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Persistent SARS-CoV-2 infection in asymptomatic young adults

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Signal Transduction and Targeted Therapy 2022年第4期7卷 961-963页

作者： Mai-Juan Ma Shao-Fu Qiu Xiao-Ming Cui Ming Ni hong-Jie Liu Run-Ze Ye Lin Yao hong-Bo Liu Wu-Chun Cao hong-bin song State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina Center for Disease Control and Prevention Chinese People’s Liberation ArmyBeijingChina Beijing Institute of Radiation Medicine BeijingChina School of Public Health Shandong UniversityJinanChina

Dear Editor,While most of the patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)cleared the virus within a few weeks of infection,some people have a persistent infection or persistent shedding viral RNA in the long *** persistent detection of viral RNA in clinical specimens is unlikely to reflect either relapse or reinfection in most cases because the replication-competent virus is generally not recoverable after ten days following symptom onset in mild to moderate cases of COVID-191 and after 20 days in severe or immunocompromised cases.

关键词： infection acute respiratory

Driving role of climatic and socioenvironmental factors on human brucellosis in China:machine-learning-based predictive analyses

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Infectious Diseases of Poverty 2023年第2期12卷 87-100页

作者： Hui Chen Meng-Xuan Lin Li-Ping Wang Yin-Xiang Huang Yao Feng Li-Qun Fang Lei Wang hong-bin song Li-Gui Wang Center for Disease Control and Prevention of Chinese People’s Liberation Army 20 Dong-Da-Jie StreetFengtai DistrictBeijing100071China Academy of Military Medical Sciences Academy of Military Science of Chinese People’s Liberation Army27 Taiping RoadHaidian DistrictBeijing100036China Chinese Centre for Disease Control and Prevention No.155 Changbai RoadChangping DistrictBeijing102206China School of Biological Science and Medical Engineering Beihang University37 Xueyuan RoadHaidian DistrictBeijing100191China Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology20 Dong-Da StreetFengtai DistrictBeijing100071China

Background Brucellosis is a common zoonotic infectious disease in *** study aimed to investigate the incidence trends of brucellosis in China,construct an optimal prediction model,and analyze the driving role of climatic factors for human *** Using brucellosis incidence,and the socioeconomic and climatic data for 2014–2020 in China,we performed spatiotemporal analyses and calculated correlations with brucellosis incidence in China,developed and compared a series of regression and Seasonal Autoregressive Integrated Moving Average X(SARIMAX)models for brucellosis prediction based on socioeconomic and climatic data,and analyzed the relationship between extreme weather conditions and brucellosis incidence using copula *** In total,327,456 brucellosis cases were reported in China in 2014–2020(monthly average of 3898 cases).The incidence of brucellosis was distinctly seasonal,with a high incidence in spring and summer and an average annual peak in *** incidence rate was highest in the northern regions’arid and continental climatic zones(1.88 and 0.47 per million people,respectively)and lowest in the tropics(0.003 per million people).The incidence of brucellosis showed opposite trends of decrease and increase in northern and southern China,respectively,with an overall severe epidemic in northern *** regression models using socioeconomic and climatic data cannot predict brucellosis *** SARIMAX model was suitable for brucellosis *** were significant negative correlations between the proportion of extreme weather values for both high sunshine and high humidity and the incidence of brucellosis as follows:high sunshine,r=−0.59 and−0.69 in arid and temperate zones;high humidity,r=−0.62,−0.64,and−0.65 in arid,temperate,and tropical *** Significant seasonal and climatic zone differences were observed for brucellosis incidence in ***,humidity,and wind speed significantly influenced brucello

关键词： Human brucellosis Socioeconomics Climatic Extreme weather Copula model

OCTA characteristics in non-arteritic central retinal artery occlusion and correlation with visual acuity

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 289-296页

作者： hong-Xia Gong bin Wu Shi-Yong Xie Wei Zhang song Chen Tianjin Key Lab of Ophthalmology and Visual Science Department of Ophthalmology for Integrated Traditional Chinese and Western MedicineTianjin Eye HospitalTianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300010China Eye Hospital Affiliated to Nankai University Tianjin 300020China

