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Tungsten 2025年第1期 120-136页

作者： Zao-Ming Wu Lin He Lin-Sen Ye Xiao-Feng Yang Jia-Jia Zhang hong-bo lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

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Serological prevalence and risk factor analysis of hepatitis G virus infection in Hubei Province of China

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World Journal of Gastroenterology 2000年第4期6卷 585-587页

作者： De Ying Tian Dao Feng Yang Ning Shao Xia Zheng Gang Zhang hong bo lei Yuan Cheng Huang Department of Infectious Diseases Tongji HospitalTongji Medical UniversityWuhan 430030Hubei ProvinceChina Unit of National Genetic Engineering Xiamen UniversityXiamen 361005Fujian ProvinceChina

Hepatitis G virus (HGV),also known as GB virus C, is a recently cloned virus which may be associated with human non A-E hepatitis[1，2] It is parenterally transmitted and usually coinfected or superinfected with hepatitis B or hepatitis C virus[3-5]. Some investigations have been reported on the seroprevalence and molecular prevalence of HGV infection in different areas and different population[6-15]. Current infection of HGV is diagnosed by detection of HGV RNA, and past infection with HGV is detectable by testing anti-HGV envelope protein (E2)[16-17]. To investigate the prevalence of HGV in Hubei Province, a central area of the People's Republic of China, ELISA and RT-PCR were employed to detect serum anti-HGV and HGV RNA in 1516 patients who were divided into 16 groups.

关键词： hepatitis G virus enzyme linked immunoabsorbent assay risk factors polymerase chain reaction prevalence transcription genetic

Proton pump inhibitor for non-erosive reflux disease:A meta-analysis

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World Journal of Gastroenterology 2013年第45期19卷 8408-8419页

作者： Ji-Xiang Zhang Meng-Yao Ji Jia Song hong-bo lei Shi Qiu Jing Wang Ming-Hua Ai Jun Wang Xiao-Guang Lv Zi-Rong Yang Wei-Guo Dong Department of Gastroenterology Renmin Hospital of Wuhan University

AIM:To evaluate the efficacy,safety and influential factors of proton pump inhibitor(PPI)treatment for non-erosive reflux disease(NERD).METHODS:PubMed,MEDLINE,EMBASE and the Cochrane Library were searched up to April 2013 to identify eligible randomized controlled trials(RCTs)that probed into the efficacy,safety and influential factors of PPI treatment for *** rates of symptomatic relief and adverse events were measured as the *** RCT selection,assessment and data collection,the pooled RRs and 95%CI were *** meta-analysis was performed using the Stata 12.0 software(Stata Corporation,College Station,Texas,United States).The level of evidence was estimated by the Grading of Recommendations Assessment,Development and Evaluation ***:Seventeen RCTs including 6072 patients met the inclusion *** results of the metaanalysis showed that PPI treatment was significantly superior to H2receptor antagonists(H2RA)treatment(RR=1.629,95%CI:1.422-1.867,P=0.000)and placebo(RR=1.903,95%CI:1.573-2.302,P=0.000)for the symptomatic relief of ***,there were no obvious differences between PPI and H2RA(RR=0.928,95%CI:0.776-1.110,P=0.414)or PPI and the placebo(RR=1.000,95%CI:0.896-1.116,P=0.997)regarding the rate of adverse *** overall rate of symptomatic relief of PPI against NERD was 51.4%(95%CI:0.433-0.595,P=0.000),and relief was influenced by hiatal hernia(P=0.030).The adverse rate of PPI against NERD was 21.0%(95%CI:0.152-0.208,P=0.000),and was affected by hiatal hernia(P=0.081)and drinking(P=0.053).CONCLUSION:PPI overmatched H2RA on symptomatic relief rate but not on adverse rate for *** relief rate and adverse rate were influenced by hiatal hernia and drinking.

关键词： Proton pump inhibitor Non-erosive reflux disease Symptomatic relief Adverse event Meta-analysis

The association between metformin use and colorectal cancer survival among patients with diabetes mellitus:An updated meta-analysis

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Chronic Diseases and Translational Medicine 2017年第3期3卷 169-175页

作者： Shan Tian hong-bo lei Yu-Lan Liu Yan Chen Wei-Guo Dong Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Oncology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China

