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Genome-wide association study of grain micronutrient concentrations in bread wheat

Journal of Integrative Agriculture 2024年第5期23卷 1468-1480页

作者： Yongchao Hao Fanmei Kong lili Wang Yu Zhao Mengyao li Naixiu Che Shuang li Min Wang Ming Hao Xiaocun Zhang Yan Zhao State Key Laboratory of Crop Biology/College of Agronomy Shandong Agricultural UniversityTai'an 271018China College of Resources and Environment Shandong Agricultural UniversityTai'an 271018China Jining liangshan Ecological Environment Affairs Center Jining 272100China College of Forestry Shandong Agricultural UniversityTai'an 271018China

Bread wheat(Triticum aestivum)is a staple food crop *** genetic dissection of important nutrient traits is essential for the biofortification of wheat to meet the nutritional needs of the world's growing ***,45,298 single-nucleotide polymorphisms(SNPs)from 55K chip arrays were used to genotype a panel of 768 wheat cultivars,and a total of 154 quantitative trait loci(QTLs)were detected for eight traits under three environments by genome-wide association study(GWAS).Three QTLs(qMn-3B.1,qFe-3B.4,and qSe-3B.1/qFe-3B.6)detected repeatedly under different environments or traits were subjected to subsequent analyses based on linkage disequilibrium decay and the P-values of significant *** SNPs in the three QTL regions formed six haplotypes for qMn-3B.1,three haplotypes for qFe-3B.4,and three haplotypes for qSe-3B.1/*** analysis revealed significant differences among *** results indicated that the concentrations of several nutrient elements have been modified during the domestication of landraces to modern *** on the QTL regions,we identified 15 high-confidence genes,eight of which were stably expressed in different tissues and/or developmental ***3B02G046100 in qMn-3B.1 and TraesCS3B02G199500 in qSe-3B.1/qFe-3B.6 were both inferred to interact with metal ions according to the Gene Ontology(GO)***3B02G199000,which belongs to qSe-3B.1/qFe-3B.6,was determined to be a member of the WRKY gene ***,this study provides several reliable QTLs that may significantly affect the concentrations of nutrient elements in wheat grain,and this information will facilitate the breeding of wheat cultivars with improved grain properties.

关键词： bread wheat nutritional element GWAS domestication haplotype

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Ergothioneine and its congeners:anti-ageing mechanisms and pharmacophore

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Protein & Cell 2024年第3期15卷 191-206页

作者： li Chen liping Zhang Xujun Ye Zixin Deng Changming Zhao Department of Geriatrics Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Key Laboratory of Combinatory Biosynthesis and Drug Discovery School of Pharmaceutical SciencesMinistry of EducationWuhan UniversityWuhan 430072China tThese authors contributed equally.

Ergothioneine,Ovothiol,and Selenoneine are sulfur/selenium-containing histidine-derived natural products widely distributed across different *** exhibit significant antioxidant properties,making them as potential lead compounds for promoting *** evidence suggests that Ergothioneine is positively correlated with healthy ageing and *** mechanisms underlying Ergothioneine's regulation of the ageing process at cellular and molecular levels are beginning to be *** this review,we provide an in-depth and extensive coverage of the anti-ageing studies on Ergothioneine and discuss its possible intracellular targeting *** addition,we highlight the recent efforts in elucidating the biosynthetic details for Ergothioneine,Ovothiol,and Selenoneine,with a particular focus on the study of their pharmacophore-forming enzymology.

关键词： Ergothioneine antioxidant anti-ageing longevity biosynthesis enzymology

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TC4合金表面Zr-Y改性渗硅涂层的组织结构及高温摩擦磨损性能

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材料工程 2024年第6期52卷 193-200页

作者：李轩吕威何瑜张晓燕贾丽娜来升袁泉四川轻化工大学机械工程学院四川自贡643000 西安长峰机电研究所西安710065 北京航空航天大学材料科学与工程学院北京100191

采用固体粉末扩散渗方法在TC4合金表面制备了Zr-Y改性的渗硅涂层,研究了渗层的组织结构、高温摩擦磨损性能及磨损机制。结果表明:Zr-Y改性渗硅涂层具有多层梯度结构,外层由TiSi_(2)和少量ZrSi_(2)组成,较薄的中间层为TiSi相,内层为Ti_(5... 详细信息