AIM:To observe the retinal and choroidal circulations in patients with non-arteritic permanent central retinal artery occlusion(NA-CRAO)via optical coherence tomography angiography(OCTA)and analyze their correlation with visual ***:Sixty-two eyes with clinically confirmed acute NA-CRAO were included in the study and divided into:A type(mild n=29),B type(moderate n=27)and C type(severe n=6)based on the degree of visual loss,retinal edema,and arterial blood flow delay in fundus fluorescence angiography(FFA).Contralateral healthy eyes were used as the control ***-corrected visual acuity(BCVA),slit lamp microscopy,indirect ophthalmoscopy,fundus color photography,OCTA,and FFA were ***’s correlation analysis was used to determine the correlations between retinal and choroidal vessels and visual ***:There were no statistically significant differences in age,gender,and intraocular pressure among the three types and the control group(P>0.05).Vessel density in deep capillary plexus(VD-DCP)significantly decreased(P<0.05)in all three types of NA-CRAO patients compared to the control *** density in superficial vascular plexus(VD-SVP)significantly decreased(P<0.05)in type A patients and choriocapillaris flow area significantly decreased(P<0.05)in type B and type C patients compared to the control group;while outer retinal flow areas significantly increased in the type A(P<0.05)and decreased in type C patients(P<0.05).The retinal thickness significantly increased in type C group(P<0.05).The VD-SVP at fovea in the type A was significantly lower than both of type B and *** VD-SVP at nasal parafovea in type A and B was significantly lower than type C(P<0.05).The logMAR BCVA of type A was significantly better than that of type B and C groups(P<0.05).Spearman’s correlation analysis showed that the logMAR BCVA was positively correlated with VD-SVP at fovea(r=0.679,P=0.031)and nasal parafovea(r=0.826,P=0.013).CONCLUSION:OCTA is valua

关键词： non-arteritic central retinal artery occlusion fundus fluorescence angiography optical coherence tomography angiography retinal vessel density visual acuity

A credible traffic prediction method based on self-supervised causal discovery

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Science China(Information Sciences) 2024年第5期67卷 244-258页

作者： Dan WANG Yingjie LIU bin song State Key Laboratory of Integrated Services Networks Xidian University

Next-generation wireless network aims to support low-latency, high-speed data transmission services by incorporating artificial intelligence(AI) technologies. To fulfill this promise, AI-based network traffic prediction is essential for pre-allocating resources, such as bandwidth and computing power. This can help reduce network congestion and improve the quality of service(QoS) for users. Most studies achieve future traffic prediction by exploiting deep learning and reinforcement learning, to mine spatio-temporal correlated variables. Nevertheless, the prediction results obtained only by the spatio-temporal correlated variables cannot reflect real traffic changes. This phenomenon prevents the true prediction variables from being inferred, making the prediction algorithm perform poorly. Inspired by causal science, we propose a novel network traffic prediction method based on self-supervised spatio-temporal causal discovery(SSTCD). We first introduce the Granger causal discovery algorithm to build a causal graph among prediction variables and obtain spatio-temporal causality in the observed data, which reflects the real reasons affecting traffic ***, a graph neural network(GNN) is adopted to incorporate causality for traffic prediction. Furthermore,we propose a self-supervised method to implement causal discovery to to address the challenge of lacking ground-truth causal graphs in the observed data. Experimental results demonstrate the effectiveness of the SSTCD method.

关键词： wireless network traffic prediction causal discovery self-supervised

Application of CFD and FEA Coupling to Predict Structural Dynamic Responses of A Trimaran in Uni-and Bi-Directional Waves

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China Ocean Engineering 2024年第1期38卷 81-92页

作者： LIAO Xi-yu XIA Jin-song CHEN Zhan-yang TANG Qin ZHAO Nan ZHAO Wei-dong GUI hong-bin Marine Design&Research Institute of China Shanghai 200011China Ship Structure Division China Ship Scientific Research CenterWuxi 214082China College of Ocean Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China School of Foreign Studies Jiangnan UniversityWuxi 214122China

