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Second-Order Optimality Conditions for Multiobjective Optimization Whose Order Induced by Second-Order Cone

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Journal of the Operations Research Society of China 2018年第2期6卷 267-288页

作者： Li-Wei zhang ji-hong zhang Yu-Le zhang School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

This paper is devoted to developing first-order necessary,second-order necessary,and second-order sufficient optimality conditions for a multiobjective optimization problem whose order is induced by a finite product of second-order cones(here named as Q-multiobjective optimization problem).For an abstract-constrained Q-multiobjective optimization problem,we derive two basic necessary optimality theorems for weak efficient solutions and a second-order sufficient optimality theorem for efficient *** Q-multiobjective optimization problem with explicit constraints,we demonstrate first-order and second-order necessary optimality conditions under Robinson constraint qualification as well as second-order sufficient optimality conditions under upper second-order regularity for the explicit *** applications,we obtain optimality conditions for polyhedral conic,second-order conic,and semi-definite conic Q-multiobjective optimization problems.

关键词： Second-order cone-induced multiobjective optimization Optimality conditions Polyhedral cone Second-order cone Semi-definite cone

t(4;11)translocation in hyperdiploid de novo adult acute myeloid leukemia:A case report

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World Journal of Clinical Cases 2022年第32期10卷 11980-11986页

作者： Min-Yu zhang Yue Zhao ji-hong zhang Hematology Laboratory Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina

BACKGROUND MLL gene rearrangement is a common genetic abnormality of acute myeloid leukemia(AML),which predicts poor prognosis and is important in clinical *** rearrangement involves many chromosomes,among which,t(4;11)translocation is rare in *** present case was t(4;11)AML,accompanied by a hyperdiploid *** cases have not been reported *** SUMMARY An adult male with self-reported symptoms of fatigue,febrility and hyperleukocytosis was diagnosed with AML by morphology and confirmed by immunophenotype ***,chromosomal and fluorescence in situ hybridization(FISH)analysis showed a hyperdiploid karyotype with t(4;11)translocation and MLL rearrangement,and a negative MLL–AF4 fusion gene *** patient died of respiratory and circulatory failure 5 days after *** t(4;11)AML with hyperdiploid karyotype has not been *** this case,t(4;11)was only detected by karyotype analysis and FISH,suggesting their importance in MLL rearrangement detection.

关键词： Acute myeloid leukemia MLL gene rearrangement Translocation t(4 11) Hyperdiploid FISH Case report

Early Aerobic Exercise Promotes Neurological Function Recovery of Rats after Cerebral Ischemia/Reperfusion by Upregulating the Expression of Heat Shock Protein A5

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Current Medical Science 2022年第2期42卷 267-273页

作者： Zhi-feng PENG Nai-bao zhang jian MENG ji-hong zhang Department of Physiology School of MedicineShanxi Datong UniversityDatong037009China Department of Neurology Luliang People’s HospitalLuliang033000China Department of Anatomy School of MedicineShanxi Datong UniversityDatong037009China

Objective The neuroprotective function of heat shock protein A5(HSPA5)in ischemic stroke has been *** study aimed to investigate the effects of early aerobic exercise on neurological function recovery from cerebral ischemia/reperfusion and to determine whether these effects are associated with the expression level of HSPA5 in the ischemic *** A total of 72 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group[middle cerebral artery occlusion(MCAO)-Ex,n=18],ischemia and sedentary group(MCAO-St,n=18),sham-surgery and exercise group(Sham-Ex,n=18),or sham-surgery and sedentary group(Sham-St,n=18).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 min,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without *** in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 min once a day for 5 consecutive *** reperfusion,the motor function of the rats was scored by the Bederson neurological function test,balance beam test,and screen *** staining was conducted to assess morphological and structural change of nerve cells in the ischemic *** reverse transcription-quantitative polymerase chain reaction was applied to detect the mRNA expression of *** blot analysis was conducted to determine the protein expression of *** deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)staining was carried out in the ischemic penumbra after *** Rats receiving early treadmill exercise had lower Bederson neurological function,balance beam,and screen test scores on the 3rd,7th,and 14th days after MCAO;in addition,more neurons survived in the ischemic penumbra after MCAO,and higher mRNA and protein expression of HSPA5 and fewer TUNEL-positive stained cells were *** Our study demonstrated that early aerobic exercise can improve neurological function recovery after ischemia/***,the increased l

关键词： early aerobic exercise heat shock protein A5 ischemia/reperfusion apoptosis behavioral score

Differentiation of a Miniature Inverted Transposable Element （MITE） System in Asian Rice Cultivars and Its Inference for a Diphyletic Origin of Two Subspecies of Asian Cultivated Rice

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Journal of Integrative Plant Biology 2006年第3期48卷 260-267页

作者： Hao Hu jie Mu hong-ji zhang Yue-Zhi Tao Bin Han National Center for Gene Research Shanghai Institutes of Biological Sciences the Chinese Academy of Sciences Shanghai 200233 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China

In the present study, we report a survey on a Miniature Inverted Transposable Element （MITE） system known as mPing in 102 varieties of Asian cultivated rice （Oryza sativa L.）. We found that mPing populations could be generalized Into two families, mPing-1 and mPing-2, according to their sequence structures. Further analysis showed that these two families of mPing had significant bias in their distribution pattern in two subspecies of rice, namely O. sativa ssp. japonica and indica. 0. sativa japonica has a higher proportion of mPing-1 as a general trait, whereas 0. sativa indica has a higher proportion of roPing-2. We also examined the mPing system In a doubled haploid （DH） cross-breeding population of jingxi 17 （japonica） and zhaiyeqing 8 （indica） varieties and observed that the mPing system was not tightly linked to major subspecies-determining genes. Furthermore, we checked the mPing system in 28 accessions of Asian common wild rice O. rufipogon and found the roPing system in 0. rufipogon. The distribution pattern of the roPing system in O. rufipogon indicated a diphyletlc origin of the Asian cultivated rice O. sativa species. We did not find the mPing system in another 20 Oryza species. These results substantiated a previous hypothesis that O. ruflpogon and O. nivara species were the closest relatives of O. sativa and that the two extant subspecies of O. sativa were evolved independently from corresponding ecotypes of O. ruflpogon.

关键词： diphyletic indica japonica Miniature Inverted Transposable Element (MITE) mPing rice.

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丙型肝炎的诊疗进展

世界华人消化杂志 2024年第7期32卷 484-489页

作者：张红吉刁婷婷刘超李晓非昆明市第三人民医院(云南省传染性疾病临床医学中心) 云南省昆明市650041

丙型肝炎(丙肝)是由丙型肝炎病毒(hepatitis C virus,HCV)引起的一种常见传染病,2019年全球有慢性HCV感染者5800万人,29万人死于HCV感染引起的肝硬化,2019年全球新发感染者约150万人.丙肝危害严重,早发现、早诊断、早治疗在其中起到重... 详细信息

丙型肝炎(丙肝)是由丙型肝炎病毒(hepatitis C virus,HCV)引起的一种常见传染病,2019年全球有慢性HCV感染者5800万人,29万人死于HCV感染引起的肝硬化,2019年全球新发感染者约150万人.丙肝危害严重,早发现、早诊断、早治疗在其中起到重要意义.因此,本文作者总结了丙肝的诊断、治疗方法.丙肝的诊断需结合流行病学史、临床表现和实验室检查等进行.应根据基因型、肝脏损伤严重程度、适应症和禁忌症等选择合适的方案.

关键词：丙型肝炎丙型肝炎病毒诊断治疗综述

Metabolomics reveals the key role of oxygen metabolism in heat susceptibility of an alpine-dwelling ghost moth, Thitarodes xiaojinensis (Lepidoptera: Hepialidae)

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Insect Science 2019年第4期26卷 695-710页

作者： Wei Zhu Qian Meng Huan zhang Meng-Long Wang Xumn Li hong-Tuo Wang Gui-Ling Zhou Lin Miao Qi-Lian Qin ji-hong zhang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China Department of Herpetology Chengdu Institute of Biology Chinese Academy of Sciences Chengdu China

Ghost moths inhabiting the alpine meadows of the Tibetan Plateau are cold? adapted stenothermal organisms that are susceptible to heat (dead within 7 days at 27 °C exposure). Exploring the metabolic basis of their heat susceptibility would extend our understanding of the thermal biology of alpine-dwelling invertebrates. Here, gas chromatography-mass spectrometry-based metabolomics was combined with physiological and transcriptional approaches to determine the metabolic mechanisms of heat susceptibility in Thitarodes xiaojinensis larvae. The metabolomics results showed that 27 °C heat stress impaired the Krebs cycle and lipolysis in T. xiaojinensis larvae, as demonstrated by the accumulation of intermediary metabolites. In addition, carbohydrate reserves were highly and exclusively consumed, and an anaerobic product, lactate, accumulated. This evidence suggested a strong reliance on glycolysis to anaerobically generate energy. The respiration rate and enzymatic activity test results indicated a deficiency in O2 metabolism;in addition, the Krebs cycle capacity was not decreased, and the metabolic flux through aerobic pathways was limited. These findings were further supported by the occurrence of hypoxia symptoms in midgut mitochondria (vacuolation and swelling) and increased transcription of hypoxia-induced factor 1-α.Overall, heat stress caused O2 limitation and depressed the overall intensity of aerobic metabolism in ghost moths, and less efficient anaerobic glycolysis was activated to sustain their energy supply. As carbohydrates were depleted, the energy supply became deficient. Our study presents a comprehensive metabolic explanation for the heat susceptibility of ghost moths and reveals the relationship between O2 metabolism and heat susceptibility in these larvae.