采用固体粉末扩散渗方法在TC4合金表面制备了Zr-Y改性的渗硅涂层,研究了渗层的组织结构、高温摩擦磨损性能及磨损机制。结果表明:Zr-Y改性渗硅涂层具有多层梯度结构,外层由TiSi_(2)和少量ZrSi_(2)组成,较薄的中间层为TiSi相,内层为Ti_(5)Si_(4)和Ti_(5)Si_(3)的混合物。涂层的显微硬度明显高于TC4合金基体,且由表及内呈梯度降低趋势。高温摩擦磨损实验(600℃)结果表明,Zr-Y改性渗硅涂层具有优良的摩擦磨损防护性能。与GCr15对磨时的磨损率约为3.59×10^(-5)mm^(3)/(N·m),是相同条件下TC4合金磨损率的36.6%,磨损机制主要为GCr15在涂层表面的擦涂和氧化磨损。与Al2O3球对磨时的磨损率为9.75×10^(-5)mm^(3)/(N·m),是相同条件下TC4合金磨损率的18.9%,磨损机制为疲劳磨损、氧化磨损和黏着磨损。

关键词： TC4合金 Zr-Y改性扩散渗硅化物涂层高温磨损磨损机制

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Highly uniform Co-Cu bimetallic sulfides for rechargeable alkaline aqueous zinc batteries

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Chinese Chemical Letters 2024年第2期35卷 521-526页

作者： Xiaofang Bai Yuwei Zhao Mangwei Cui Tianshuo Guo Zijie Tang Chuan li Heng Gao Shuo Yang lingzhi Zhao Chunyi Zhi hongfei li Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Dongguan 523808China Department of Materials Science and Engineering City University of Hong KongHong KongChina International Centre for Quantum and Molecular Structures Department of PhysicsShanghai UniversityShanghai 200444China Guangdong Provincial Engineering Technology Research Center for Low Carbon and Advanced Energy Materials Institute of Semiconductor Science and TechnologySouth China Normal UniversityGuangzhou 510631China

Rechargeable alkaline aqueous zinc batteries(RAZBs)have attracted increasing ***,most RAZBs are hindered by the limited availability of cathode *** practical electrochemical performance of most cathode materials is lower than the theoretical value due to their poor electrical conductivity and low utilization *** this work,we develop a facile hydrothermal procedure to prepare highly uniform bimetallic sulfides as novel cathode materials for ***-cobalt binary metallic oxides materials possess higher conductivity and larger capacity compared with their mono-metal oxides compounds due to bimetallic synergistic effects and multiple oxidation ***,bimetallic sulfide compounds have smaller bond energy and longer bond length than their oxides,leading to less structural damage,faster kinetics of electrochemical reactions,and better *** as-prepared Co-Cu bimetallic sulfides show enhanced electrochemical performance due to various valences of Co and Cu as well as the existence of *** a result,aqueous Zn/CuCo_(2)S_(4) battery shows a high specific capacity of 117.4 mAh/g at 4 A/g and a good cycle life of over 8000 *** on PANa hydrogel electrolytes,a flexible Zn/CuCo_(2)S_(4) battery demonstrates excellent cycling *** battery can also meet the requirements of electronic devices with different shapes and performs well in extreme environments,such as freezing,drilling,and *** work opens new avenues to obtain high-rate and long-life cathode materials for RAZBs by utilizing the synergistic effects of bimetallic sulfides and provides a new platform for flexible energy storage devices.

关键词： Aqueous zinc batteries Bimetallic sulfides Cathode materials Rate performance Cycling stability

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川西锦鸡儿灌木扩张对高寒草地土壤有机碳矿化的影响

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生态学报 2024年第16期44卷 7150-7159页

作者：黎萱耿行高永恒陈东毅李良安王平甘肃农业大学资源与环境学院兰州730070 中国科学院成都生物研究所成都610041 贵州省黔西南布依族苗族自治州能源局兴义562400

以川西锦鸡儿(Caragana erinacea)灌丛草地为研究对象,分析川西锦鸡儿灌木不同扩张程度下(原生草地、中度灌木扩张和重度灌木扩张)0—10 cm、10—20 cm和20—40 cm土壤理化性质及土壤有机碳(SOC)矿化的变化特征,探究灌木扩张对高寒草地... 详细信息

以川西锦鸡儿(Caragana erinacea)灌丛草地为研究对象,分析川西锦鸡儿灌木不同扩张程度下(原生草地、中度灌木扩张和重度灌木扩张)0—10 cm、10—20 cm和20—40 cm土壤理化性质及土壤有机碳(SOC)矿化的变化特征,探究灌木扩张对高寒草地SOC矿化的影响机制。结果表明:(1)灌木扩张对土壤全氮(TN)含量无显著影响,显著增加各土层SOC含量,显著增加10—20 cm土壤矿物矿质结合态有机碳(MAOC)含量及其占SOC比例,显著减小0—20 cm土壤含水量(SWC)。重度灌木扩张显著增加10—40 cm土壤微生物生物量碳(MBC)含量,显著减小0—10 cm土层MBC/SOC和MAOC/SOC。(2)不同土壤深度对SOC矿化激发效应存在差异,灌木扩张显著降低0—10 cm土壤有机碳潜在矿化碳库(C_(0)),重度灌木扩张显著增加10—40 cm土层C_(0)。(3)相关性分析表明,SOC矿化过程与SWC、SOC、TN、MBC和MAOC显著正相关,与MAOC/SOC显著负相关。逐步回归分析表明,SOC矿化与MBC和SWC相关性最强,可以有效解释C_(0)变化的91.1%。由此推断,川西锦鸡儿灌木扩张后该区域SOC矿化的变化,主要是由于灌木扩张影响MBC和SWC所致,土壤浅表水分减少影响微生物活动使得SOC矿化减弱,灌木根系发育土层微生物量增多使得SOC矿化增强。

关键词：土壤有机碳矿化灌木扩张高寒草地川西锦鸡儿

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Discontinuity development patterns and the challenges for 3D discrete fracture network modeling on complicated exposed rock surfaces

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2154-2171页

作者： Wen Zhang Ming Wei Ying Zhang Tengyue li Qing Wang Chen Cao Chun Zhu Zhengwei li Zhenbang Nie Shuonan Wang Han Yin College of Construction Engineering Jilin UniversityChangchun130026China liaoning Nonferrous Geological Exploration and Research Institute Co. Shenyang110013China School of Earth Sciences and Engineering Hohai UniversityNanjing210098China Northeastern University Shenyang110819China

Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and *** study presents a systematic outcrop research of fracture pattern variations in a complicated rock slope,and the qualitative and quantitative study of the complex phenomena impact on threedimensional(3D)discrete fracture network(DFN)*** the studies of the outcrop fracture pattern have been so far focused on local variations,thus,we put forward a statistical analysis of global *** entire outcrop is partitioned into several subzones,and the subzone-scale variability of fracture geometric properties is analyzed(including the orientation,the density,and the trace length).The results reveal significant variations in fracture characteristics(such as the concentrative degree,the average orientation,the density,and the trace length)among different ***,the density of fracture sets,which is approximately parallel to the slope surface,exhibits a notably higher value compared to other fracture sets across all *** improve the accuracy of the DFN modeling,the effects of three common phenomena resulting from vegetation and rockfalls are qualitatively analyzed and the corresponding quantitative data processing solutions are ***,the 3D fracture geometric parameters are determined for different areas of the high-steep rock slope in terms of the subzone *** results show significant variations in the same set of 3D fracture parameters across different regions with density differing by up to tenfold and mean trace length exhibiting differences of 3e4 *** study results present precise geological structural information,improve modeling accuracy,and provide practical solutions for addressing complex outcrop issues.

关键词： Complicated exposed rock surfaces Discontinuity characteristic variation Three-dimensional discrete fracture network modeling Outcrop study Vegetation cover and rockfalls

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Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests

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Journal of Mountain Science 2024年第1期21卷 182-199页

作者： HUANG Beixiu QIAO Sijia CHEN Xulei li lihui QI Shengwen Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong *** extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains *** research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active *** prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation *** results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)*** PGAs of different engineering structures were weakened by the fault rupture ***,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic ***,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active *** findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor.

关键词： Dynamic response Engineering structure Sichuan-Tibet transportation corridor Active fault Earthquake Model test

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The AMPK and AKT/GSK3β pathways are involved in recombinant proteins fibroblast growth factor 1(rFGF1 and rFGF1a) improving glycolipid metabolism in rainbow trout(Oncorhynchus mykiss) fed a high carbohydrate diet

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Animal Nutrition 2024年第2期17卷 11-24页

作者： Huixia Yu Shuo Geng Shuai li Yingwei Wang Xin Ren Debin Zhong Haolin Mo Mingxing Yao Jiajia Yu Yang li lixin Wang College of Animal Science and Technology Northwest A&F University Meixian Aquaculture Farm of Shitouhe Reservoir Administration