To predict the wave loads of a flexible trimaran in different wave fields,a one-way interaction numerical simulation method is proposed by integrating the fluid solver(Star-CCM+)and structural solver(Abaqus).Differing from the existing coupled CFD-FEA method for monohull ships in head waves,the presented method equates the mass and stiffness of the whole ship to the hull shell so that any transverse and longitudinal section stress of the hull in oblique waves can be ***,verification study and sensitivity analysis are carried out by comparing the trimaran motions using different mesh sizes and time step *** on the wave elevation of uni-and bi-directional waves is also carried *** a comprehensive analysis on the structural responses of the trimaran in different uni-directional regular wave and bi-directional cross sea conditions is carried out,***,the differences in structural response characteristics of trimaran in different wave fields are *** results show that the present method can reduce the computational burden of the two-way fluid-structure interaction simulations.

关键词： CFD-FEA fluid-structure coupling structural responses trimaran bi-directional cross sea

Simultaneous acceleration of sulfur reduction and oxidation on bifunctional electrocatalytic electrodes for quasi-solid-state Zn–S batteries

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Science China Chemistry 2024年第5期67卷 1531-1538页

作者： Mingli Wang hong Zhang Tianhang Ding Fangjun Wu Lin Fu bin song Pengfei Cao Ke Lu Institutes of Physical Science and Information Technology School of Materials Science and EngineeringKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationAnhui UniversityHefei 230601China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

The incomplete sulfur reduction and high ZnS re-oxidation energy barrier along with severe side reactions during the battery cycling compromise the practical application of Zn–S electrochemistry. Herein, a bifunctional electrocatalytic sulfur matrix that simultaneously accelerates the sulfur reduction and ZnS oxidation is proposed to realize a highly-efficient Zn–S cell. It is revealed that the N-heteroatom hotspots are more favorable for facilitating the conversion of S to ZnS while the CoO nanocrystal substantially lowers the ZnS activation energy barrier thereby suppressing the formation of disproportionation species(e.g.,SO_(4)^(2-)) and accumulation of inactive ZnS. Accordingly, the Co O anchored on the N-doped carbon-supported sulfur cathode delivers a high Zn^(2+)storage capacity of 1,172 m Ahg^(-1)and outstanding cycling stability with a capacity retention of 71.6% after500 cycles with a high average Coulombic efficiency of 97.8%. Simultaneously, the stable cycling of solid-state Zn–S pouch cells with an energy density of 585 Whkg^(-1)sulfuris also demonstrated. Moreover, the postmortem analysis reveals that the degradation of Zn–S cells is mainly attributed to the limited reversibility of Zn anodes rather than the ZnS decomposition and/or accumulation. The approach to the bidirectional catalysis manipulated the sulfur redox provides a new perspective to realize the theoretical potentials of Zn–S cells.

关键词： Zn–S battery bifunctional catalysts solid-state battery sulfur redox degradation mechanism

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Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor

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World Journal of Gastroenterology 2024年第8期30卷 863-880页

作者： Gui-Ming Deng Hai-bin song Zhong-Ze Du Ying-Wei Xue hong-Jiang song Yuan-Zhou Li Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND The development and progression of gastric cancer(GC)are closely linked to the nutritional status of *** immunotherapy has been demonstrated to be clinically effective,the relationships of sarcopenia and myosteatosis with the use of immune checkpoint inhibitors(ICIs)in patients with gastric cancer remain to be *** We performed a retrospective study of patients who were undergoing immuno-therapy for *** the evaluation of sarcopenia,the optimal cut-off value for the skeletal muscle index was established using receiver operating characteristic analysis of data obtained from pre-treatment computed tomography images at the L3 vertebral *** was defined using the mean skeletal muscle density(SMD),with a threshold value of<41 Hounsfield units(HU)for patients with a body mass index(BMI)<25 kg/m^(2)and<33 HU for those with a BMI≥25 kg/m^(2).The log-rank test was used to compare progression-free survival(PFS)and overall survival(OS),and a Cox proportional hazard model was used to identify prognostic *** were developed to predict the PFS and OS of patients on the basis of the results of multivariate *** We studied 115 patients who were undergoing ICI therapy for GC,of whom 27.4%had sarcopenia and 29.8%had *** with sarcopenia or myosteatosis had significantly shorter PFS and OS than those without these ***,both sarcopenia and myosteatosis were found to be independent predictors of PFS and OS in patients with GC administering an *** prediction models created for PFS and OS were associated with C-indexes of 0.758 and 0.781,*** The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.

