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Selective and stable elimination of endosymbionts from multiple-infected whitefly Bemisia tabaci by feeding on a cotton plant cultured in antibiotic solutions

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Insect Science 2020年第5期27卷 964-974页

作者： Dong-Xiao Zhao Zhi-Chun Zhang hong-tao niu Hui-Fang Guo Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingChina

The maternally heritable endosymbiont provides many ecosystem *** elimination of a specific symbiont and establishment of experimental host lines lacking certain symbionts enable the roles of a given symbiont to be *** whitefly Bemisia tabaci(Gennadius)in China harbors obligate symbiont Portiera infecting each in-dividual,as well as facultative symbionts,such as Hamiltonella,Rickettsia and Cardinium,with co-infections occurring relatively *** far no studies have evaluated the selectivity and efficacy of a specific symbiont elimination using antibiotics in whiteflies co-infected with different ***,no success has been achieved in estab-lishing certain symbiont-free *** *** this study,we treated Hamiltonella infected *** line,Hamiltonella-Rickettsia-co infected line and Hamiltonella-Cardinium co-infected line by feeding *** adults with cotton plants cultured in water containing ri-fampicin,ampicillin or a mixture of them,aiming to selectively curing symbiont infections and establishing stable symbiont-free *** found ampicillin selectively eliminated Cardinium without afecting Portiera,Hamiltonella and Rickettsia,although they coex-isted in the same host ***,all of the symbionts considered in our study can be removed by *** reduction of facultative symbionts occurred at a much quicker pace than obligate symbiont Portiera during rifampicin ***,we measured the stability of symbiont elimination in whitefly successive generations and established Rickettsia-infected and Cardinium-infected lines which are absent in natural *** results provide new protocols for selective elimination of symbionts co-existing in a host and establishment of different symbiont-infected host lines.

关键词： antibiotic treatment Bemisia tabaci co-infections endosymbionts infection frequency

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Quasi-Z Source Inverter Control of PV Grid-Connected Based on Fuzzy PCI

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Journal of Electronic Science and Technology 2021年第3期19卷 274-286页

作者： tao Hou Chen-Yang Zhang hong-Xia niu School of Automation and Electrical Engineering Lanzhou Jiaotong UniversityLanzhou 730070 Automatic Control Research Institute Lanzhou Jiaotong UniversityLanzhou 730070

The photovoltaic grid-connected inverter is an important interface between the photovoltaic power generation system and power *** high-quality operation is directly related to the output power quality of the power *** order to further optimize the control effect of the quasi-Z source grid-connected photovoltaic inverter,a fuzzy proportional complex integral control(PCI)method is proposed for the current internal loop *** method can eliminate the steady-state error,and has the characteristic of zero steady-state error adjustment for the AC disturbance signal of a specific *** inductance-capacitance-inductance(LCL)filter is adopted in the grid-connected circuit,and the feedback capacitive current is taken as the control variable of the inner loop to form the active damping control method,which can not only effectively suppress the resonance of the LCL circuit,but also significantly inhibit the high-order harmonics in the grid-connected ***,a system simulation model is built in MATLAB/Simulink to verify the superiority and effectiveness of the proposed method.

关键词： Frequency of harmonic distortion fuzzy proportional complex integral inductance-capacitance-inductance(LCL)filtering circuit photovoltaic grid-connection quasi-Z source inverter

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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Microstructural adjustments and mechanical properties of a cold-rolled biomedical near β-Ti alloy sheet

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Rare Metals 2018年第10期37卷 846-851页

作者： Xi-Qun Ma hong-Zhi niu Zhen-tao Yu Sen Yu Chang Wang Northwest Institute for Nonferrous Metal Research Xi'an 710016 China School of Materials Science and Engineering Northeastern University Shenyang 110819 China

In this study, microstructural adjustments and mechanical properties of a cold-rolled near β-type alloy Ti-25Nb-3Zr-3Mo-2Sn （wt%） sheet were investigated. Microstructures and phase transformation products strongly depended on aging temperatures. Solution treatments within single β-phase field removed the stress-induced at martensites and produced a few new lath-shaped ones, but metastable β phase still dominated. This is exactly the reason why current alloy exhibits the lowest modulus （54 GPa） and best elongation to fracture （39 %）, but the worst yield strength of only 340 MPa, at solutiontreated state. A fairly large number of ellipsoidal ω phase nanoparticles precipitated throughout parent β phase during aging at 380℃. These ω nanoparticles possess remarkable strengthening effect, but deteriorate ductility seriously. A novel post-aging process was proposed to remove brittle ω phase. By contrast, aging at 450 ℃ resulted in sufficient precipitation of fine needle-like α phase. This brought about the best combination of high yield strength （770 MPa） and moderate elastic modulus （75 GPa） and good elongation （15 %） for biomedical implants.

关键词： Near β-Ti alloy Microstructures Phase transformation Mechanical properties

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Vascularization ability of glioma stem cells in different three-dimensional microenvironments

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Regenerative Biomaterials 2024年第1期3卷 34-43页

作者： Xuanzhi Wang tao Xu Chaoshi niu Department of Neurosurgery The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230036China Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072People's Republic of China Center for Bio-intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in ShenzhenTsinghua UniversityShenzhen 518057People's Republicof China

Glioblastoma(GBM)is among the most common and aggressive adult central nervous system *** prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis and prognosis has been *** reconstructing this neovascula-rization and tumor microenvironment through personalized in vitro disease models presents a significant ***,it is crucial to develop new anti-angiogenic therapies for *** this study,3D bioprinted glioma stem cell(GSC)-laden hydrogel scaffolds,hybrid Gsc hydrogels and ceil-free hydrogel scaffolds were manufactured to investigate the vas-cularization ability of GsCs in varying 3D microenvironments.

