检索结果-南通市图书馆

微观组织对叠片结构钨基面向等离子体材料的热疲劳效应的影响

在线全文

学校读者我要写书评

暂无评论

物理学报 2024年第11期73卷 101-109页

作者：祁超马玉田齐艳飞肖善曲王波北京工业大学材制学部北京100124 中国科学院电工研究所北京100190 华北理工大学冶金与能源学院唐山063210

钨(W)作为面向等离子体材料的最佳候选者,对热冲击载荷的响应是未来聚变装置研究中的重要问题.在热负荷作用下,钨基面向等离子体材料(W-based plasma-facing material,W-PFM)的表面会产生热损伤,包括脆性开裂和疲劳裂纹.本文提出了抑制W... 详细信息

钨(W)作为面向等离子体材料的最佳候选者,对热冲击载荷的响应是未来聚变装置研究中的重要问题.在热负荷作用下,钨基面向等离子体材料(W-based plasma-facing material,W-PFM)的表面会产生热损伤,包括脆性开裂和疲劳裂纹.本文提出了抑制W-PFM热损伤的新方案,即叠片结构W-PFM方案.利用电子束设备对不同厚度和热处理工艺的W箔组成的叠片结构W进行了热疲劳实验.样品施加功率密度为48 MW/m^(2)的热脉冲,循环5000次.随着W箔片厚度的减小,叠片结构W表面的裂纹损伤减轻.叠片结构W在循环热载荷作用后表面产生的主裂纹均近似平行于箔片厚度方向.厚度较小的W箔表面只有主裂纹,厚度较大的W箔表面除了出现主裂纹外,还会形成裂纹网络,且主裂纹宽度较大.最终选取热损伤区域的扫描电子显微镜图像,并利用计算机图片处理软件和分析软件,对表面热疲劳裂纹损伤进行了定量分析.发现相同厚度下应力态W的裂纹面积最小,裂纹数量最少,说明去应力态W的抗辐照损伤能力最强.实验结果还表明,除了微观组织的影响,叠片结构W-PFM的单轴应力状态和裂纹阻断机制也都对其热疲劳性能的提高有所贡献.

关键词：聚变面向等离子体材料钨热疲劳

基于P-糖蛋白信号通路研究龙血竭对大鼠失重空肠屏障损伤的保护机制

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

北京理工大学学报 2024年第5期44卷 546-552页

作者：张瀚文刘珊潘秋霞张波李玉娟北京理工大学生命学院北京100081 战略支援部队特色医学中心北京100101

传统中药龙血竭在航天肠道损伤的防护中发挥重要作用,但其保护失重屏障损伤的作用机制尚不清楚.P-糖蛋白(P-glycoprotein,P-gp)是肠上皮细胞膜上的外排转运体,能够将毒素、有害菌等外排以维持肠屏障完整性.文中采用大鼠尾吊模型模拟微... 详细信息

传统中药龙血竭在航天肠道损伤的防护中发挥重要作用,但其保护失重屏障损伤的作用机制尚不清楚.P-糖蛋白(P-glycoprotein,P-gp)是肠上皮细胞膜上的外排转运体,能够将毒素、有害菌等外排以维持肠屏障完整性.文中采用大鼠尾吊模型模拟微重力效应,灌胃给药龙血竭(Dragon’s Blood,DB)21d后,观察大鼠空肠组织形态、测定肠屏障通透性标志物质量浓度、检测P-gp与Wnt/β-Catenin信号通路相关蛋白的表达.结果表明,龙血竭可通过激活Wnt/β-Catenin信号通路促进空肠中P-gp基因及蛋白的表达,能够缓解模拟微重力效应下的大鼠空肠屏障损伤.研究结果或可为航天员在轨肠道损伤防护提供基础研究数据.

关键词：龙血竭(DB) 微重力空肠屏障 P-糖蛋白 Wnt/β-Catenin信号通路

Research progress of traditional Chinese medicine in the treatment of endocrine metabolic diseases in 2023

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第12期9卷 51-65页

作者： Ming-Yao Fan Jing Ru Si Wang Yan Chen Xiao-Xia Zhang Guo-Long Li Qing-shan Hai Wei-bo Wen Huan-Tian Cui College of Basic Medical of Yunnan University of Chinese Medicine Kunming 650000China Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment Kunming 650000China The First Clinical Medical College of Yunnan University of Chinese Medicine Kunming 650000China Department of Endocrinology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Yunnan Engineering Research Centre of Preventive Treatment of Chinese Medicine First Affiliated HospitalYunnan University of Chinese MedicineKunming 650000China

This study aimed to provide a comprehensive review of the research progress in Chinese medicine in the treatment of endocrine metabolic diseases in 2023,covering traditional Chinese medicine(TCM)monomers,TCM extracts,and TCM combinations,including non-alcoholic fatty liver disease,type 2 diabetes mellitus and its complications,obesity,hyperuricaemia,and thyroid *** systematic sorting and summary,we found that in 2023,the research focusing on the application of TCM for endocrine metabolic diseases was still on the mechanism of action at the cellular and molecular levels,which not only influenced the classical pathways of lipid metabolism,but also delved into the key mechanisms of anti-inflammation,anti-oxidation,anti-insulin resistance,and so ***,TCM has shown remarkable results in the treatment of endocrine metabolic diseases by improving intestinal flora disorders and abnormal cellular iron *** research results provide valuable ideas,methods,and tools for TCM in the prevention and treatment of endocrine metabolic diseases,and provide important references and guidance for future research and practice.

关键词： endocrine metabolic diseases traditional Chinese medicine Chinese medicine extracts Chinese medicine compound therapeutic mechanism

A model of five genes of tumor microenvironment predicts prognosis in Cholangiocarcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Advances 2024年第2期7卷 1-12页

作者： Jin-shan Yang Chuan-Xin Wu Kai Li Ling-Xiang Xu Xing-Lang Wu Qin-bo Wang Lun-Wei Chen Na Wang Hang Sun Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Hepatobiliary Surgery The Third People’s Hospital of Sichuan ProvinceChengdu 610100China Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China

Background:Cholangiocarcinoma(CCA)is highly malignant and has a poor prognosis has a high malignant degree and poor *** purpose of this study is to develop a new prognostic model based on genes related to the tumor microenvironment(TME).Methods:Derived from the discerned differentially expressed genes within The Cancer Genome Atlas(TCGA)dataset,this investigation employed the methodology of weighted gene co-expression network analysis(WGCNA)to ascertain gene co-expressed modules intricately linked to the Tumor Microenvironment(TME)among Cholangiocarcinoma(CCA)*** genes associated with prognosis,as identified through Cox regression analysis,were employed in the formulation of a predictive *** model underwent validation,leading to the development of a risk score formula and ***,we validated the model’s reliability using data from CCA patients in the Gene Expression Omnibus(GEO)database(accession:GSE107943).Results:6139 DEGs were divided into 10 co-expressed gene modules using *** these,two modules(blue module with 832 genes and brown module with 1379 genes)showed high correlation with the *** prognostic genes(BNIP3,COL4A3,SPRED3,CEBPB,PLOD2)were identified through Cox regression analysis,and a prognostic model and risk score formula were developed based on these *** score formula:Risk score=BNIP3×1.70520-COL4A3×2.39815+SPRED3×1.17936+CEBPB×0.40456+PLOD2×***-Meier survival analysis revealed that the survival probabilities of the low-risk group were significantly higher than those of the high-risk ***,the related evaluation indexes suggested that the model exhibited strong predictive ***:The prognostic model,based on five TME-related genes(BNIP3,COL4A3,SPRED3,CEBPB,PLOD2),could accurately assess the prognosis of CCA patients to aid in guiding clinical decisions.

关键词： Cholangiocarcinoma tumor microenvironment prognostic prediction model nomogram

Haplotype-resolved and chromosome-scale genomes provide insights into co-adaptation between the Amur tiger and Amur leopard

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第3期45卷 464-467页

作者： Hai-Meng Li bo-Yang Liu Min-Hui Shi Le Zhang shang-Chen Yang Sunil Kumar Sahu Liang-Yu Cui shan-Lin Liu Nicolas Dussex Yue Ma Dan Liu Wei-Yao Kong Hao-Rong Lu Yue Zhao Love Dalén Huan Liu Tian-Ming Lan Guang-Shun Jiang Yan-Chun Xu College of Wildlife and Protected Area Northeast Forestry UniversityHarbinHeilongjiang 150040China State Key Laboratory of Agricultural Genomics BGI ResearchShenzhenGuangdong 518083China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China BGI Research WuhanHubei 430074China Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China Centre for Palaeogenetics Svante Arrhenius väg 20CStockholm 10691Sweden Department of Zoology Stockholm UniversityStockholm 10691Sweden Department of Bioinformatics and Genetics Swedish Museum of Natural HistoryStockholm 10691Sweden Heilongjiang Siberian Tiger Park HarbinHeilongjiang 150000China Jinlin Provincial Academy of Forestry Science ChangchunJilin 130033China China National GeneBank BGI ResearchShenzhenGuangdong 518120China Guangdong Provincial Key Laboratory of Genome Read and Write BGI ResearchShenzhenGuangdong 518083China BGI Life Science Joint Research Center Northeast Forestry UniversityHarbinHeilongjiang 150040China Feline Research Center of National Forestry and Grassland Administration College of Wildlife and Protected AreaNortheast Forestry UniversityHarbinHeilongjiang 150040China National Forestry and Grassland Administration Research Center of Engineering Technology for Wildlife Conservation and Utilization HarbinHeilongjiang 150040China

DEAR EDITOR,Big cats,such as Amur tigers(Panthera tigris altaica)and Amur leopards(*** orientalis),are apex predator and have evolved specialized traits for hunting and carnivory(Moya et al.,2022),thus playing a crucial role in maintaining biodiversity and ecosystem integrity by regulating prey-predator ***,human-induced pressures,habitat fragmentation,and environmental alterations have restricted these species in small and isolated ***,all extant big cats are categorized as endangered or threatened according to their conservation *** tigers and Amur leopards share overlapping geographic ranges,habitats,and certain prey species in the forests of Northeast Asia(Jiang et al.,2015).To reduce interspecies conflict,these carnivores exhibit differentiated dietary and temporal *** tigers predominantly prey on large ungulates,while Amur leopards hunt small to medium-sized animals(Sugimoto et al.,2016).Additionally,they occupy different temporal niches,with tigers being active at night and leopards more active during the *** spatial and temporal niche partitioning,interspecific competition between these two species is ***,benefiting from their greater size,have a competitive advantage over leopards,which can manifest in occasional leopard predation by tigers and declines in leopard populations with increasing tiger density(Jiang et al.,2015).Tigers also displace leopards from marginal habitats in nature reserves where they coexist.

关键词： habitat Panthera resolved

核泄漏大气扩散与环境风险模拟:以山东半岛为例

在线全文

学校读者我要写书评

暂无评论

环境科学学报 2024年第6期44卷 292-299页

作者：单皖粤梁玉函王刚伯鑫徐鑫北京化工大学环境科学与工程系北京100029 北京化工大学北化中国工业碳中和研究院北京100029 三捷环境工程咨询(杭州)有限公司杭州310012

以山东半岛为研究区域,利用CALPUFF模型定量模拟了2018年1月1日—12月31日虚拟核电站在不同沿海网格内的放射性核素泄漏扩散情况.在此基础上,采用综合考虑人群影响与污染物浓度情况下的网格环境风险值的计算方法,表征核泄漏事故过程中... 详细信息

以山东半岛为研究区域,利用CALPUFF模型定量模拟了2018年1月1日—12月31日虚拟核电站在不同沿海网格内的放射性核素泄漏扩散情况.在此基础上,采用综合考虑人群影响与污染物浓度情况下的网格环境风险值的计算方法,表征核泄漏事故过程中潜在的核素环境风险影响,从而得到研究区域内的最优和最不利的厂址布点.此外,结合最优和最不利的厂址所在区域的风场资料,分析了不同季节的I-131的大气扩散情况.结果表明,位于威海市的44号网格总环境风险值为1.73×10^(10),总环境风险最低,为本研究中核电站的最优布局点.而位于青岛市的35号网格总环境风险值为9.98×10^(11),总环境风险值最高,不适合作为核电站布局点.I-131的大气扩散主要受所在区域主导风向的影响,最优和最不利的情景中I-131的月均浓度最大值均出现在夏季.对于核电厂的选址,应综合考虑风向、地形和人口因素,人口少、处于主导风向下风向的沿海地区更适合作为核电厂厂址.研究结果可为定量评估核电站布局选址的潜在核泄漏环境风险提供方法学参考,并为核电站现有的布局和选址方法提供新思路和技术支持.