Objective: Recent studies have reported conflicting results on the correlation between metformin use and outcomes in patients with colorectal cancer (CRC). A meta-analysis was performed to evaluate the efficacy of metformin therapy on the prognosis of CRC patients with type 2 diabetes mellitus (T2DM).Methods: We conducted a systematic search of PubMed, EMBASE, the Cochrane Library, and the Web of Science for related articles up to August 2016. Two investigators independently identified and extracted information. Pooled risk estimates [hazard ratios (HRs)] and 95% confidence intervals (CIs) were calculated using fixed-effects models. The risk of publication bias was assessed by examining funnel plot asymmetry as well as Egger's test and Begg's ***: Of 81 articles identified, 8 retrospective cohort studies, representing 6098 cases of CRC patients with T2DM who used metformin and 4954 cases of CRC patients with T2DM who did not use metformin, were included in this meta-analysis. There was no significant heterogeneity and quality difference between studies. Metformin users had significantly improved overall survival (OS) (HR=0.82, 95%CI:0.77-0.87, P=0.000). However, Metformin use cannot affect CRC-specific survival (HR=0.84, 95%CI:0.69-1.02, P=0.079) compared to ***: This meta-analysis suggests that metformin use may improve survival among CRC patients with T2DM. However, prospective controlled studies are still needed to rigorously evaluate the efficacy of metformin as an anti-tumor agent.

关键词： Metformin Colorectal cancer Survival Anti-tumor agent Meta-analysis

In vivo therapeutic effect of in situ injection of recombinant adenovirus expressing mIFN-y gene on glioblastoma

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中国实验血液学杂志 1997年第3期5卷 307-308页

作者： ZhijianYue, bo hong, hong lei, Xuclno Cao Department of Neurosurgery, Changhai Hospital, The Second Military Medical University, Shangliai 200433 Department of Immunology, The Second Military Medical University, Shanghai 200433

Patients with malignant glioma have a poorprognosis despite the combined use of surgery,irradiation, chemotherapy, and a variety ofimmunotherapies. These patient are known to showdecreased circulatory immune function ... 详细信息

关键词： expressing adenovirus suppression glioma chemotherapy Interferon irradiation despite necrotic subcutaneous

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han bo lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei lei Liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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氧自由基失衡微环境对骨关节炎进展的影响

中国骨与关节杂志 2016年第12期5卷 939-943页

作者：李红波彭磊海南医学院附属医院骨科海口570102 海南医学院研究生院海口571199

骨关节炎（osteoarthritis,OA）主要表现为病变关节的关节软骨退行性变、继发性骨质增生,可累及病变关节滑膜、关节囊和关节其它毗邻结构[1],涉及关节软骨的侵蚀、骨赘形成、软骨下硬化以及滑膜和关节囊的一系列生化和形态学改变的慢性... 详细信息

骨关节炎（osteoarthritis,OA）主要表现为病变关节的关节软骨退行性变、继发性骨质增生,可累及病变关节滑膜、关节囊和关节其它毗邻结构[1],涉及关节软骨的侵蚀、骨赘形成、软骨下硬化以及滑膜和关节囊的一系列生化和形态学改变的慢性迁延性疾病[2]。骨关节炎自被发现以来,其定义一直存在争议,osteoarthritis最初由John Spender于1886年讲到类风湿关节炎的更适合名称时提出，

关键词：氧自由基自由基骨关节炎关节炎关节疾病

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

电流体动力喷射3D打印工艺参数对泰勒锥和打印图形的影响和规律

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工程科学学报 2018年第3期40卷 373-380页

作者：邹淑亭兰红波钱垒赵佳伟周贺飞朱晓阳张广明彭子龙青岛理工大学青岛市3D打印工程研究中心

电流体动力喷射3D打印是一种新型微纳增材制造技术,它具有成本低、结构简单、精度高、打印材料广泛等突出特点和优势.但是,由于电流体动力喷射3D打印的打印速度快、喷嘴和基底打印距离小,特别是对于微尺度特征图形的打印,其实际图形及... 详细信息

电流体动力喷射3D打印是一种新型微纳增材制造技术,它具有成本低、结构简单、精度高、打印材料广泛等突出特点和优势.但是,由于电流体动力喷射3D打印的打印速度快、喷嘴和基底打印距离小,特别是对于微尺度特征图形的打印,其实际图形及打印质量难以直接观测,而且影响打印图形精度和质量的工艺参数较多,各个工艺参数相互耦合和相应作用.因而直接有效的控制打印图形的精度（线宽）和质量（线边缘粗糙度）是其面临的一个挑战性难题.本文提出一种通过调整打印工艺参数间接控制泰勒锥形状和尺寸,进而实现对于打印图形精度和质量有效控制的新方法.建立了线宽与工艺参数、材料性能和基底关系的理论模型;通过实验,系统研究并揭示了电流体动力喷射3D打印工艺参数对泰勒锥和打印图形的影响及其规律;优化出针对同一喷嘴较为理想的喷印工艺窗口;并通过典型实验工程案例研究,采用内径60μm喷嘴实现了最小线宽3μm打印,验证了实验研究结果的正确性和有效性.本文提出的方法和实验研究结果为电流体动力喷射3D打印的打印精度、图形质量和打印稳定性改进及提高奠定了基础,并为简化和易于操作提供了一种切实可行的方法.

关键词：电流体动力喷射3D打印泰勒锥锥射流微纳增材制造工艺优化