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Abnormal expression of WIF1 in hepatocellular carcinoma cells and its regulating effect on invasion and metastasis factors of TIMP-3 and caveolin-1 of hepatocellular carcinoma

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 934-939页

作者： Guang Song hong-xia cao Shao-Xin Yao Cang-Tuo Li Department of Interventional Therapy Affiliated Tangshan Workers Hospital of Hebei Medical University

Objective:To discuss the abnormal expression of Wnt inhibitory factor(WIFI) in hepatocellular carcinoma cells and its regulating effect on the hepatocellular carcinoma invasion and metastasis factors of tissue inhibitor of matrix metalloproteinases-3(TIMP-3)and ***:RT-PCR and Western blot were employed to detect the expression of WIF1 in six hepatocellular carcinoma eell lines of HepG2,Hep3 B,Huh7,PLC/PRF/***-7721 and MHCC97 and the immortalized human liver cell line ***,Lipofectamine 2000 was employed to transfect the eukaryotic expression vector ***1 and blank plasmid pcDNA3.1 into hepatocellular carcinoma cell *** assay was used to detect the effect of WIF1 on the invasion ability of hepatocellular carcinoma cells;Western blot was used to detect the effect of WIF1 on the expression of TIMP-3 and caveolin-1in hepatocellular carcinoma cells,it also discussed the effect on the expression of β-***:The expression of WIF1 in hepatocellular carcinoma cell lines was lower than that in the normal liver cell lines(P<0.01);while there was basically no expression of WIF1 in the human highly metastatic cell line MHCC-97 and moderate expression in HepG2 and ***,HepG2 and SMMC-7721 were chosen as the further experimental cell *** transfecting the eukaryotic expression vector peDNA3.1-WEFl and blank plasmid pcDNA3.1 into hepatocellular carcinoma eell lines,compared with(he blank plasmid group,the cell viability and invasion ability in the WIF1 group were all reduced(P<0.01),the expression of TIMP-3,caveolin-1 and mRNA were all down-regulated(P<0.01),and the expression of β-catenin was decreased(P<0.01).Conclusions:Because of down-regulation or missing of expression of WIFI in hepatocellular carcinoma cell lines,the up-regulation of WIFI expression can significantly inhibit the invasion and metastasis of HepG2 and SMMC-7721 of hepatocellular carcinoma cell lines,which are related to the up-regula

关键词： WIF1 Hepatocellular carcinoma TIMP-3 Caveolin-1

Correlation between microRNA-21 and expression of Th17 and Treg cells in microenvironment of rats with hepatocellular carcinoma

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Asian Pacific Journal of Tropical Medicine 2015年第9期8卷 747-750页

作者： Shao-Xin Yao Gui-Song Zhang hong-xia cao Guang Song Zang-Tuo Li Wei-Tao Zhang Department of Interventional Therapy Affiliated Tangshan Workers Hospital of Hebei Medical University Department of Interventional Therapy Luanxian People's Hospital

Objective: To study the correlation between mi R-21 and Treg/Th17 ratio in the microenvironment of rats with hepatocellular carcinoma. Methods: Diethylnitrosamine was used to build the hepatocel ular carcinoma model of rats; the content of Treg cells and Th17 cells and the expression of mi R-21 in the peripheral blood of rats with hepatocellular carcinoma were detected. The statistical analysis was performed on the correlation between mi R-21 expression and Treg/Th17 ratio. Results: Hepatocellular carcinoma model of rats was successfully constructed. The proportion of Th17 cells among all CD4+T cells in the peripheral blood of rats with hepatocellular carcinoma was 5.319%, which was higher than the control group; while the proportion of Treg cells was 9.472%, which was higher than the control group. Treg/Th17 ratio in the model group was 1.781, compared with 1.478 in the control group. The expression of mi R-21 was increased in the peripheral blood of rats with hepatocellular carcinoma and it showed a positive correlation with the ratio of Treg/Th17. Conclusions: There is a positive correlation between the expression level of miR-21 and the ratio of Treg/Th17.

关键词： Hepatocellular carcinoma Th17 Cells Treg Cells miR-21 Correlation analysis

Highly dispersed Ni nanoparticles on 3D-mesoporous KIT-6 for CO methanation: Effect of promoter species on catalytic performance

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Chinese Journal of Catalysis 2017年第7期38卷 1127-1137页

作者：曹红霞张军郭成龙陈经广任相坤中国矿业大学低碳能源研究院哥伦比亚大学地球与环境工程系中国矿业大学电气与动力工程学院哥伦比亚大学化学工程系

Promoter-modified Ni-based catalysts were synthesized by an incipient-wetness impregnation method using 3D-mesoporous KIT-6 as a support modified by ethylene glycol, and evaluated for the catalytic production of synthetic natural gas （SNG） from CO methanation. Characterization results suggested that the addition of promoter species could remarkably improve the low-temperature catalytic activity for CO methanation, which was due to a large dispersion of Ni nanoparticles, an enhanced interaction between metal and support as well as a confinement effect of 3D-mesopores. Among all catalysts, Ni-V/KIT-6 possessed the best catalytic performance, which was ascribed to the largest H2 uptake of 177.6 ^mol/g and Ni dispersion of 26.5%, an intimate interaction with the support from the formation of Si-O-V linkage and an enhanced confinement effect of 3D-mesopores to effectively prevent the growth of Ni nanoparticles and carbon filaments. In consequence, Ni-V/KIT-6 displayed excellent catalytic performance as well as high catalytic stability, which can be regarded as a promising candidate for CO methanation.

关键词： Nickel-based catalyst Methanation Promoter Support 3D-mesopore

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蛋糕生产中添加果胶的作用研究

食品科技 2004年第9期29卷 20-21页

作者：夏红曹卫华苏州农业职业技术学院苏州215008

添加1.0%的果胶粉,使蛋糕的比体积增加。果胶的添加还可提高蛋糕糊的稳定性,保持口感的松软。

关键词：果胶蛋糕添加剂

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Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao xia Jianing LIANG Yuhao JIANG Zhiyang PENG Jiaxu LI Chen xiaO Renyou XU Wenwen WANG xiantao SHANG Shiyang LU Dapeng ZHU hong-Xi LIU Kaihua cao Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-Lin Jiang Bao-xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-cao （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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风电变流器IGBT模块的冷板设计

车辆与动力技术 2017年第1期 51-54页

作者：姜红霞谷操靳霏赵真中国北方车辆研究所北京100072 三一重型能源装备有限公司北京102202

针对某2.0MW风电变流器IGBT模块的散热需求,对其散热部件——冷板进行几何参数和性能参数(表面温度和流动阻力)的设计和计算,特别是对介质的对流换热系数进行了理论推导和计算.对冷板的仿真分析和装机试验的结果进行分析,结果表明所设... 详细信息

针对某2.0MW风电变流器IGBT模块的散热需求,对其散热部件——冷板进行几何参数和性能参数(表面温度和流动阻力)的设计和计算,特别是对介质的对流换热系数进行了理论推导和计算.对冷板的仿真分析和装机试验的结果进行分析,结果表明所设计的冷板能够同时满足表面温度低于80℃、介质流动阻力小于1bar的参数要求,保证了IGBT模块可靠工作.

关键词：风电变流器 IGBT模块冷板

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二甲基-β-丙酸噻亭对凡纳滨对虾幼虾生长、蜕壳和渗透调节的影响

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水产学报 2006年第3期30卷 404-409页

作者：赵红霞曹俊明周萌吴建开朱选杨大伟广东省农业科学院畜牧研究所广东省农业科学院畜牧研究所广东广州510640

在低盐度5~6和水温25~29℃条件下,分别投喂1种对照饲料和7种添加二甲基-β-丙酸噻亭(DMPT)(添加量分别为100、2003、00、400、5006、00和***-1)的试验饲料,饲养初始体重约每尾0.77g的凡纳滨对虾56d,观察DMPT对凡纳滨对虾的生长、蜕壳和... 详细信息

在低盐度5~6和水温25~29℃条件下,分别投喂1种对照饲料和7种添加二甲基-β-丙酸噻亭(DMPT)(添加量分别为100、2003、00、400、5006、00和***-1)的试验饲料,饲养初始体重约每尾0.77g的凡纳滨对虾56d,观察DMPT对凡纳滨对虾的生长、蜕壳和渗透压调节的影响。实验结果表明,添加DMPT的各组凡纳滨对虾增重率随着DMPT添加量的增加,呈现先升后降的趋势,在***-1凡纳滨对虾增重率达到最高,显著高于对照组;与对照组相比,各试验组凡纳滨对虾的饲料系数均不同程度降低,***-1DMPT组凡纳滨对虾的饲料系数降低达到显著水平。添加DMPT对凡纳滨对虾的蜕壳次数无显著影响。除***-1DMPT组外,DMPT组凡纳滨对虾的渗透压均明显低于对照组,其中,添加300和***-1组凡纳滨对虾的渗透压降低呈现显著性差异。凡纳滨对虾肌肉粗蛋白和粗脂肪含量随着DMPT水平增加呈现出先上升后下降的趋势。粗蛋白含量在DMPT添加量为***-1时达到最高,粗脂肪含量在DMPT添加量为***-1时达到最高,均显著高于对照组。以增重率为判定指标,DMPT在凡纳滨对虾饲料中的适宜添加量为***-1。

关键词：凡纳滨对虾二甲基-β-丙酸噻亭生长蜕壳渗透调节

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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