 JAK2 STAT3

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang Xiao-Rui Pan Xin-Xing zeng Zheng-Zheng Li bo-Fan Chen Hai-Min zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism