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Comprehensive metabolic profiling of dioxin-like compounds exposure in laying hens:Implications for toxicity assessment

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Journal of Environmental Sciences 2025年第2期148卷 107-115页

作者： Xiaoxu Hu Tong Xu Yangsheng chen Qian Zhang Lijuan Tang Liping Zheng Chu Wang Pu Wang Shujun Dong Ruiguo Wang Su Zhang Qinghua Zhang Heidi Qunhui Xie Li Xu bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Cardiology Beijing HospitalNational Center of GerontologyBeijing 100730China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Hubei Key Laboratory of Industrial Fume and Dust Pollution Control School of Environment and HealthJianghan UniversityWuhan 430056China Institute of Quality Standards and Testing Technology for Agro-Products Chinese Academy of Agricultural SciencesBeijing 100081China

The evaluation of toxicity related to polychlorinated dibenzo-p-dioxins and furans(PCDD/Fs)and dioxin-like polychlorinated biphenyls(DL-PCBs)is crucial for a comprehensive risk assessment in real-world exposure *** study employed a controlled feeding experiment to investigate the metabolic effects of dioxin-like compounds(DLCs)on laying hens via feed *** enriched with two concentrations(1.17 and 5.13 pg toxic equivalents(TEQ)/g dry weight(dw))were administered over 14 days,followed by 28 days of clean *** analyses of blood samples revealed significant metabolic variations between PCDD/Fs and DL-PCBs exposed groups and controls,reflecting the induced metabolic *** changes were observed in sphingosine,palmitoleic acid,linoleate,linolenic acid,taurocholic acid,indole acrylic acid,and dibutyl phthalate levels,implying possible connections between PCDD/Fs and DL-PCBs toxic effects and energy-neuronal imbalances,along with lipid accumulation and anomalous amino acid metabolism,impacting taurine ***,we identified three differential endogenous metabolites—L-tryptophan,indole-3-acetaldehyde,and indole acrylic acid—as potential ligands for the aryl hydrocarbon receptor(AhR),suggesting their role inmediating PCDD/Fs and DL-PCBs *** comprehensive investigation provides novel insights into the metabolic alterations induced by PCDD/Fs and DL-PCBs in laying hens,thereby enhancing our ability to assess risks associated with their exposure in human populations.

关键词： Polychlorinated dibenzo-p-dioxins and furans Dioxin-like polychlorinated biphenyls Laying hens Metabolomic

Anti-Swelling Polyelectrolyte Hydrogel with Submillimeter Lateral Confinement for Osmotic Energy Conversion

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Nano-Micro Letters 2025年第4期17卷 96-110页

作者： Yongxu Liu Jiangnan Song Zhen Liu Jialin chen Dejuan Wang Hui Zhi Jiebin Tang Yafang Zhang Ningbo Li Weijia Zhou Meng An hong Liu Guobin Xue Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022People’s Republic of China College of Mechanical and Electrical Engineering Shaanxi University of Science and TechnologyXi’an 710021People’s Republic of China School of Physics and Technology University of JinanJinan 250022People’s Republic of China State Key Laboratory of Crystal Materials Shandong University27 Shandanan RoadJinan 250100People’s Republic of China

Harvesting the immense and renewable osmotic energy with reverse electrodialysis(RED)technology shows great promise in dealing with the ever-growing energy *** key challenge is to improve the output power density with improved trade-off between membrane permeability and ***,polyelectrolyte hydrogels(channel width,2.2 nm)with inherent high ion conductivity have been demonstrated to enable excellent selective ion transfer when confined in cylindrical anodized aluminum pore with lateral size even up to the submillimeter scale(radius,0.1 mm).The membrane permeability of the anti-swelling hydrogel can also be further increased with cellulose *** real seawater and river water,the output power density of a three-chamber cell on behalf of repeat unit of RED system can reach up to 8.99 W m^(-2)(per unit total membrane area),much better than state-of-the-art *** work provides a new strategy for the preparation of polyelectrolyte hydrogel-based ion-selective membranes,owning broad application prospects in the fields of osmotic energy collection,electrodialysis,flow battery and so on.

