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Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

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Science China Chemistry 2024年

作者： Shuguang Yang Lijun hu hong Xiao Zecong Xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

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Salinity causes differences in stratigraphic methane sources and sinks

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Environmental Science and Ecotechnology 2024年第3期19卷 141-151页

作者： Ying Qu Yuxiang Zhao Xiangwu Yao Jiaqi Wang Zishu Liu Yi hong Ping Zheng Lizhong Wang Baolan hu Department of Environmental Engineering Zhejiang UniversityHangzhouChina Ocean College Zhejiang UniversityZhoushanChina Zhejiang Province Key Laboratory for Water Pollution Control and Environmental Safety HangzhouChina

Methane metabolism,driven by methanogenic and methanotrophic microorganisms,plays a pivotal role in the carbon *** seawater intrusion and soil salinization rise due to global environmental shifts,understanding how salinity affects methane emissions,especially in deep strata,becomes ***,insights into stratigraphic methane release under varying salinity conditions remain *** we investigate the effects of salinity on methane metabolism across terrestrial and coastal strata(15-40 m depth)through in situ and microcosm simulation *** strata,exhibiting a salinity level five times greater than terrestrial strata,manifested a 12.05%decrease in total methane production,but a staggering 687.34%surge in methane oxidation,culminating in 146.31%diminished methane *** emerged as a significant factor shaping the methane-metabolizing microbial community's dynamics,impacting the methanogenic archaeal,methanotrophic archaeal,and methanotrophic bacterial communities by 16.53%,27.25%,and 22.94%,***,microbial interactions influenced strata system methane *** pathway analyses suggested Atribacteria JS1's potential role in organic matter decomposition,facilitating methane production via *** study thus offers a comprehensive lens to comprehend stratigraphic methane emission dynamics and the overarching factors modulating them.

关键词： Shallow gas strata Salinity Methane emission Microbial community Microbial interactions

The importance of Righi-Leduc heat flux to the ablative Rayleigh-Taylor instability during a laser irradiating targets

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High Power Laser Science and Engineering 2024年第3期12卷 9-19页

作者： ye Cui Xiao-hu Yang Yan-Yun Ma Guo-Bo Zhang Bi-Hao Xu Ze-Hao Chen Ze Li Fu-Qiu Shao Jie Zhang Department of Nuclear Science and Technology National University of Defense TechnologyChangshaChina College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangshaChina Department of Physics National University of Defense TechnologyChangshaChina Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Centre of IFSA Shanghai Jiao Tong UniversityShanghaiChina

The Righi±Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh±Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic *** perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of *** Righi±Leduc effect plays an essential impact both in the linear and nonlinear stages,and it deflects the total heat flux towards the spike *** to the case without the self-generated magnetic field included,less heat flux is concentrated at the spike tip,finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike *** is shown that the linear growth rate is increased by about 10%and the amplitude during the nonlinear stage is increased by even more than 10%due to the feedback of the magnetic field,*** results reveal the importance of Righi±Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field,especially during the acceleration stage in inertial confinement fusion.

关键词： amplitude linear growth rate Rayleigh-Taylor instability Righi-Leduc heat flux self-generated magnetic field

A flame-retardant binder with high polysulfide affinity for safe and stable lithium–sulfur batteries

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Science China Chemistry 2024年第3期67卷 1028-1036页

作者： Guowei Yu Guofeng ye Cheng Wang Chenyang Wang Zhaoyun Wang Pu hu Yu Li Xi-Xi Feng Shuang-Jie Tan Min Yan Sen Xin Zhitian Liu hubei Key Laboratory of Plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Lithium-sulfur(Li-S) batteries have shown promises for the next-generation, high-energy electrochemical storage, yet are hindered by rapid performance decay due to the polysulfide shuttle in the cathode and safety concerns about potential thermal runaway. To address the above challenges, herein, we show a flame-retardant cathode binder that simultaneously improves the electrochemical stability and safety of batteries. The combination of soft and hard segments in the polymer framework of binders allows high flexibility and mechanical strength for adapting to the drastic volume change during the Li(de)intercalation of the S cathode. The binder contains a large number of polar groups, which show the high affinity to polysulfides so that they help to anchor active S species at the cathode. These polar groups also help to regulate and facilitate the Li-ion transport, promoting the kinetics of polysulfide conversion reaction. The binder contains abundant phosphine oxide groups, which, in the case of battery's thermal runaway, decompose and release PO· radicals to quench the combustion reactions and stop the fire. Consequently, Li-S batteries using the new cathode binder show the improved electrochemical performance, including a low-capacity decay of 0.046% per cycle for 800 cycles at 1 C and favorable rate capabilities of up to 3 C. This work offers new insights on the practical realization of high-energy rechargeable batteries with stable storage electrochemistry and high safety.

