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The dawn−dusk asymmetry in mesosphere and lower thermosphere temperature disturbances during geomagnetic storms at high latitude

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Earth and Planetary Physics 2024年第2期8卷 356-367页

作者： GuanChun Wei JianYong Lu Fen Tang JingYuan li Meng Sun Institute of Space Weather School of Atmospheric PhysicsNanjing University of Information Science&TechnologyNanjing 210044China College of Information and Communication National University of Defense TechnologyWuhan 430019China

Utilizing observations by the Sounding of the Atmosphere using Broadband Emission Radiometry(SABER)instrument,we quantitatively assessed the dawn-dusk asymmetry in temperature disturbances within the high-latitude mesosphere and lower thermosphere(MLT)during the main phase of geomagnetic storms in this *** analysis of five geomagnetic superstorm events indicated that during the main phase,negative temperature disturbances were more prevalent on the dawn side than on the dusk side in the high-latitude MLT *** of a statistical analysis of 54 geomagnetic storm events also revealed a notable disparity in temperature disturbances between the dawn and dusk *** high latitudes,38.2%of the observational points on the dawn side exhibited negative temperature disturbances(less than−5 K),whereas on the dusk side,this percentage was only 29.5%.In contrast,at mid-latitudes,these proportions were 34.1%and 36.5%,respectively,showing no significant *** also conducted a statistical analysis of temperature disturbances at different altitudes,which revealed an increase in the proportion of warming disturbances with ***,the proportion of cooling disturbances initially rose with altitude,reaching a peak around 105 km,and subsequently *** temperature disturbance differences could be explained by the day-night asymmetry in vertical wind disturbances during storm conditions.

关键词： dawn dusk asymmetry SABER(Sounding of the Atmosphere using Broadband Emission Radiometry) geomagnetic storms mesosphere and lower thermosphere

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一流核心课程建设背景下数据挖掘课程教学改革实践

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漯河职业技术学院学报 2024年第5期23卷 95-100页

作者：李娜宣贺君河南工业大学漯河工学院河南漯河462000 信阳师范大学河南信阳464000

课程建设是高等教育发展的重要基石,不断加强课程建设,确保高等教育的高质量可持续发展,以落实立德树人为根本任务,持续开展一流核心课程建设,推进教育教学改革是课程优化的重要驱动力。分析数据挖掘课程,传统教学存在的问题,提出“一... 详细信息

课程建设是高等教育发展的重要基石,不断加强课程建设,确保高等教育的高质量可持续发展,以落实立德树人为根本任务,持续开展一流核心课程建设,推进教育教学改革是课程优化的重要驱动力。分析数据挖掘课程,传统教学存在的问题,提出“一引领、两结合、四一体”的教学改革理念,建设优质多模态的课程资源,进行系统的教学模式改革,打造一流核心课程,培养高素质、创新型的数字工匠。

关键词：一流核心课程数据挖掘教学改革课程思政类比教学法

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Detecting bulk and edge exceptional points in non-Hermitian systems through generalized Petermann factors

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Frontiers of physics 2024年第2期19卷 169-177页

作者： Yue-Yu Zou Yao Zhou li-Mei Chen Peng Ye School of Physics State Key Laboratory of Optoelectronic Materials and Technologiesand Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSun Yat-sen UniversityGuangzhou 510275China

Non-orthogonality in non-Hermitian quantum systems gives rise to tremendous exotic quantum phenomena,which can be fundamentally traced back to *** this paper,we introduce an interesting quantity(denoted asη)as a new variant of the Petermann factor to directly and efficiently measure non-unitarity and the associated non-Hermitian *** tuning the model parameters of underlying non-Hermitian systems,we find that the discontinuity of bothηand its first-order derivative(denoted as■η)pronouncedly captures rich physics that is fundamentally caused by *** concretely,in the 1D non-Hermitian topological systems,two mutually orthogonal edge states that are respectively localized on two boundaries become non-orthogonal in the vicinity of discontinuity ofηas a function of the model parameter,which is dubbed"edge state transition".Through theoretical analysis,we identify that the appearance of edge state transition indicates the existence of exceptional points(EPs)in topological edge *** the discontinuity of■η,we investigate a two-level non-Hermitian model and establish a connection between the points of discontinuity of■ηand EPs of bulk *** studying this connection in more general lattice models,we find that some models have discontinuity of■η,implying the existence of EPs in bulk states.