关键词： Gastric cancer Sarcopenia Myosteatosis,Immune checkpoint inhibitor Prognostic factor Overall survival Progression-free survival

Ratiometric fluorescence probe for accurate detection of Concanavalin A by coupling fluorescent microsphere with boric acid functionalized carbon dots

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Chinese Chemical Letters 2024年第2期35卷 460-463页

作者： Mingyue Xie Juan Chen Yufei Wang Bojun Liu Rong-bin song hong-Min Meng Zhaohui Li College of Chemistry Institute of Analytical Chemistry for Life ScienceHenan Joint International Research Laboratory of Green Construction of Functional Molecules and their Bioanalytical ApplicationsZhengzhou UniversityZhengzhou 450001China Zhengzhou Key Laboratory of Forensic Science and Technology Railway Police CollegeZhengzhou 450053China School of Ecology and Environment Zhengzhou UniversityZhengzhou 450001China

Accurate and sensitive strategies for Concanavalin A(Con A)sensing are conducive to the better cognition of various important biological and physiological ***,by designing dextran-functionalized fluorescent microspheres(DxFMs)and boric acid-modified carbon dots(BCDs)as recognition unit and built-in signal reference respectively,a ratiometric fluorescent detection platform was proposed for Con A detection with high *** this protocol,the BCDs/DxFMs precipitation was formed due to the covalent interactions between cis-diol of DxFMs and boronic acid groups of BCDs,thus only fluorescence of BCDs could be detected in the *** Con A was presented,it could bind to DxFMs through its carbohydrate recognition ability and suppress the subsequent assembly between DxFMs and BCDs,leading to the simultaneous capture of DxFMs and BCDs fluorescence in the *** the BCDs content was superfluous,their fluorescence intensities were basically constant in all *** on the unchanged BCDs fluorescence signal and target-dependent DxFMs fluorescence signal in supernatant,the ratiometric detection of Con A was *** optimized conditions,this ratiometric fluorescent platform displayed a linear detection range from 0.125μg/mL to 12.5μg/mL with a detection limit of 0.089μg/***,satisfied analytical outcomes for Con A detection in serum samples were obtained,manifesting huge application potential of this ratiometric fluorescent platform in clinical diagnosis.

关键词： Concanavalin A Fluorescent microspheres Carbon dots Ratiometric fluorescent assay Reliability

Advances in targeted drugs for allergic diseases

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Chinese Medical Journal 2021年第16期134卷 2006-2008页

作者： Xue-song Wang Guo-Yan Wang hong-bin song Yong-hong Lei hong-Tian Wang Department of Otorhinolaryngology-Head and Neck Surgery Binzhou Central Hospital Affiliated to Binzhou Medical CollegeBinzhouShandong 251700China Department of Ophthalmology First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Dermatology First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Hospitalization and Medical Record Management Hainan BranchChinese PLA General HospitalSanyaHainan 517000China Department of Otorhinolaryngology-Head and Neck Surgery Hainan BranchChinese PLA General HospitalSanyaHainan 517000China Department of Allergy Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Otorhinolaryngology-Head and Neck Surgery First Medical CenterChinese PLA General HospitalBeijing 100853China.

To the Editor:Since the first IgE monoclonal antibody was approved by the Food and Drug Administration in the USA in 2003,at least 14 kinds of targeted drugs are in the clinical application or pre-clinical *** two monoclonal antibodies targeting IgE are omalizumab and *** drugs targeting interleukin 4(IL-4)or IL-4R are pascolizumab,pitrakinra,altrakincept,and *** monoclonal antibodies targeting IL-5/IL-5R are mepolizumab,reslizumab,and *** monoclonal antibodies targeting IL-13 are lebrikizumab and *** monoclonal antibody targeting thymic stromal lymphopoietin(TSLP)is ***2 cytokine inhibitor is *** targeted drugs have achieved good results,but most of them are still in the pre-clinical *** article reviews the history,marketing situation,indications,contraindications,efficacy,and safety of these targeted drugs.

关键词： drugs allergic Th2 IgE