关键词：核泄漏事故放射性核素扩散 CALPUFF模型厂址布局优化

基于卫星遥感的中国人为CO_(2)与大气污染物排放协同关系

在线全文

学校读者我要写书评

暂无评论

中国环境科学 2024年第6期44卷 3111-3121页

作者：王震山李新妹肖薇蒋宁萱柳艺博南京信息工程大学中国气象局生态系统碳源汇重点开放实验室江苏南京210044 南京信息工程大学气象灾害预报预警与评估协同创新中心江苏南京210044 民航西南空管局气象中心四川成都610202 福建省福州市气象局福建福州350008

基于多源卫星遥感数据和大气输送模型研究我国人为CO_(2)与大气污染物(NO_(2)和CO)排放协同关系以及新冠疫情管控期间污碳排放变化特征.结果表明:高人为CO_(2)排放对应高浓度的NO_(2)和CO排放,以省级行政区为单位的2018~2020年非生长季X... 详细信息

基于多源卫星遥感数据和大气输送模型研究我国人为CO_(2)与大气污染物(NO_(2)和CO)排放协同关系以及新冠疫情管控期间污碳排放变化特征.结果表明:高人为CO_(2)排放对应高浓度的NO_(2)和CO排放,以省级行政区为单位的2018~2020年非生长季XCO_(2)异常与XNO_(2)的相关性(r=0.79)高于与XCO的相关性(r=0.61),且高人为CO_(2)排放地区燃烧排放效率更高;2020年2月(疫情管控期)我国XCO_(2)异常、XNO_(2)、XCO下降的区域范围为2019年2月(疫情同比期)面积的50%、70%和49%,2020年2月XCO_(2)异常与XNO_(2)的相关性(r=0.71,P<0.01)高于2019年2月(r=0.59,P<0.01),而XCO_(2)异常与XCO的相关性(r=0.44,P<0.01)低于2019年2月(r=0.68,P<0.01);受大气输送的影响,2020年2月京津冀受西南方向人为排放地区输送的影响高于2019年2月,而长三角受北部长距离输送的影响降低,珠三角受大气输送的影响最小.研究结果表明卫星遥感可有效用于区域污碳协同排放时空变化特征监测.

关键词：人为CO_(2)排放大气污染协同关系新冠疫情卫星遥感

EXL-50 球形托卡马克装配测量基准的建立

在线全文

学校读者我要写书评

暂无评论

核聚变与等离子体物理 2024年第1期44卷 13-18页

作者：杨圆明陈博白仁华宋韵洋王宇贾朋美臧红薄晓坤袁保山河北省紧凑型聚变重点实验室廊坊065001

在EXL-50球形托卡马克安装过程中,通过在装置大厅布置参考点建立测量基准网,以真空室中心柱轴线和中平面建立全局坐标系,并以此构建了装置安装和测量基准网。通过该基准网的定位,对EXL-50装置真空室、环向场线圈、极向场线圈以及内部件... 详细信息

在EXL-50球形托卡马克安装过程中,通过在装置大厅布置参考点建立测量基准网,以真空室中心柱轴线和中平面建立全局坐标系,并以此构建了装置安装和测量基准网。通过该基准网的定位,对EXL-50装置真空室、环向场线圈、极向场线圈以及内部件偏滤器、限制器进行了安装和测量,主机安装结果符合设计要求。

关键词： EXL-50装置测量基准参考网

在线全文

学校读者我要写书评

暂无评论

泰州乡村旅游产业城乡融合建设对策研究

泰州职业技术学院学报 2024年第4期24卷 67-69,79页

作者：费诗伯刘红葛杉泰州职业技术学院江苏泰州225300

习近平总书记在党的二十大报告中强调:“加快建设农业强国,扎实推动乡村产业、人才、文化、生态、组织振兴。”这为新时代新征程全面推进乡村振兴、加快农业农村现代化提供了根本遵循。旅游产业城乡融合是江苏省委、省政府立足江苏实际... 详细信息

习近平总书记在党的二十大报告中强调:“加快建设农业强国,扎实推动乡村产业、人才、文化、生态、组织振兴。”这为新时代新征程全面推进乡村振兴、加快农业农村现代化提供了根本遵循。旅游产业城乡融合是江苏省委、省政府立足江苏实际、着眼乡村振兴做出的一项战略决策。文章以泰州乡村为研究对象,从生态、经济、产业、村民、村落等多个方面就乡村旅游产业城乡融合建设这一主题开展对策研究。

关键词：乡村旅游产业城乡融合