关键词： non-Hermitian Su−Schrieffer−Heeger(SSH)model exceptional point

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Plastid engineering with an efficient RNAi delivery system based on bacteriophage MS2 virus-like particles enhances plant resistance to cotton bollworm

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Molecular Plant 2024年第7期17卷 987-989页

作者： Chunmei Jiang Jinqiu Fu Fujun li Kai Xia Shengchun li ling Chang Ralph Bock Jiang Zhang State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei Hongshan LaboratoryHubei UniversityWuhan 430062China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518000China Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476Potsdam-GolmGermany

Dear Editor,RNA-based pesticides are approaching the market,offering great potential to control agricultural pests such as the coleopteran insect Diabrotica virgifera virgifera(Head et al.,2017).However,application to lepidopteran pests has been hampered by their inconsistent response to RNA interference(RNAi).As a notorious lepidoptera pest,Helicoverpa armigera feeds on over 300 species of host plants(Fu et al.,2022).Although transgenicplants expressingdouble-stranded RNAs or microRNAs that target essential insect genes can inhibit the growth of larvae,complete protection of the plants and efficient killing of this insect have not been achieved(Bally et al.,2020;Chung et al.,2021;li et al.,2023).The relatively low RNAi efficiency in lepidopterans is mainly attributable to the degradation and intracellular sequestration of double-stranded RNA(Shukla et al.,2016;Zhu and Palli,2020).To overcome these obstacles and improve RNAi efficiency in ***,we attempted to deliver RNAi molecules using a bacteriophage MS2 virus-like particle(VLP)-based delivery system(Wang et al.,2016).

关键词： overcome offering approaching

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Preface to special issue on celebrating the 100th anniversary of Xinjiang University

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Nano Research 2024年第1期17卷 1-4页

作者： Dianzeng Jia Ruimao Hua Xian-He Bu Yuliang li State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830017China Department of Chemistry Tsinghua UniversityBeijing 100084China School of Materials Science and Engineering Nankai UniversityTianjin 300350China CAS Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China

Xinjiang University originated from Xinjiang College of Russian Language,Political Science and Law in *** 1935 and 1960,the college was re-organized and re-named as Xinjiang College and Xinjiang University,*** 1978,Xinjiang University was appointed by the State Council as the only national key university in *** 1997,it was designated as one of the first batch of key construction universities in the“211 Project”of *** 2000,Xinjiang University was rebuilt through merging with Xinjiang Institute of Technology.

关键词： Xinjiang anniversary originated

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Flow resistance in the channel-bar landscape of large alluvial rivers

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Frontiers of Earth Science 2024年第2期18卷 412-421页

作者： Yong HU Congcong liU Jinyun DENG Wei ZHANG Yitian li State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China CCCC Second Harbor Engineering Company Ltd Wuhan 430040China Key Laboratory of Large-span Bridge Construction Technology Wuhan 430040China Research and Development Center of Transport Industry of Intelligent Manufacturing Technologies of Transport Infrastructure Wuhan 430040China CCCC Highway Bridge National Engineering Research Centre Co.Ltd Wuhan 430040China

Accurate approaches for estimating flow resistance in large alluvial rivers are fundamental for simulating discharge,sediment transport,and flood ***,methods for estimating riverbed resistance and additional resistance in the channel-bar landscapes remain poorly *** this study,we used in situ river bathymetry,sediment,and hydraulic data from the Shashi Reach in the Yangtze River to develop a semi-empirical approach for calculating flow *** method quantitatively separates flow resistance into riverbed resistance and additional resistance and shows high accuracy in terms of deviation ratio(~20%),root-mean-square error(~0.008),and geometric standard deviation(~3).Additional resistance plays a dominant role under low-flow conditions but a secondary role under high flows,primarily due to the reduction in momentum exchange in channel-bar regions as discharge *** resistance first decreases and then increases,which might be attributed to bedform changes in the lower and transitional flow regimes as flow velocity ***,our findings further the understanding of dynamic changes in flow resistance in the channel-bar landscapes of large river systems and have important implications for riverine ecology and flood management.

关键词： flow resistance channel-bar landscape interaction region large river bedform

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Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3643-3660页

作者： Jie Wang Zilong Zhang Yan Zhuo Zhuan Zhang Rongrong Chen li liang Xiaohe Jiang Di Nie Chang liu Zhiwen Zou Xiang li Jiaxin li Bingqi Wang Rui Wang Yong Gan Miaorong Yu School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Jiangxi Medical College Nanchang UniversityNanchang 330006China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum(ER)presents an opportunity to amplify the synergistic effects of chemotherapy and *** this study,we initially validated celastrol(CEL)as an inducer of immunogenic cell death(ICD)by promoting ER stress and autophagy in colorectal cancer(CRC)***,an ER-targeted strategy was posited,involving the codelivery of CEL with PD-L1 small interfering RNAs(siRNA)using KDEL peptide-modified exosomes derived from milk(KME),to enhance chemoimmunotherapy *** findings demonstrate the efficient transportation of KME to the ER via the Golgi-to-ER *** to their non-targeting counterparts,KME exhibited a significant augmentation of the CEL-induced ICD ***,it facilitated the release of danger signaling molecules(DAMPs),thereby stimulating the antigen-presenting function of dendritic cells and promoting the infiltration of T cells into the ***,the ER-targeted delivery of PD-L1 siRNA resulted in the downregulation of both intracellular and membrane PD-L1 protein expression,consequently fostering the proliferation and activity of CD8^(+)T ***,the ER-targeted formulation exhibited enhanced anti-tumor efficacy and provoked anti-tumor immune responses against orthotopic colorectal tumors in ***,a robust ER-targeted delivery strategy provides an encouraging approach for achieving potent cancer chemoimmunotherapy.