Fibroblast growth factor 1(FGF1) regulates vertebrate cell growth, proliferation and differentiation, and energy metabolism. In this study, we cloned rainbow trout(Oncorhynchus mykiss) fgf1 and fgf1a, prepared their recombinant proteins(rFGF1 and rFGF1a), and described the molecular mechanisms by which they improve glycolipid metabolism in carnivorous fish. A 31-d feeding trial was conducted to investigate whether they could enhance glycolipid metabolism in rainbow trout on high-carbohydrate diets(HCD). A total of 720 rainbow trout(8.9 ± 0.5 g) were equally divided into 4 groups: the chow diet(CD) group injected with PBS, the HCD group injected with PBS, the HCD group injected with rFGF1(400 ng/g body weight), and the HCD group injected with rFGF1a(400 ng/g body weight). The results showed that short-term HCD had a significant positive effect on the specific growth rate(SGR) of rainbow trout(P liver, serum TG, GOT, and GPT contents caused by HCD(P lied the promotion of TG catabolism. Moreover, rFGF1 and rFGF1a contributed to promoting lipolysis by activating the AMPK pathway and reducing lipid accumulation in the liver caused by HCD. In addition,the rFGF1 and r FGF1a-treated groups significantly reduced serum glucose levels and elevated hepatic glycogen content under HCD, and increased glucose uptake by hepatocytes. We observed a decrease in mRNA levels for pepck, g6pase, and pygl, along with an increase in mRNA levels for gys, glut2, and gk in the liver. Furthermore, these proteins regulated hepatic gluconeogenesis and glycogen synt

关键词： Rainbow trout Recombinant proteins Fibroblast growth factor 1 Glycogen synthesis lipid deposition

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scEpiTools: a database to comprehensively interrogate analytic tools for single-cell epigenomic data

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Journal of Genetics and Genomics 2024年第4期51卷 462-465页

作者： Zijing Gao Xiaoyang Chen Zhen li Xuejian Cui Qun Jiang Keyi li Shengquan Chen Rui Jiang Ministry of Education Key Laboratory of Bioinformatics Bioinformatics Division at the Beijing National Research Center for Information Science and TechnologyCenter for Synthetic and Systems BiologyDepartment of AutomationTsinghua UniversityBeijing 100084China School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China

Recent advances in single-cell sequencing technologies provide significant implications for understanding cellular heterogeneity,developmental biology,and disease *** fully exploit the potential of these data,numerous tools have been proposed for upstream and downstream *** the the single-cell RNA sequencing(scRNA-seq)community,scRNA-tools(Zappia et al.,2018)was proposed to help researchers navigate the plethora of tools by *** its inception,scRNA-tools has been widely used and its updated version further reveals trends in the field with over 1000 collected tools(Zappia and Theis,2021),providing a valuable guidance in selecting tools for analyses.

关键词： analytic selecting Tools

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微波能化工应用领域研究述评与展望

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天津大学学报（自然科学与工程技术版） 2024年第7期57卷 669-686页

作者：高鑫焦夏欣李洪赵振宇天津大学化工学院天津300350 物质绿色创造与制造海河实验室天津300192

微波凭借其快速加热、体加热、选择性加热等独特的加热供能方式,已成为化工生产中一项极其重要的过程强化方法.本文对微波化工领域近20年的研究成果及延拓方向进行总结概述,依据微波化工技术的不同强化机理进行分类阐述.微波对极性分子... 详细信息

微波凭借其快速加热、体加热、选择性加热等独特的加热供能方式,已成为化工生产中一项极其重要的过程强化方法.本文对微波化工领域近20年的研究成果及延拓方向进行总结概述,依据微波化工技术的不同强化机理进行分类阐述.微波对极性分子的选择性加热会诱导极性-非极性混合物的相对挥发度发生改变,利用这一特性开发了基于混合物组分介电性质差异的微波分离技术,通过搭建理论模型指导设计了薄膜蒸发器、喷雾蒸发器等微波诱导分离装置,并将该工艺拓展至微波强化反应精馏过程和微波强化膜分离过程;微波对吸波颗粒的选择性加热会诱导产生局部热点,该热点效应使得微波技术在非均相反应、材料合成和催化热解等过程中展现出显著可观的强化效果,通过纳米荧光技术进行该热点温度直接测量,可实现微波强化化工过程的精准调控;微波对宏观物体或相态的选择性加热以及电磁波不均匀分布会导致宏观尺度局部过热,该效应的难以调控和预测是微波化工技术大规模应用的瓶颈问题,为此有必要采用多物理场数值模拟与温敏材料测试结合的手段,实现微波加热过程温度场的可视化,从而指导微波能化工应用装置的合理设计.微波能化工应用的未来研究有赖于微波加热过程原位测试手段,从而能够深入揭示微波诱导过程强化的内在机理,助力开发合理高效的微波强化化工技术.

关键词：过程强化微波化工选择性加热强化机理

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