关键词： lithium–sulfur battery polymer binder polysulfide affinity flame retardancy

Mechanism of mesenchymal stem cells in liver regeneration:Insights and future directions

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World Journal of Stem Cells 2024年第9期16卷 842-845页

作者： Yu-Xin Jin Hang-Qi hu Jia-Cheng Zhang Xi-Yan Xin Yu-Tian Zhu Yang ye Dong Li Department of Traditional Chinese Medicine Peking University Third HospitalBeijing 100191China

Mesenchymal stem cells(MSCs)are a prevalent source for stem cell therapy and play a crucial role in modulating both innate and adaptive immune ***-alcoholic fatty liver disease(NAFLD)is characterized by the accumulation of triglycerides in liver cells and involves immune system activation,leading to histological changes,tissue damage,and clinical symptoms.A recent publication by Jiang et al,highlighted the potential of MSCs to mitigate in NAFLD progression by targeting various molecular pathways,including glycolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and *** this editorial,we comment on their research and discuss the efficacy of MSC therapy in treating NAFLD.

关键词： Mesenchymal stem cells Liver regeneration Non-alcoholic fatty liver disease Immune cells Therapeutic strategy

Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi ye Xinqian hu Xiaoyan He Jia Wang Gaofeng Chen Chengyu Zou Daichao Xu hongbing Zhang Junying Yuan Yunhong Zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS ***1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(Phuman ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

Relative position of seeds driven the seedling growth are mediated by root-leaf traits

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Journal of Plant Ecology 2024年第2期17卷 24-35页

作者： Jing Zhu Xue-Lin Wang Xing Jin Lan Jiang hong-Yu Lin Yang hu Jin-Fu Liu Zhong-Sheng He College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China Key Laboratory of Fujian Universities for Ecology and Resource Statistics Fujian Agriculture and Forestry UniversityFuzhou 350002China Zhenjiang Natural Resources and Planning Bureau Economic and Technological Development Zone Branch Zhenjiang 212132China

Variations in plant traits are indicative of plant adaptations to forest environments,and studying their relationships with tree growth provides valuable insights into forest *** spatial arrangement of plant seeds within the forest litter or soil critically infuences the variations of root-leaf traits,thereby affecting the adaptive strategies of emerging ***,our current understanding of the impacts of individual root-leaf traits on seedling growth in different relative position,and whether these traits together affect growth,remains *** study focuses on the dominant tree species,Castanopsis kawakamii,within the Sanming *** Nature Reserve of *** present experiment aimed to examine the variations in root-leaf traits of seedling,focus on the relative positions of seeds within different layers:beneath or above the litter layer,or within the bare soil layer(without litter).Our fndings provided evidence supporting a coordinated relationship between root and leaf traits,wherein leaf traits varied in conjunction with root traits in the relative positions of ***,we observed that seedlings exhibited higher values for specifc leaf area and average root diameter,while displaying lower root tissue *** mixed model explained 86.1%of the variation in root-leaf traits,surpassing the variation explained by the relative ***,soil nitrogen acted as a mediator,regulating the relationship between seedling growth and root-leaf traits,specifcally leaf dry matter content and root tissue ***,future studies should consider artifcially manipulating tree species diversity based on root-leaf traits characteristics to promote forest recovery.

关键词： relative growth rate coordination leaf traits root traits soil nitrogen content seed relative positions

Effect of CO_(2) Opposing Multiple Jets on Thermoacoustic Instability and NO_(x) Emissions in a Lean-Premixed Model Combustor

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Journal of Thermal Science 2024年第1期33卷 207-221页

作者： ZHOU Hao hu Liubin Institute for Thermal Power Engineering State Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China

This paper experimentally studied the effect of CO_(2) opposing multiple jets on the thermoacoustic instability and NO_(x) emissions in a lean-premixed model *** feasibility was verified from three variables:the CO_(2) jet flow rate,hole numbers,and hole diameters of the *** indicate that the control effect of thermoacoustic instability and NO_x emissions show a reverse trend with the increase of open area ratio on the whole,and the optimal jet flow rate range is 1-4 L/min with CO_(2) opposing multiple *** this flow rate range,the amplitude and frequency of the dynamic pressure and heat release signals CH~* basically decrease as the CO_(2) flow rate increases,which avoids high-frequency and high-amplitude thermoacoustic *** amplitude-damped ratio of dynamic pressure and CH*can reach as high as 98.75% and 93.64% with an optimal open area ratio of 3.72%.NO_(x) emissions also decrease as the jet flow rate increases,and the maximum suppression ratio can reach 68.14%.Besides,the flame shape changes from a steep inverted "V" to a more flat "M",and the flame length will become shorter with CO_(2) opposing multiple *** research achieved the synchronous control of thermoacoustic instability and NO_(x) emissions,which could be a design reference for constructing a safer and cleaner combustor.

关键词： thermoacoustic instability lean-premixed model combustor CO_(2)opposing multiple jets open area ratio NO_(x)emissions

Multi-Axis Attention With Convolution Parallel Block for Organoid Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1295-1297页

作者： Pengwei hu Xun Deng Feng Tan Lun hu Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of SciencesUrumqi 830011 University of Chinese Academy of Sciences Beijing 100049 Xinjiang Laboratory of Minority Speech and Language Information Processing Urumqi 830011China Merck KGaA Darmstadt 64293Germany

Dear Editor,This letter presents an organoid segmentation model based on multi-axis attention with convolution parallel *** adeptly captures dynamic dependencies within bright-field microscopy images,improving global ... 详细信息

关键词： letter convolution organo