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Mechanical Stress-evoked but AngiotensinⅡ-independent Activation of Angiotensin Ⅱ type 1 Receptor Induces Cardiac Hypertrophy through Calcineurin Pathway

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Mechanical Stress-evoked but AngiotensinⅡ-independent Activ...

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

第八届海峡两岸心血管科学研讨会

作者： Ning Zhou,Lei Li,Hui Gong,Man Wu,yu-hong niu, Ai-jun Sun,Jun-bo Ge,yun-zeng Zou~* (Institutes of Biomedical Science,Fudan University,Shanghai 200032,China)

Background Mechanical stress can induce cardiac hypertrophy through angiotensin Ⅱ (Ang Ⅱ ) type 1(AT1) receptor independently of Angll,however,the intracellular mechanisms remain largely indeterminate. Since calcineurin,a Ca-dependent phosphatase,plays a critical role in pressure overload - induced cardiac hypertrophy,we therefore,askedwhether calcineurin is involved in the AT1 receptor - mediated but Ang Ⅱ independent cardiac *** and Results Mechanical stretch failed to elicit hypertrophic responses in COS7 cells co - transfected with plasmid of AT1 receptor and siRNA of *** stresses for 2 weeks in vivo and for 24 h in vitro significantly induced upregulation of calcineurin expression and hypertrophic responses,such as the increases in cardiomyocytes size and specific gene expressions, in cardiomyocytes of angiotensinogen gene knockout(ATG - KO) mice,both of which were significantly suppressed by a specific calcineurin inhibitor FK506,suggesting a critical role of calcineurin in mechanical stress - induced cardiac hypertrophy in the ATG - KO ***,an AT1 receptor blocker,Losartan not only attenuated cardiac hypertrophy but also abrogated upregulation of cardiac calcineurin expression induced by mechanical stresses in the Angll - lacking mice,indicating that calcineurin expression is regulated by AT1 receptor without the involvement of Angll after mechanical *** These findings collectively suggest that mechanical stress - evoked but Angll - independent activation of AT1 receptor induces cardiac hypertrophy through calcineurin pathway.

关键词： angiotensin Ⅱ type 1 receptor Ca2+ -dependent phosphatase cardiac hypertrophy

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li yu Deng hongbin Wu Xiaojian Xu Fei niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Simulation and prediction of the thuringiensin degradation processes in aqueous by a radius basis artificial neural network based on pH and temperature

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Simulation and prediction of the thuringiensin degradation p...

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

第十届全国杀虫微生物学术研讨会暨全国生物农药与化学生物学研究与产业化会议

作者： Zhou Jing-Wen, Xu Zheng-hong, yu Zi-niu, Chen Shou-Wen State Key Laboratory of Agricultural Microbiology, Wuhan 430070, P. R. China Key Laboratory of Industrial Biotechnology, Ministry of Education, Wuxi 214036, P.R. China

In this research, the thuringiensin degradation processes in aqueous under different conditions, which the pH ranged from 5.0 to 9.0 while the temperature ranged from 10 ℃ to 40 ℃, were systematically investigated. The half-lives of thuringiensin were calculated by an exponential decay model, and the half-lives were ranged from 2.72 to 16.19 d in the conditions investigated. This indicated that thuringiensin was an easily degradable antibiotic. In this study, an artificial neural network (ANN) was employed to further describe the degradation processes. The radius basis neural network (RBF) model, which the accuracy was 0.1 while the SPREAD value was five, could well simulate and predict the degradation processes. The Mean Absolute Error (MAE) of the simulation and prediction were within 2.9 μg·ml-1 and 2.3 μg·ml-1, respectively. The Regression Coefficient (R2) of the simulation and the prediction were within 0.996 and 0.998, respectively.

关键词： thuringiensin half-life degradation artificial neural network radius basis neural network

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Heat Shock Transcription Factor 1 Protects Heart after Pressure Overload through Promoting Myocardial Angiogenesis

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Heat Shock Transcription Factor 1 Protects Heart after Press...

