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Autophagy-targeting modulation to promote peripheral nerve regeneration

Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen hongxia Deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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Blimp-1 protein and Hans classification on prognosis of diffuse large B-cell lymphoma and their interrelation

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Chinese Journal of Cancer 2010年第9期29卷 781-786页

作者： Yan song Zhi Cao Ling Li hong-Tu zhang Xun zhang Department of Pathology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing100021 P. R. China

Background and Objective:Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma (NHL), is heterogeneous on molecular and clinical levels, therefore, its prognosis is difficult to *** study aimed to evaluate the value of Blimp-1 protein and Hans classification in predicting the prognosis of DLBCL and their ***:The clinical records of 136 patients with DLBCL were *** patients were followed up for 5-80 months (median, 39 months).Immunohistochemical staining for CD10, MUM1, Bcl-6, and Blimp-1 were performed on paraffin-embedded tumor tissues from the 136 *** correlations of Blimp-1 protein and Hans classification in prognosis of DLBCL and their interrelation were ***:Blimp-1 was detected in 38 (30.0%) patients, and was associated with a significantly shorter overall survival (OS) (P=0.030).Using the Hans classification based upon the expression of CD10, Bcl-6, and MUM1, 54 patients had germinal center B-cell (GCB) phenotype and 82 had non-GCB *** 5-year OS rate was 75% in the GCB group and 52% in the non-GCB group (P=0.020).The positive rate of Blimp-1 was 22.2% in the GCB group and 31.7% in the non-GCB group (P=0.329).The Cox regression multivariate analysis showed that international prognosis index (IPI) and Hans classification had independent prognostic significance, whereas Blimp-1 was not an independent prognostic ***:The patients with GCB subtype of DLBCL had better prognosis than the non-GCB *** level of Blimp-1 expression in the patients with DLBCL implies a shorter survival, but it is not associated with Hans classification.

关键词： B细胞淋巴瘤分类价值弥漫性预后飞艇蛋白发电机断路器免疫组织化学染色

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Recent advances of magnesium hydride as an energy storage material

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Journal of Materials Science & Technology 2023年第18期149卷 99-111页

作者： Mengchen song Liuting zhang Fuying Wu Haoyu zhang Hu Zhao Lixin Chen hong Li School of Energy and Power Instrumental Analysis CenterJiangsu University of Science and TechnologyZhenjiang 212003China School of Mechanical and Aerospace Engineering Nanyang Technological University639798Singapore State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Energy storage is the key for large-scale application of renewable energy,however,massive efficient en-ergy storage is very *** hydride(MgH_(2))offers a wide range of potential applications as an energy carrier due to its advantages of low cost,abundant supplies,and high energy storage ***,the practical application of MgH_(2) for energy storage is still impeded by its sluggish kinetics,poor cycling stability,***,we provide an overview of recent advances of MgH_(2) for enhancing the hydrogen storage,lithium-ion storage,and heat storage *** hydrogen storage,a particular emphasis was put on altering the kinetics and thermodynamics of MgH_(2) via catalyzing,alloying,nano-sizing,and *** to MgH_(2) as a battery anode material mainly focus on the effect of additives,electrolytes,and structure *** heat storage apparatus was proposed based on MgH_(2) and coupled with other materials or systems to improve the heat storage and economic ***,prospects of MgH_(2) in these fields are *** review would stimulate more insightful and pioneering research for the design and preparation of MgH_(2) with excellent energy storage performances.

关键词： Magnesium hydride Energy storage Hydrogen storage Li-ion battery Heat storage

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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan zhang Yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

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Microstructure and properties of TP2 copper tube with La microalloying by horizontal continuous casting

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China Foundry 2018年第1期15卷 31-36页

作者： Jin-hu Wu Shi-hong zhang Yan Chen Hai-hong Li hong-wu song Ming Cheng Jin-song Liu Institute of Metal Research Chinese Academy of Sciences Shenvang 110016 China University of Chinese Academy of Sciences Beijing 100049. China School of Environment and Materials Engineering Yantai University Yantai 264005 China

The TP2 copper tube was prepared with La microalloying by horizontal continuous casting(HCC). The absorptivity of La and its effects on microstructure, tensile and corrosion properties of HCC TP2 copper tube were studied by means of the inductively coupled plasma optical emission spectrometer(ICP-OES), optical microscope(OM), scanning electron microscope(SEM) and potentiodynamic polarization measurements. The results show that the absorptivity of La in the HCC TP2 copper tube is about 15% under antivacuum conditions due to the good chemical activities of La. The impurity elements in copper tube such as O, S, Pb and Si can be significantly reduced, and the average columnar dendrite spacing of the copper tube can also be reduced from 2.21 mm to 0.93 mm by adding La. The ultimate tensile strength and the elongation with and without La addition are almost unchanged. However, the annual corrosion rate of the HCC TP2 copper tube is reduced from 10.18 mm·a^(-1) to 9.37 mm·a^(-1) by the purification effect of trace La.