关键词： Chemoimmunotherapy Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death siRNA Chemoimmunotherapy Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death siRNA

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Study on the vertical deformations induced by terrestrial water storage changes in Huang-Huai-Hai river basin

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Geodesy and Geodynamics 2024年第4期15卷 352-365页

作者： liansheng Deng Yugang Xiao Qusen Chen Feifei liao Zhao li School of Electrical and Electronic Information Engineering Hubei Polytechnic UniversityHuangshi 435003China Hubei Luojia Laboratory GNSS Research CenterWuhan UniversityWuhan 430079.China Changjiang Spatial Information Technology Engineering Co. Ltd.Wuhan 430010China

Terrestrial water storage(TWs)variations are associated with water mass movements,which may cause the deformation displacements of the Global Navigation Satellite System(GNSS)*** study investigates the spatio-temporal Tws variations and addresses the relationship between deformation variations observed in the Huang-Huai-Hai River Basin(HHHRB)and local hydrological *** indicate that the vertical velocities at the GNSS stations induced by TWS changes are relatively small,and the impacts of the terrestrial water storage changes are mainly reflected in the changes of seasonal *** there is a downward TWS trend from 2011 to 2022 in most HHHRB areas,velocities from the vertical displacements of both Gravity Recovery and Climate Experiment(GRACE)and GRACE Follow-On(GFO)and the GNSS reflect that the HHHRB is undergoing an uplift process,while the magnitude of the GRACE/GFO derived velocities is much smaller than that of the GNSS *** hydrological deformations estimated from GRACE/GFO and GNSS measurements reveal that the TWS-derived displacements can explain 54.5%of the GNSS seasonal variations,with the phases of terrestrial water storage advancing by about one month relative to GNss common signal ***,the decrease of the groundwater storage in the HHHRB has been accelerating since *** reaching its lowest level around mid-2020,it began to rise rapidly,which might be closely related to the implementation of the South-North Water Transfer Central Project.

关键词： Terrestrial waterstorage GRACE GNSS Vertical deformations Huang-Huai-Hairiverbasin

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Wetting front migration model of ion-adsorption rare earth during the multi-hole unsaturated liquid injection

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 483-496页

作者： Yu Wang Xiaojun Wang Yuchen Qiu Hao Wang Gang li Kaijian Hu Wen Zhong Zhongqun Guo Bing li Chunlei Zhang Guangxiang Ye Jiangxi Key Laboratory of Mining Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Resources and Environment Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Civil Engineering and Surveying&Mapping Engineering Jiangxi University of Science and TechnologyGanzhou341000China Ganzhou Nonferrous Metallurgy Research Institute Ganzhou341000China

In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still ***,wetting front migration distance and leaching time are usually required to optimize the leaching *** this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head *** the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were *** the postintersection stage,the intersection accelerated the wetting front *** using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the ***,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was *** analysis results showed that the proposed model can accurately simulate the infiltration process under experimental *** research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.

关键词： Ion-adsorption rare earth ore Multi-hole unsaturated liquid injection In situ leaching Intersection effect Calculation model

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Defining Cities by Water: Addressing Capital Misallocation in a Race to Conserve Resources

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China Economist 2024年第1期19卷 86-102页

作者： Yao Peng li Jinze School of Economics Qufu Normal UniversityQufuChina School of Economics Shandong UniversityJinanChina School of Economics Ocean University of ChinaQingdaoChina

As part of its efforts to promote a sustainable and high-quality development,China has pledged to reduce water consumption and create a water-efficient *** the basis of identifying the institutional root causes of excessive capital allocation and excessive water consumption in China’s water-intensive industrial sectors,this study elaborates how the national water-efficient cities assessment contributes to optimized capital *** research shows that national water-efficient cities assessment has motivated local governments to compete for water *** conserve water,local governments regulated the entry and exit of water-intensive enterprises,discouraged excessive investments in water-intensive sectors,and phased out obsolete water-intensive capacities within their *** approach has resulted in mutually beneficial outcomes,including improved allocation of capital,enhanced water efficiency,and reduced *** paper offers policy recommendations for establishing a water-efficient society throughout the 14^(th) Five-Year Plan(2021-2025)period by presenting empirical evidence on the policy effects of resource efficiency evaluation.

关键词： Competitive evaluation for resource efficiency national water-efficient cities assessment capital misallocation water efficiency emissions abatement

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