Environmental Isotopes and Cl/Br Ratios Evidences for Delineating Arsenic Mobilization in Aquifer System of the Jianghan Plain,Central China

第八届海峡两岸心血管科学研讨会

作者： Ji-ming LI,hong MA,hong JIANG,Jie yuAN,Hui GONG, Yan-yan LIANG,Ai-li GUAN,Jian WU,Lei LI,Ning ZHOU,yu-hong niu, Ai-jun SUN,yun-zeng ZOU (1.Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032,China 2.Institutes of Biomedical Science,Fudan University,Shanghai 200032,China)

＜正＞Background Heat shock transcription factor 1（HSFl） plays an important role in excise - in- duced cardiac ***,its role in pressure overload - induced cardiac hypertrophy is not completely *** here elucidate whether and how HSF1 protects heart against chronic pressure overload. Methods and Results A sustained constriction of transverse aorta（TAC） was imposed to HSF1 transgenic （TG）,knockout（KO） and their littermate wild type（WT） mice to induce a pressure *** weeks later,adaptive responses to TAC,such as cardiac hypertrophy,contractility and angiogenesis evaluated by echocardiography,catheterization and immunohistochemistry,were well preserved in the TG but less in the KO compared to those in the WT *** angiogenesis inhibitor TNP - 470 abrogated all these adaptive responses in the TG mice,while cardiac transfection of VEGF with angiopoietin - 1 repaired the maladaptive heart in the KO *** response to TAC,p53 was downregulated and hypoxia - inducing transcription factor - 1（HIF - 1 ） was upregulated not only in heart tissues but also in cultured cardiac endothelial cells（EC） of the TG mice compared to WT mice whereas these changes became opposite in the KO mice.A small interfere RNA（siRNA） of HIF - 1 but not ap53 gene impaired the adaptive responses of the heart and EC in TG mice,and a siRNA of p53 but not a HIF - 1 gene significantly reversed the heart and EC disorders in the KO mice after pressure *** We conclude that HSF1 promotes cardiac angiogenesis through suppression of p53 and subsequent upregulation of HIF - 1 in endothelial cells during chronic pressure overload,leading to the maintenance of cardiac adaptation.

关键词： angiogenesis cardiac hypertrophy endothelial cell HSF1 pressure verload

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Journal of Earth Science 2023年第2期34卷 571-579页

作者： yu Zhang Qian yu Chongwen Shi Ping Li hong niu College of Resources and Environmental Science South-Central University for NationalitiesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Environment isotopes(δ18O andδ2H)and Cl/Br ratios in surface water and groundwater are combined to investigate arsenic mobilization in aquifer system of the Jianghan *** groundwater has relatively high arsenic concentrations,ranging from 3.6 to 1055.3μg/L with an average of 102.2μg/L,which exceeds China’s drinking water standard(10μg/L).The arsenic content of surface water samples is quite low with the range of 6.0–14.3μg/L,averaging 9.5μg/L.δ18O andδ2H values for surface water and groundwater samples plot close to the local meteoric water line(LMWL),reflecting their meteoric origin;a subset of the samples(shallow wells,10 m)shows a shift to LMWL,commensurate with mixing with surface water and *** correlations betweenδ18O values and Cl concentration and Cl/Br ratios as well as arsenic concentration demonstrated that surface water and groundwater interactions,including active exchange between river/pond water and groundwater and vertical infiltration from agricultural and aquacultural soils,were dominated processes affecting arsenic mobilization in shallow groundwater system and lateral recharge was the main process controlling arsenic behavior in deep groundwater *** results of this study will be beneficial to understanding the causes of arsenic mobilization in Jianghan groundwaters at different depths.

关键词： environment isotope CI/Br ratios arsenic surface water and groundwater interaction Jianghan Plain geochemistry

重组人促红细胞生成素防治早产儿贫血的临床研究

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中华妇幼临床医学杂志（电子版） 2005年第1期1卷 35-36页

作者：余涛刘华伟王红毛小兰杨涛毅柳宇红谢为成都市第三人民医院四川大学华西第二医院儿科610041 成都市第三人民医院检验科四川省妇幼保健院儿科成都市妇产科医院新生儿科成都市第三人民医院儿科

目的探讨重组人类促红细胞生成素(rhEPO)防治早产儿贫血的临床效果。方法 20例早产儿随机分成治疗组和对照组,每组10例。两组均于出生后第2周口服铁剂[元素铁5mg／(kg·d)],观察 4周。治疗组第2周给予rhEPO 700IU／(kg·w),皮下注射,隔... 详细信息

目的探讨重组人类促红细胞生成素(rhEPO)防治早产儿贫血的临床效果。方法 20例早产儿随机分成治疗组和对照组,每组10例。两组均于出生后第2周口服铁剂[元素铁5mg／(kg·d)],观察 4周。治疗组第2周给予rhEPO 700IU／(kg·w),皮下注射,隔日1次,每周3次,共4周。结果治疗前两组间血红蛋白(Hb)、血清转铁蛋白受体(sTfR)、血清铁蛋白(SF)比较均无统计学差异,P>0．05。治疗后治疗组的Hb和sTfR均明显高于对照组(P0．05。结论 rhEPO能减轻早产儿贫血的程度,并可能减少输血。

关键词：早产儿重组人类促红细胞生成素贫血临床研究防治