关键词： Ionic polymer Hydrogel Confinement effect Anti-swelling Osmotic energy conversion

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： bin Xie Yuanhui Guo Yun chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

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苏轼、苏辙《郭纶》诗史事发微

西北大学学报(哲学社会科学版) 2025年第1期55卷 58-67页

作者：陈峰陈宾西北大学宋辽金史研究院暨历史学院陕西西安710127

苏轼、苏辙兄弟早年同作有题为《郭纶》的诗文,都是为一介武官郭纶所写,全文既记述了其生平概况,也充分表达了同情之意。借助二苏诗文提供的线索,再结合有关史料记载,不仅这位职官不显的人物事迹得以还原,并且还进一步印证了宋仁宗时代... 详细信息

苏轼、苏辙兄弟早年同作有题为《郭纶》的诗文,都是为一介武官郭纶所写,全文既记述了其生平概况,也充分表达了同情之意。借助二苏诗文提供的线索,再结合有关史料记载,不仅这位职官不显的人物事迹得以还原,并且还进一步印证了宋仁宗时代西北边防的相关问题。苏轼、苏辙兄弟这些诗文表露的主旨,反映了其入仕前曾经对武臣的认识。及至他们从政后,因逐渐受到士大夫群体主流观念的影响,对武臣以及武功的态度遂发生了较大的变化。由此,也为观察苏轼兄弟二人的文武观及其变化提供了不可多得的切入点。

关键词：苏轼苏辙郭纶武臣御夏战争

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

IL-17A mediates inflammation-related retinal pigment epithelial cells injury via ERK signaling pathway

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 15-27页

作者： Hui-Min Zhong bing-Qiao Shen Yu-hong chen Xiao-Huan Zhao Xiao-Xu Huang Min-Wen Zhou Xiao-Dong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China National Clinical Research Center for Ophthalmic Diseases Shanghai 200080China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Key Laboratory of Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China

AIM:To investigate whether interleukin-17A(IL-17A)gets involved in the mechanisms of inflammation-related retinal pigment epithelium(RPE)cells injury and its significance in age-related macular degeneration(AMD).MRTHODS:A sodium iodate(NaIO3)mouse model as well as IL-17A-/-mice were *** effects of inflammatory cytokines in RPE cells and retinal microglia before and after NaIO3 modeling in vivo and in vitro,were investigated using immunofluorescence,immunoprotein blotting,and quantitative real-time fluorescence polymerase chain reaction(qRT-PCR),*** using recombinant IL-17A protein(rIL-17A)or IL-17A neutralizing antibody(IL-17A NAb)were used to observe the subsequent differences in fundus,fundus photography and optical coherence tomography(OCT),cell viability,and expression of oxidative stress-related markers before and after modeling,and to screen for key signaling ***:In the scenario of NaIO3 stimulation,RPE cells obviously tended to *** proliferation and activation of retinal microglia was confirmed in NaIO3-stimulated mice,whereas such effects induced by NaIO3 were significantly ameliorated with IL-17A NAb intervention or in IL-17A-/-*** addition,IL-17A promoted the proliferation and activation of microglia as well as oxidative damage and the secretion of inflammatory cytokines alongside NaIO3-induced damage in RPE cells in vivo and ex ***,the extracellular signalregulated kinase(ERK)signaling pathway was shown to be participated in the regulation of NaIO3-induced RPE cells injury mediated by IL-17A in vivo and ex vivo,as IL-17A induced inflammatory cytokines release in the NaIO3 model was alleviated after blocking the ERK ***:IL-17A probably promotes the NaIO3-induced RPE cells injury through exacerbating inflammation in terms of retinal microglia activation and inflammatory cytokines release via ERK signaling *** of IL-17A may be a new potential ta

关键词： age-related macular degeneration retinal pigment epithelium NaIO3 microglia IL-17A

Research progress on secondary formation,photosensitive reaction mechanism and human health effects of chromophoric brown carbon

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Journal of Environmental Sciences 2025年第5期151卷 310-330页

作者： Baihang chen Jiangyao chen Guiying Li Taicheng An Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangdong Technology Research Center for Photocatalytic Technology Integration and Equipment Engineering Guangzhou Key Laboratory of Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China

Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human ***,BrC was a physically defined class of ***,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its ***,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly ***,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic *** chromophore precursor species exhibit variations,and their formation mechanisms are also ***,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human ***,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of *** all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.