关键词： 3D bioprinting xenograft tumors GSC-laden hydrogel scaffold glioblastoma angiogenesis

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Electrodeposition of functionally graded Ni-W/Er2O3 rare earth nanoparticle composite film

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International Journal of Minerals,Metallurgy and Materials 2020年第6期27卷 818-829页

作者： Guo-quan Lai hong-zhong Liu Bang-dao Chen Dong niu Biao Lei Wei-tao Jiang State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China

Multi-layered functionally graded(FG)structure Ni-W/Er2O3 nanocomposite films were prepared by continuously changing the deposition parameters,in which the Er2O3 and W contents varied with *** microstructure and chemical composition of the electrodeposited Ni-W/Er2O3 films were determined by scanning electron microscopy(SEM)and energy-dispersive X-ray spectroscopy(EDS).The anti-corrosion and wear properties of the electrodeposition films were investigated by electrochemical measurement and ball-on-disk friction *** microhardness distribution of the cross section of nanocomposites was measured by *** results showed that with decreasing agitation rate or increasing average current density,the contents of Er2O3 nanoparticles and tungsten were distributed in a gradient along the thickness,and the contents on the surface were *** comparison,FG Ni-W/Er2O3 films had better anti-corrosion and wear properties than the uniform Ni-W/Er2O3 *** force microscopy(AFM)and profilometry measurements indicated that Er2O3 nanoparticles had an effect on the surface roughness.

关键词： nickel-tungsten electrodeposition functionally graded material nanocomposite erbium oxide nanoparticle

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Genetic variation in the triosephosphate isomerase gene of the fall armyworm and its distribution across China

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INSECT SCIENCE 2024年第6期31卷 1984-1997页

作者： Liang, Xin-Yue Zhang, Lei Li, hong-Ran niu, Xiao-Ping Xiao, Yu-tao Chinese Acad Agr Sci Agr Genom Inst Shenzhen Shenzhen Branch Guangdong Lab Lingnan Modern AgrMinist Agr & Rur Shenzhen Guangdong Peoples R China South China Agr Univ Coll Life Sci Guangzhou Peoples R China Xingping Plant Protect & Plant Quarantine Stn Xian Peoples R China

The fall armyworm (FAW), Spodoptera frugiperda, has colonized and caused consistent damage in the Eastern hemisphere. The identification of various FAW strains is essential for developing precise prevention and control measures. The triosephosphate isomerase (Tpi) gene is recognized as an effective marker closely linked to FAW subpopulations. However, most current studies primarily focus on the comparison of variations in specific gene sites of this gene. In this study, we conducted full-length sequencing of the Tpi genes from 5 representative FAW groups. Our findings revealed that the Tpi genes varied in length from 1220 to 1420 bp, with the primary variation occurring within 4 introns. Notably, the exon lengths remained consistent, at 747 bp, with 37 observed base variations;however, no amino acid variations were detected. Through sequence alignment, we identified 8 stable variation sites that can be used to distinguish FAW strains in the Eastern hemisphere. Additionally, we performed strain identification on 1569 FAW samples collected from 19 provinces in China between 2020 and 2021. The extensive analysis indicated the absence of the rice strain in the samples. Instead, we only detected the presence of the corn strain and the Zambia strain, with the Zambia strain being distributed in a very low proportion (3.44%). Furthermore, the corn strain could be further categorized into 2 subgroups. This comprehensive study provides a valuable reference for enhancing our understanding of FAW population differentiation and for improving monitoring and early warning efforts.

关键词： corn strain molecular marker rice strain Spodoptera frugiperda Tpi Zambia strain

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Precipitation Behavior and Its Strengthening Effect of X100 Pipeline Steel

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Journal of Iron and Steel Research International 2010年第11期17卷 73-78页

作者： niu tao KANG Yong-lin GU hong-wei YIN Yu-qun QIAO Ming-liang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China Nanjing Iron and Steel Co Ltd Nanjing 210035 Jiangsu China

Using TEM （transmisson electron microscopy）, electron diffraction, EDX （energy dispersive X-ray） analysis and physicochemical phase analysis, the morphology, crystal structure, size distribution and chemical composition of precipitates in the microstructure of high strength Nb-microalloyed Xl00 pipeline steel were investigated, and the strengthening effect of precipitation was quantitatively calculated with Ashhy-Orowan correction model. The precipitates obtained in X100 pipeline steel can be divided into two kinds：＂complex＂ and ＂single＂ particles by morphology. The EDX analysis of ＂single＂ precipitates reveals that the chemical composition matches well with particle dimensions, especially the Nb to Ti ratio regularly decreases with the increase of particle size. The yield strength increments in the way of precipitation strengthening of X100 pipeline steel reached about 52 MPa, suggesting that the precipitation strengthening is not the dominative strengthening mechanism for X100 pipeline steel.

关键词： X100 pipeline steel carbonitride precipitation behavior strengthening effect

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