关键词： energy metabolism ghost moths metabolomics thermal intolerance oxygen limitation respiration rate

COMBINATION OF γ-INTERFERON WITH TRAIL AND CISPLATIN OR ETOPOSIDE INDUCES APOPTOSIS IN HUMAN NEUROBLASTOMA CELL LINE SH-SY5Y

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Chinese Medical Sciences Journal 2007年第1期22卷 38-43页

作者： Hai-xia Tong Chun-wei Lu ji-hong zhang Li Ma jin-hua zhang Laboratory of Hematology Shengjing Hospital China Medical University Shenyang 110004 Section of Health Testing College of Public Health China Medical University Shenyang 110001 Department of Infectious Diseases Shengjing Hospital China Medical University Shenyang 110004

Objective To study the effect of γ-interferon （IFNγ）, tumor necrosis factor related apoptosis inducing ligand （TRAIL）, and cisplatin or etoposide induced apoptosis in human neuroblastoma cell line SH-SY5Y and its possible molecular mechanisms. Methods The expressions of Caspase 8 mRNA and protein were detected with RT-PCR and Western blot analysis. The effects of IFNγ, TRAIL, IFNγ ＋ TRAIL, IFNγ ＋ Caspase 8 inhibitor ＋ TRAIL, IFNγ ＋ cisplatin ＋ TRAIL, and IFNγ ＋ etoposide ＋ TRAIL on the growth and apoptosis of SH-SY5Y cells were detected with the methods of MTT and flow cytometry. The relative Caspase 8 activity was measured with colorimetric assay. Results Caspase 8 was undetectable in SH-SY5Y cells but an increased expression of Caspase 8 mRNA and protein was found after treatment with IFNγ. SH-SY5Y ceils themselves were not sensitive to TRAIL, but those expressing Caspase 8 after treatment with IFNγ were. The killing effect of TRAIL on SH-SY5Y cells expressing Caspase 8 was depressed by Caspase 8 inhibitor. Cisplatin and etoposide could enhance the sensitivity of TRAIL on SH-SY5Y cells. The relative Caspase 8 activity of SH-SY5Y cells in IFNγ ＋ TRAIL group was significantly higher than those of control group, IFNγ group, TRAIL group, and inhibitor group （ P 〈 0. 01 ）. There was no significant difference among IFNγ ＋ TRAIL group, IFNγ ＋ cisplatin ＋ TRAIL group, and IFNγ ＋ etoposide ＋ TRAIL group. Conclusions IFNγ could sensitize SH-SY5Y cells to TRAIL-induced apoptosis and this may be realized by the up-regulation of Caspase 8. Cisplatin and etoposide could enhance the killing effect of TRAIL on SH-SY5Y cells.

关键词： neuroblastoma apoptosis tumor necrosis factor related apoptosis inducing ligand γ-interferon

A 16-bit 18-MSPS flash-assisted SAR ADC with hybrid synchronous and asynchronous control logic

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Journal of Semiconductors 2024年第6期45卷 3-12页

作者： Junyao ji Xinao ji Ziyu Zhou Zhichao Dai Xuhui Chen jie zhang Zheng jiang hong zhang School of Microelectronics Xi'an Jiaotong UniversityXi'an 710049China Qingdao Hi-image Tech.Co.Ltd. Qingdao 266100China

This paper presents a 16-bit,18-MSPS(million samples per second)flash-assisted successive-approximation-register(SAR)analog-to-digital converter(ADC)utilizing hybrid synchronous and asynchronous(HYSAS)timing control logic based on an on-chip delay-locked loop(DLL).The HYSAS scheme can provide a longer settling time for the capacitive digital-to-analog converter(CDAC)than the synchronous and asynchronous SAR ***,the issue of incomplete settling or ringing in the DAC voltage for cases of either on-chip or off-chip reference voltage can be solved to a large *** addition,the fore-ground calibration of the CDAC’s mismatch is performed with a finite-impulse-response bandpass filter(FIR-BPF)based least-mean-square(LMS)algorithm in an off-chip FPGA(field programmable gate array).Fabricated in 40-nm CMOS process,the proto-type ADC achieves 94.02-dB spurious-free dynamic range(SFDR),and 75.98-dB signal-to-noise-and-distortion ratio(SNDR)for a 2.88-MHz input under 18-MSPS sampling rate.

关键词： SAR ADC control logic reference ringing DAC incomplete settling

Adaptive PMD compensation experiment in 40 Gb/s CSRZ system

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Optoelectronics Letters 2007年第3期3卷 207-210页

作者： zhang Qi CHEN Ming-hua CHEN hong-wei zhang ji-yu Department of Electronic Engineering Tsinghua Univ. Beijing 100084 China

In 40 Gb/s systems with low polarization-mode dispersion(PMD) fibers,first-order PMD is the dominate factor with quite small value. An adaptive PMD compensator consisting of an electrical polarization controller(PC) ,a section of polariza-tion maintaining fiber(PMF) ,a degree of polarization(DOP) detector and a feedback control module is employed in 40 Gb/s NSFCNet. This compensator has a simple structure and high speed,which can compensate up to 20 ps first-order PMD adaptively and the average searching time is 2 ms.

关键词：自适应PMD补偿器补偿实验 CSRZ系统一阶PMD 光纤极化