关键词： Brown carbon Constituent characteristics Secondary formation mechanism Photosensitive Human health effects

DHA and EPA protect against cognitive impairment induced by chronic sleep deprivation through regulating iron-mitophagy homeostasis

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Food Science and Human Wellness 2025年

作者： Lu chen Yueqi Yang Ning Zhang bin Sun hongxia Che Zhengping Wang Jun Han Min Wen Institute of Biopharmaceutical Research， Liaocheng University College of Marine Science and Biological Engineering， Qingdao University of Science and Technology Pet Nutrition R research and Development Center Gambol Pet Group Co.，Ltd.

The cognitive impairments resulting from insufficient sleep have emerged as a significant public health concern in contemporary society， lacking effective treatments due to the absence of elucidation regarding its molecular mechanism. This study aimed to investigate the efficacy of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against cognitive deficits in a mouse model of chronic sleep deprivation (CSD)， and to elucidate the underlying mechanisms. CSD mice display significant cognitive deficits in the Morris water maze task with obviously neuronal damage. We observed that dysregulation of iron transport proteins (IRP1， TfR1， DMT1， and FPN1) in CSD mice resulted in iron deposition in the cortex. Subsequent assessment revealed upregulation of mitophagy and neuronal lipid peroxidation and downregulation of proteins in the mitochondrial respiratory chain complexes (I-V). Further molecular analysis revealed inhibition of the Sirt3-Nrf2 pathway and its downstream antioxidant molecules (e.g. GPX4， HO-1， SOD2， and NQO1). In contrast， dietary supplementation with DHA or EPA alleviated CSD-induced cognitive impairment by inhibiting neuronal ferroptosis through regulating iron-mitophagy homeostasis. Notably， EPA showed superior efficiency in ameliorating cognitive impairment， potentially due to its stronger interaction with Sirt3 compared to DHA.

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Analysis of metal ions in exhaled breath using a handheld sampler coupled to inductively coupled plasma mass spectrometry

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Science China Chemistry 2025年

作者： bin Li Mingjin He Tenggao Zhu Tongtong Yang Liyun Hu Xiaoping Zhang Rui Su Huanwen chen Academician Workstation Jiangxi University of Chinese Medicine Cancer Research Center Jiangxi University of Chinese Medicine State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation East China University of Technology

Various metals are fundamental elements in the human body. Detection of metals in the human body plays an important role in understanding health and disease but poses a great challenge to analytical science in noninvasiveness, sensitivity, and detection speed. In this study, a non-invasive handheld sampler was developed to couple to inductively coupled plasma mass spectrometry（ICP-MS） for sensitive detection of metal ions in exhaled breath. Fourteen endogenous exhaled breath metals were simultaneously detected. The limits of detection（LOD） of 14 metals were found to be 0.046–0.134 ng L-1. Linear dynamic responses were found to range from 1.0 to 500 ng L-1. Satisfactory measurement precision（RSD: 1.18%–11.93%） was also *** concentrations of metal ions ranging from ng mL-1to mg mL-1levels in breath and blood, it is interesting to find that there is a relatively stable ratio(Rblood/breath: 3.55 ± 0.23) by comparing the levels of 9 metal ions in blood and exhaled ***, sensitive detections of 14 breath metal ions from patients with liver cancer and lung cancer were also successfully conducted. A multivariate statistical approach is established for biomarker discovery of breath metals between healthy volunteers and cancer patients, elucidating that cancer progression plays multifaceted roles in affecting the metal ions in exhaled ***, our data demonstrated that the new method can be not only used for the quantitative detection of trace metal species with high accuracy and high throughput but also for new insights into compositions and changes of metals in exhaled breath.

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