关键词： rare earth microstructure mechanical properties corrosion resistance HCC TP2 copper tube

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Enhanced Impurity-Free Intermixing Bandgap Engineering for InP-Based Photonic Integrated Circuits

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Chinese Physics Letters 2014年第4期31卷 64-67页

作者： CUI Xiao zhang Can LIANG song ZHU hong-Liang HOU Lian-Ping Key Laboratory of Semiconductor Materials Science Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 School of Engineering University of Glasgow Oakfield Avenue Glasgow G12 8LT UK

hnpurity-free intermixing of InGaAsP multiple quantum wells （MQW） using sputtering Cu/Si02 layers followed by rapid thermal processing （RTP） is demonstrated. The bandgap energy could be modulated by varying the sputtering power and time of Cu, RTP temperature and time to satisfy the demands for lasers, modulators, pho- todetector, and passive waveguides for the photonic integrated circuits with a simple procedure. The blueshift of the bandgap wavelength of MQW is experimentally investigated on different sputtering and annealing conditions. It is obvious that the introduction of the Cu layer could increase the blueshift more greatly than the common impurity free vacancy disordering technique. A maximum bandgap blueshift of 172nm is realized with an anneal- ing condition of 750~C and 200s. The improved technique is promising for the fabrication of the active/passive optoeleetronic components on a single wafer with simple process and low cost.

关键词： QUANTUM wells SPUTTERING (Physics) ANNEALING of metals ENERGY gaps (Physics) INTEGRATED circuits

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Corrosion Resistance of Superhydrophobic Mg-Al Layered Double Hydroxide Coatings on Aluminum Alloys

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Acta Metallurgica Sinica(English Letters) 2015年第11期28卷 1373-1381页

作者： Fen zhang Chang-Lei zhang Liang song Rong-Chang Zeng Lan-Yue Cui hong-Zhi Cui College of Materials Science and Engineering Shandong University of Science and Technology State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences

A superhydrophobic surface was successfully constructed to modify the layered double hydroxide （LDH） coatings on aluminum alloy using stearic acid. The characteristics of the coatings were investigated using SEM, XRD, FT- IR and XPS. The corrosion resistance of the prepared coatings was studied using potentiodynamic polarization and electrochemical impedance spectrum. The results revealed that the superhydrophobic surface considerably improved the corrosion-resistant performance of the LDH coatings on the aluminum alloy substrate. The formation mechanism of the superhydrophobic surface was proposed.

关键词： Aluminum alloy Layered double hydroxide Superhydrophobic Stearic acid Corrosion

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Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 826-832页

作者： hong-Yan Zhou Wei Zhong hong zhang Miao-Miao Bi Shuang Wang Wen-song zhang Department of Ophthalmology China-Japan Union HospitalJilin University Department of Glaucoma the Second Hospital of Jilin University

·Fungal keratitis(FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response. The inflammatory process is related to a variety of immune cells, including macrophages, helper T cells, neutrophils, dendritic cells, and Treg cells, and is associated with proinflammatory, chemotactic and regulatory cytokines. All-trans retinoic acids(ATRA)have diverse immunomodulatory actions in a number of inflammatory and autoimmune conditions. These retinoids regulate the transcriptional levels of target genes through the activation of nuclear *** acid receptor α(RAR α), retinoic acid receptor γ(RAR γ), and retinoid X receptor α(RXR α) are expressed in the cornea and immune cells. This paper summarizes new findings regarding ATRA in immune and inflammatory diseases and analyzes the perspective application of ATRA in FK.

关键词： nuclear receptor all-trans retinoic acid fungal keratitis cornea

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli zhang Tian Li Jie Miao Zhina zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Destabilization of Basic Fibroblast Growth Factor by Oligodeoxynucleotides

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Chinese Chemical Letters 2006年第3期17卷 415-418页

作者： Qiang WU Ju WANG Ling zhang An hong Jin song REN Sub division of Biological Inorganic Chemistry Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 Bioengineering Institute of Jinan University Guangzhou 510632

The effects of oligodeoxynucleotide （ODN） on the conformation of basic fibroblast growth factor （bFGF） were studied by spectral method. The results showed that ODN destabilized the protein.

关键词： Basic fibroblast growth factor oligodeoxynucleotide (ODN) conformational changes

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